I-EGCG (Epigallocatechin Gallate): Izibonelelo, Isikali, kunye noKhuseleko

Umxholo

• Yintoni i-EGCG?
• Ngokwendalo ifumaneka kukutya okwahlukeneyo
• Ngamana unokunika izibonelelo zempilo ezinamandla
• Iziphumo zokuchasana nokudumba
• Impilo yentliziyo
• Ukuhla ukusinda
• Impilo yobuchopho
• Isisombululo kunye neziphumo ebezingalindelekanga ezinokwenzeka
• Iziphumo ebezingalindelekanga ezinokwenzeka
• Umgca wezantsi

I-Epigallocatechin gallate (i-EGCG) sisityalo esikhethekileyo esifumana uninzi lwempembelelo enokubakho kwimpilo.

Kucingelwa ukunciphisa ukudumba, ukunceda ukunciphisa umzimba, kunye nokunceda ukuthintela isifo sentliziyo kunye nengqondo.

Eli nqaku liphonononga i-EGCG, kubandakanya izibonelelo zayo zempilo kunye neziphumo ebezingalindelekanga ezinokubakho.

Yintoni i-EGCG?

Eyaziwa ngokuba yi-epigallocatechin gallate, i-EGCG luhlobo lwento esekwe kwisityalo ebizwa ngokuba yi-catechin. IiCatechins zingahlulwahlulwa zibe liqela elikhulu lezityalo ezaziwa ngokuba ziipolyphenols ().

I-EGCG kunye nezinye iikatekini ezinxulumene noko zisebenza njengee-antioxidants ezinokuthi zikhusele kumonakalo weselfowuni obangelwa zii-radicals zasimahla ().

Iiradicals zasimahla ziisuntswana ezisebenzayo ezenziwa emzimbeni wakho ezinokonakalisa iiseli zakho xa amanani abo ephezulu kakhulu. Ukutya ukutya okuphezulu kwii-antioxidants ezinje ngeekatekini kunokunceda ukunciphisa umonakalo omkhulu wasimahla.

Ukongeza, uphando lubonisa ukuba iikatekini ezinjenge-EGCG zinokunciphisa ukudumba kwaye zithintele iimeko ezithile ezingapheliyo, kubandakanya isifo sentliziyo, isifo seswekile, kunye neminye imihlaza (,).

I-EGCG ikhona ngokwendalo kukutya okutya okusekwe kwizityalo kodwa ikwafumaneka njengesongezelelo sokutya esihlala sithengiswa ngendlela yesicatshulwa.

I-EGCG luhlobo lwesityalo esineekatekini. Uphando lubonisa ukuba iikatekini ezifana ne-EGCG zinokudlala indima ekukhuseleni iiseli zakho ekonakaleni nasekukhuseleni izifo.

Ngokwendalo ifumaneka kukutya okwahlukeneyo

I-EGCG mhlawumbi yaziwa kakhulu ngendima yayo njengeyona nto iphambili esebenzayo kwiti eluhlaza.

Ngapha koko, izibonelelo ezininzi zempilo ezinxulunyaniswa nokusela iti eluhlaza zihlala zifakwa kumxholo we-EGCG ().

Nangona i-EGCG ifunyenwe ikakhulu kwiti eluhlaza, ikwakhona ngesixa esincinci kwezinye ukutya, njenge (3):

• Iti: luhlaza, mhlophe, oolong, kunye neti emnyama
• Iziqhamo: I-cranberries, i-strawberries, i-blackberries, i-kiwis, i-cherries, iipereya, iiperesi, ii-apula kunye nee-avocado
• Amantongomane: ii-pecans, iipistachios, kunye neehazelnuts

Ngelixa i-EGCG yeyona katekin iphandwayo kwaye inamandla, ezinye iintlobo ezinje nge-epicatechin, epigallocatechin, kunye ne-epicatechin 3-gallate zinokubonelela ngezibonelelo ezifanayo. Ngapha koko, uninzi lwazo lufumaneka ngokubanzi kunikezelo lokutya (3,).

Iwayini ebomvu, itshokholethi emnyama, iimbotyi, kunye neziqhamo ezininzi yimizekelo embalwa yokutya okunika idosi ephezulu yekatekini ezikhuthaza impilo ().

I-EGCG ixhaphake kakhulu kwiti eluhlaza kodwa ikwafunyanwa ngamanani amancinci kwezinye iintlobo zeti, iziqhamo, kunye namandongomane. Ezinye iikatekini ezonyusa impilo zininzi kwiwayini ebomvu, itshokholethi emnyama, iimbotyi, kunye neziqhamo ezininzi.

Ngamana unokunika izibonelelo zempilo ezinamandla

Ityhubhu yovavanyo, isilwanyana, kunye nezifundo ezimbalwa zabantu zibonisa ukuba i-EGCG ibonelela ngezibonelelo ezininzi zempilo, kubandakanya ukunciphisa ukudumba, ukunciphisa umzimba, kunye nokuphucula impilo yentliziyo nengqondo.

Ekugqibeleni, uphando olongezelelekileyo luyafuneka ukuqonda ngcono ukuba ingasetyenziswa njani i-EGCG njengesixhobo sothintelo okanye unyango lwezifo, nangona idatha yangoku iyathembisa.

Iziphumo zokuchasana nokudumba

Uninzi lwebango le-EGCG lodumo luvela kumandla alo anamandla e-antioxidant kunye nokukwazi ukunciphisa uxinzelelo kunye nokudumba.

Iiradicals zasimahla ziisuntswana ezisebenzayo ezinokubangela ukonakala kwiiseli zakho. Ukuveliswa kwemveliso yasimahla okugqithisileyo kukhokelela kuxinzelelo lwe-oxidative.

Njenge-antioxidant, i-EGCG ikhusela iiseli zakho kumonakalo onxulunyaniswa noxinzelelo lwe-oxidative kwaye icinezela umsebenzi weekhemikhali ezinokuthomalalisa eziveliswe emzimbeni wakho, ezinjenge-tumor necrosis factor-alpha (TNF-alpha) ().

Uxinzelelo kunye nokudumba kunxulunyaniswa nezifo ezingapheliyo, kubandakanya umhlaza, isifo seswekile kunye nesifo sentliziyo.

Ke, iziphumo ezichasene nokudumba kunye ne-antioxidant ye-EGCG kucingelwa ukuba sesinye sezona zizathu siphambili sokwenza isicelo sayo esibanzi sokuthintela izifo ().

Impilo yentliziyo

Uphando lubonisa ukuba i-EGCG ekwiti eluhlaza inokuxhasa impilo yentliziyo ngokunciphisa uxinzelelo lwegazi, icholesterol, kunye nokuqokelelwa kwethala kwimithambo yegazi- zonke izinto ezinobungozi besifo sentliziyo (,).

Kwisifundo seeveki ezisi-8 kubantu abangama-33, ukuthatha i-250 mg ye-EGCG equlathe iti eluhlaza yonke imihla kukhokelele ekunciphiseni okuphawulekayo kwe-4.5% ye-LDL (embi) ye-cholesterol ().

Isifundo esahlukileyo kubantu abangama-56 safumana ukuncitshiswa okubonakalayo kuxinzelelo lwegazi, i-cholesterol, kunye neempawu zokukrala kwabo bathatha idosi yemihla ngemihla ye-379 mg ye-tea eluhlaza ekhutshwe ngaphezulu kweenyanga ezi-3 ().

Nangona ezi ziphumo zikhuthaza, uphando olongezelelekileyo luyafuneka ukuqonda ngcono ukuba i-EGCG iti eluhlaza inokunciphisa njani ingozi yesifo sentliziyo.

Ukuhla ukusinda

I-EGCG inokukhuthaza nokulahleka kwesisindo, ngakumbi xa ithathwa ecaleni kwe-caffeine ngokwendalo efumaneka kwiti eluhlaza.

Nangona uninzi lweziphumo zophando kwiziphumo ze-EGCG kwisisindo zingahambelani, olunye uphando olwenziweyo lwexesha elide luqaphele ukuba ukutya malunga neekomityi ezi-2 (14.7 ii-ounces okanye i-434 ml) yeti eluhlaza ngemini yayanyaniswa namafutha omzimba asezantsi kunye nobunzima ().

Izifundo ezongezelelekileyo zabantu zifumene ngokudibeneyo ukuba ukuthatha i-100-460 mg ye-EGCG kunye ne-80-300 mg ye-caffeine ubuncinci iiveki ze-12 inxulunyaniswa nokwehla kobunzima kunye nokunciphisa amanqatha omzimba ().

Okwangoku, utshintsho kubunzima okanye ukwakheka komzimba alubonakali ngokungaguqukiyo xa i-EGCG ithathwa ngaphandle kwe-caffeine.

Impilo yobuchopho

Uphando lwakwangoko lubonisa ukuba i-EGCG iti eluhlaza inokudlala indima ekuphuculeni ukusebenza kweeseli zemithambo-luvo kunye nokuthintela izifo zengqondo eziwohlokayo.

Kwezinye izifundo, iinaliti ze-EGCG ziphucule kakhulu ukudumba, kunye nokubuyiselwa kunye nokuvuselelwa kweeseli ze-neural kwiimpuku ezinokulimala kwentambo yomqolo (,).

Ukongeza, izifundo ezininzi zokujonga ebantwini zifumene ikhonkco phakathi kokutya okuphezulu kweti eluhlaza kunye nokunciphisa umngcipheko wokuhla kwengqondo okunxulumene nobudala, kunye nesifo sika-Alzheimer's kunye nesifo sikaParkinson. Nangona kunjalo, idatha ekhoyo ayihambelani ().

Ngaphezulu, kuhlala kungacacanga nokuba i-EGCG ngokuthe ngqo okanye mhlawumbi ezinye izinto zeekhemikhali zeti eluhlaza zinezi ziphumo.

Olunye uphando luyafuneka ukuqonda ngcono ukuba ngaba i-EGCG inokuthintela ngokufanelekileyo okanye inyange izifo zengqondo eziwohlokayo ebantwini.

I-EGCG ngeti eluhlaza inokubonelela ngezibonelelo ezahlukeneyo zempilo, ezinje ngokunciphisa ukudumba, ukwehla kobunzima, kunye nokuthintela izifo zentliziyo nengqondo. Okwangoku, uphando oluthe kratya ngokusebenza kwayo luyafuneka.

Isisombululo kunye neziphumo ebezingalindelekanga ezinokwenzeka

Nangona i-EGCG ifundwe amashumi eminyaka, iziphumo zayo zomzimba ziyahluka kakhulu.

Ezinye iingcali zikholelwa ekubeni oku kungenxa yokuba i-EGCG ithoba ngokulula ubukho beoksijini, kwaye abantu abaninzi abayifunxi ngokufanelekileyo kwindawo yokugaya ukutya ().

Isizathu soku asiqondakali ngokupheleleyo, kodwa inokunxulunyaniswa nenyaniso yokuba uninzi lwe-EGCG lugqitha amathumbu amancinci ngokukhawuleza kwaye luphela luthotywa ziintsholongwane kumathumbu amakhulu ().

Oku kuye kwenza ukuba kube nzima ukukhulisa iingcebiso zedosi.

Ikomityi enye (ii-ounces eziyi-8 okanye i-250 ml) yeti eluhlaza yenziwe iqulethe malunga ne-50-100 mg ye-EGCG. Imilinganiselo esetyenziswe kwizifundo zesayensi ihlala iphezulu kakhulu, kodwa eyona mali ibingahambelani (,).

Ukufakwa imihla ngemihla okulingana okanye ngaphezulu kwe-800 mg ye-EGCG ngemini kukonyusa amanqanaba egazi e-transaminases, isalathiso somonakalo wesibindi (17).

Elinye iqela labaphandi licebise inqanaba lokutya elikhuselekileyo le-338 mg ye-EGCG ngosuku xa lifakwe kwifom yokuxhasa eyomeleleyo (18).

Iziphumo ebezingalindelekanga ezinokwenzeka

Kubalulekile ukuba uqaphele ukuba i-EGCG ayikho i-100% ekhuselekileyo okanye engenabungozi. Ngapha koko, izongezo ze-EGCG zidityaniswe neziphumo ebezingalindelekanga ezimandundu, ezinje nge ():

• ukusilela kwesibindi kunye nezintso
• isiyezi
• iswekile esezantsi yegazi
• ianemia

Ezinye iingcali zichaza ukuba ezi ziphumo zingalunganga zinxulumene nongcoliseko olunetyhefu lwezongezo hayi i-EGCG uqobo, kodwa nokuba kunjalo, kuya kufuneka ulumke kakhulu ukuba ucinga ukuthatha olu ncediso.

Ukuthatha amathamo ongezelelweyo e-EGCG akucetyiswa ukuba ukhulelwe, njengoko inokuphazamisa imetabolism ye-folate-i-vitamin B ebalulekileyo ekukhuleni komntwana kunye nasekuphuhliseni-ukwandisa umngcipheko weziphene zokuzalwa njenge-spina bifida ().

Kuhleli kungacacanga nokuba ngaba izongezo ze-EGCG zikhuselekile kwabasetyhini abancancisayo, ngoko ke kungcono ukuba ukukuphepha kude kube kufumaneke uphando ().

I-EGCG inokuphazamisa ukufunxwa kwamayeza amiselweyo, kubandakanya iintlobo ezithile zokunciphisa i-cholesterol kunye neziyobisi ezichasayo ().

Ukuqinisekisa ukhuseleko, soloko unxibelelana nomboneleli wakho wezempilo ngaphambi kokuqala isongezelelo esitsha sokutya.

Okwangoku akukho ngcebiso icacileyo yedosi ye-EGCG, nangona i-800 mg yonke imihla ukuya kuthi ga kwiiveki ezi-4 isetyenziswe ngokukhuselekileyo kwizifundo. Izongezo ze-EGCG zidityaniswe neziphumo ebezingalindelekanga ezibi kwaye zinokuphazamisa ukufunxwa kwamayeza.

Umgca wezantsi

I-EGCG sisixhobo esinamandla esinokuxhamla impilo ngokunciphisa ukudumba, ukunceda ukunciphisa umzimba, kunye nokuthintela izifo ezithile ezinganyangekiyo.

Igcwele kakhulu iti eluhlaza kodwa ikwafumaneka nakwezinye ukutya kwezityalo.

Xa ithathwa njengesongezelelo, i-EGCG ngamanye amaxesha inxulunyaniswa neziphumo ebezingalindelekanga ezibi. Eyona ndlela ikhuselekileyo kukubonisana nomboneleli wakho wezempilo ngaphambi kokongeza i-EGCG kwisiqhelo sakho ukuqinisekisa ukuba oku kongezwa kukulungele.