Uvavanyo lwe-CPK: yeyantoni kwaye kutheni itshintshiwe
Umxholo
I-Creatinophosphokinase, eyaziwa ngokuba yi-CPK okanye i-CK, yi-enzyme esebenza ikakhulu kwizicubu zemisipha, kwingqondo nakwintliziyo, kwaye idosi yayo iyacelwa ukuba iphande ngomonakalo onokubakho kula malungu.
Ugqirha unokuyalela olu vavanyo xa umntu efika esibhedlele ekhalaza ngentlungu yesifuba okanye ukujonga iimpawu zestroke okanye nasiphi na isifo esichaphazela izihlunu, umzekelo.
Amaxabiso esalathiso
Amaxabiso esalathiso se-creatine phosphokinase (CPK) are I-32 kunye ne-294 U / L yamadoda kwaye I-33 kuye kwi-211 U / L yabasetyhini kodwa zinokwahluka ngokuxhomekeke kwilabhoratri apho uvavanyo lwenziwa khona.
Yenzelwe ntoni
Uvavanyo lwe-creatinophosphokinase (CPK) luluncedo ekuchongeni izifo ezinje ngokuhlaselwa yintliziyo, izintso okanye ukusilela kwemiphunga, phakathi kwabanye. Le enzyme yahlulwe yaziindidi ezintathu ngokokuma kwayo:
- CPK 1 okanye BB: Inokufumaneka kwimiphunga nakwingqondo, ikakhulu;
- CPK 2 okanye MB: Ifunyenwe kwimisipha yentliziyo kwaye ke inokusetyenziswa njengophawu lwe-infarction, umzekelo;
- CPK 3 okanye MMIkho kwizihlunu zemisipha kwaye imele i-95% yazo zonke i-creatine phosphokinases (BB ne-MB).
Umthamo wohlobo ngalunye lwe-CK lwenziwa ngeendlela ezahlukeneyo zelabhoratri ngokweempawu zayo nangokweempawu zonyango. Xa umyinge we-CPK uceliwe ukuba uvavanye infarction, umzekelo, i-CK MB ilinganiswa ukongeza kwezinye iimpawu zentliziyo, ezinje nge-myoglobin kunye ne-troponin, ikakhulu.
Ixabiso le-CK MB elilingana okanye elingaphantsi kwe-5 ng / mL ithathwa njengesiqhelo kwaye uxinizelelo lwayo luhlala luphezulu kwimeko yesifo sentliziyo. Amanqanaba e-CK MB ahlala enyusa iiyure ezi-3 ukuya kwezi-5 emva kwempembelelo, efikelela kwinqanaba ukuya kuthi ga kwiiyure ezingama-24 kwaye ixabiso libuyela esiqhelweni phakathi kweeyure ezingama-48 ukuya kwezingama-72 emva kokuthelekiswa. Ngaphandle kokuqwalaselwa njengesiphawuli sentliziyo esifanelekileyo, imilinganiselo ye-CK MB yokufumanisa isifo se-infarction kufuneka yenziwe kunye ne-troponin, ikakhulu ngenxa yokuba amaxabiso e-troponin abuyela esiqhelweni malunga neentsuku ezili-10 emva kwentsingiselo, ngenxa yoko, ethe ngqo. Jonga ukuba yintoni uvavanyo lwe troponin.
Ithetha ukuthini i-CPK ephezulu nephantsi
Ukonyuka koxinzelelo lwe-enzyme ye-creatinophosphokinase inokubonisa:
| High CPK | I-CPK esezantsi | |
| I-CPK BB | Isifo, ukubetha, ithumba lobuchopho, ukuxhuzula, ukusilela kwemiphunga | -- |
| I-CPK MB | Ukudumba kwentliziyo, ukonzakala kwesifuba, ukothuka ngombane, kwimeko yokwehliswa kwentliziyo, uqhaqho lwentliziyo | -- |
| MM CPK | Ukutyumka ukwenzakala, ukwenza umthambo kakhulu, ukungasebenzi kakuhle ixesha elide, ukusetyenziswa kweziyobisi ezingekho mthethweni, ukudumba emzimbeni, i-muscular dystrophy, emva kwe-electromyography | Ukuphulukana nobunzima bemisipha, i-cachexia kunye nokungondleki |
| I-CPK YONKE | Ukutya kakhulu iziselo ezinxilisayo, ngenxa yokusebenzisa amayeza afana ne-amphotericin B, i-clofibrate, i-ethanol, i-carbenoxolone, i-halothane kunye ne-succinylcholine elawulwa kunye, ityhefu nge-barbiturates | -- |
Ukwenza i-CPK dosing, ukuzila ukutya akunyanzelekanga, kwaye kunakho okanye kungacetyiswa ngugqirha, nangona kunjalo kubalulekile ukunqanda ukwenza umthambo onzima ubuncinci iintsuku ezi-2 ngaphambi kokwenza uviwo, njengoko le enzyme inokuphakanyiswa emva kokuzilolonga ngenxa kwimveliso yayo ngezihlunu, ukongeza ekunqunyanyisweni kwamayeza, anje nge-Amphotericin B kunye neClofibrate, umzekelo, njengoko zinokuphazamisa iziphumo zovavanyo.
Ukuba uviwo luyacelwa ngenjongo yokufumanisa isifo sentliziyo, kuyacetyiswa ukuba ubudlelwane phakathi kwe-CPK MB kunye ne-CPK buvavanywe kusetyenziswa le fomyula ilandelayo: 100% x (CK MB / CK iyonke). Ukuba iziphumo zolu lwalamano zingaphezulu kwe-6%, ibonisa ukwenzakala kwentliziyo yemisipha, kodwa ukuba ingaphantsi kwe-6%, luphawu lokonzakala kwizihlunu zamathambo, kwaye ugqirha kufuneka aphande unobangela.
Amanqaku Ngenxa Yakho
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