Ngaba i-Ketamine inganceda ukunyanga ukudakumba?

Umxholo

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Ukudakumba kuxhaphake kakhulu kunokuba unokucinga. Ichaphazela ngaphezu kwe-15 yezigidi zabantu baseMelika, kwaye uMbutho wezeMpilo weHlabathi uqikelela ukuba inani likhula ukuya kwi-300 yezigidi xa usanda kwihlabathi jikelele. Kukho ukubulawa kweendlela zonyango ezahlukeneyo ezikhoyo ukunceda ukunciphisa iimpawu zayo-ukucinga uxinzelelo, ukungalali, ukudinwa, kunye nokuphelelwa ngumdla wokutya phakathi kwabanye-olona nyango luxhaphakileyo njenge-serotonin reuptake inhibitors (okanye ii-SSRIs). Kodwa ukusukela malunga no-2000, oogqirha kunye nabaphandi bezama ukusebenzisa i-ketamine-ekuqaleni iyeza lokulawula iintlungu, ngoku liphathwa gadalala njengechiza lasesitalatweni ngenxa yeempembelelo ze-hallucinogenic-njengenye indlela yokunyanga le meko, ngokukaRuben Abagyan, Ph.D. , Unjingalwazi we-pharmacology kwiYunivesithi yaseCalifornia San Diego (UCSD).

Mhlawumbi ucinga, "Yima! Intoni?" Ukuba uvile nge-ketamine, ekwabizwa ngokuba yi-Special K, uyazi ukuba ayisiqhulo okanye isiyobisi se-OTC. Ngapha koko, yaziwa njenge-dissociative anesthetic (ethetha ichiza eligqwetha umbono wokubona kunye nesandi, ngelixa livelisa iimvakalelo ezizizo zokuzimela kunye nokusingqongileyo). Isetyenziswa ikakhulu ngoogqirha bezilwanyana ekunyangeni iintlungu kwizilwanyana, kodwa inokumiselwa nakubantu ukuba balawule iintlungu kakhulu, ngakumbi abo banemicimbi ye-neuropathic, uhlobo lwentlungu engapheliyo, ngokophando olwenziwe ngo-2014. Ijenali yaseBritane yePharmacology.

"Kuyaziwa ukuba iintlungu nokudakumba kunxibelelene," utshilo uIsaac Cohen, umfundi owenza amayeza owayesebenza kolu phando. Uthi: "Abantu abadandathekileyo banokuthi bahlale kwiintlungu kwaye abantu abaneentlungu ezingapheliyo banokudandatheka ngenxa yokunciphisa ukuhamba, ukukwazi ukunciphisa umzimba, kunye nezinye izinto," uthi. ukudakumba ngaxeshanye, nto leyo ekhokelela kwiziphumo ezingcono kuzo zombini ezi meko." Kwaye ngoku izazinzulu ziyaphikisana ukuba abukho nje ubungqina be-anecdotal, kodwa nolwazi lwamanani olubonisa i-ketamine inokunceda ukunciphisa iimpawu zokudakumba.

Kuhlalutyo lokuqala olukhulu lohlobo lwayo, olupapashwe kwi Indalo, Abaphandi bafumanise ukuba izigulana ezifumene i-ketamine zichaze iimeko zokudakumba. Olu phando, olwenziwa siSikolo seKhemesti kunye neSayensi yezoPhando kwi-UCSD, luqinisa idatha ye-anecdotal kunye nezifundo ezincinci zabantu eziye zacebisa iziphumo zokudakumba kwe-ketamine.

Yintoni eyenza i-ketamine ihluke kolunye unyango, ngokukodwa, yindlela ekhawuleza ngayo ukusebenza. "Unyango lwangoku oluvunywe yi-FDA lokudakumba aluphumeleli kwizigidi ngenxa yokuba alusebenzi ngokukhawuleza," utshilo u-Abaygan. I-Ketamine isebenza kwimiba yeeyure. Oko kungaphantsi kakhulu kune-SSRIs, umzekelo, enokuthatha iiveki ezintandathu ukuya kwezilishumi ukufikelela kumthamo wazo opheleleyo. Kwaye umahluko kumaxesha ngokwenyani unokuba ngumcimbi wobomi okanye wokufa, ngakumbi abo bafumana iingcinga zokuzibulala.

Kuphando lwabo, u-Abaygan kunye neqela lakhe baphonononge idatha kwiNkqubo yeNgxelo yezehlakalo eziGwenxa ze-FDA, iarhente eqokelela ulwazi malunga neziphumo ezibi (okanye iziphumo ezingalunganga zalo naluphi na uhlobo) lwaso nasiphi na isiyobisi esivunyiweyo esixeliweyo ngoosokhemesti noogqirha. Ngokukodwa, bafumana izigulana ezingama-40,000 ezazichazelwe amayeza entlungu kwaye zahlulahlula zaba ngamaqela amabini-abo bathatha i-ketamine kunye nabo baphathwa ngamanye amayeza eentlungu (ngaphandle kwee-NSAID).

Iziphumo zibonise "ibhonasi" ebaluleke kakhulu, nangona ibingajongwanga, isiphumo. Isiqingatha sabantu abanyanga iintlungu zabo nge-ketamine bachaze ukudakumba kancinci kunabo bathathe ezinye iintlobo zamayeza okunciphisa iintlungu. Nangona singazi ukuba kukho naziphi na kwezi zi gulane, ngakumbi ezo zikwi-ketamine, zineempawu zokudakumba ngaphambi kokuba zithathe nayiphi na imithi, isiphumo esihle kwisimo sengqondo, esidityaniswe nekhonkco eliqhelekileyo phakathi kweentlungu kunye nokudakumba, kunokuqinisekisa ukuba kukho enye ingxoxo malunga nokusetyenziswa kwe-ketamine. phatha uxinzelelo ngokuthe ngqo.

Ngokwabaphandi, i-ketamine ayibizi kakhulu kwaye ukuba ngaphambili ukhe wazama amanye amayeza amathathu oxinzelelo ngaphandle kokuphumelela, ihlala igutyungelwe zizicwangciso zeinshurensi yezempilo. Ingongoma? Sukukhawuleza ukubhala i-ketamine nje nge-hallucinogen. Inokuba ikhethekileyo ngokwenene emva kwayo yonke loo nto. (Kwaye ukuba akukho nto yimbi, bafana, khangela ezi ndlela zokulawula uxinzelelo okanye ukudandatheka nangaliphi na ixesha.)

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