Ukulahleka kweenwele kunye neTesttosterone

Umxholo

• Iindlela ezahlukeneyo ze testosterone
• Ubume benkqayi
• I-DHT: Ihomoni emva kokulahleka kweenwele
• I-DHT kunye nezinye iimeko
• Yimfuza yakho
• Iintsomi: Ukuhamba kunye nokulahleka kweenwele
• Ukulahleka kweenwele kubafazi
• Unyango lokulahleka kweenwele

Ukuluka okunzima

Ubudlelwane phakathi kwe testosterone kunye nokulahleka kweenwele kunzima. Inkolelo ethandwayo yeyokuba amadoda anempandla anamanqanaba aphezulu e-testosterone, kodwa ngaba yinyani leyo?

Impandla yamadoda, okanye i-androgenic alopecia, ichaphazela amadoda aqikelelwa kwizigidi ezingama-50 kunye nabafazi abazizigidi ezingama-30 eUnited States, ngokweZiko leSizwe lezeMpilo (i-NIH). Ukulahleka kweenwele kungenxa yokuncipha kweefollic zeenwele kunye nefuthe lesiphumo kumjikelo wokukhula. Iinwele ezintsha ziba ngcono kwaye zicole de kungabikho zinwele zishiyekileyo kwaye iifollic ziye zalala. Oku kulahleka kweenwele kubangelwa zihomoni kunye nohlobo oluthile.

Iindlela ezahlukeneyo ze testosterone

I-testosterone ikhona emzimbeni wakho ngeendlela ezahlukeneyo. Kukho i "testosterone" yasimahla engabotshelelwanga kwiiproteni emzimbeni wakho. Le yeyona fomu ye testosterone ifumaneka kakhulu ngaphakathi komzimba.

I-Testosterone nayo ingabophelelwa kwi-albhamuin, iprotheni egazini. Uninzi lwe testosterone lubotshelelwe kwiprotein ebopha i-hormone-binding globulin (SHBG) kwaye ayisebenzi. Ukuba unenqanaba eliphantsi le-SHBG, unokuba nenqanaba eliphezulu le testosterone yasimahla kwigazi lakho.

I-Dihydrotestosterone (DHT) yenziwa nge testosterone nge-enzyme. I-DHT inamandla aphindwe kahlanu kune testosterone. I-DHT isetyenziswa ikakhulu ngumzimba kwiprostate, kulusu nakwizinwele.

Ubume benkqayi

Impandla yamadoda (MPB) inemilo eyahlukileyo. Iinwele zangaphambili ziyehla, ngakumbi emacaleni, zenza imilo engu-M. Le yinkqayi engaphambili. Isithsaba sentloko, esaziwa njenge-vertex, siba nenkqayi. Ekugqibeleni ezi ndawo zimbini zidibanisa ubume be "U". I-MPB inokude ifikelele nakwinwele zesifuba, ezinokubhitya njengoko uneminyaka yobudala. Ngokumangalisayo, iinwele kwiindawo ezahlukeneyo emzimbeni zinokuphendula ngokwahlukileyo kutshintsho lwehomoni. Umzekelo, ukukhula kweenwele ebusweni kunokuphucula ngelixa ezinye iindawo zinempandla.

I-DHT: Ihomoni emva kokulahleka kweenwele

I-Dihydrotestosterone (i-DHT) yenziwa kwi-testosterone yi-enzyme ebizwa ngokuba yi-5-alpha reductase. Inokwenziwa kwakhona kwi-DHEA, ihomoni exhaphake kakhulu kwabasetyhini. I-DHT ifunyenwe kulusu, iifollic hair, kunye neprostate. Izenzo ze-DHT kunye novakalelo lwee-follicles zeenwele kwi-DHT zezona zinto zibangela ukulahleka kweenwele.

I-DHT ikwasebenza kwi-Prostate. Ngaphandle kwe-DHT, iprotrate ayikhuli ngokwesiqhelo. Nge-DHT eninzi kakhulu, indoda inokukhulisa i-benign prostate hypertrophy, ekwabizwa ngokuba yi-prostate eyandisiweyo.

I-DHT kunye nezinye iimeko

Kukho ubungqina bokunxibelelana phakathi kwempandla kunye nomhlaza wedlala lesinye kunye nezinye izifo. I-Harvard Medical School inika ingxelo yokuba amadoda ane-vertex baldness anamaxesha aphindwe kabini nesihlanu kumngcipheko wokuba nomhlaza wedlala lobudoda kunamadoda angenawo amabala. Umngcipheko wesifo se-coronary disease siphezulu ngaphezu kweepesenti ezingama-23 kumadoda ane-vertex bald amabala. Uphando luyaqhubeka malunga nokuba ngaba kukho unxibelelwano phakathi kwamanqanaba e-DHT kunye ne-metabolic syndrome, isifo seswekile kunye nezinye iimeko zempilo.

Yimfuza yakho

Ayisiyo imali ye testosterone okanye ye-DHT ebangela ukuba yinkqayi; kukuziva ubuntununtunu beenwele zakho. Olovakalelo lubonwa yimfuza. Uhlobo lwe-AR lwenza ukuba ukwamkelwa kwizinwele zentloko ezisebenzisana ne testosterone kunye ne-DHT. Ukuba ii-receptors zakho zinobuthathaka ngakumbi, zibangelwa lula ngamanani amancinci e-DHT, kwaye ukulahleka kweenwele kwenzeka ngokulula njengesiphumo. Ezinye iintlobo zemfuza zinokudlala indima.

Ubudala, uxinzelelo, kunye nezinye izinto zinokuba nefuthe ekubeni uva ilahleko yeenwele. Kodwa iijethi zidlala indima ebalulekileyo, kwaye amadoda anezihlobo ezisondeleyo zamadoda kunye ne-MPB anomngcipheko ophezulu kakhulu wokuphuhlisa i-MPB ngokwabo.

Iintsomi: Ukuhamba kunye nokulahleka kweenwele

Zininzi iintsomi phaya malunga namadoda anebalding. Enye yazo kukuba amadoda ane-MPB ahlala enobungozi kwaye anamanqanaba aphezulu e-testosterone. Oku akunjalo. Amadoda ane-MPB anokuba nenqanaba lokujikeleza elisezantsi le testosterone kodwa amanqanaba aphezulu e-enzyme eguqula i-testosterone iye kwi-DHT. Ngenye indlela, unokuba neentlobo zofuzo ezikunika iifollic zeenwele ezibuthathaka kakhulu kwi-testosterone okanye kwi-DHT.

Ukulahleka kweenwele kubafazi

Abasetyhini banokufumana ilahleko yeenwele ngenxa ye-androgenetic alopecia. Nangona abasetyhini benamanqanaba asezantsi kakhulu e-testosterone kunamadoda, kunokwanela ukubangela ilahleko yeenwele ze-androgenetic.

Abasetyhini bafumana ipateni eyahlukileyo yokulahleka kweenwele. Ukucoca kwenzeka ngaphezulu kwentloko yentloko ekhayeni kwipateni "yomthi weKrisimesi", kodwa umgca wangaphambili wenwele awupheli. Ipateni yokulahleka kweenwele zabasetyhini (i-FPHL) ikwangenxa yezenzo ze-DHT kwiifollic zeenwele.

Unyango lokulahleka kweenwele

Iindlela ezininzi zokunyanga i-MPB kunye ne-FPHL zibandakanya ukuphazamisa isenzo se testosterone kunye ne-DHT. IFinasteride (Propecia) sisiyobisi esithintela i-5-alpha reductase enzyme eguqula i-testosterone iye kwi-DHT. Kuyingozi ukusebenzisa kwabasetyhini abanokukhulelwa, kwaye kunokubakho neziphumo ebezesondo zeli chiza kubo bobabini abesilisa nabasetyhini.

Enye i-5-alpha reductase inhibitor ebizwa ngokuba yi-dutasteride (Avodart) ngoku ijongwa njengonyango olunokubakho kwi-MPB. Okwangoku kwintengiso yonyango lweprostate eyandisiweyo.

Olunye ukhetho lonyango olungabandakanyi i-testosterone okanye i-DHT lubandakanya:

• minoxidil (Rogaine)
• ketoconazole
• Unyango lwe-laser
• uqhaqho lofakelo lweenwele