I-cortisol ephezulu: inokuba yintoni, iimpawu kunye nendlela yokukhuphela

Umxholo

• Izizathu eziphambili
• Iimpawu ezinokubakho kunye nefuthe emzimbeni
• Ungawathoba njani amanqanaba e-cortisol
• Kutheni le nto ukukhulelwa kunyusa i-cortisol

I-cortisol ephezulu ibangelwa kukusetyenziswa kwe-corticosteroids ngaphezulu kweentsuku ezili-15, okanye ngokunyuka kwemveliso yeli hormone kwincindi yeadrenal, ngenxa yoxinzelelo olungapheliyo okanye ithumba elithile.

Xa le ngxaki ikrokrelwa, ngenxa yeziphumo ezibi ze-cortisol egqithisileyo, njengokufumana ubunzima, uxinzelelo lwegazi oluphezulu, isifo seswekile kunye ne-osteoporosis, ugqirha jikelele unokuyalela uvavanyo lwe-cortisol, ngokulinganisa igazi, umchamo okanye amathe.

Ukulawulwa kwale hormone kwenziwa ngokusebenza ngokwasemzimbeni kunye nokusetyenziswa kokutya okulawula uxinzelelo kunye neswekile esegazini, ezinje ngee-yam, ii-oats, amaqanda, iflakisi kunye nobisi kunye nezinye izinto, umzekelo. Nangona kunjalo, xa amanqanaba aphezulu e-cortisol eqatha, unyango olusekwe kwiziyobisi okanye nakwinkqubo yotyando, ekhokelwa yi-endocrinologist, iyafuneka.

Izizathu eziphambili

Ukusetyenziswa kweziyobisi ze-corticosteroid, ezinje nge-prednisone okanye i-dexamethasone, ngaphezulu kweentsuku ezili-15 lolona hlobo luqhelekileyo lwe-cortisol egqithisileyo egazini, kodwa ke ezinye izizathu zezi:

• Uxinzelelo olungapheliyo kunye nokulala ngokungaqhelekanga: Banako ukurhoxisa imveliso ye-cortisol kwaye ibangele ukuba inyuke emzimbeni;
• Ukungasebenzi kakuhle kwamadlala adrenal: kubangelwa bubukho be-tumor okanye ukucinywa kweeseli zayo, ezinokuvelisa i-cortisol engaphezulu;
• Ithumba lobuchopho: inokuvuselela ukhuseleko lwecortisol ngamadlala eadrenal.

Uxinzelelo luhlala lubangela utshintsho oluncinci kumaxabiso e-cortisol, ngelixa olona nyango lukhulu kakhulu kwaye lubangelwa lutshintsho oluthe ngqo kwiincindi zeadrenal kunye nengqondo.

Iimpawu ezinokubakho kunye nefuthe emzimbeni

Xa iveliswa kwincindi yeadrenal, icortisol ikhutshwa ekuhanjisweni ngenjongo yokulawula ukusebenza komzimba. Nangona kunjalo, xa ugqithisile, kwaye ixesha elide, kunokubangela iziphumo ezibi ezinje:

• Ukunyuka kobunzima, ukujikeleza kwesinqe kunye nokuqunjelwa, ngokugcina ulwelo, kunye nokwaba kwakhona amanqatha omzimba;
• Iswekile kunye namanqanaba eswekile egazi aphakamileyo, yokukhuthaza isenzo sesibindi ukuvelisa iswekile;
• Unyango, ngokunciphisa ukufakwa kwe-calcium ngumzimba kunye nokunciphisa i-collagen;
• Ukwanda koxinzelelo, ukucaphuka noxinzelelo, ngokubangela ukukhutshwa kwe-adrenaline kunye nokusebenza ngokuthe ngqo kwingqondo;
• Cholesterol ephezulu, ngokwandisa ukuveliswa kwamafutha sisibindi kunye nokukhutshelwa ekujikelezeni;
• Ukunciphisa izihlunu kunye nobuthathaka, kuba inciphisa ukuveliswa kweeproteni kwaye ithoba iiproteni kwizicwili;
• Uxinzelelo oluphezuluUkubangela ukugcinwa kwesodiyam kunye nolwelo, kunye nokonyusa ukukhutshwa kweadrenaline ekujikelezeni kwegazi;
• Ukunciphisa ukukhuselwa komzimba, ngokuthintela ukudumba kunye nokuzikhusela;
• Ukunyuka kwamanqanaba eehomoni zesilisa emzimbeni, apho kwabasetyhini kunokubangela iimpawu ezingathandekiyo, ezinje ngeenwele ezingaphezulu, ukuqina kwelizwi kunye nelahleko yeenwele;
• Utshintsho kumjikelo wokuya exesheni kunye nobunzima bokukhulelwa, ekucimiseni ulawulo lwamahomoni ababhinqileyo;
• Ubuqhophololo eluswini, ukwanda kwamanxeba, iziphako zolusu kunye neempawu zokolula, ngokunciphisa i-collagen kunye nokunciphisa isiphumo sokunyanga komzimba.

Igama lolu tshintsho lubangelwe kukunyuka okungapheliyo kwe-cortisol yi-Cushing's syndrome. Xa le syndrome okanye ukunyuka kwe-cortisol kurhanelwa, ugqirha oqhelekileyo okanye ugqirha we-endocrinologist unokuyalela ukuvavanywa kwegazi, umchamo okanye amathe, okubonisa ukwanda kwale hormone emzimbeni.

Ukuba ezi mvavanyo zixabiseke kakhulu, ugqirha uya kuthi emva koko aphande unobangela we-cortisol egqithileyo, ngovavanyo lweklinikhi, nange-tomography okanye nge-MRI, isisu kunye nengqondo, i-PET okanye i-scintigraphy.

Fumana ngakumbi malunga nokuba uvavanyo lwe-cortisol lwenziwa njani.

Ungawathoba njani amanqanaba e-cortisol

Njengoko i-cortisol inxibelelene ngokusondeleyo nenkqubo yeemvakalelo, indlela elungileyo yokulawula i-cortisol kukunciphisa uxinzelelo kunye noxinzelelo, kunye nonyango lwengqondo kunye nexesha lokuzonwabisa. Ukongeza, ukwenza imisebenzi yomzimba kunye nokutya ukutya okune-protein kunye ne-potassium, njengamaqanda, ubisi kunye neemveliso zobisi, intlanzi, i-oats, iiamangile, ii-chestnuts, i-chia kunye nembewu yeflakisi, nazo zinokunceda.

Kakade, ukuba ukugqithisa kwe-cortisol kubangelwa kukusetyenziswa kwe-corticosteroids, kufuneka isuswe ngokuthe chu, ngaphezulu kweentsuku ezininzi, ngokukhokelwa ngugqirha oqhelekileyo okanye ugqirha we-endocrinologist.

Xa unobangela wokunyuka, i-cortisol ibaxekileyo, njenge-tumor, unyango lwenziwa ngokusetyenziswa kwamayeza ukulawula inani lehomoni, njenge-metyrapone, aminoglutetimide, umzekelo, kunye notyando lokususa eli thumba , eziya kugqitywa kwaye zicwangciswe phakathi kwesigulana, ugqirha wezonyango kunye nogqirha.

Funda ngendlela yokwenza unyango lwendalo olunceda ukulawula i-cortisol ephezulu.

Kutheni le nto ukukhulelwa kunyusa i-cortisol

Amanqanaba aphezulu e-cortisol aqhelekile ekukhulelweni, ngakumbi kwiiveki zokugqibela zokukhulelwa, njengoko i-placenta ivelisa i-hormone, eyaziwa ngokuba yi-CRH, evuselela ukudibanisa kwe-cortisol, inyusa amanqanaba ayo emzimbeni womfazi okhulelweyo.

Nangona kunjalo, ngokuchaseneyo nokwenzekayo ngaphandle kokukhulelwa, la manqanaba aphezulu e-cortisol ngexesha lokukhulelwa kubonakala ngathi akayichaphazeli impilo kamama okanye yosana, njengoko kunyukile ukonga ukugcina ukukhulelwa okusempilweni kwaye kubonakala ngathi kuyanceda Ingqondo yomntwana kunye nophuhliso lwemiphunga. Ngesi sizathu, abantwana abazelwe ngaphambi kwexesha kunokwenzeka ukuba babe neengxaki zokuphefumla. Ke, xa umfazi okhulelweyo esemngciphekweni omkhulu wokuzalwa ngaphambi kwexesha, kuqhelekile ukuba ugqirha obelethisayo acebise ukulawulwa kwe-corticosteroids eyenziweyo, ukunceda ekukhuleni kwamalungu omntwana.

Iingxaki ze-cortisol ephezulu, ezinje nge-Cushing's syndrome, zinqabile kakhulu ngexesha lokukhulelwa kwanakwithuba lasemva kokubeleka, njengoko amanqanaba e-cortisol ethanda ukuwela kumaxabiso aqhelekileyo emva kokuba umntwana ezelwe.