I-minocycline yeRheumatoid Arthritis: Ngaba iyasebenza?

Umxholo

• Malunga nokusetyenziswa kweziyobisi ezingekho kwilebula
• Luthini uphando?
• Imbali yokuqala yophando
• Amagqabantshintshi ezifundo kunye ne-minocycline
• Isebenza njani i-minocycline ukuphatha i-RA?
• Ngubani oza kuxhamla kwiminocycline yeRA?
• Ithini iprotocol?
• Zithini iziphumo ebezingalindelekanga?
• Ukuthatha

Ushwankathelo

I-Minocycline yintsholongwane kwi-tetracycline yosapho. Isetyenziselwe ngaphezulu kokulwa uluhlu olubanzi losulelo.

, Abaphandi babonakalise iipropathi zayo ezichaseneyo nokudumba, ukuzivikela komzimba, kunye neproprotective.

Ukusukela oko, ezinye iingcali ze-rheumatologists zisebenzise ngempumelelo i-tetracyclines ye-rheumatoid arthritis (RA). Oku kubandakanya minocycline. Njengokuba iiklasi ezintsha zamachiza zazifumaneka, ukusetyenziswa kwe-minocycline kwehlile. Kwangelo xesha, kubonise ukuba i-minocycline iluncedo kwi-RA.

I-Minocycline ayigunyaziswanga ngokuthe ngqo yi-U.S. Ngamanye amaxesha imiselwe "ngaphandle kwelebula".

Ngaphandle kweziphumo zayo eziluncedo kwizilingo, i-minocycline ngokubanzi ayisetyenziswanga ukunyanga i-RA namhlanje.

Malunga nokusetyenziswa kweziyobisi ezingekho kwilebula

Ukusetyenziswa kweziyobisi ngaphandle kwelebheli kuthetha ukuba ichiza elivunyiweyo yi-FDA ngenjongo enye lisetyenziselwa injongo eyahlukileyo engavunyelwanga. Nangona kunjalo, ugqirha usenokulisebenzisa iyeza ukulungiselela loo njongo. Kungenxa yokuba i-FDA ilawula ukuvavanywa kunye nokuvunywa kwamachiza, kodwa hayi indlela abagqirha abazisebenzisa ngayo iziyobisi ukunyanga izigulana zabo.Ke ugqirha wakho unokuyalela ichiza kodwa bacinga ukuba yeyona nto ilungileyo ukuba unyamekele. Funda ngakumbi malunga nokusetyenziswa kwelebheli emiselweyo

Luthini uphando?

ukusukela emva kwexesha kwee-1930s ukuba iintsholongwane ziyabandakanyeka ekubangeleni iRA.

Uphando lwezonyango kunye nophando olulawulwayo lokusetyenziswa kwe-minocycline ye-RA ngokubanzi kugqiba ukuba i-minocycline iluncedo kwaye ikhuselekile kubantu abane-RA.

Ezinye i-antibiotics zibandakanya i-sulfa compounds, nezinye i-tetracyclines kunye ne-rifampicin. Kodwa i-minocycline ibingumbandela wezifundo ezibini ezingaboniyo kunye novavanyo lweklinikhi ngenxa yeepropathi zayo ezibanzi.

Imbali yokuqala yophando

Ngomnyaka we-1939, ugqirha wamathambo waseMelika uThomas McPherson-Brown kunye noogxa bakhe bahlukanisa intsholongwane efana neentsholongwane kwizicubu zeRA. Bayibiza ngokuba yi-mycoplasma.

Emva kwexesha uMcPherson-Brown waqalisa ukuvavanya unyango lwe-RA ngamayeza okubulala iintsholongwane. Abanye abantu ekuqaleni baba mandundu. UMcPherson-Brown ubange ukuba oku kubangelwe yiHerxheimer, okanye "ukufa": Xa ibacteria ihlaselwa, ikhupha ityhefu eqala ibangele ukuba isifo sivele. Oku kubonisa ukuba unyango luyasebenza.

Kwixesha elide, abaguli baye bangcono. Uninzi luphumelele uxolelo emva kokuthatha i-antibiotiki ukuya kuthi ga kwiminyaka emithathu.

Amagqabantshintshi ezifundo kunye ne-minocycline

Izifundo ezili-10 zithelekisa i-tetracycline antibiotics kunyango oluqhelekileyo okanye indawo ye-RA. Isifundo sigqibe kwelokuba unyango lwe-tetracycline (kwaye ngakumbi i-minocycline) lwalunxulunyaniswa nokuphuculwa okubalulekileyo ekliniki.

Isifundo esilawulwa ngo-1994 se-minocycline kunye nabathathi-nxaxheba abangama-65 baxele ukuba i-minocycline iluncedo kwabo bane-RA esebenzayo. Uninzi lwabantu kolu phononongo babephumelele i-RA.

I-219 yabantu abane-RA ngokuthelekisa unyango kunye ne-minocycline kwi-placebo. Abaphandi bagqiba kwelokuba i-minocycline yayisebenza kwaye ikhuselekile kwiimeko ezinobulali ukuya kweziphakathi ze-RA.

Uphononongo luka-2001 lwabantu abangama-60 abaneRA bafanisa unyango kunye ne-minocycline ne-hydroxychloroquine. IHydroxychloroquine sisiyobisi esiguqula i-antirheumatic drug (DMARD) esisetyenziselwa ukunyanga iRA. Abaphandi bathi i-minocycline yayisebenza ngakumbi kune-DMARD ye-RA yangaphambi kwexesha seropositive.

Ukulandelwa kweminyaka emine kujonge kwizigulana ezingama-46 kwisifundo esingaboni kabini esithelekisa unyango kunye ne-minocycline kwi-placebo. Ikwacebise ukuba i-minocycline yayilunyango olusebenzayo kwi-RA. Abantu abaphathwe nge-minocycline banezinto ezimbalwa zokuxolelwa kwaye bafuna unyango olungaphantsi kwesiko. Kwakunjalo nangona ikhosi ye-minocycline yayiziinyanga nje ezintathu ukuya kwezintandathu.

Kubalulekile ukuba uqaphele ukuba uninzi lwezi zifundo lubandakanya ukusetyenziswa kwethutyana kwe-minocycline. UMcPherson-Brown ugxininise ukuba ikhosi yonyango yokufumana ukuxolelwa okanye ukuphuculwa okubalulekileyo kunokuthatha ukuya kwiminyaka emithathu.

Isebenza njani i-minocycline ukuphatha i-RA?

Indlela echanekileyo ye-minocycline njengonyango lwe-RA ayiqondakali ngokupheleleyo. Ukongeza kwi-antimicrobial action, i-minocycline inezixhobo ezichasayo. Ngokukodwa, minocycline ukuya:

• ichaphazela i-nitric oxide synthase, ebandakanyeka ekonakaleni kwe-collagen
• ukuphucula i-interleukin-10, ethintela i-cytokine ye-pro-inflammatory kwi-synovial tissue (izicubu ezinxulumene namalungu)
• Ukucinezela ukusebenza kweeseli zomzimba

IMinocycline inokuba nayo. Oku kuthetha ukuba inokuphucula unyango lwe-RA xa ludibene namachiza angasebenziyo okulwa nokudumba okanye amanye amayeza.

Ngubani oza kuxhamla kwiminocycline yeRA?

Kucetyiswa ukuba abagqatswa abalungileyo ngabo bakwisigaba sokuqala seRA. Kodwa olunye uphando lubonisa ukuba abantu abane-RA ehambele phambili banokufumana izibonelelo.

Ithini iprotocol?

Inkqubo yesiqhelo yeziyobisi kwizifundo zophando zii-100 milligrams (mg) kabini ngemini.

Kodwa umntu ngamnye wahlukile, kwaye iprothokholi ye-minocycline ingahluka. Abanye abantu banokufuna ukuqala ngethamo elisezantsi kwaye basebenze ukuya kuthi ga kwi-100 mg okanye ngaphezulu kabini ngemini. Abanye banokufuna ukulandela inkqubo yokumpompa, ukuthatha i-minocycline iintsuku ezintathu ngeveki okanye ukuyitshintsha nezinye iziyobisi.

Njengonyango lwe-antibiotiki yesifo seLyme, akukho ndlela yokulingana nayo yonke indlela. Kwakhona kungathabatha ukuya kwiminyaka emithathu ukubona iziphumo kwezinye iimeko zeRA.

Zithini iziphumo ebezingalindelekanga?

IMinocycline ngokubanzi inyamezeleka kakuhle. Iziphumo ebezingalindelekanga ezinokubakho zimodareyitha kwaye ziyafana nezo zonyango. Ziquka:

• iingxaki zesisu
• isiyezi
• intloko ebuhlungu
• irhashalala
• ukwanda kovakalelo kwilanga
• usuleleko igwele lobufazi
• Ukongezwa kwehyperse

Ukuthatha

I-Minocycline, ngakumbi isetyenzisiweyo ixesha elide, ibonakalisiwe ukuphucula iimpawu ze-RA kunye nokunceda ukubeka abantu kuxolelo. Ayisetyenziswa ngokubanzi namhlanje, ngaphandle kwengxelo eqinisekisiweyo.

Iingxoxo eziqhelekileyo ezinikezelwa ngokuchasene nokusetyenziswa kweminocycline yeRA zezi:

• Akukho zifundo zaneleyo.
• I-Antibiotic ineziphumo ebezingalindelekanga.
• Amanye amachiza asebenza ngcono.

Abanye abaphandi kunye neengcali ze-rheumatologists abavumelani nale mpikiswano kwaye balatha kwiziphumo zezifundo ezikhoyo.

Kubalulekile ukubandakanyeka ekucwangciseni unyango lwakho kunye nokuphanda ezinye iindlela. Xoxa nogqirha wakho onokuthi ulunge ngakumbi kwimeko yakho ethile.

Ukuba ungathanda ukuzama i-minocycline kwaye ugqirha wakho uyayityhafisa, buza ukuba kutheni. Khombisa imbali ebhaliweyo yokusetyenziswa kweminocycline. Thetha nogqirha malunga neziphumo ebezingalindelekanga zokuthatha i-steroids ixesha elide xa kuthelekiswa neziphumo ebezingalindelekanga ezinobungakanani be-minocycline. Unokufuna ukukhangela iziko lophando elisebenze nge-minocycline kunye neRA.