Uvavanyo lweHormone lokukhula: Into ekufuneka uyazi

Umxholo

• Umgaqo-nkqubo wovavanyo lwe-GH kunye neentlobo
• Uvavanyo lwe-serum ye-GH
• I-insulin efana nokukhula okufana novavanyo-1
• Uvavanyo lokucinezelwa kweGH
• Uvavanyo lokuvuselela i-GH
• Iindleko zovavanyo lweGH
• Ukutolika iziphumo zovavanyo lweGH
• Uluhlu oluqhelekileyo lweziphumo zovavanyo lweGH
• Uvavanyo lwe-GH ebantwaneni
• Uvavanyo lwe-GH kubantu abadala
• Ukuthatha

Ushwankathelo

Ihomoni yokukhula (GH) yenye yehomoni ezininzi eziveliswa yidlala yebhinqa kwingqondo yakho. Kwakhona kwaziwa ngokuba yi-hormone yokukhula komntu (HGH) okanye i-somatotropin.

I-GH idlala indima ebalulekileyo ekukhuleni komntu ngokwesiqhelo kunye nokukhula, ngakumbi ebantwaneni nakwishumi elivisayo. Amanqanaba e-GH aphezulu okanye asezantsi kunokuba kufanelekile anokukhokelela kwiingxaki zempilo kubo bobabini nakubantu abadala.

Ukuba ugqirha wakho ukrokrela ukuba umzimba wakho unokuvelisa kakhulu okanye i-GH encinci, baya kuyala iimvavanyo zokulinganisa amanqanaba e-GH egazini lakho. Ukuchonga nayiphi na imiba enxulumene ne-GH kuya kunceda ugqirha wakho enze uxilongo kwaye abone eyona ndlela ilungileyo yokunyanga.

Umgaqo-nkqubo wovavanyo lwe-GH kunye neentlobo

Kukho iintlobo ezahlukeneyo zovavanyo lweGH, kwaye inkqubo ethile yovavanyo iyahluka ngokuxhomekeka kuvavanyo lwakho.

Njengazo zonke iimvavanyo zonyango, kubalulekile ukuba ulandele yonke imiyalelo yokulungiselela evela kwiqela lakho lokhathalelo lwempilo. Ngokubanzi, kuvavanyo lwe-GH ugqirha wakho uya kukucela ukuba:

• ukuzila ukutya ixesha elithile phambi kovavanyo
• yeka ukuthatha i-vitamin biotin, okanye i-B7, ubuncinci iiyure ezili-12 ngaphambi kovavanyo
• yeka ukuthatha amayeza athile amiselweyo kwiintsuku ezimbalwa ngaphambi kovavanyo, ukuba zinokuphazamisa iziphumo zovavanyo

Kwezinye iimvavanyo, ugqirha wakho unokubonelela ngemiyalelo eyongezelelweyo yokulungiselela.

Akuqhelekanga ukuba abantu babe namanqanaba e-GH ngaphandle kwoluhlu oluqhelekileyo, ngoko ke iimvavanyo ze-GH azenziwa rhoqo. Ukuba ugqirha wakho ucinga ukuba amanqanaba e-GH emzimbeni wakho anokungaqhelekanga, baya kuthi bayalele enye okanye nangaphezulu kwezi mvavanyo zilandelayo.

Uvavanyo lwe-serum ye-GH

Uvavanyo lwe-GH serum lusetyenziselwa ukulinganisa isixa se-GH egazini lakho xa kutsalwa igazi. Kuvavanyo, ingcali yezempilo iya kusebenzisa inaliti ukuqokelela isampulu yegazi lakho. Uvavanyo ngokwalo luqhelekile kwaye alunabunzima okanye umngcipheko.

Isampulu yegazi iya kuthunyelwa elebhu ukuvavanywa. Iziphumo zovavanyo lwe-serum ye-GH zibonisa ugqirha wakho inqanaba le-GH egazini lakho kwindawo enye ngexesha lokuthathwa kwesampulu yegazi lakho.

Nangona kunjalo, oku akunakuba nolwazi olwaneleyo ukunceda ugqirha wakho ukuba enze uxilongo kuba amanqanaba e-GH emzimbeni wakho ngokwendalo aphakama kwaye awe ngalo lonke usuku.

I-insulin efana nokukhula okufana novavanyo-1

Uvavanyo lwe-insulin efana nokukhula kwe-factor-1 test (uvavanyo lwe-IGF-1) ihlala ilandelwa ngaxeshanye novavanyo lwe-GH serum. Ukuba ugqithisile okanye usilela kwi-GH, uya kuba namanqanaba aphezulu- okanye asezantsi kunalawo aqhelekileyo e-IGF-1.

Uncedo oluphambili lokuvavanya i-IGF kukuba, ngokungafaniyo ne-GH, amanqanaba ayo ahlala ezinzile. Isampulu yegazi enye kuphela efunekayo kuzo zombini iimvavanyo.

Uvavanyo lwe-GH serum kunye ne-IGF-1 aluhlali lubonelela ugqirha wakho ngolwazi olwaneleyo lokwenza uxilongo. Ezi mvavanyo zihlala zisetyenziselwa uhlolo, ukuze ugqirha wakho athathe isigqibo sokuba kuyafuneka na ukuvavanywa ngakumbi. Ukuba ugqirha wakho ukrokrela ukuba umzimba wakho uvelisa kakhulu okanye i-GH encinci, baya kuthi baodole uvavanyo loxinzelelo lwe-GH okanye uvavanyo lwe-GH lokukhuthaza.

Uvavanyo lokucinezelwa kweGH

Uvavanyo lwe-GH lokuncitshiswa kunceda ugqirha wakho aqinisekise ukuba umzimba wakho uvelisa kakhulu iGH.

Kolu vavanyo, ingcali kwezempilo iya kusebenzisa inaliti okanye i-IV ukuthatha isampulu yegazi. Emva koko uya kucelwa ukuba usele isisombululo esisezantsi esiqukethe iswekile, uhlobo lweswekile. Oku kuya kunambitheka kamnandi kancinci kwaye kunokuza kwiincasa ezahlukeneyo.

Ingcali kwezononophelo lwempilo izakuzoba ezinye iisampulu zegazi lakho ngamathuba amiselweyo ngexesha leeyure ezimbini emva kokuba usele isisombululo. Ezi iisampulu ziya kuthunyelwa kwilebhu yohlalutyo.

Uninzi lwabantu, iswekile iyayithoba imveliso yeGH. Ilebhu iya kujonga amanqanaba akho e-hormone ngokuchasene namanqanaba alindelekileyo kwithuba ngalinye lokuvavanya.

Uvavanyo lokuvuselela i-GH

Uvavanyo lokukhuthaza i-GH lunceda ugqirha wakho ukuba afumane ukugqitha okanye ukusilela kwimveliso yeGH.

Kolu vavanyo, ingcali yezempilo iya kuthi isebenzise i-IV ukuthatha isampulu yegazi yokuqala. Emva koko baya kukunika iyeza elibangela ukuba umzimba wakho ukhulule i-GH. Ingcali yezempilo iya kukujonga kwaye ithathe iisampulu zegazi ezininzi ngamathuba athile ngaphezulu kweeyure ezimbini.

Iisampulu ziya kuthunyelwa elebhu kwaye zithelekiswe namanqanaba alindelekileyo e-GH kwinqanaba ngalinye emva kokuthatha into evuselelayo.

Iindleko zovavanyo lweGH

Iindleko zovavanyo lwe-GH ziyahluka ngokusekwe kwi-inshurensi yakho, indawo apho kuvavanyo lwenziwe, kwaye yeyiphi ilebhu esetyenziselwa ukwenza uhlalutyo.

Olona vavanyo lulula zii-GH serum kunye ne-IGF-1 zovavanyo, ezifuna kuphela ukuzoba igazi. Ixabiso eliqhelekileyo kuvavanyo ngalunye lumalunga ne- $ 70 ukuba iyalelwe ngokuthe ngqo kwilebhu. Iindleko zakho zokwenyani zingahluka ngokuxhomekeka ekubeni iqela lakho lokhathalelo lwempilo lihlawulisa malini ngeenkonzo, njengokutsala igazi lakho ulithumele elebhu.

Ukutolika iziphumo zovavanyo lweGH

Ugqirha wakho uya kufumana iziphumo zakho zeelebhu aze azitolike. Ukuba iziphumo zakho zovavanyo zibonisa ukuba unokuba nemeko enxulumene ne-GH okanye ukuba ufuna olunye uvavanyo, iofisi kagqirha wakho iya kuhlala inxibelelana nawe ukulungiselela ukuqeshwa.

Ngokubanzi, iziphumo zovavanyo lwe-serum ye-GH kunye novavanyo lwe-IGF-1 alunikezeli ngolwazi olwaneleyo lokufumanisa isifo esimalunga ne-GH. Ukuba iziphumo aziqhelekanga, ugqirha wakho uya kuthi a-odole uxinzelelo lwe-GH okanye uvavanyo lokukhuthaza.

Ukuba inqanaba lakho le-GH ngexesha lovavanyo lokucinezela liphezulu, oko kuthetha ukuba iswekile ayikhange yehlise imveliso yakho ye-GH njengoko kulindelwe. Ukuba i-IGF-1 yakho ibiphezulu, ugqirha wakho unokufumanisa ukuba ukuveliswa ngokugqithisileyo kwe-GH. Ngenxa yokuba iimeko ezinxulumene nokukhula kwehomoni kunqabile kwaye kunokuba ngumceli mngeni ekuchongeni, ugqirha wakho unokucebisa ngovavanyo olongezelelweyo.

Ukuba amanqanaba akho e-hormone ngexesha lovavanyo lokuvuselela i-GH aphantsi, umzimba wakho awuzange ukhuphe i-GH eninzi njengoko kulindelwe. Ukuba inqanaba lakho le-IGF-1 laliphantsi, linokubonisa ukusilela kweGH. Kwakhona, ugqirha wakho uya kuphakamisa uvavanyo oluthe kratya ukuze aqiniseke.

Uluhlu oluqhelekileyo lweziphumo zovavanyo lweGH

Uvavanyo loxinzelelo, iziphumo ezingaphantsi kwe-0.3 nanograms ngeemililitha (ng / mL) zithathwa njengoluhlu oluqhelekileyo, ngokweKliniki yaseMayo. Nantoni na ephezulu ibonisa ukuba umzimba wakho unokuvelisa ukukhula kakhulu kwehomoni.

Uvavanyo lokukhuthaza, uxinzelelo oluphezulu ngaphezulu kwe-5 ng / mL ebantwaneni nangaphezulu kwe-4 ng / mL kubantu abadala ngokubanzi kuthathelwa ingqalelo kuluhlu oluqhelekileyo.

Nangona kunjalo, uluhlu lweziphumo eziqhelekileyo lunokwahluka ngokuxhomekeke kwilebhu kunye nomboneleli wakho wezempilo. Umzekelo, ezinye izikhokelo zithanda uxinzelelo oluphezulu ebantwaneni ukuze bakhuphe ngokupheleleyo ukusilela kwe-GH kusetyenziswa iimvavanyo zokukhuthaza.

Uvavanyo lwe-GH ebantwaneni

Ugqirha unokuyalela ukuvavanywa kwe-GH yabantwana ababonisa iimpawu zokusilela kwe-GH. Oku kubandakanya:

• ukukhula okucothayo kunye nokukhula kwethambo
• ukulibaziseka kokufikisa
• ubude obungaphantsi komndilili

I-GHD inqabile kwaye ayisoloko ingunobangela wokunqongophala komntwana okanye ukukhula kancinci. Umntwana unokuba ngaphantsi komndilili wokuphakama ngenxa yezizathu ezininzi, kubandakanya nemfuza elula.

Amaxesha okukhula kancinci aqhelekile ebantwaneni, ngakumbi ngaphambi kokufikisa. Abantwana abanesiphene se-GH bahlala bekhula ngaphantsi kwe-intshi ezimbini ngonyaka.

Ukuvavanywa kwe-GH kunokuba luncedo ukuba kukho imiqondiso yokuba umzimba womntwana uvelisa kakhulu i-GH. Umzekelo, oku kunokwenzeka kwimeko enqabileyo eyaziwa ngokuba yi-gigantism, ebangela ukuba amathambo amade, izihlunu kunye namalungu akhule ngokugqithileyo ebuntwaneni.

Uvavanyo lwe-GH kubantu abadala

Imizimba yabantu abadala ixhomekeke kwi-GH ukugcina ubunzima bemisipha kunye nokuxinana kwethambo, kunye nokulawula imetabolism.

Ukuba wenza i-GH encinci, unokunciphisa ubungakanani bamathambo kunye nobunzima bemisipha. Uvavanyo lwegazi oluqhelekileyo olubizwa ngokuba yiprofayili ye-lipid lunokubonisa utshintsho kumanqanaba amanqatha egazini lakho. Nangona kunjalo, ukusilela kwe-GH kunqabile.

I-GH eyongezelelweyo kubantu abadala inokubangela imeko enqabileyo ebizwa ngokuba yi-acromegaly, eyenza ukuba amathambo atyebe. Ukushiya kunganyangwa, i-acromegaly inokubangela iingxaki ezininzi, kubandakanya umngcipheko ophezulu we-arthritis kunye neengxaki zentliziyo.

Ukuthatha

Amanqanaba e-GH aphezulu kakhulu okanye asezantsi kakhulu anokubonisa iimeko zempilo ezinzulu. Nangona kunjalo, kubalulekile ukugcina engqondweni ukuba le miba inqabile.

Ugqirha wakho unokuyalela ukuvavanywa ukuze ujonge amanqanaba akho e-GH usebenzisa uxinzelelo lwe-GH okanye uvavanyo lokukhuthaza. Ukuba iziphumo zakho zovavanyo zibonisa amanqanaba e-GH angaqhelekanga, ugqirha wakho unokuyalela ukuvavanywa ngakumbi.

Ukuba ufumene imeko enxulumene ne-GH, ugqirha wakho uya kukucebisa malunga nonyango olungcono. I-Synthetic GH ihlala ichazwa kwabo banokusilela kwe-GH. Kubantu abadala kunye nabantwana, ukubhaqwa kwangethuba kubalulekile ukwandisa amathuba eziphumo ezilungileyo.