Umbhali: Louise Ward
Umhla Wokudalwa: 4 Eyomdumba 2021
Hlaziya Umhla: 1 Eyekhala 2024
Anonim
Inbrija® (levodopa inhalation powder) Demonstration Video
Ividiyo: Inbrija® (levodopa inhalation powder) Demonstration Video

Umxholo

Yintoni u-Inbrija?

I-Inbrija ligama elichaza amayeza asetyenziswayo ukunyanga isifo sika-Parkinson. Imiselwe abantu abanokubuya ngesiquphe kweempawu zikaParkinson ngelixa bethatha indibaniselwano yeziyobisi ebizwa ngokuba yi-carbidopa / levodopa. Oku kubuya kweempawu kubizwa ngokuba "lixesha elingavumelekanga." Kuyenzeka xa iziphumo ze-carbidopa / levodopa ziphela okanye ichiza lingasebenzi njengoko kufanelekile.

Emva kokuba uthathe i-Inbrija, ifikelela kwingqondo yakho kwaye ijike ibe yinto ebizwa ngokuba yi-dopamine. I-Dopamine inceda ukukhulula iimpawu zesifo sika-Parkinson.

I-Inbrija iza njengecapsule enepowder ngaphakathi kuyo. Qho xa uthenga i-Inbrija, uya kufumana isixhobo se-inhaler. Ubeka iifomsile kwisixhobo kwaye uphefumlele i-Inbrija ngomlomo wakho. Iyeza lifumaneka kuphela kumandla omnye: 42 milligrams (mg) ngephilisi nganye.

Ukusebenza ngempumelelo

I-Inbrija ifunyenwe iyasebenza ekunyangeni ixesha lesifo sika-Parkinson.

Kwisifundo seklinikhi, iziphumo ze-Inbrija zafaniswa ne-placebo (unyango ngaphandle kwesiyobisi esisebenzayo) kubantu abangama-226 abanesifo sikaParkinson. Bonke abantu abakwisifundo babethatha i-carbidopa / levodopa kodwa babesenempawu ezibonisa ngesiquphe zeParkinson's.


U-Inbrija wanikwa abantu ngalo lonke ixesha ebuya kwangoko. Emva kokuthatha i-Inbrija, i-58% yabantu ibuyele "kwixesha" lesifo sikaParkinson. Ixesha lixa ungaziva naziphi na iimpawu. Kubantu abathathe indawo ye-placebo, i-36% ibuyele kwixesha lika-Parkinson.

Inbrija generic

I-Inbrija (levodopa) ifumaneka kuphela njengonyango lwegama lophawu. Okwangoku ayifumaneki ngendlela eqhelekileyo.

Iziphumo ebezingalindelekanga ze-Inbrija

I-Inbrija inokubangela iziphumo ebezingalindelekanga ezinobulali okanye ezinobuzaza. Olu luhlu lulandelayo luqulathe ezinye zeziphumo ebezingalindelekanga ezinokubakho ngelixa uthatha i-Inbrija. Olu luhlu alubandakanyi zonke iziphumo ebezingalindelekanga ezinokubakho.

Ngolwazi oluthe kratya malunga neziphumo ebezingalindelekanga ze-Inbrija, thetha nogqirha wakho okanye usokhemesti. Banokukunika iingcebiso malunga nendlela yokujongana nayo nayiphi na imiphumela emibi enokuthi ikhathaze.

Iziphumo eziqhelekileyo ezichaphazelekayo

Iziphumo eziqhelekileyo eziqhelekileyo ze-Inbrija zingabandakanya:

  • ukukhohlela
  • usulelo oluphezulu lokuphefumla, njengokubanda okuqhelekileyo
  • isicaphucaphu esihlala ixesha elide (jonga "Iinkcukacha zeziphumo ebezingalindelekanga" ngezantsi)
  • ulwelo olunombala omnyama ofana nomchamo okanye ukubila (jonga “Iinkcukacha zeziphumo ezisecaleni” apha ngezantsi)

Uninzi lweziphumo ebezingalindelekanga zinokuhamba zingaphelanga iintsuku okanye iiveki ezimbalwa. Ukuba zinzima kakhulu okanye azihambi, thetha nogqirha wakho okanye usokhemesti.


Iziphumo ebezingalindelekanga ezimandundu

Iziphumo ezibi kakhulu ezivela kwi-Inbrija aziqhelekanga, kodwa zinokwenzeka. Shayela ugqirha wakho ngokukhawuleza ukuba unemiphumo emibi. Tsalela umnxeba ku-911 ukuba iimpawu zakho ziziva zisongela ubomi okanye ukuba ucinga ukuba unempilo kaxakeka.

Iziphumo ebezingalindelekanga ezimandundu kunye neempawu zazo zinokubandakanya:

  • ukurhoxisa isifo
  • i-hypotension (uxinzelelo lwegazi oluphantsi)
  • I-psychosis kunye nemibono (ukubona okanye ukuva into engekhoyo)
  • izibongozo ezingaqhelekanga
  • I-dyskinesia (ukungalawuleki kunye nokuhamba komzimba ngokukhawuleza)
  • ukulala ngexesha lemisebenzi yesiqhelo
  • iziphumo ezingaqhelekanga kwiimvavanyo zaselebhu, kubandakanya neemvavanyo zesibindi (inokuba luphawu lomonakalo wesibindi)

Phawula: Jonga icandelo le "Iinkcukacha zeziphumo ebezingalindelekanga" icandelo elingezantsi ukuze ufunde okungakumbi malunga nenye yeziphumo ebezingalindelekanga.

Iinkcukacha zesiphumo

Unokuzibuza ukuba zenzeka kangaphi iziphumo ebezingalindelekanga ngeli chiza, okanye nokuba ngaba ezinye iziphumo ebezingalindelekanga zinxulumene nalo. Nazi ezinye iinkcukacha kwiziphumo ebezingalindelekanga ezinokubangela okanye ezingabangeli.


Isifo sokurhoxa

Unokufumana isifo sokurhoxa emva kokuba wehlise ngesiquphe idosi yakho ye-Inbrija okanye uyeke ukuyithatha. Kungenxa yokuba umzimba wakho uqhela ukuba ne-Inbrija. Xa uyeka ngesiquphe ukuyithatha, umzimba wakho awunalo ixesha lokuhlengahlengisa ngokufanelekileyo ukungabinayo.

Iimpawu zesifo sokurhoxa zinokubandakanya:

  • umkhuhlane okanye ifiva ehlala ixesha elide
  • ukudideka
  • ukuqina kwemisipha
  • isingqi sentliziyo esingaqhelekanga (utshintsho kwintliziyo yakho)
  • utshintsho ekuphefumlweni

Tshela ugqirha wakho ukuba unazo naziphi na iimpawu zokurhoxa. Ungaqali ukuthatha i-Inbrija kwakhona ukuba uziva iimpawu zokurhoxa ngaphandle kokuba ugqirha ukucebisa. Banokukuyalela amayeza ukunceda kwiimpawu zakho.

Hypotension (uxinzelelo lwegazi olusezantsi)

Unokuba noxinzelelo lwegazi oluphantsi xa uthatha i-Inbrija. Kwisifundo seklinikhi, iipesenti ezi-2 zabantu abathatha i-Inbrija babenoxinzelelo lwegazi olusezantsi. Akukho namnye wabantu abathathe indawo ye-placebo (unyango ngaphandle kwesiyobisi esisebenzayo) owayenexinzelelo lwegazi.

Ngamanye amaxesha, uxinzelelo lwegazi oluphantsi lunokukwenza ukuba ulahlekelwe ngumgangatho kunye nokuwa. Ukukunceda ukunqanda oku, vuka kancinci ukuba ubuhleli okanye ulele kangangexesha elithile.

Iimpawu zoxinzelelo lwegazi oluphantsi zinokubandakanya:

  • isiyezi
  • isicaphucaphu esihlala ixesha elide
  • isiqaqa
  • ulusu lweclammy

Xelela ugqirha wakho ukuba ufumana iimpawu zoxinzelelo lwegazi ezisezantsi ezingahambiyo. Banokujonga uxinzelelo lwegazi ukuze babone ukuba une-hypotension. Kananjalo banokukunceda wenze isicwangciso sesondlo okanye ukumisela amayeza onyusa uxinzelelo lwegazi.

Ingqondo

Unokufumana iziqendu zengqondo (kubandakanya nemibono) ngelixa uthatha i-Inbrija. Ngeziqendu zengqondo, imeko yakho yokwenyani inokutshintshwa. Ungabona, uve, okanye uve izinto ezingezizo ezokwenyani. Ayaziwa ukuba ixhaphake kangakanani le mpembelelo yecala nge-Inbrija.

Iimpawu zesifo sengqondo zinokubandakanya:

  • nemibono
  • ukudideka, ukudideka, okanye ukucinga okungalungelelananga
  • ukulala (kunzima ukulala)
  • ndiphupha kakhulu
  • paranoia (ucinga ukuba abantu bafuna ukukulimaza)
  • ukukhohlisa (ukukholelwa izinto ezingeyonyani)
  • Ukuziphatha gwenxa
  • ukuphazamiseka okanye ukuziva ungonwabanga

Iziqendu zengqondo kufuneka zinyangwe ukuze zingakubangeli bubi. Yazisa ugqirha wakho ngoko nangoko ukuba uneempawu zengqondo. Banokuyalela amayeza ukunceda ngeempawu kunye neziqendu zengqondo. Tsalela umnxeba ku-911 ukuba iimpawu zakho ziziva zisongela ubomi okanye ukuba ucinga ukuba unempilo kaxakeka.

Izibongozo ezingaqhelekanga

I-Inbrija inokuchaphazela iindawo zobuchopho bakho ezilawula into ofuna ukuyenza. Ukuthatha i-Inbrija kunokutshintsha into kwaye nini xa ufuna ukwenza izinto. Ngokukodwa, unokuziva unomnqweno ogqithisileyo wokwenza izinto oqhele ukuzenza.

Iimpawu zingabandakanya:

  • umnqweno wokungcakaza ngesiquphe
  • ukuziphatha okunyanzelekileyo (njengokutya okanye ukuthenga)
  • umnqweno ogqithisileyo wesini

Ayaziwa ukuba ixhaphake kangakanani le mpembelelo yecala.

Ngamanye amaxesha, abantu abathatha i-Inbrija abakwazi ukuqaphela iminqweno yabo engaqhelekanga. Nika ingqalelo ekhethekileyo ukuba umhlobo okanye ilungu losapho lithi awuzenzi njengaye. Usenokuba neminqweno engaqhelekanga ungazi.

Tshela ugqirha wakho ukuba wena, usapho lwakho, okanye abahlobo bakho baphawula isimilo esingaqhelekanga kuwe. Ugqirha wakho unokunciphisa idosi yakho ye-Inbrija ukunceda ukunciphisa umngcipheko wokuba nezi zibongozo zingaqhelekanga.

IDyskinesia

Unokuba ne-dyskinesia (ukungalawuleki kunye nokuhamba komzimba ngokukhawuleza) ngelixa uthatha i-Inbrija. Kwisifundo seklinikhi, iipesenti ezi-4 zabantu abathatha i-Inbrija babene-dyskinesia. Xa kuthelekiswa, iipesenti ezi-1 zabantu abathatha indawo ye-placebo babene-dyskinesia. Ezi ntshukumo zenzeke ebusweni babantu, iilwimi, nakwezinye iindawo zomzimba wabo.

Iimpawu zedyskinesia zinokubandakanya:

  • Ukuhambisa intloko phezulu nasezantsi
  • fidgeting
  • ukungakwazi ukuphumla
  • ukujikeleza komzimba
  • ukuxhuma kwezihlunu
  • kuphithizela

Yazisa ugqirha wakho ukuba uneempawu zedyskinesia ngelixa uthatha i-Inbrija. Ugqirha wakho uya kujonga imeko yakho ukuze anqume ukuba i-Inbrija lelona nyango lilungileyo kuwe.

Ukulala ngexesha lemisebenzi yesiqhelo

U-Inbrija unokutshintsha ukuba ulala njani kwaye nini. Unokuziva uvukile ngokupheleleyo kodwa ulale ngequbuliso. Ayaziwa ukuba ixhaphake kangakanani le mpembelelo yecala.

Ngelixa uthatha i-Inbrija, unokulala ngequbuliso ngelixa usenza imisebenzi yesiqhelo, enje:

  • ukuqhuba
  • ukusebenzisa okanye ukuphatha izinto eziyingozi ezinje ngeemela
  • ukutya
  • ukwenza imisebenzi ebonakalayo, njengokuphakamisa izinto ezinzima
  • ukuthetha nabantu

Ngequbuliso ukulala kunokuba yingozi, kuxhomekeke kwinto oyenzayo. Umzekelo, unokuzenzakalisa kakubi wena kunye nabanye ukuba ulale xa uqhuba. Ke ngoko, kuya kufuneka uphephe ukuqhuba okanye ukuphatha izinto eziyingozi, ezinje ngeemela okanye ezinye izixhobo, ngelixa uthatha i-Inbrija.

Yazisa ugqirha wakho ukuba ukulala ngequbuliso kuchaphazela imisebenzi yakho yemihla ngemihla. Baza kukucebisa ngendlela yokujongana kakuhle nale mpembelelo yecala. Baza kuphinda baxoxe ukuba i-Inbrija iyeza elifanelekileyo kuwe.

Ukulala ngequbuliso kunokuqhubeka ukwenzeka ngaphezulu konyaka emva kokuba uqale ukuthatha u-Inbrija. Ukuba uyeka ukuthatha i-Inbrija, buza ugqirha wakho malunga nokuqhuba, ukusebenzisa oomatshini nokuphakamisa izinto ezinzima. Banokukucebisa malunga nokuba ngaba le misebenzi ikhuselekile kuwe ngeli xesha.

Iziphumo ezingaqhelekanga zovavanyo lwelabhoratri

I-Inbrija inokubangela iziphumo ezingezizo kuvavanyo lweelebhu, kubandakanya uvavanyo lwesibindi. Ezi ziphumo ezingaqhelekanga zinokuba luphawu lomonakalo wesibindi. Ayaziwa ukuba ixhaphake kangakanani le mpembelelo yecala.

Ukuba ucinga ukuba iziphumo zovavanyo lwaselebhu aziqhelekanga (ukuba into leyo iphezulu kakhulu), buza ugqirha wakho. Banokujonga kwiziphumo zakho ukujonga ukuba ngaba kukho into engalunganga.

Isicaphucaphu

Kwisifundo seklinikhi, iipesenti ezintlanu zabantu abathathe i-Inbrija babene-nausea. Xa kuthelekiswa, iipesenti ezi-3 zabantu abathathe indawo ye-placebo babene-nausea. Kuzo zombini ezi meko, isicaphucaphu besingenzima, kwaye khange sibangele naziphi na iingxaki ezinzima.

Thetha nogqirha wakho ukuba unesicaphucaphu ngaphezulu kweentsuku ezintathu. Banokukunceda wenze isicwangciso sesondlo ukunceda ukukhulula isicaphucaphu. Ukuba utshintsho kwindlela otya ngayo alunakunceda, ugqirha wakho unokukunika amayeza okuphelisa isicaphucaphu.

Umchamo omnyama-mnyama

Ngelixa uthatha i-Inbrija, unokuba nomchamo omnyama-mnyama. Olunye ulwelo lomzimba olufana nokubila, amathe okanye i-phlegm inokuba yimibala emnyama ngokunjalo. Ngokubanzi, oku akunabungozi kwaye akunampembelelo imbi emzimbeni wakho.

Ukuba uqhubeka nokuba nomchamo omnyama okanye olunye ulwelo lomzimba kwaye uqala ukukhathazeka, thetha nogqirha wakho. Banokucebisa uvavanyo lwegazi ukuqinisekisa ukuba i-Inbrija ikhuselekile kuwe.

Uxinzelelo (hayi isiphumo esisecaleni)

Uxinzelelo aluzange luxelwe njengeziphumo ebezingalindelekanga kuso nasiphi na isifundo sonyango se-Inbrija. Nangona kunjalo, uxinzelelo lunokuba sisiphumo esibi sesifo sikaParkinson.

Kuqikelelwa ukuba malunga neepesenti ezingama-35 zabantu abanesifo sikaParkinson banokuba neempawu zokudakumba. Le pesenti ingahluka ngokobudala babantu. Ngokwesiqhelo, abantu abancinci abaneParkinson banomngcipheko ophezulu woxinzelelo.

Iimpawu zoxinzelelo kubantu abanesifo sikaParkinson bahlukile kunabantu abangenayo le meko. Iimpawu zoxinzelelo eziqhelekileyo kubantu abaneParkinson zibandakanya:

  • lusizi
  • uxinzelelo olugqithisileyo
  • ukucaphuka
  • idysphoria (ndiziva ndingonwabanga bubomi)
  • ukungathembeki (ukuziva ngathi yonke into imbi okanye ulindele ezona ziphumo zibi)
  • iingcinga zokuzibulala

Thetha nogqirha wakho ukuba ucinga ukuba unokudakumba. Banokunxibelelana nezixhobo kunye nenkxaso ukukunceda uzive ungcono. Ukuba banokukufumanisa ukuba unoxinzelelo, banokuyalela amayeza ukuba anyangwe.

Ukungasebenzi kakuhle kwe-Erectile (hayi isiphumo esisecaleni)

Ukungasebenzi kakuhle kwe-Erectile (i-ED) khange kuxelwe njengempembelelo esecaleni nakuphi na ukufundwa kweklinikhi kwe-Inbrija.Kodwa amadoda anesifo sika-Parkinson anokuba ne-ED.

Kuqikelelwa ukuba i-79% yamadoda ane-Parkinson's ane-ED, iingxaki zokuchama, okanye ingxaki yokuba ne-orgasm. Ukuba isifo seParkinson sowesilisa siqhubele phambili, sinokubangela ukuba sibe no-ED obukrakra ngakumbi.

Amadoda anesifo sika-Parkinson abanalo noxinzelelo, uxinzelelo, okanye uxinzelelo banokuthi bandise i-ED xa kuthelekiswa nabanye. Ukusela utywala kunye nokutshaya icuba kunokwenza i-ED ibe nzima ngakumbi. Kuya kufuneka uphephe ukusela okanye ukutshaya ukuba unayo i-ED.

Yazisa ugqirha wakho ukuba unayo i-ED engapheliyo. Banokuyalela amayeza ukunyanga i-ED yakho.

Ukubila (hayi isiphumo esisecaleni)

Ukubila okugqithisileyo akuzange kuchazwe njengempembelelo yecala kuyo nayiphi na isifundo seklinikhi ye-Inbrija. Kodwa ukubila kunokuba luphawu lwe-hypotension (uxinzelelo lwegazi olusezantsi). Uxinzelelo lwegazi olusezantsi sisiphumo esibi se-Inbrija.

Uxinzelelo lwegazi oluphantsi oluchaphazela ibhalansi yakho kunye nokuma komzimba kuthiwa yi-orthostatic hypotension. Ukubila luphawu oluqhelekileyo loku. Ezinye iimpawu eziqhelekileyo ze-orthostatic hypotension zibandakanya:

  • isiyezi
  • isicaphucaphu
  • isiqaqa

Yazisa ugqirha wakho ukuba ufumana ukubila kakhulu okanye ezinye iimpawu ze-orthostatic hypotension. Baza kulinganisa uxinzelelo lwegazi ukuze babone ukuba une-hypotension. Ukuba wenza njalo, banokukunceda wenze isicwangciso sesondlo sokwandisa uxinzelelo lwegazi. Ukuba ayonyuki ngokutshintsha kwindlela otya ngayo, ugqirha wakho unokukunika amayeza okunyusa uxinzelelo lwegazi.

Inbrija idosi

Inbrija idosi ugqirha oyimiselayo iya kuxhomekeka kubuzaza bemeko oyisebenzisayo i-Inbrija ukunyanga kunye nendlela umzimba wakho osabela ngayo kwichiza.

Ngokuqhelekileyo, ugqirha wakho uya kukuqala kwiqondo eliphantsi. Emva koko baya kuyilungisa ngokuhamba kwexesha ukufikelela kwisixa esifanelekileyo kuwe. Ugqirha wakho uya kuthi ekugqibeleni anike idosi encinci enika isiphumo esifunayo.

Olu lwazi lulandelayo luchaza iidosi eziqhelekileyo ezisetyenziswayo okanye ezicetyiswayo. Nangona kunjalo, qiniseka ukuthatha idosi ekumisela ugqirha wakho. Ugqirha wakho uya kugqiba eyona milinganiselo ilungele iimfuno zakho.

Iifom zamachiza kunye namandla

I-Inbrija iza njengecapsule oyifaka ngaphakathi usebenzisa i-inhaler. Itholakala kuphela kumandla omnye: i-42 mg nge-capsule nganye.

Umyinge wesifo sika-Parkinson

Umthamo oqhelekileyo we-Inbrija zii-capsules ezimbini “ngexesha elishiyiweyo” lesifo sika-Parkinson. Ixesha eliphumayo xa unempawu zeParkinson ngaphandle kwonyango lwe-carbidopa / levodopa.

Akufanele uthathe idosi engaphezulu kwesinye (iipilisi ezimbini) ze-Inbrija ngexesha ngalinye. Kwakhona, sukuthatha ngaphezulu kweedosi ezintlanu (iicapsule ezili-10) ze-Inbrija ngosuku.

Kuthekani ukuba ndiphose idosi?

I-Inbrija kufuneka isetyenziswe kuphela xa unethuba lokuphumla. Ukuba awunalo ixesha lokuphumla, awudingi ukuthatha i-Inbrija. Ukuba unemibuzo malunga nokuba kufuneka uthathe nini i-Inbrija, thetha nogqirha wakho.

Ngaba kuya kufuneka ndisebenzise eli chiza ixesha elide?

I-Inbrija yenzelwe ukuba isetyenziswe njengonyango oluqhubekayo. Ukuba wena nogqirha wakho uthatha isigqibo sokuba i-Inbrija ikhuselekile kwaye iyasebenza kuwe, uya kuthatha ichiza ixesha elide.

Inbrija yesifo sika-Parkinson

Ulawulo lokutya kunye neziyobisi (i-FDA) livuma amayeza amiselweyo anje nge-Inbrija ukunyanga iimeko ezithile.

I-Inbrija ivunyiwe yi-FDA ukunyanga "amaxesha okuphuma" kwesifo sika-Parkinson kubantu abathatha indibaniselwano yeziyobisi ebizwa ngokuba yi-carbidopa / levodopa.

Amaxesha okuphuma e-Parkinson ayenzeka xa iziphumo ze-carbidopa / levodopa zinxibile okanye ichiza alisebenzi njengoko kufanelekile. Ukuba oku kuyenzeka, unokuba neempawu ezinzima zeParkinson's, kubandakanya iintshukumo ezingalawulekiyo. Emva kwexesha lokuphela, i-carbidopa / levodopa ingaqala ukusebenza kakuhle kwakhona.

Ukusebenza ngempumelelo

Kwisifundo seklinikhi, i-Inbrija yayisebenza ngokunyanga amaxesha esi sifo sika-Parkinson kubantu abathatha i-carbidopa / levodopa. U-Inbrija wazikhulula iimpawu ezinzima ze-Parkinson ezazinabantu ngexesha ngalinye lesithuba. Uninzi lwabantu abathatha i-Inbrija babenexesha labo lokuphela emva kokuthatha idosi.

Kolu phando, i-58% yabantu abafumana iimpawu ngequbuliso zesifo sika-Parkinson kwaye bathatha u-Inbrija bakwazi ukubuyela kwinqanaba labo "kwinqanaba" (kungekho zimpawu zeParkinson's). Xa kuthelekiswa, i-36% yabantu abathathe indawo ye-placebo (unyango ngaphandle kwesiyobisi esisebenzayo) babuyela kwixesha labo.

Kolu phononongo, ukusebenza kwe-Inbrija kulinganiswe kusetyenziswa i-UPDRS Icandelo III leemoto isikali semizuzu engama-30 emva kokuthatha idosi. Eli linqanaba elilinganisela ukuba zinzima kangakanani iimpawu zomzimba zomntu onesifo sikaParkinson. Ukwehla kwamanqaku kuthetha ukuba iimpawu zomntu azibi qatha kunangaphambili.

Emva kweeveki ezili-12, abantu abathathe i-Inbrija baye bancipha kwi-UPDRS Part III yemoto ye-9.8. Oku kuthelekiswa nokwehla kwamanqaku ayi-5.9 kubantu abathathe i-placebo.

Inbrija notywala

Akukho nxibelelwano lwaziwayo phakathi kwe-Inbrija kunye notywala. Nangona kunjalo, i-Inbrija kunye notywala zinokubangela ukuba nesiyezi kunye nokozela xa zisetyenziswa zodwa. Kwakhona, unokuba nengxaki yokugxila kunye nokusebenzisa ugwebo olulungileyo kubo bonke. Ukusela utywala ngelixa uthatha i-Inbrija kunokwenza ezi ziphumo zibe mbi ngakumbi.

Ukuba usela utywala, thetha nogqirha wakho malunga nokuba kukhuselekile na ukuba usele ngelixa uthatha i-Inbrija.

Ukusebenzisana kwe-Inbrija

I-Inbrija inokusebenzisana namanye amayeza. Iyakwazi ukusebenzisana nezibonelelo ezithile.

Unxibelelwano olwahlukileyo kunokubangela iziphumo ezahlukeneyo. Umzekelo, olunye unxibelelwano lunokuphazamisa ukusebenza kakuhle kwe-Inbrija. Olunye unxibelelwano lunokunyusa iziphumo zalo ebezingalindelekanga okanye lubenze bube nzima ngakumbi.

Inbrija kunye namanye amayeza

Apha ngezantsi kukho uluhlu lwamayeza anokusebenzisana no-Inbrija. Olu luhlu alunazo zonke iziyobisi ezinokuthi zinxibelelane no-Inbrija.

Ngaphambi kokuba uthathe i-Inbrija, thetha nogqirha wakho kunye nosokhemesti. Baxelele ngawo onke amayeza kagqirha, ekhawuntareni, kunye nezinye iziyobisi ozithathayo. Baxelele malunga nazo naziphi na iivithamini, amayeza esintu kunye nezixhasi ozisebenzisayo. Ukwabelana ngolu lwazi kunokukunceda uphephe unxibelelwano olunokubakho.

Ukuba unemibuzo malunga nokunxibelelana kweziyobisi okunokuchaphazela, buza ugqirha wakho okanye usokhemesti.

Inbrija kunye neziyobisi ezithile zoxinzelelo

I-Monoamine oxidase inhibitors (MAOIs) ziziyobisi ezisetyenziselwa ukunyanga uxinzelelo. Abantu abathatha uhlobo oluthile lala machiza, abizwa ngokuba zii-MAOIs ezingakhethiyo, akufuneki bathathe i-Inbrija.Ukuwathatha nge-Inbrija kunokubangela uxinzelelo lwegazi oluphezulu, olunokubangela iingxaki ezinzulu ezifana nesifo sentliziyo.

Ukuba uthatha i-MAOI engakhethiyo, kuya kufuneka ulinde iiveki ezimbini ubuncinci emva kwethamo lakho lokugqibela ngaphambi kokuba uqalise i-Inbrija.

Ii-MAOIs ezingakhethiyo eziqhelekileyo ezisetyenziselwa ukudakumba zibandakanya:

  • Isocarboxazid (iMarplan)
  • phenelzine (uNardil)
  • I-tranylcypromine (iParnate)

Thetha nogqirha wakho ukuba uthatha i-MAOI engakhethiyo. Banokumisela enye indlela kwi-Inbrija okanye kwi-antidepressant enokuthi ikhuseleke kuwe.

Ukuba uthatha olunye uhlobo lwe-MAOI, ebizwa ngokuba yi-MAO-B-inhibitor, ungathatha i-Inbrija. Nangona kunjalo, ukuthatha la machiza kunye kunokuphakamisa umngcipheko wokuba ne-hypotension (uxinzelelo lwegazi olusezantsi). Ngokukodwa, inokunyusa ithuba lakho lokuba noxinzelelo lwegazi oluchaphazela ukuma kwakho kunye nokulingana. Oku kunokukwenza ukuba ulahlekelwe yimali yakho kwaye uwele.

I-MAO-B-inhibitors eziqhelekileyo zisetyenziselwa ukudakumba zibandakanya:

  • irasagiline (Azilect)
  • iselegiline (Emsam, Zelapar)

Thetha nogqirha wakho ukuba uthatha i-MAO-B-inhibitor. Bangakwazi ukujonga uxinzelelo lwegazi ukuze babone ukuba unayo i-hypotension. Ukuba kuyimfuneko, banokukunceda wenze isicwangciso sesondlo okanye ukumisela amayeza okulawula uxinzelelo lwegazi.

Phawula: Ngolwazi oluthe kratya malunga noxinzelelo lwegazi oluphantsi, jonga icandelo le- "Inbrija icala" apha ngasentla.

Inbrija kunye ne-dopamine D2 receptor antagonists

Ukuthatha i-dopamine D2 receptor antagonists ene-Inbrija kunokwenza ukuba i-Inbrija ingasebenzi kakuhle. Kungenxa yokuba i-D2 receptor antagonists kunye ne-Inbrija baneziphumo ezichaseneyo kwingqondo yakho. I-D2 receptor antagonists yehlisa amanqanaba e-dopamine kwingqondo yakho, ngelixa i-Inbrija ibonyusa.

I-D2 receptor antagonists isetyenziselwa ukunyanga isifo sengqondo. I-dopamine D2 receptor antagonists eqhelekileyo ibandakanya:

  • prochlorperazine
  • chlorpromazine
  • iHaloperidol (iHaldol)
  • irisperidone (irisperdal)

Omnye umchasi we-D2, i-metoclopramide (Reglan), isetyenziselwa ukunyanga isifo se-reflux se-gastroesophageal, esisifo esinganyangekiyo se-acid reflux.

Yazisa ugqirha wakho ukuba uthatha i-dopamine D2 receptor antagonist. Banokuthetha nawe malunga nokuba ungathatha i-Inbrija okanye ukuba elinye iyeza lingangcono kuwe.

Inbrija kunye ne-isoniazid

I-Isoniazid yintsholongwane esetyenziselwa ukunyanga isifo sephepha (TB). Sebenzisa i-Inbrija kunye ne-isoniazid kunokwenza ukuba i-Inbrija ingasebenzi kakuhle. Kungenxa yokuba amachiza amabini anokubangela iziphumo ezichaseneyo kwingqondo yakho. I-Isoniazid inciphisa amanqanaba e-dopamine kwingqondo yakho, ngelixa i-Inbrija ibonyusa.

Xelela ugqirha wakho ngoko nangoko ukuba ngaba umiselwe i-isoniazid ukunyanga i-TB ngelixa uthatha i-Inbrija. Ungathetha malunga nokuba ngaba lelinye iyeza lokubulala iintsholongwane lingangcono kuwe. Ukuba i-isoniazid yeyona ndlela ilungileyo, ugqirha wakho unokutshintsha kwi-Inbrija uye kwelinye iyeza ukunyanga isifo sika-Parkinson.

Inbrija kunye neetyiwa zentsimbi okanye iivithamini

Ukuthatha i-Inbrija kunye namayeza aqukethe iityuwa zentsimbi okanye iivithamini kunokwenza ukuba i-Inbrija ingasebenzi kakuhle. Kungenxa yokuba iityiwa zentsimbi kunye neevithamini zinokunciphisa inani le-Inbrija efikelela kwingqondo yakho.

Yazisa ugqirha wakho ngawo onke amayeza owathathayo, kubandakanya neekhawuntareni. Ungathetha malunga nokuba uyeke na ukuthatha iziyobisi ezineetyuwa zentsimbi okanye iivithamini kuzo ngelixa uthatha i-Inbrija.

Inbrija kunye nemifuno kunye nezongezelelo

Abanye abantu bathatha isityalo semifuno esibizwa ngokuba IMucuna pruriens (Mucuna) ukunceda ukukhulula iimpawu zesifo sikaParkinson. IMucuna iza njengepilisi okanye umgubo. Zombini i-Inbrija kunye neMucuna ziqulathe i-levodopa, kwaye zombini zonyusa inani le-dopamine kwingqondo yakho.

Ukuba ne-dopamine eninzi kwingqondo yakho kunokuba yingozi. Inokubangela iziphumo ebezingalindelekanga ezimandundu, kubandakanya uxinzelelo lwegazi oluphantsi, isifo sengqondo, kunye nedyskinesia (jonga icandelo le- "Inbrija icala" apha ngasentla).

Thetha nogqirha wakho ukuba uthatha okanye ufuna ukuthatha iMucuna ngelixa usebenzisa i-Inbrija. Ungaxoxa malunga nokuba ngaba oku kukhuselekile, kwaye ukuba kunjalo, yeyiphi idosi kaMucuna ekhuthazwayo.

U-Inbrija usebenza njani

Isifo sikaParkinson sisifo esine-neurodeergenerative. Oku kuthetha ukuba kubangela iiseli (ezibizwa ngokuba zii-neuron) kwingqondo yakho kunye nasentanjeni ukuba zife. Akukaziwa ukuba kutheni iiseli zisifa kwaye kutheni iiseli ezintsha zingakhuli endaweni yazo.

Isifo sikaParkinson senza ukuba ulahlekelwe ziiseli ezininzi kumalungu omzimba wakho avelisa i-dopamine (into efunekayo ukulawula iintshukumo). Kungoko kwenziwa i-dopamine encinci, enegalelo kuphuhliso lweempawu zikaParkinson.

Ixesha elingaphezulu, ilahleko yeeseli ichaphazela ulawulo lwakho kwimizimba yakho. Xa oku kuphulukana nolawulo kusenzeka, ezona mpawu zixhaphakileyo zesifo sikaParkinson zihlala ziqala ukubonakala (kubandakanya iintshukumo ezingalawulwayo).

Wenza ntoni u-Inbrija?

I-Inbrija isebenza ikakhulu ngokwandisa inani le-dopamine kwingqondo yakho.

Amanani aphezulu edopamine anceda iiseli zakho ezisele ziphucule ukusebenza kwazo. Oku kunceda ukukhulula iimpawu zesifo sika-Parkinson kwaye kukuvumela ukuba ulawule ngcono iintshukumo zakho.

Kuthatha ixesha elingakanani ukusebenza?

U-Inbrija uqala ukusebenza kwisithuba semizuzu emva kokuba uyithathile. Kwabaninzi abantu, iimpawu ezibi zesifo sikaParkinson ziyakhululwa kwisithuba semizuzu engama-30 yokuthatha i-Inbrija.

I-Inbrija isetyenziselwa kuphela ukunyanga iimpawu ezinzima ngexesha "lokuvala ixesha" lesifo sikaParkinson. Iimpawu zakho zingabuya emva kweziphumo ze-Inbrija. Kule meko, thatha i-Inbrija kwakhona njengoko kucetyiswa ngugqirha wakho (jonga icandelo le- "Inbrija dosage" apha ngasentla).

Thetha nogqirha wakho ukuba unamaxesha angaphezu kwesihlanu kwisifo sikaParkinson ngemini. Ngokudibeneyo, unokuthatha isigqibo sokuba amayeza akho emihla ngemihla kaParkinson asebenzela wena okanye ukuba kufuneka uzame ichiza elahlukileyo.

Ixabiso le-Inbrija

Njengawo onke amayeza, iindleko ze-Inbrija ziyahluka. Ukufumana amaxabiso akhoyo ngoku e-Inbrija kwindawo yakho, jonga WellRx.com. Iindleko ozifumana kwi-WellRx.com yinto onokuyihlawula ngaphandle kwe-inshurensi. Ixabiso langempela oza kulihlawula lixhomekeke kwisicwangciso sakho seinshurensi, indawo okuyo, kunye nekhemesti oyisebenzisayo.

Kubalulekile ukuba uqaphele ukuba i-Inbrija inokufumaneka kuphela kwiikhemesti ezikhethekileyo. Ezi ziikhemesti ezigunyazisiweyo ukuba ziphathe amayeza awodwa (amayeza antsonkothileyo, anamaxabiso aphezulu, okanye kunzima ukuwathatha).

Uncedo lwezezimali kunye neinshurensi

Ukuba ufuna inkxaso yemali ukuhlawulela i-Inbrija, okanye ukuba ufuna uncedo lokuqonda i-inshurensi yakho, uncedo luyafumaneka.

Acorda Therapeutics Inc. Le nkqubo inokukwazi ukunceda ukunciphisa iindleko zonyango lwakho. Ngolwazi oluthe kratya kunye nokufumanisa ukuba uyilungele na inkxaso, tsalela umnxeba ku-888-887-3447 okanye undwendwele iwebhusayithi yenkqubo.

Inbrija libanda

Sebenzisa ngaphezulu komthamo ocetyiswayo we-Inbrija kunokukhokelela kwiziphumo ebezingalindelekanga ezibi.

Iimpawu libanda

Iimpawu zokudlula ngaphezulu zinokubandakanya:

  • iingxaki zentliziyo, kubandakanya i-arrhythmia (isantya sentliziyo esikhawulezayo okanye esingaqhelekanga) kunye ne-hypotension (uxinzelelo lwegazi oluphantsi)
  • i-rhabdomyolysis (ukuphazamiseka kwezihlunu)
  • iingxaki zezintso
  • Ingqondo (jonga "icandelo leziphumo ze-Inbrija" apha ngasentla)

Kufuneka wenze ntoni xa uthe wagqithisa?

Ukuba ucinga ukuba uthathe i-Inbrija kakhulu, biza ugqirha wakho. Ungabiza uMbutho waseMelika wamaZiko oLawulo lweTyhefu ku-800-222-1222 okanye usebenzise isixhobo esikwi-Intanethi. Kodwa ukuba iimpawu zakho zinzima, tsalela umnxeba ku-911 okanye uye kwigumbi likaxakeka elikufutshane ngoko nangoko.

Ezinye iindlela ze-Inbrija

Ezinye iziyobisi ziyafumaneka ukunyanga isifo sika-Parkinson. Ezinye zinokukulungela ngcono kunabanye.

Ezinye iindlela eziqhelekileyo ze-Inbrija eziphatha "iziqendu ezingekhoyo" zibandakanya:

  • apomorphine (Apokyn)
  • i-safinamide (Xadago)

Iindlela eziqhelekileyo zokunyanga isifo sikaParkinson zibandakanya:

  • icarbidopa / levodopa (iSinemet, iDuopa, iRytary)
  • ipramipexole (Mirapex, Mirapex ER)
  • i-ropinirole (i-Requip, i-Xip ye-Xip)
  • irotigotine (Neupro)
  • iselegiline (iZelapar)
  • irasagiline (Azilect)
  • I-entacapone (iComtan)
  • benztropine (Cogentin)
  • zekisoft

Ukuba unomdla ekufumaneni enye indlela ye-Inbrija, thetha nogqirha wakho. Banokukuxelela ngamanye amayeza anokukusebenzela.

Inbrija vs. Apokyn

Unokuzibuza ukuba i-Inbrija ithelekisa njani namanye amayeza amiselwe ukusetyenziswa okufanayo. Apha sijonga indlela i-Inbrija kunye neApokyn ezifanayo kwaye zahlukile.

Sebenzisa

Ukutya kunye noLawulo lweeDrug (i-FDA) ivumile i-Inbrija kunye ne-Apokyn ukunyanga abantu "abanamaxesha ongekhoyo" kwisifo sika-Parkinson. Amaxesha okuphuma ayenzeka xa abantu bethatha amayeza kaParkinson ngequbuliso bahlakulela iimpawu ezinzima zeParkinson's.

Abantu kuphela abathatha i-carbidopa / levodopa ukunyanga iParkinson's kufuneka bathathe i-Inbrija. Isetyenziselwa ukunyanga nayiphi na impawu yeParkinson.

I-Apokyn inokusetyenziswa kubantu abathatha naluphi na unyango lwe-Parkinson. Isetyenziselwa ukunyanga ukunciphisa ukunyakaza komzimba ngexesha lokuhamba kweParkinson.

I-Inbrija iqulethe ichiza levodopa. I-Apokyn iqulethe i-apomorphine yeziyobisi.

Inbrija kunye neApokyn bobabini bonyusa umsebenzi we-dopamine kwingqondo yakho. Oku kuthetha ukuba baneziphumo ezifanayo emzimbeni wakho.

Iifom zeziyobisi kunye nolawulo

I-Inbrija iza njengephilisi ene-powder oyifakileyo. Iyafumaneka ngamandla omnye: 42 mg. Umthamo oqhelekileyo we-Inbrija yi-84 mg (iipilisi ezimbini) ngexesha lesifo sika-Parkinson.

Uthatha i-Apokyn ngokuyifaka ngaphakathi kwesikhumba sakho (inaliti yangaphantsi). I-Apokyn ifumaneka ngamandla omnye: 30 mg. Umthamo ocetyiswayo yi-2 mg ukuya kwi-6 mg ngexesha ngalinye leParkinson.

Iziphumo kunye neengozi

U-Inbrija no-Apokyn baneziphumo ebezingalindelekanga ezifanayo kunye nezinye ezahlukileyo. Apha ngezantsi kunemizekelo yeziphumo ebezingalindelekanga.

Iziphumo eziqhelekileyo ezichaphazelekayo

Olu luhlu lunemizekelo yeziphumo ebezingalindelekanga ezinokubakho nge-Inbrija, kunye ne-Apokyn, okanye zombini iziyobisi (xa zithathwa ngokwahlukeneyo).

  • Inokwenzeka nge-Inbrija:
    • ukukhohlela
    • usulelo oluphezulu lokuphefumla, njengokubanda okuqhelekileyo
    • ulwelo olunombala omnyama olufana nomchamo okanye ukubila
  • Inokwenzeka nge-Apokyn:
    • ukuzamla okugqithisileyo
    • ukozela
    • isiyezi
    • impumlo enemifinya
    • ukugabha okuhlala ixesha elide
    • ukubona izinto ezingekhoyo (ukubona okanye ukuva into engekhoyo)
    • ukudideka
    • ukudumba emilenzeni, emaqatheni, ezinyaweni, ezandleni, okanye kwamanye amalungu omzimba
    • ukusabela kwendawo yenaliti, njengokugruzuka, ukudumba, okanye ukurhawuzelela
  • Inokwenzeka zombini Inbrija kunye Apokyn:
    • isicaphucaphu esihlala ixesha elide

Iziphumo ebezingalindelekanga ezimandundu

Olu luhlu lunemizekelo yeziphumo ebezingalindelekanga ezinokubakho nge-Inbrija, kunye ne-Apokyn, okanye zombini iziyobisi (xa zithathwa ngokwahlukeneyo).

  • Inokwenzeka nge-Inbrija:
    • iziphumo ezingaqhelekanga kwiimvavanyo zaselebhu, kubandakanya neemvavanyo zesibindi (inokuba luphawu lomonakalo wesibindi)
  • Inokwenzeka nge-Apokyn:
    • negazi lakho
    • amahlwili egazi
    • ukuwa
    • iingxaki zentliziyo, kubandakanya isifo sentliziyo
    • isingqisho sentliziyo esingaqhelekanga
    • iingxaki ze-fibrotic (utshintsho kwizicubu zakho)
    • ukuxhomekeka (ixesha elide, ukunyuka okubuhlungu)
  • Inokwenzeka zombini Inbrija kunye Apokyn:
    • ngengqondo
    • izibongozo ezingaqhelekanga
    • I-dyskinesia (ukungalawuleki kunye nokuhamba komzimba ngokukhawuleza)
    • ukulala ngexesha lemisebenzi yesiqhelo
    • ukurhoxisa isifo, kunye neempawu ezinje ngomkhuhlane okanye isingqisho sentliziyo esingaqhelekanga
    • i-hypotension (uxinzelelo lwegazi oluphantsi)

Ukusebenza ngempumelelo

La machiza khange athelekiswe ngokuthe ngqo kwizifundo zeklinikhi. Nangona kunjalo, uphando lufumene i-Inbrija kunye ne-Apokyn ukuba isebenze ekunyangeni amaxesha esi sifo sika-Parkinson.

Iindleko

U-Inbrija kunye no-Apokyn bobabini baneziyobisi. Okwangoku azikho iintlobo zohlobo oluthile lwamayeza. Amayeza egama leBrand ahlala exabisa ngaphezu kwegeneric.

Ngokwengqikelelo kwi-WellRx, i-Inbrija kunye ne-Apokyn ngokubanzi zibiza malunga nokufanayo. Ixabiso oza kulihlawula i-Inbrija okanye i-Apokyn liya kuxhomekeka kwisicwangciso sakho seinshurensi, indawo okuyo, kunye nekhemesti oyisebenzisayo.

Kubalulekile ukuba uqaphele ukuba i-Inbrija kunye ne-Apokyn zinokufumaneka kuphela kwiikhemesti ezikhethekileyo. Ezi ziikhemesti ezigunyazisiweyo ukuba ziphathe amayeza awodwa (amayeza antsonkothileyo, anamaxabiso aphezulu, okanye kunzima ukuwathatha).

Uyithatha njani i-Inbrija

I-Inbrija iza njengephilisi ene-powder oyifakileyo. Thatha i-Inbrija ngokomyalelo kagqirha wakho okanye ekhemesti. Iwebhusayithi ye-Inbrija inevidiyo ebonisa kunye nemiyalelo yamanyathelo ngamanyathelo ukukunceda uthathe i-Inbrija ngokuchanekileyo.

Kuya kufuneka uthathe i-Inbrija ngokuyifaka ngaphakathi. Kubalulekile ukuba ungavuli okanye uginye nayiphi na i-Inbrija capsule. Iifomsile kufuneka zibekwe kuphela kwisixhobo se-inbrija inhaler. Isixhobo siya kusebenzisa umgubo ngaphakathi kwiifomsile ukukuvumela ukuba uphefumle iziyobisi.

Sukusebenzisa iipilisi ze-Inbrija kuso nasiphi na isixhobo se-inhaler ngaphandle kwe-Inbrija inhaler. Kwakhona, musa ukungenisa elinye iyeza ngokusebenzisa i-Inbrija inhaler yakho.

Buza ugqirha wakho okanye usokhemesti ukuba unengxaki yokuthatha i-Inbrija. Baya kukuhamba kuwo onke amanyathelo ukuze uqiniseke ukuba uthatha ngendlela eyiyo.

Nini ukuthatha

Kuya kufuneka uthathe i-Inbrija ekuqaleni kwexesha lesifo sika-Parkinson. Nangona kunjalo, sukuthatha ngaphezulu kweedosi ezintlanu (iicapsule ezili-10) ze-Inbrija ngosuku olunye. Ukuba usenokuphumla emva kokuthatha iidosi ezintlanu ze-Inbrija ngosuku, tsalela ugqirha wakho. Unokuxoxa malunga nokuba ufuna amayeza ahlukeneyo emihla ngemihla ukunyanga isifo sikaParkinson ukuze ungasebenzisi i-Inbrija rhoqo.

Ungayeki ukuthatha amanye amayeza akho emihla ngemihla ukunyanga iParkinson's ngexesha okanye emva kokuthatha i-Inbrija.

Inbrija kunye nokukhulelwa

Akukho zifundo zeklinikhi ze-Inbrija kwabasetyhini abakhulelweyo. Kwizifundo zezilwanyana, u-Inbrija waba neziphumo ezibi kwizilwanyana zabantwana. Iintsana zazalwa ziziphene zokuzalwa, kubandakanya iingxaki kumalungu nakumathambo abo. Nangona kunjalo, izifundo zezilwanyana azisoloko zibonisa okwenzekayo ebantwini.

Thetha nogqirha wakho ukuba ukhulelwe okanye uceba ukukhulelwa ngelixa uthatha i-Inbrija. Unokuxoxa ngobungozi kunye nezibonelelo zokuthatha i-Inbrija.

Inbrija kunye nolawulo lokuzalwa

Ayaziwa ukuba i-Inbrija ikhuselekile ukuyisebenzisa ngexesha lokukhulelwa. Ukuba usebenza ngokwesondo kwaye wena okanye iqabane lakho unokukhulelwa, thetha nogqirha wakho malunga neemfuno zakho zokulawula ukuzalwa ngelixa usebenzisa i-Inbrija.

Inbrija kunye nokuncancisa

Akukho zifundo zonyango ezijonga iziphumo ze-Inbrija ngexesha lokuncancisa. Kodwa iimvavanyo zaselebhu zibonisa ukuba i-Inbrija idlula kubisi lomntu lwebele. Kwakhona, uphononongo lubonisa ukuba i-Inbrija inokubangela ukuba umzimba wakho uvelise ubisi oluncinci. Ayaziwa ukuba le micimbi ingaba yingozi kuwe okanye kumntwana wakho.

Tshela ugqirha wakho ukuba uncelisa okanye uceba ukuncelisa xa uthatha i-Inbrija. Unokuthetha malunga nokuba kukhuselekile na kuwe ukuba uthathe i-Inbrija ngelixa uncancisa.

Imibuzo eqhelekileyo malunga no-Inbrija

Nazi iimpendulo kwimibuzo ebuzwa rhoqo malunga no-Inbrija.

Kuthetha ukuthini ukuba 'nexesha elingaphandle' lesifo sikaParkinson?

Amaxesha okuphuma kwesifo sikaParkinson ngamaxesha apho amayeza akho emihla ngemihla ukunyanga isifo sikaParkinson sinxibe okanye singasebenzi njengoko kufanelekile. Xa oku kusenzeka, iimpawu zakho zeParkinson zibuyela ngesiquphe.

Abantu abanesifo sikaParkinson bathatha amayeza ukunyusa inani le-dopamine kwingqondo yabo. I-Dopamine yinto efunekayo ukulawula ukuhamba komzimba wakho. Ngaphandle kwe-dopamine, umzimba wakho awukwazi ukuhamba kakuhle. Oku kubangela ukuba iimpawu zeParkinson zivele.

Amayeza okwandisa inani le-dopamine kwingqondo yakho ahlala esebenza kakuhle ngexesha elide. Kodwa ngamanye amaxesha bayayeka ukusebenza kancinci. Ngeli xesha abangasebenziyo, unokuba neempawu zikaParkinson. La maxesha xa iyeza lakho lingasebenzi libizwa ngokuba ngamaxesha eParkinson's.

Ngaba ndiza kuba nakho ukufumana i-Inbrija kwikhemesti yasekhaya?

Mhlawumbi akunjalo. Unokwazi ukufumana i-Inbrija kuphela kwiikhemesti ezikhethekileyo, ezigunyazisiweyo ukuba zithwale amayeza awodwa. La ngamachiza antsonkothileyo, anamaxabiso aphezulu, okanye kunzima ukuthatha.

Buza ugqirha wakho ukuba awuqinisekanga ukuba ungayifumana phi i-Inbrija. Banokucebisa ukuba ufumane ikhemesti ekhethekileyo kwindawo yakho.

Ngaba i-Inbrija iyakuthatha indawo yedosi yam yesiqhelo ye-carbidopa / levodopa?

Hayi, ngekhe. I-Inbrija isetyenziselwa kuphela ukunyanga ixesha lesifo sika-Parkinson. Akufanele ithathwe imihla ngemihla ukufaka endaweni yokusebenzisa i-carbidopa / levodopa.

Thetha nogqirha wakho ukuba unenkxalabo malunga nokuthatha zombini i-carbidopa / levodopa kunye ne-Inbrija. Ugqirha wakho unokuchaza ukubaluleka kwazo zombini unyango ukulawula ngokupheleleyo iimpawu zesifo sikaParkinson.

Ngaba kufuneka ndilandele ukutya okuthile ngelixa ndisebenzisa i-Inbrija?

Kungenzeka ukuba ugqirha wakho unokukucebisa ukuba ulandele ukutya okuthile ngelixa uthatha i-Inbrija.

Ukutya okunotye kakhulu kwiiproteni okanye iivithamini kunokwenza i-Inbrija ingasebenzi kakuhle xa isetyenziswa ngaxeshanye neli chiza. Kungenxa yokuba iiproteni kunye neevithamini zinokunciphisa inani le-Inbrija efikelela kwingqondo yakho. I-Inbrija kufuneka ifikelele kwingqondo yakho ukuze isebenze emzimbeni wakho.

Ugqirha wakho unokucebisa utshintsho xa uthatha idosi yakho ye-Inbrija ukunqanda ukuyithatha ngexesha elinye usitya ukutya okunotye iivithamini okanye iiproteni.

Thetha nogqirha wakho ukuba unemibuzo malunga nokutya okutyayo. Unokunikwa isicwangciso sesondlo ekufuneka usilandele ngelixa uthatha i-Inbrija.

Ndingayiginya i-Inbrija capsule?

Hayi, awukwazi. Ukuginya i-Inbrija capsule kunokwenza ukuba kungasebenzi kakuhle. Kungenxa yokuba i-Inbrija encinci iya kuba nakho ukufikelela kwingqondo yakho.

Iifomsile ze-Inbrija kufuneka zibekwe kwisixhobo se-inbrija inhaler esiza neepilisi. Kwisixhobo, iifomsile zikhupha umgubo owuphefumlayo.

Buza ugqirha wakho okanye usokhemesti ukuba unemibuzo malunga nokuthatha i-Inbrija. Bangachaza indlela yokusebenzisa isixhobo se-inhaler ukuqinisekisa ukuba uthatha i-Inbrija ngokuchanekileyo. Unokutyelela iwebhusayithi ye-Inbrija ukubona umboniso wevidiyo kwaye ufumane inyathelo ngenyathelo ngemiyalelo yokuthatha i-Inbrija ngokuchanekileyo.

Ngaba ndiza kuba neempawu zokurhoxa ukuba ngequbuliso ndiyeke ukuthatha i-Inbrija?

Kusenokwenzeka. Unokuba neempawu zokurhoxa ukuba ngequbuliso unciphise idosi yakho ye-Inbrija okanye uyeke ukuyithatha. Kungenxa yokuba umzimba wakho uqhela u-Inbrija. Xa uyeka ngesiquphe ukuyithatha, umzimba wakho awunalo ixesha lokuhlengahlengisa ngokufanelekileyo ukungabinayo.

Iimpawu zokurhoxa onokufumana kwi-Inbrija zibandakanya:

  • umkhuhlane ophezulu kakhulu okanye ohlala ixesha elide
  • ukudideka
  • izihlunu eziqinileyo
  • izingqisho zentliziyo engaqhelekanga (utshintsho kwintliziyo)
  • utshintsho ekuphefumlweni

Tshela ugqirha wakho ukuba uziva iimpawu zokurhoxa emva kokuba wehlise idosi yakho ye-Inbrija okanye uyeke ukuyithatha. Banokukuyalela amayeza ukunceda kwiimpawu zakho.

Ndingayithatha i-Inbrija ukuba ndinesifo esinganyangekiyo semiphunga (COPD) okanye isifuba?

Mhlawumbi akunjalo. I-Inbrija inokubangela iingxaki ngokuphefumla kwakho kwaye inokwenza ukuba iimpawu zesifo semiphunga ezingapheliyo (zexesha elide) zibe nzima kakhulu. Ngoko ke, i-Inbrija ayikhuthazwa kubantu abane-asthma, i-COPD, okanye ezinye izifo ezingapheliyo zamaphaphu.

Thetha nogqirha wakho ukuba unesifo esinganyangekiyo semiphunga. Banokukunceda ufumane amayeza anokulungela ngakumbi.

Inbrija izilumkiso

Ngaphambi kokuba uthathe i-Inbrija, thetha nogqirha wakho malunga nembali yakho yezempilo. I-Inbrija isenokungakulungeli ukuba uneemeko ezithile zonyango. Oku kubandakanya:

  • Ingqondo. I-Inbrija inokubangela iimpawu zengqondo yengqondo, eyenzekayo xa imeko yakho yokwenyani itshintsha. Ungabona, uve, okanye uve izinto ezingezizo ezokwenyani. Ngaphambi kokuba uthathe i-Inbrija, xelela ugqirha wakho ukuba ngaba uneempawu zengqondo ngaphambili. Ukuba unayo, ukuthatha i-Inbrija akunakulunga kuwe.
  • Ukuphazamiseka kolawulo. I-Inbrija inokuchaphazela iindawo zobuchopho bakho ezilawula into ofuna ukuyenza. Inokukwenza uzimisele ngakumbi ukwenza izinto oqhele ukungazenzi, ezinjengokungcakaza nokuthenga. Ukuphazamiseka kulawulo lokuchaphazeleka kuchaphazela nento abantu abafuna ukuyenza kunye nexesha abafuna ukuyenza ngalo. Ukuthatha i-Inbrija kunokunyusa ezi zibongozo zingaqhelekanga ukuba unembali yokuphazamiseka kolawulo.
  • IDyskinesia. Ukuba unayo i-dyskinesia (ukungalawuleki okanye ukunyakaza komzimba ngokukhawuleza) ngaphambili, i-Inbrija ayinakukhuseleka kuwe. Ukuthatha i-Inbrija kunokunyusa umngcipheko wokuba nedyskinesia ukuba ubukhe wanayo imeko ngaphambili.
  • Iglaucoma. Ukuba une-glaucoma (isifo samehlo esichaphazela umbono wakho), i-Inbrija isenokungakhuseleki kuwe. Kungenxa yokuba i-Inbrija inokubangela ukonyuka koxinzelelo lwe-intraocular (ukwanda koxinzelelo emehlweni), okunokuthi kuyenze mandundu i-glaucoma yakho. Ukuba unayo i-glaucoma, ugqirha wakho uya kujonga uxinzelelo lwamehlo ngelixa uthatha i-Inbrija ukubona ukuba uxinzelelo luyanda na. Ukuba uxinzelelo lwamehlo luphezulu, ugqirha wakho unokuyeka ukuthatha i-Inbrija kwaye uzame elinye iyeza.
  • Izifo ezingapheliyo (zexesha elide) zezifo zemiphunga. I-Inbrija ayikhuthazwa kubantu abane-asthma, isifo esingapheliyo sokuphazamiseka kwemiphunga (COPD), okanye ezinye izifo ezingapheliyo zemiphunga. I-Inbrija inokubangela iingxaki ngokuphefumla kwakho kwaye inokwenza ukuba ezi zifo zemiphunga zibe nzima ngakumbi.

Phawula: Ngolwazi oluthe kratya malunga neziphumo ezibi ezinokubakho ze-Inbrija, jonga icandelo le-Inbrija kwicala elingentla.

Ukuphelelwa lixesha kwe-Inbrija, ukugcinwa kunye nokulahlwa

Xa ufumana i-Inbrija ekhemesti, usokhemesti uya kongeza umhla wokuphelelwa kwileyibhile kwiphakheji. Lo mhla uqhele ukuba ngunyaka omnye ukusukela kumhla wokuhambisa kwabo amayeza.

Umhla wokuphelelwa unceda ukuqinisekisa ukuba i-Inbrija iya kusebenza ngeli xesha. Isimo sangoku soLawulo lwezoKutya kunye noLawulo lweziyobisi (i-FDA) kukuphepha ukusebenzisa amayeza aphelelwe lixesha. Ukuba awusebenzisanga iyeza elidlulileyo kumhla wokuphelelwa kwalo, thetha nosokhemesti wakho malunga nokuba unganako na ukuyisebenzisa.

Ukugcina

Kude kube nini iyeza lihlala lilungile ukuba ulisebenzise kunokuxhomekeka kwizinto ezininzi, kubandakanya ukuba uligcina phi kwaye phi.

Iifomsile ze-Inbrija kufuneka zigcinwe kubushushu begumbi (i-68 ukuya kwi-77 ° F okanye i-20 ukuya kwi-25 ° C) kwisitya esitywinwe ngokuqinileyo kwaye singanyangeki ukukhanya. Ungalonyusa uluhlu lobushushu ukuya kuma-59 ukuya kuma-86 ° F (15 ukuya kuma-30 ° C) ukuba uhamba.

Iifomsile ze-Inbrija akufuneki zigcinwe kwi-inbrija inhaler. Oku kunganciphisa ixesha elithathwa zii-capsules zihlala zilungile. Iicapsules ezingalunganga zinokuba yingozi kuwe.

Lahla isixhobo se-inhaler emva kokuba usebenzise zonke iifomsile ngaphakathi kwebhokisi. Uya kufumana i-inhaler entsha ngalo lonke ixesha ufumana ukuzaliswa kwe-Inbrija prescription yakho.

Ukulahla

Ukuba akusafuneki uthathe i-Inbrija kwaye unamayeza aseleyo, kubalulekile ukuba uyilahle ngokukhuselekileyo. Oku kunceda ukuthintela abanye, kubandakanya abantwana kunye nezilwanyana zasekhaya, ekubeni bathathe iyeza ngengozi. Kuyanceda ukugcina ichiza lingonzakalisi okusingqongileyo.

Iwebhusayithi ye-FDA ibonelela ngeengcebiso ezininzi eziluncedo ngokulahla amayeza. Unokucela ikhemesti yakho ukuba ikwazi ukuba ulahla njani na amayeza akho.

Ulwazi lobungcali lwe-Inbrija

Olu lwazi lulandelayo lubonelelwe ngoochwephesha kunye nabanye abaqeqeshi bezempilo.

Iimpawu

I-Inbrija iboniswa ukunyanga "amaxesha okuphuma" kwesi sifo sikaParkinson. Ukubonakaliswa kwayo kunqunyelwe kwizigulana ezinyangwa nge-carbidopa / levodopa.

Indlela yokusebenza

Indlela yokusebenza apho i-Inbrija inciphisa iimpawu zamaxesha okuphuma kwesifo sika-Parkinson ayaziwa.

Inbrija iqulethe i-levodopa, eyandulela i-dopamine. I-Levodopa iwela isithintelo segazi-nengqondo. Engqondweni, i-levodopa iguqulwa ibe yi-dopamine. I-Dopamine efikelela kwi-basal ganglia icingelwa ukuba inciphise iimpawu zeziqendu zesifo sika-Parkinson.

I-Pharmacokinetics kunye ne-metabolism

Kubukho be-carbidopa, ulawulo olunye lwe-Inbrija 84 mg lufikelela koxinzelelo oluphezulu kwimizuzu engama-30 emva kolawulo. Ubungakanani bayo be-dose-normal peak concentration malunga ne-50% yeepilisi zomlomo ezikhutshwa kwangoko ze-levodopa.

Ukufumaneka kwe-Inbrija malunga ne-70% yeepilisi zomlomo ezikhutshwa kwangoko ze-levodopa. Nje ukuba kwinkqubo, i-Inbrija 84 mg ifikelela kumthamo wokuhanjiswa kwe-168 L.

Uninzi lwe-Inbrija ludlula kwi-enzymatic metabolism. Iindlela eziphambili ze-metabolic zibandakanya i-decarboxylation yi-dopa decarboxylase kunye ne-O-methylation yi-catechol-O-methyltransferase. Kubukho be-carbidopa, ulawulo olunye lwe-Inbrija 84 mg ine-half-life terminal yeeyure eziyi-2.3.

Akukho mahluko uxeliweyo kwingxinano yencopho (Cmax) kunye nendawo ephantsi kwegophe (AUC) phakathi kwamadoda nabasetyhini abathatha i-Inbrija. Akukho mahluko uye waqwalaselwa phakathi kwabantu abatshayayo kunye nabo bangatshayiyo.

Ukungqinelana

Ukusetyenziswa kwe-Inbrija kuyaphikiswa kwizigulana ezithatha i-nonselective monoamine oxidase inhibitors (MAOIs). Kukwachasene nezigulana ezithathe ii-MAOIs ezingakhethiyo kwiiveki ezimbini.

Indibaniselwano ye-Inbrija kunye nee-MAOIs ezingakhethiyo kunokubangela uxinzelelo lwegazi. Ukuba isigulana siqala ukuthatha i-MAOI engakhethiyo, unyango nge-Inbrija kufuneka luyeke.

Ukugcina

Iifomsile ze-Inbrija kufuneka zihlale kwiphakheji yazo yoqobo. Iphakheji kunye nekhonteyina kufuneka igcinwe kuma-68 ukuya kuma-77 ° F (20 ukuya kuma-25 ° C). Eli bushushu linokunyuswa liye kuma-59 ukuya kuma-86 ° F (15 ukuya kuma-30 ° C) xa useluhambeni.

Ukugcina iipilisi ze-Inbrija kwisixhobo se-inbrija inhaler kunokutshintsha uzinzo lweziyobisi. Izigulana kufuneka zilumkiswe malunga nokugcina iifomsile kwizikhongozeli zazo zentsusa.

Iphepha elichazayo ukuba awusenanto oyifunayo: Iindaba zezoNyango namhlanje zenze zonke iinzame zokuqinisekisa ukuba zonke iinkcukacha zichanekile, zibanzi kwaye zihlaziyiwe. Nangona kunjalo, eli nqaku akufuneki lisetyenziswe endaweni yolwazi kunye nobuchule bengcali yezempilo enelayisensi. Kuya kufuneka usoloko uqhagamshelana nogqirha wakho okanye nolunye uqeqesho kwezonyango ngaphambi kokuba uthathe nawaphi na amayeza. Ulwazi lweziyobisi oluqulethwe apha luyakwazi ukutshintsha kwaye alujoliswanga ekusetyenzisweni konke okunokwenzeka, imikhombandlela, izilumkiso, izilumkiso, ukuhlangana kweziyobisi, ukungahambelani komzimba, okanye iziphumo ezibi. Ukungabikho kwezilumkiso okanye olunye ulwazi ngesiyobisi esinikiweyo akubonisi ukuba indibaniselwano yeziyobisi ikhuselekile, iyasebenza, okanye ifanelekile kuzo zonke izigulana okanye konke ukusetyenziswa okuthile.

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