Sebenzisa i-Imuran ukunyanga i-Ulcerative Colitis (UC)

Umxholo

• Isebenza njani i-Imuran
• Ubungakanani
• Iziphumo ebezingalindelekanga zeImuran
• Umngcipheko owandisiweyo weentlobo ezithile zomhlaza
• Ukwanda kwezifo
• Ukuphendula ngokuchaseneyo
• Ipancreatitis
• Izilumkiso kunye nonxibelelwano
• Thetha nogqirha wakho

Ukuqonda i-ulcerative colitis (UC)

I-ulcerative colitis (i-UC) sisifo esizimele. Ibangela ukuba amajoni akho omzimba ahlasele amalungu omzimba wakho. Ukuba unayo i-UC, amajoni akho omzimba abangela ukudumba kunye nezilonda kuludwe lwekholoni yakho.

I-UC inokusebenza ngakumbi ngamanye amaxesha kwaye ingasebenzi kwabanye. Xa isebenza ngakumbi, uneempawu ezingaphezulu. La maxesha ayaziwa njengama-flare-ups.

Ukunceda ukuthintela i-flare-ups, ungazama ukunciphisa inani lefayibha ekutyeni kwakho okanye ukunqande ukutya okuthile okuneziqholo kakhulu. Nangona kunjalo, uninzi lwabantu abane-UC bafuna uncedo lwamayeza.

I-Imuran lunyango lomlomo olunokukunceda ulawule iimpawu zokumodareyitha ukuya kwi-UC ebukhali, kubandakanya isisu kunye neentlungu, urhudo, kunye nokugcina igazi.

Isebenza njani i-Imuran

Ngokwezikhokelo zeklinikhi zamva nje, unyango olukhethwayo lokunciphisa ukuxolelwa kwabantu abane-UC ukuya kuthi ga ngoku kubandakanya:

• icorticosteroids
• Unyango lwe-anti-tumor necrosis factor (anti-TNF) ngamachiza e-biologic adalimumab, golimumab, okanye infliximab
• I-vedolizumab, elinye ichiza lebhayoloji
• tofacitinib, iyeza lomlomo

Oogqirha bahlala bemisela i-Imuran kubantu abaye bazama ezinye iziyobisi, ezinje nge-corticosteroids kunye ne-aminosalicylates, ezingancediyo ukukhulula iimpawu zabo.

I-Imuran ligama elinguhlobo lwegama lesichazi i-azathioprine. Ikwiklasi yamachiza abizwa ngokuba zii-immunosuppressants. Isebenza ngokunciphisa impendulo yomzimba wakho.

Esi siphumo siya:

• ukunciphisa ukudumba
• gcina iimpawu zakho zijongiwe
• ukunciphisa amathuba akho okuhla

I-Imuran inokusetyenziswa ecaleni kwe-infliximab (i-Remicade, i-Inflectra) ukunyanzelisa ukuxolelwa okanye kukodwa ukugcina uxolelo. Nangona kunjalo, ezi zezokusetyenziswa kwelebheli ye-Imuran.

Ukusetyenziswa kweziyobisi ngaphandle kwelebheli kuthetha ukuba ichiza elivunyiweyo yi-FDA ngenjongo enye lisetyenziselwa injongo eyahlukileyo engekavunywa. Nangona kunjalo, ugqirha usenokulisebenzisa iyeza ukulungiselela loo njongo. Kungenxa yokuba i-FDA ilawula ukuvavanywa kunye nokuvunywa kwamachiza, kodwa hayi indlela abagqirha abazisebenzisa ngayo iziyobisi ukunyanga izigulana zabo. Ke, ugqirha wakho unokuyalela ichiza kodwa bacinga ukuba kokona kulungileyo ukukhathalela kwakho.

Kungathatha ukuya kwiinyanga ezintandathu ngaphambi kokuba i-Imuran iqale ukukhulula iimpawu zakho. I-Imuran inokuwunciphisa umonakalo odubulayo onokukhokelela kutyelelo lwesibhedlele kunye nemfuno yotyando.

Kukwabonakalisiwe ukunciphisa isidingo se-corticosteroids ezisoloko zisetyenziselwa ukunyanga i-UC. Oku kunokuba luncedo, kuba iicorticosteroids inokubangela iziphumo ebezingalindelekanga ezininzi xa isetyenziswa ixesha elide.

Ubungakanani

Kubantu abane-UC, idosi eqhelekileyo ye-azathioprine yi-1.5-2.5 milligrams ngokweekhilogram zobunzima bomzimba (mg / kg). Imuran ifumaneka kuphela njengecwecwe le-50-mg.

Iziphumo ebezingalindelekanga zeImuran

Imuran inokubangela neziphumo ebezingalindelekanga ezinokubakho. Ngelixa uyithathayo, licebo elihle ukubona ugqirha wakho rhoqo njengoko becebisa. Ngale ndlela, banokukujonga ngokusondeleyo kwiziphumo ebezingalindelekanga.

Iziphumo ezinobuzaza ze-Imuran zinokubandakanya isicaphucaphu kunye nokugabha. Iziphumo ebezingalindelekanga ezibi kakhulu zezi:

Umngcipheko owandisiweyo weentlobo ezithile zomhlaza

Ukusebenzisa i-Imuran ixesha elide kunokunyusa umngcipheko womhlaza wolusu kunye ne-lymphoma. I-Lymphoma ngumhlaza ochaphazela iiseli zakho zomzimba.

Ukwanda kwezifo

Imuran yehlisa umsebenzi wamajoni akho omzimba. Oku kuthetha ukuba amajoni akho omzimba anokungasebenzi kakuhle ukulwa nosulelo. Ngenxa yoko, ezi ntlobo zilandelayo zosulelo ziziphumo ebezingalindelekanga eziqhelekileyo:

• umngundo
• intsholongwane
• Intsholongwane
• iprotozoal

Nangona ziqhelekile, usulelo lusenokuba lukhulu.

Ukuphendula ngokuchaseneyo

Iimpawu zokungalungelani zihlala zenzeka kwiiveki zokuqala zonyango. Ziquka:

• isicaphucaphu
• ukugabha
• urhudo
• irhashalala
• ifiva
• ukudinwa
• iintlungu zemisipha
• isiyezi

Ukuba unayo le mpawu, qhagamshelana nogqirha wakho kwangoko.

Ipancreatitis

I-Pancreatitis, okanye ukudumba kwepancreas, sisiphumo esinqabileyo secala le-Imuran. Ukuba unempawu ezinje ngesisu esibuhlungu, ukugabha, okanye isitulo esinamafutha, biza ugqirha ngoko nangoko.

Izilumkiso kunye nonxibelelwano

I-Imuran inokusebenzisana nala mayeza alandelayo:

• ii-aminosalicylates, ezinje nge-mesalamine (Canasa, Lialda, Pentasa), ezihlala zimiselwe abantu abane-UC emnene ukuya kumodareyitha
• igazi elincinci le-warfarin (Coumadin, Jantoven)
• ii-angiotensin-converting enzyme (ACE) inhibitors, ezisetyenziselwa ukunyanga uxinzelelo lwegazi
• i-allpurinol (iZyloprim) kunye ne-febuxostat (i-Uloric), enokusetyenziselwa iimeko ezinjenge-gout
• i-ribavirin, iyeza le-hepatitis C
• co-trimoxazole (Bactrim), isibulali zintsholongwane

Ukuba ngoku uthatha elinye lala mayeza, ugqirha wakho unokuyeka ukusetyenziswa kwawo ngaphambi kokuba uqale i-Imuran.

Banokucebisa ngomthamo we-Imuran kuwe omncinci kunedosi yesiqhelo ye-Imuran. Idosi encinci iya kunceda ukunciphisa ukuhlangana kweziyobisi.

Thetha nogqirha wakho

Ugqirha wakho unokucebisa i-Imuran ukuba iziyobisi ezinje nge-aminosalicylates kunye ne-corticosteroids khange zisebenze ukulawula iimpawu zakho ze-UC. Inokukunceda ukunciphisa i-flare-ups kwaye ikuncede ulawule iimpawu zakho.

I-Imuran iza nomngcipheko weziphumo ebezingalindelekanga ezibi, kubandakanya ukwanda komngcipheko womhlaza kunye nosulelo. Nangona kunjalo, ukuthatha i-Imuran kunokukunceda ukuba uphephe iziphumo ebezingalindelekanga ezinxulunyaniswa nokusetyenziswa kwe-corticosteroid yexesha elide.

Thetha nogqirha wakho ukumisela ukuba ngaba i-Imuran lukhetho olufanelekileyo kuwe.