I-H2 Isamkeli seBlocker

Umxholo

• Zithini iiH2 Receptor blocker?
• Zisebenza njani ii-H2 Receptor blockers?
• Zithini iziphumo ebezingalindelekanga ze-H2 Receptor blocker?
• I-H2 Receptor Blockers vs iProton Pump Inhibitors (ii-PPIs)
• Olunye unyango
• Q:
• A:

UKURhoxiswa KWE-RANITIDINE

Ngo-Epreli 2020, uceliwe ukuba zonke iintlobo zokumiselwa kunye ne-over-the-counter (OTC) ranitidine (Zantac) zisuswe kwimarike yase-US. Olu ngcebiso lwenziwe kuba amanqanaba angamkelekanga e-NDMA, enokubangela i-carcinogen (imichiza ebangela umhlaza), yafunyanwa kwezinye iimveliso ze-ranitidine. Ukuba umiselwe i-ranitidine, thetha nogqirha wakho malunga nezinye iindlela ezikhuselekileyo ngaphambi kokuyeka iyeza. Ukuba uthatha i-OTC ranitidine, yeka ukuthatha ichiza kwaye uthethe nomboneleli wakho wezempilo malunga nezinye iindlela. Endaweni yokuthatha iimveliso ze-ranitidine ezingasetyenziswanga kwindawo yokubuyisela iziyobisi, zilahle ngokwemiyalelo yemveliso okanye ngokulandela i-FDA's.

Zithini iiH2 Receptor blocker?

I-H2 block blockers yiklasi yamayeza anokusetyenziselwa ukunyanga iimeko ezibangela ukuqaqanjelwa sisisu esiswini. La mayeza ayafumaneka ekhawuntarini nangemigqaliselo. I-H2 block blocker eqhelekileyo ibandakanya:

• nizatidine (Axid)
• ifototidine (iPepcid, iPepcid AC)
• cimetidine (iTagamet, iTagamet HB)

I-H2 receptor blockers ixhaphake kakhulu ukunyanga i-gastritis, okanye isisu esidumbileyo, kunye nokunyanga izilonda ezishushu. Izilonda ze-Peptic zizilonda ezibuhlungu ezenza ulusu lwesisu, umqala ongezantsi, okanye i-duodenum, eyinxalenye yokuqala yamathumbu amancinci. Bahlala bekhula njengesiphumo sokudumba kunye ne-acid engaphezulu kwesisu. Oogqirha banokucebisa i-H2 receptor blockers ukugcina izilonda zep peptic ekubuyeni.

I-H2 block blockers zihlala zisetyenziselwa ukunciphisa iimpawu zesifo se-reflux se-gastroesophageal (GERD). I-GERD luhlobo olungapheliyo lwe-acid reflux, ebangela ukuba imixholo yesisu esine-asidi ibuyele umva uye kwi-esophagus. Ukuvezwa rhoqo kwesisu esiswini kunokucaphukisa umqala kwaye kukhokelele kwiimpawu ezingathandekiyo, njengokuqaqamba kwentliziyo, isicaphucaphu, okanye ingxaki yokuginya.

I-H2 blockers inokusetyenziselwa ukunyanga iimeko eziqhelekileyo ezifana ne-Zollinger-Ellison syndrome, imeko ebangela ukwanda kwemveliso yesisu esiswini.

Oogqirha banokucebisa i-H2 receptor blocker ekusebenziseni iilebheli ezingekhoyo. Oku kuthetha ukusebenzisa amayeza ukunyanga imeko engavunyelwanga ukuba inyangwe. Umzekelo, ii-block blockers ze-H2 zinokusetyenziselwa ukunyanga iingxaki zepancreatic okanye zisetyenziswe kwimeko yokungavumi, nangona zingasetyenziswanga ngokwesiqhelo kwezi njongo.

Zisebenza njani ii-H2 Receptor blockers?

Xa uthatha i-H2 receptor blocker, izinto ezisebenzayo zisiya kwii-receptors ezithile kumphezulu weeseli zesisu ezikhupha iiasidi. Amayeza athintela ukusabela okuthile kweekhemikhali kwezi seli ukuze zingabinako ukuvelisa i-asidi eninzi. NgokweZiko leSizwe lezeMpilo, ii-H2 receptor blockers zinciphisa ukufihlwa kwesisu ngaphezulu kweeyure ezingama-24 ngama-70 epesenti. Ngokunciphisa inani leasidi esiswini, naziphi na izicwili ezonakalisiweyo zivunyelwe ixesha lokuphilisa.

Zithini iziphumo ebezingalindelekanga ze-H2 Receptor blocker?

Uninzi lweziphumo ebezingalindelekanga ezinxulunyaniswa ne-H2 receptor blockers zithambile kwaye zihlala zisihla njengoko umntu ethatha iyeza ekuhambeni kwexesha. Kuphela yi-1.5 yeepesenti yabantu abayekayo ukuthatha i-H2 receptor blocker ngenxa yeziphumo ebezingalindelekanga.

Ezinye zeziphumo ebezingalindelekanga ezinokuthi zenzeke nge-H2 receptor blocker zibandakanya:

• ukuqhina
• urhudo
• ubunzima bokulala
• umlomo owomileyo
• isikhumba esomileyo
• intloko ebuhlungu
• kukhala ezindlebeni
• impumlo esibalekayo
• ingxaki yokuchama

Biza ugqirha wakho ukuba unazo naziphi na ezinye iimpawu okrokrela ukuba zinokubangelwa kukuthatha i-H2 receptor blocker.

Kwiimeko ezinqabileyo, ii-block blockers ze-H2 zinokubangela iziphumo ezibi kakhulu, ezinje:

• iblita, ukutshisa, okanye ukukala ulusu
• utshintsho kumbono
• ukudideka
• ukuphazamiseka
• ubunzima bokuphefumla
• ukuvutha
• ukuqina kwesifuba
• ukubetha kwentliziyo ngokungaqhelekanga
• nemibono
• Iingcinga zokuzibulala

Fowunela ugqirha wakho okanye uye esibhedlele kwangoko ukuba unazo naziphi na kwezi mpawu.

Ngaphandle kweziphumo ebezingalindelekanga ezinokubakho, ii-block blockers ze-H2 zihlala zilunyango olusebenzayo kwiimeko ezibangela ukuqaqanjelwa sisisu esiswini. Wena kunye nogqirha wakho unokuxoxa ngobungozi obunokubakho kwaye unqume ukuba ngaba ii-block blockers ze-H2 zezona zilungileyo kwimeko yakho ethile. Akufanele uyeke ukuthatha amayeza akho ungakhange uthethe nogqirha wakho malunga nawo kuqala.

I-H2 Receptor Blockers vs iProton Pump Inhibitors (ii-PPIs)

Iiproton pump inhibitors (ii-PPIs) lolunye uhlobo lwamayeza asetyenziselwa ukunciphisa isisu esiswini kunye nokunyanga i-acid reflux okanye iGERD. Imizekelo yee-PPIs ibandakanya i-esomeprazole (Nexium) kunye ne-pantoprazole (Protonix).

Omabini la mayeza asebenza ngokuthintela kunye nokunciphisa ukuveliswa kwesisu esiswini, kodwa ii-PPI zithathwa ngokuba zomelele kwaye zikhawulezile ekunciphiseni iiasidi zesisu. Nangona kunjalo, ii-block blockers ze-H2 zinciphisa ngokuthe ngqo i-asidi ekhutshwe ngorhatya, negalelo eliqhelekileyo kwizilonda ezisemzimbeni. Kungenxa yoko le nto i-H2 receptor blockers imiselwe ngokukodwa kubantu abanezilonda ezisemngciphekweni wokuzifumana. Ii-PPIs zihlala zichazwe kubantu abane-GERD okanye i-acid reflux.

Oogqirha bahlala bengacebisi ukuthatha zombini i-PPI kunye ne-H2 receptor blocker ngaxeshanye. I-H2 block blockers inokuphazamisa ukusebenza kwee-PPIs. Ukuba iimpawu zakho ze-GERD aziphucuki ngokusetyenziswa kwe-PPI, ugqirha wakho unokucebisa nge-H2 receptor blocker endaweni yoko.

Olunye unyango

Ukuba unezilonda ze-peptic okanye i-GERD, ugqirha wakho uya kuncoma ukuba ugweme ukuthatha amayeza athile kwaye wenze utshintsho oluthile lokuphila ukuze unciphise iimpawu zakho.

Ukuba unezilonda ze-peptic, ugqirha unokucebisa ukuba unciphise ukusebenzisa kwakho iziyobisi ezichasayo (i-NSAID), ezinjenge-aspirin kunye ne-ibuprofen. Ukusetyenziswa rhoqo kunye nexesha elide kwezi ntlobo zamayeza kunokunyusa umngcipheko wesifo se-ultic peptic. Ugqirha wakho unokucebisa ukuba uthathe i-acetaminophen endaweni yoko. Nangona kunjalo, akufuneki uyeke ukuthatha nawaphi na amayeza ungakhange uthethe nogqirha wakho kuqala.

Ukwenza uhlengahlengiso kwindlela yokuphila kunokunceda ekunciphiseni iimpawu zesilonda. Oku kubandakanya:

• ukunciphisa ukusela utywala
• ukunqanda ukutya okuneziqholo
• ukunciphisa uxinzelelo
• ukuyeka ukutshaya

Ukuba unayo i-GERD okanye i-acid reflux, iindlela zokunyanga ezinokuthi zinciphise iimpawu zibandakanya:

• ukutya ukutya okuncinci okuncinci ngemini endaweni yokutya ezintathu ezinkulu
• ukunqanda utywala, icuba, kunye nokutya kunye neziselo ezaziwayo ezibangela iimpawu
• ukuphakamisa intloko yebhedi malunga nee-intshi ezi-6
• Ukutya amanqatha amancinci
• ukunqanda ukulala phantsi ubuncinci iiyure ezimbini emva kokutya
• ukunqanda amashwamshwam phambi kokulala

Thetha nogqirha wakho ukuba iimpawu zakho aziphuculanga ngonyango okanye iindlela zokuphila. Unokufuna unyango olunobundlongondlongo okanye utyando ukuphelisa isilonda okanye ukunciphisa i-asidi ye-asidi.

Kuya kufuneka ufune unyango kwangoko ukuba kukho ezi mpawu zilandelayo:

• ukhula iintlungu zesisu ezibi kakhulu kunokuba ubuqhele ukukufumana
• uhlakulela umkhuhlane omkhulu
• ufumana amava okugabha okungancedi lula
• uhlakulela utywala kunye nobunzima

Le miqondiso yeengxaki ezivela kwisifo sezilonda sesilonda esifuna ukulungiswa ngokukhawuleza.

Q:

Ngaba ukhona umntu ongafanelekanga ukuba athathe ii-block blockers ze-H2?

Isigulana esingaziwayo

A:

Zizigulana kuphela ezineempendulo ezibi okanye ezisongela ubomi kwii-H2 blocker ekufuneka zithintele ukuzithatha. Olu luhlu lwamayeza ludidi B ekukhulelweni oko kuthetha ukuba kukhuselekile ukuthatha ngexesha lokukhulelwa.

UTyler Walker, iimpendulo ze-MDA zimele izimvo zeengcali zethu zonyango. Yonke imixholo inolwazi ngokungqongqo kwaye akufuneki ukuba ithathelwe ingqalelo njengengcebiso yezonyango.