Umbhali: Louise Ward
Umhla Wokudalwa: 6 Eyomdumba 2021
Hlaziya Umhla: 11 Eyokwindla 2025
Anonim
Pegfilgrastim in a nutshell - Fulphila; Neulasta - Neulasta Onpro - Nyvepria - Udenyca - Ziextenzo
Ividiyo: Pegfilgrastim in a nutshell - Fulphila; Neulasta - Neulasta Onpro - Nyvepria - Udenyca - Ziextenzo

Umxholo

Yintoni iNeulasta?

I-Neulasta ligama lonyango elichaza amayeza. Ivunyiwe yi-FDA koku kulandelayo :

  • Ukunciphisa umngcipheko wosulelo ngenxa yemeko ebizwa ngokuba yi-febrile neutropenia kubantu abanee-cancer ezingasebenziyo. Ukuze usebenzise i-Neulasta, kuya kufuneka uthathe iyeza elichasene nomhlaza elinokubangela i-febrile neutropenia (inqanaba eliphantsi leeseli ezimhlophe zegazi ezibizwa ngokuba yi-neutrophils).
  • Ukunyanga ukugula kwemitha. Uhlobo lokugula kwemitha okusetyenziselwa i-Neulasta lubizwa ngokuba yi-hematopoietic subsyndrome.

Iklasi yeziyobisi yeNeulasta kunye neefom

I-Neulasta iqulethe isiyobisi esinye esisebenzayo: i-pegfilgrastim. I-Neulasta yeyiklasi yeziyobisi ekuthiwa zizinto ezikhula ngeleukocyte. Iklasi yeziyobisi liqela lamayeza asebenza ngendlela efanayo.

I-Neulasta iza ngeendlela ezimbini. Inye yethamo elinye lesirinji ekhethiweyo. Le fomu inikwa usuku emva kokuba une-chemotherapy njengenaliti engaphantsi (inaliti ngqo phantsi kolusu lwakho).

Umboneleli wezempilo uya kukunika inaliti ye-Neulasta, okanye usenokukwazi ukukunika inaliti ekhaya emva kokuba uqeqeshiwe. Isirinji iyafumaneka kumandla omnye: 6 mg / 0.6 mL.


Ifom yesibini ibizwa ngokuba yiNeulasta Onpro, eyinto yokufaka umzimba emzimbeni (OBI). Umboneleli wezempilo uya kuyifaka esiswini sakho okanye ngasemva kwengalo yakho ngalo mini ufumana ichemotherapy.

I-Neulasta Onpro ihambisa idosi yeziyobisi malunga nosuku emva kokuba kufakwe i-OBI. Oku kuthetha ukuba akukho mfuneko yokuba ubuyele kwi-ofisi kagqirha wakho ngenaliti. I-Neulasta Onpro iyafumaneka kumandla omnye: 6 mg / 0.6 mL.

Phawula: Ngelixa isirinji ye-Neulasta inokusetyenziselwa ukunyanga zombini ezi meko zidweliswe apha ngasentla, i-Neulasta Onpro ayisetyenziswanga ukunyanga ukugula kwemitha.

Ukusebenza ngempumelelo

Ngolwazi malunga nokusebenza kweNeulasta, jonga icandelo elithi "Neulasta isebenzisa" icandelo elingezantsi.

I-Neulasta generic okanye i-biosimilar

I-Neulasta iyafumaneka njengonyango lwegama lophawu. INeulasta ineenguqulelo ezintathu zebiosimilar: UFulphila, Udenyca, kunye noZiextenzo.

I-biosimilar sisiyobisi esifana nonyango lwegama lophawu. Ichiza elenza lafana nalawo aveliswe ngumenzi, kwelinye icala, liyikopi ngqo yesithako esisebenzayo kwiyeza elinegama lophawu.


I-Biosimilars isekelwe kumachiza e-biologic, adalwe kwiindawo zezinto eziphilayo. Iijenerikhi zisekwe kunyango oluqhelekileyo olwenziwe kwiikhemikhali. I-Biosimilars kunye ne-genics nazo zihlala zibiza ixabiso elingaphantsi kuneziyobisi ezinamagama.

I-Neulasta iqulethe isiyobisi esinye esisebenzayo: i-pegfilgrastim. Oku kuthetha ukuba i-pegfilgrastim sisithako esenza ukuba i-Neulasta isebenze.

Iziphumo ebezingalindelekanga ze-Neulasta

I-Neulasta inokubangela iziphumo ebezingalindelekanga ezinobulali okanye ezinobuzaza. Olu luhlu lulandelayo luqulathe ezinye zeziphumo ebezingalindelekanga ezinokubakho ngelixa uthatha i-Neulasta. Olu luhlu alubandakanyi zonke iziphumo ebezingalindelekanga ezinokubakho.

Ngolwazi oluthe kratya malunga neziphumo ebezingalindelekanga zeNeulasta, thetha nogqirha wakho okanye usokhemesti. Banokukunika iingcebiso malunga nendlela yokujongana nayo nayiphi na imiphumela emibi enokuthi ikhathaze.

Phawula: Ukutya kunye noLawulo lweeDrug (FDA) kulandelela iziphumo ebezingalindelekanga ezivunyiweyo. Ukuba ungathanda ukunika ingxelo kwi-FDA isiphumo secala osele unaso nge-Neulasta, ungakwenza oko ngeMedWatch.


Iziphumo ebezingalindelekanga ezinobulali

Iziphumo ezinobulali zeNeulasta zinokubandakanya:

  • iintlungu zethambo (ulwazi oluthe kratya "kwiinkcukacha zempembelelo yecala" apha ngezantsi)
  • iintlungu ezingalweni okanye emilenzeni

Uninzi lweziphumo ebezingalindelekanga zinokuhamba zingaphelanga iintsuku okanye iiveki ezimbalwa. Kodwa ukuba ziba nzima ngakumbi okanye azihambi, thetha nogqirha wakho okanye usokhemesti.

Iziphumo ebezingalindelekanga ezimandundu

Iziphumo ebezingalindelekanga ezimandundu ezivela kwiNeulasta aziqhelekanga, kodwa zinokwenzeka. Shayela ugqirha wakho ngokukhawuleza ukuba unemiphumo emibi. Tsalela umnxeba ku-911 ukuba iimpawu zakho ziziva zisongela ubomi okanye ukuba ucinga ukuba unempilo kaxakeka.

Iziphumo ebezingalindelekanga ezimandundu kunye neempawu zazo zinokubandakanya:

  • I-aortitis (ukudumba kwe-aorta, eyona mithetho iphambili yentliziyo). Iimpawu zingabandakanya:
    • umqolo obuhlungu
    • i-malaise (iimvakalelo zokuphazamiseka okanye ukungazithembi)
    • ifiva
    • isisu esibuhlungu

Ezinye iziphumo ebezingalindelekanga ezimandundu, ezichazwe ngokubanzi apha ngezantsi "Iinkcukacha zeziphumo ebezingalindelekanga," zibandakanya:

  • negazi lakho
  • isifo sokuphefumula (uhlobo lwemeko yemiphunga)
  • I-capillary leak syndrome (imeko apho imithambo yegazi encinci ivuza khona)
  • glomerulonephritis (iqela leemeko zezintso)
  • leukocytosis (ukwanda kwenqanaba leeseli ezimhlophe ezibizwa ngokuba ziiukocyte)
  • i-spleen ephukile (ukuvulwa komzimba obizwa ngokuba yi-spleen)

Iinkcukacha zesiphumo

Unokuzibuza ukuba zenzeka kangaphi ezinye iziphumo ebezingalindelekanga ngeli chiza. Nazi ezinye iinkcukacha kwezinye zeziphumo ebezingalindelekanga ezinokuthi zenzeke ngefuthe le-Neulasta okanye ipatch.

Ukuphendula ngokuchaseneyo

Njengokuba kuninzi lweziyobisi, abanye abantu banokuphendula emva kokuthatha i-Neulasta. Ayaziwa ukuba bangaphi abantu ababenomdla kwi-Neulasta kwizilingo zeklinikhi. Kodwa uninzi lwempendulo lwenzeka kubantu abafumene ithamo le-Neulasta okokuqala.

Kwaye kwabanye abantu, impendulo yaphinda yenzeka emva kweentsuku, emva kokuba unyango lwempendulo egulayo lwaluyekisiwe. Isincamathelisi se-acrylic sisetyenziswa kunye ne-Neulasta emzimbeni wokufaka inaliti (i-OBI) kwaye kunokubangela ukungalungelani komzimba xa kukho umntu onengxaki yokuncamathela.

Iimpawu zokuphendula kancinci kunokubandakanya:

  • irhashalala
  • ukucheba
  • ukucoca (ukufudumala nokubomvu kwesikhumba sakho)

Impendulo eyingozi kakhulu inqabile kodwa inokwenzeka. Iimpawu zokungaziphathi kakuhle kunokubandakanya:

  • ukudumba phantsi kolusu lwakho, ikakhulu kwiinkophe zakho, imilebe, izandla, okanye iinyawo
  • ukudumba kolwimi lwakho, umlomo, okanye umqala
  • ingxaki yokuphefumla

Biza ugqirha wakho ngoko nangoko ukuba uneempendulo ezomeleleyo kwi-Neulasta. Tsalela umnxeba ku-911 ukuba iimpawu zakho ziziva zisongela ubomi okanye ukuba ucinga ukuba unempilo kaxakeka.

Intlungu yethambo

Iintlungu zethambo ziziphumo ebezingalindelekanga eziqhelekileyo zeNeulasta. Kwizifundo zeklinikhi, iipesenti ezingama-31 zabantu abathathe i-Neulasta baxela iintlungu zethambo xa kuthelekiswa ne-26% yabantu abathathe i-placebo (unyango ngaphandle kwesiyobisi esisebenzayo).

Ayaziwa ngokuthe ngqo ukuba kutheni uNeulasta ebangela iintlungu zethambo kwabanye abantu. Enye ithiyori ibandakanya i-histamine, iprotein eyenziwa ngamajoni akho omzimba ukunceda ukulwa usulelo.

I-Neulasta ivuselela amajoni akho omzimba ekuveliseni iiseli ezimhlophe zegazi, ezikhokelela ekubeni kudalwe i-histamine. Kwaye ukukhutshwa kwe-histamine kunxulunyaniswe nokudumba komongo wethambo kunye nentlungu. Kodwa kufuneka uphando oluninzi ngaphambi kokuba lwaziwe ngokuqinisekileyo ukuba kutheni i-Neulasta ibangela iintlungu zethambo.

Ukuba unentlungu xa usebenzisa i-Neulasta, xelela ugqirha wakho. Banokumisela amayeza entlungu, njenge-ibuprofen okanye i-naproxen. Okanye banokukutshintshela kwelinye iyeza ngaphandle kweNeulasta.

Isifo esibuhlungu sokuphefumla (ARDS)

Isifo esibuhlungu sokuphefumla (i-ARDS) sisiphumo esibi seNeulasta, kodwa kunqabile ukwenzeka. I-ARDS ayichazwanga ngexesha lovavanyo lweklinikhi yeziyobisi, kodwa imeko ixeliwe kubantu abambalwa abathatha iNeulasta okoko yafika kwintengiso.

Nge-ARDS, imiphunga yakho igcwaliswa lulwelo kwaye ayinakho ukuhambisa ioksijini eyaneleyo kuwo wonke umzimba wakho. Oku kunokukhokelela kwezinye iingxaki zemiphunga ezifana nenyumoniya okanye usulelo.

Iimpawu ze-ARDS zingabandakanya:

  • ukudideka
  • owomileyo, okhohlela
  • ndiziva ndibuthathaka
  • ifiva
  • uxinzelelo lwegazi oluphantsi

I-ARDS yimeko esongela ubomi efuna ukhathalelo lonyango olukhawulezileyo. Ukuba uthatha i-Neulasta kwaye unengxaki yokuphefumla, ukuphefumla okukhawulezayo, okanye ukuphefumla okufutshane, tsalela umnxeba ku-911 okanye uye kwigumbi likaxakeka.

Isifo sokuvuza kwesifo seCapillary

I-Capillary leak syndrome yinto enqabileyo kodwa enokubangela isiphumo seNeulasta. Ayaziwa ngokuqinisekileyo ukuba kwenzeka kangaphi kwizifundo zeklinikhi.

IiCapillaries yimithambo yegazi encinci. ICapillary leak syndrome yenzeka xa ulwelo kunye neeproteni zilawula ukuphuma kwii-capillaries nakwisihlunu somzimba esijikelezileyo. Oku kunokubangela uxinzelelo lwegazi olusezantsi kunye ne-hypoalbuminemia (amanqanaba asezantsi eprotein ebalulekileyo ebizwa ngokuba yialbumin).

Iimpawu ze-capillary leak syndrome zinokubandakanya:

  • i-edema (ukuqunjelwa kunye nokugcinwa kwamanzi)
  • urhudo
  • ukudinwa (ukunqongophala kwamandla)
  • Ndiziva ndinxaniwe
  • isicaphucaphu
  • isisu esibuhlungu

Njengoko kukhankanyiwe ngasentla, i-capillary leak syndrome inqabile, kodwa inokubulala. Ke ukuba ucinga ukuba uneempawu ze-capillary leak syndrome ngelixa uthatha i-Neulasta, tsalela umnxeba ku-911 okanye uye kwigumbi likaxakeka.

IGlomerulonephritis

Nangona i-glomerulonephritis ingakhange ixelwe kwizifundo zeklinikhi ze-Neulasta, kuye kwaxelwa kubantu abathathe iyeza ukusukela oko lafika kwintengiso.

IGlomerulonephritis ibhekisa kukudumba (ukudumba) kweglomeruli, ezingamaqela emithambo yegazi kwizintso zakho. IGlomeruli inceda ukucoca iimveliso zenkunkuma egazini lakho kwaye uzidlulisele kumchamo.

Iimpawu ze-glomerulonephritis zinokubandakanya:

  • Ukudumba nokudumba ngenxa yokugcina amanzi, ngakumbi ebusweni, iinyawo, izandla okanye isisu
  • igazi elonyukayo
  • umchamo onombala opinki okanye omnyama ngombala
  • umchamo ojongeka unogwebu

Ukuba ucinga ukuba une-glomerulonephritis ngelixa uthatha i-Neulasta, xelela ugqirha wakho. Banokunciphisa idosi yakho, ehlala icoca i-glomerulonephritis. Kodwa ukuba ayisebenzi, ugqirha wakho uya kuthi uyeke ukuthatha i-Neulasta. Banokuzama amayeza ahlukileyo endaweni yoko.

Leukocytosis

Ileukocytosis yinto enqabileyo kodwa enokuba nefuthe elibi le-Neulasta.

Kwizifundo zonyango, i-leukocytosis yenzeke ngaphantsi kwe-1% yabantu abathathe iyeza. I-Neulasta yafaniswa ne-placebo, kodwa ayaziwa nokuba okanye kwenzeka kaninzi kangakanani i-leukocytosis kubantu abathathe i-placebo. Akukho zingxaki zinxulumene neleukocytosis ezichaziweyo kwezi zifundo.

Ileukocytosis yimeko apho inqanaba leeseli ezimhlophe ezibizwa ngokuba ziiukocyte liphezulu kunesiqhelo. Oku kuhlala kungumqondiso wokuba umzimba wakho uzama ukulwa usulelo. Nangona kunjalo, i-leukocytosis inokuba luphawu lwe-leukemia (umhlaza ochaphazela umongo wethambo okanye igazi).

Iimpawu ze-leukocytosis zingabandakanya:

  • ukopha okanye ukugruzuka
  • iingxaki zokuphefumla ezinje ngevili
  • ifiva

Ngenxa yokuba usemngciphekweni wokosuleleka ngelixa uthatha i-Neulasta, xelela ugqirha wakho ngoko nangoko ukuba uba nomkhuhlane okanye ezinye iimpawu ze-leukocytosis. Baza kukunceda ukumisela unobangela kwaye loluphi unyango olulungele wena.

Udakada oluvunyiweyo

I-spleen eyandisiweyo kunye ne-spleen spleen azizange zichazwe kwizilingo zeklinikhi ze-Neulasta. Nangona kunjalo, le miqathango ixeliwe kubantu abathathe i-Neulasta okoko ichiza lafika emarikeni.

Udakada lilungu elingasekhohlo kumphezulu wesisu sakho, phantsi kweembambo zakho. Kuyasebenza ukucoca igazi kunye nokulwa nosulelo.

Iimpawu zepleen ephukileyo zingabandakanya:

  • ukudideka
  • Ukuziva uxhalabile okanye ungazoli
  • intloko elula
  • isicaphucaphu
  • iintlungu kwindawo ephezulu yasekhohlo yesisu
  • ulusu oluthuthu
  • iintlungu zamagxa

I-spleen ephukileyo yimeko esongela ubomi efuna ukhathalelo lonyango olukhawulezileyo. Ukuba uthatha i-Neulasta kwaye uneentlungu egxalabeni lasekhohlo okanye kwindawo ephezulu yesisu ngasekhohlo, xelela ugqirha wakho ngoko nangoko.

Umkhuhlane (hayi isiphumo esisecaleni)

Umkhuhlane awuyiyo impembelelo yecala elindelekileyo lokuthatha i-Neulasta.

Ukuphuhlisa umkhuhlane ngexesha lonyango lwe-Neulasta kunokuthetha ukuba unosulelo. Umkhuhlane unokuba luphawu lweempawu ezinqabileyo kodwa ezinzulu ze-Neulasta, ezinje ngesifo sokuphefumla esiqatha (i-ARDS), i-aortitis, okanye i-leukocytosis. (Ngakumbi malunga ne-ARDS kunye neukocytosis, jonga la macandelo angezantsi.)

Ukuba uhlakulela umkhuhlane ngelixa uthatha i-Neulasta, xelela ugqirha wakho ngoko nangoko. Banganceda ukufumanisa ukuba yintoni ebangela umkhuhlane wakho kunye nendlela efanelekileyo yokuyinyanga.

Umthamo weNeulasta

Idosi ye-Neulasta emiselweyo ngugqirha iya kuxhomekeka kwizinto ezininzi. Oku kubandakanya:

  • uhlobo kunye nobunzima bemeko oyisebenzisayo ukunyanga i-Neulasta
  • iminyaka yakho
  • ifom yeNeulasta oyithathayo
  • ezinye iimeko zonyango onokuba nazo

Ngokuqhelekileyo, ugqirha wakho uya kukuqala kwiqondo eliphantsi. Emva koko baya kuyilungisa ngokuhamba kwexesha ukufikelela kwisixa esifanelekileyo kuwe. Ugqirha wakho uya kuthi ekugqibeleni anike idosi encinci enika isiphumo esifunayo.

Olu lwazi lulandelayo luchaza iidosi eziqhelekileyo ezisetyenziswayo okanye ezicetyiswayo. Nangona kunjalo, qiniseka ukuthatha idosi ekumisela ugqirha wakho. Ugqirha wakho uya kugqiba eyona milinganiselo ilungele iimfuno zakho.

Iifom zamachiza kunye namandla

I-Neulasta iza ngeendlela ezimbini. Inye yethamo elinye lesirinji ekhethiweyo. Le fomu inikwa usuku emva kokuba une-chemotherapy njengenaliti engaphantsi (inaliti ngqo phantsi kolusu lwakho).

Umboneleli wezempilo uya kukunika inaliti ye-Neulasta, okanye usenokukwazi ukukunika inaliti ekhaya emva kokuba uqeqeshiwe. Isirinji iyafumaneka kumandla omnye: 6 mg / 0.6 mL.

Ifom yesibini ibizwa ngokuba yiNeulasta Onpro, eyinto yokufaka umzimba emzimbeni (OBI). Umboneleli wezempilo uya kuyifaka esiswini sakho okanye ngasemva kwengalo yakho ngalo mini ufumana ichemotherapy.

I-Neulasta Onpro ihambisa idosi yeziyobisi malunga nosuku emva kokuba kufakwe i-OBI. Oku kuthetha ukuba akukho mfuneko yokuba ubuyele kwi-ofisi kagqirha wakho ngenaliti. I-Neulasta Onpro iyafumaneka kumandla omnye: 6 mg / 0.6 mL.

Kubalulekile ukuba uqaphele ukuba i-Neulasta Onpro ayisetyenziselwa ukunyanga ukugula kwemitha.

Isisombululo sokuthintela usulelo ngexesha le-chemotherapy

Ukuthintela usulelo ngexesha le-chemotherapy, i-Neulasta inikwa idosi enye kube kanye kumjikelo ngamnye wekhemotherapy. Idosi enye inaliti enye kunye nesirinji okanye ukusetyenziswa kweNeulasta Onpro enye.

Akufanele usebenzise i-Neulasta nokuba ziintsuku ezili-14 ngaphambi okanye iiyure ezingama-24 emva kokuba unechemotherapy.

Isisombululo sokugula kwemitha

Ukunyanga i-hematopoietic subsyndrome ye-radiation syndrome (ukugula kwemitha), i-Neulasta inikwa njengeedosi ezimbini. Uya kuba nazo i-1 ngeveki ngaphandle. Idosi enye yinaliti enye kunye nesirinji.

Idosi yabantwana

I-Neulasta yamkelwe ukunceda ukuthintela usulelo kubantwana abafumana ichemotherapy. Iyeza livunyiwe ukuba lisetyenziswe kubantwana abanesifo semitha. Akukho zithintelo zisusela kubudala bokusebenzisa i-Neulasta.

Kwiidosi ze-Neulasta kubantwana abanobunzima obungaphezulu kweeponti ezingama-99 (45 kg), jonga amacandelo edosi apha ngasentla.

Imilinganiselo yabantwana abanobunzima obungaphantsi kweepawundi ezingama-99 (45 kg) isekwe kubunzima. Ugqirha womntwana wakho uya kugqiba ukuba yiyiphi imilinganiselo ye-Neulasta efanelekileyo kumntwana wakho.

Kuthekani ukuba ndiphose idosi?

Ukuba uyaphoswa kukuzinika inaliti yeNeulasta ngesirinji, tsalela umnxeba kwangoko emva kokuba uyiqondile le nto. Banokukucebisa xa uthatha idosi yakho.

Ukuba uphoswa idinga le-Neulasta injection, biza ugqirha wakho kwiofisi. Abasebenzi banokukuhlengahlengisa kwaye bahlengahlengise ixesha lotyelelo lwexesha elizayo, ukuba kukho imfuneko.

Kuyenzeka ukuba uphoswe ithamo ngelixa usebenzisa i-Neulasta Onpro. Kungenxa yokuba isitofu somzimba ngamanye amaxesha sisilela ukusebenza okanye ukuvuza. Ukuba oku kuyenzeka, tsalela umnxeba iofisi kagqirha wakho kwangoko. Abasebenzi baya kucwangcisa ixesha lokuba ungene ngenaliti yeNeulasta ukuze ufumane idosi yakho epheleleyo.

Ukukunceda uqiniseke ukuba awuphosi idosi, zama ukuseta isikhumbuzi kwifowuni yakho. Ungabhala kwakhona ishedyuli yakho yonyango kwikhalenda.

Ngaba kuya kufuneka ndisebenzise eli chiza ixesha elide?

I-Neulasta yenzelwe ukuba isetyenziswe njengonyango lwexesha elide, ukuba nje ufumana ichemotherapy. Ukuba wena nogqirha wakho nigqiba ekubeni i-Neulasta ikhuselekile kwaye iyasebenza kuwe, uya kuyithatha ixesha elide.

Imibuzo eqhelekileyo malunga neNeulasta

Nazi iimpendulo kwimibuzo ebuzwa rhoqo malunga neNeulasta.

Ngaba uClaritin angandinceda ukulawula iziphumo ebezingalindelekanga zeNeulasta?

Kusenokwenzeka. I-Neulasta isebenza ngokubangela amajoni akho omzimba ukuba enze iiseli ezimhlophe zegazi.

Iiproteni ezithile ezibizwa ngokuba zii-histamines nazo zikhutshwa yile nkqubo. Ayaziwa ncam ukuba kutheni ukukhutshwa kwe-histamines kukhokelela kwiziphumo ebezingalindelekanga ezinjengeentlungu zethambo. Kodwa uphando lubonakalisile ukuba i-histamine iyabandakanyeka kukudumba, okunokubangela iintlungu.

I-Claritin yonyango lwe-antihistamine. Isebenza ngokuthintela isenzo se-histamine. Ngokwenza njalo, uClaritin unokunceda ukunciphisa iintlungu zethambo kubantu abathatha i-Neulasta, kodwa uphando oluninzi luyafuneka.

Ukuba uthatha i-Neulasta kwaye uneentlungu kwithambo, thetha nogqirha wakho. Banokuphonononga unyango olufumanekayo kwaye bancede baqonde ukuba loluphi olulungele wena.

Zithatha ixesha elingakanani iziphumo ebezingalindelekanga zeNeulasta?

Ayaziwa kuba akukho datha yaneleyo malunga nokuba zide kangakanani iziphumo ebezingalindelekanga zokudubula kweNeulasta.

Kwizifundo zeklinikhi, abanye abantu baxele iintlungu zethambo okanye iintlungu ezingalweni okanye emilenzeni emva kokufumana i-Neulasta. Kodwa abaphandi abazange babhale ukuba zide kangakanani iziphumo ebezingalindelekanga.

Ngolwazi oluthe kratya malunga neziphumo ebezingalindelekanga ezinokubakho zeNeulasta, nceda ujonge kwicandelo "lempembelelo zeNeulasta" apha ngasentla. Unokufikelela kugqirha wakho.

Uhlala ixesha elingakanani uNeulasta kwinkqubo yakho?

Ixesha linokwahluka. Izifundo zeklinikhi zibonise ukuba ukucoca i-Neulasta emzimbeni kuchaphazeleka ubunzima bomzimba wakho kunye nenani le-neutrophils (uhlobo lweseli emhlophe yegazi) egazini lakho.

Ngokubanzi, emva kwenaliti enye, iNeulasta isuswe ngokupheleleyo kwinkqubo yakho kwiintsuku ezili-14.

Xa ndibhabha, ngaba kufuneka ndixelele ukhuseleko kwisikhululo seenqwelomoya ukuba ndineNeulasta Onpro?

Ewe. Umenzi weNeulasta unekhadi lesaziso loLawulo loKhuseleko kuThutho (i-TSA) onokuprinta kwaye ubonise abasebenzi bezokhuseleko kwisikhululo senqwelomoya. Cofa apha ukufikelela kwikhadi.

Nangona kunjalo, kuyacetyiswa ukuba ukunqande ukuhamba (kubandakanya ukuqhuba) ngefestile yeeyure ezingama-26 ukuya kwezingama-29 emva kokufumana iNeulasta Onpro. Isixhobo sihambisa iyeza emzimbeni wakho ngeli xesha. Kwaye ukuhamba kunokunyusa umngcipheko we-Neulasta Onpro onkqonkqozwa emzimbeni wakho.

Ukuba unemibuzo malunga nonyango lwakho lwe-Neulasta xa useluhambeni, thetha nogqirha wakho.

Kutheni le nto kufuneka ndigcine iNeulasta Onpro ikude neeselfowuni kunye nezinye izixhobo zombane?

Iimpawu ezivela kwezi zixhobo zombane zinokuphazamisa iNeulasta Onpro kwaye ziyigcine ekunikezeleni idosi yakho.

Kuyacetyiswa ukuba ugcine i-Neulasta Onpro ubuncinci i-intshi ezi-4 kude nezixhobo zombane, kubandakanya iifowuni kunye nee-microwaves.

Ukuba unemibuzo malunga nokusebenzisa i-Neulasta Onpro, buza ugqirha wakho.

Ndingayilahla njani iNeulasta Onpro?

Emva kokuba ufumene idosi yakho epheleleyo yeNeulasta ngokusebenzisa iNeulasta Onpro, kuya kufuneka uyilahle isixhobo ngokusifaka kwisitya seSharps.

Umvelisi weNeulasta uneNkqubo yokuCoca iNkunkuma yeSharps ukukunceda ulahle ngokukhuselekileyo iNeulasta Onpro. Oku kunikezelwa ngaphandle kweendleko ezongezelelweyo kuwe. Ungacofa apha ukuze ubhalisele le nkqubo (jonga icandelo le- “Injector Disposal Programme”), okanye utsalele umnxeba ku-1-844-696-3852.

I-Neulasta isebenzisa

Ulawulo lokutya kunye neziyobisi (i-FDA) livuma amayeza amiselweyo anjengeNeulasta ukunyanga iimeko ezithile. I-Neulasta inokusetyenziselwa ngaphandle kwelebheli yezinye iimeko. Ukusetyenziswa kwelebula engekho xa kusebenze iyeza elamkelweyo ukunyanga imeko enye lisetyenziselwa ukunyanga imeko eyahlukileyo.

I-Neulasta yokuthintela usulelo ngexesha lekhemotherapy

I-Chemotherapy luhlobo lonyango lomhlaza olusebenzisa amayeza ukubulala ukwahlula iiseli zomhlaza. Oku kunceda ukuthintela umhlaza ekukhuleni nasekusasazeni.

Nangona kunjalo, i-chemotherapy ayibalulekanga kwiiseli zomhlaza. I-Chemotherapy iphinda itshabalalise ezinye iiseli ezahlula umzimba, kubandakanya iiseli eziluncedo ezifana neeseli ezimhlophe zegazi.

I-Neutropenia yimeko yegazi apho amanqanaba e-neutrophil ephantsi. I-neutrophils luhlobo lweeseli ezimhlophe zegazi ezikhusela umzimba wakho kusulelo. Ukuba amanqanaba akho e-neutrophil aphantsi, umzimba wakho awuyi kukwazi ukulwa ngokufanelekileyo neebhaktheriya. Ke ukuba i-neutropenia yonyusa umngcipheko wosulelo.

I-neutropenia ye-Febrile yenzeka xa une-neutropenia kwaye uvelisa umkhuhlane, onokuba luphawu losulelo. Kwaye ukuba ne-neutropenia kuthetha ukuba awukwazi ukulwa nosulelo njengesiqhelo. Ke i-febrile neutropenia yimeko encomekayo ekufuneka ugqirha ayiqwalasele kwangoko.

Into eyenziwa nguNeulasta

I-Neulasta isetyenziselwa ukunceda ukuthintela usulelo kubantu abanomhlaza othile abafumana ichemotherapy. Iicancer zibizwa ngokuba zii-non-myeloid cancer, ezingabandakanyi umongo wethambo (izicwili ezingaphakathi kwamathambo ezenza iiseli zegazi). Umzekelo womhlaza ongena-myeloid ngumhlaza webele.

I-Neulasta ikunceda ekudaleni i-neutrophils kunye nezinye iiseli ezimhlophe zegazi. Oku kunceda umzimba wakho ukuba ukulungele ngakumbi ukulwa nosulelo, uncede ukuthintela i-neutropenia ene-febrile, kwaye unciphise ukuba une-neutropenia ixesha elingakanani.

Ukusebenza ngempumelelo

Kwizifundo zeklinikhi, i-Neulasta ibonakalisiwe ukunciphisa umngcipheko we-febrile neutropenia kunye nokuba imeko ihlala ixesha elingakanani kubantu abayikhulisayo.

Olunye uphononongo luthelekise i-Neulasta kunye ne-filgrastim (Neupogen), lelinye ichiza eliqinisekisiweyo ukunceda ukuthintela nokunyanga i-neutropenia engafakwanga. Abaphandi bafuna ukubona ukuba i-Neulasta yayisebenza kakuhle njenge-filgrastim ekunciphiseni ukuba ihlala ixesha elingakanani i-neutropenia.

Kolu phando, abantu bafumana irejimeni yonyango (isicwangciso sonyango) esine-doxorubicin kunye ne-docetaxel rhoqo ngeentsuku ezingama-21. Iirejimeni ezifanayo zinxulunyaniswe ne-neutropenia enzima eyenzeke kuzo zonke iimeko.

Le meko yahlala malunga neentsuku ezi-5 ukuya kwezi-7 ngokwe-avareji, kwaye malunga neepesenti ezingama-30 ukuya kuma-40% abantu bakhula nefebrile neutropenia.

Abantu babelwa ngokulandelelana ukuba bafumane i-Neulasta okanye i-filgrastim. Abaphandi bafumanisa ukuba i-Neulasta yayisebenza ngokufana ne-filgrastim.

Abantu abafumene i-Neulasta kwaye bakhula i-neutropenia enzima banemeko yomndilili weentsuku eziyi-1.8. Abantu abafumene i-filgrastim kwaye bakhula i-neutropenia enzima babenemeko ye-avareji yeentsuku eziyi-1.7.

Isifundo sesibini ngokuseta okufanayo kufumene neziphumo ezifanayo. Abantu abafumene i-Neulasta kwaye bakhula i-neutropenia enzima babenemeko ye-avareji yeentsuku eziyi-1.7. Oku kuthelekiswa nomndilili weentsuku eziyi-1.6 kubantu abafumene ifilgrastim.

I-Neulasta yokugula kwemitha

I-Neulasta ikwavunyiwe yi-FDA ukunyanga ukugula kwemitha. Imeko inokuthi ibhekiswe kuyo njenge-radiation syndrome okanye i-radiation toxicity.

Uhlobo lokugula kwemitha okusetyenziselwa i-Neulasta lubizwa ngokuba yi-hematopoietic subsyndrome. Ixabiso lokuvezwa kwemitha ebangela ukuba le syndrome ichazwe njenge-myelosuppressive, oko kuthetha ukuba bakhokelela kumongo wethambo lakho ukwenza iiseli zegazi ezimbalwa.

Ukugula ngemitha kwenzeka xa umntu echaphazeleka kwiidosi eziphezulu zemitha ngexesha elifutshane kakhulu (ngesiqhelo yimizuzu nje embalwa). Amanani aphezulu emitha anokubulala iiseli emzimbeni wakho. Ukugula ngemitha kunokuba yingozi xa ukubonakaliswa yimitha kunzima ngokwaneleyo.

Ngezizathu zokuziphatha, abaphandi babengenako ukuvavanya amandla kaNeulasta okunyanga ukugula kwemitha ebantwini. Endaweni yoko, iyeza lavunywa ukuba liphathe ukugula kwemitha ngokusekwe kwizifundo zezilwanyana, ukongeza kwidatha ekhankanywe kwi "Neulasta yokuthintela usulelo ngexesha lekhemotherapy" icandelo elingentla.

Phawula: I-Neulasta Onpro (i-Neulasta on-body injector) akufuneki isetyenziselwe ukunyanga ukugula kwemitha.

Ukusetyenziswa kwelebheli engekho kwi-Neulasta

Ukongeza kusetyenziso oludweliswe apha ngasentla, i-Neulasta inokusetyenziswa ngaphandle kwelebheli kwiimeko ezithile. Ukusetyenziswa kweziyobisi ezingekho kwilebula kuxa iziyobisi ezivunyiweyo zisetyenziselwa ukusetyenziswa kwesinye zisetyenziselwa enye eyahlukileyo engavunyelwanga.

Ukutshintshwa kweseli emva kwe hematopoietic

I-Neulasta ayivunyelwanga yi-FDA ukuba isetyenziselwe ukufakelwa kweseli emva kwe-hematopoietic (HCT). Nangona kunjalo, ichiza linokusetyenziselwa ngaphandle kwelebheli ukulungiselela le njongo.

I-HCT yinkqubo eyenziwa emva kokuba une-chemotherapy. Nje ukuba i-chemotherapy isetyenziselwe ukubulala iiseli zomhlaza, iiseli zeziqu zitshintshelwa kuwe ngexesha le-HCT. Oku kwenziwa kuba ichemotherapy ayihlaseli nje iiseli zomhlaza. Inokubulala neeseli ezenziweyo ezenziwe ngumongo wethambo lakho.

Iiseli zestem zihlala ziiplatelets (iiseli zegazi ezinceda ukujiya kwegazi lakho), iiseli ezibomvu zegazi, kunye neeseli ezimhlophe zegazi, zinto ezo zibalulekile ekugcineni impilo.

Xa i-HCT inikwa abantu abanomhlaza wegazi, usulelo lunokwenzeka. Kungenxa yokuba iiseli ezintsha azisebenzi ngokupheleleyo kanye emva kokufakelwa.

Ukusebenzisa i-Neulasta emva kwe-HCT kunceda umzimba wakho wenze iiseli ezintsha ezimhlophe zegazi, kubandakanya i-neutrophils. Inqanaba eliphilileyo le-neutrophils linceda umzimba wakho ukuba ulwe nosulelo ngcono.

Ukusebenza ngempumelelo

Nangona i-Neulasta ingagunyaziswanga yi-FDA ukuba isetyenziswe emva kwe-HCT, izifundo zeklinikhi zibonise ukuba ichiza liyasebenza kolu setyenziso.

Olunye uphononongo luthelekise i-Neulasta kunye neziyobisi ezifanayo, i-filgrastim (Neupogen), evunyiweyo yi-FDA ukuba isetyenziswe emva kwe-HCT. I-Neulasta inikwa nje ngenaliti enye, ngelixa i-filgrastim inikwa njengezitofu ezininzi kwiintsuku ezininzi.

Kwisifundo, abantu abali-14 abane-non-Hodgkin lymphoma, i-myeloma, okanye i-amyloidosis bafumana i-Neulasta emva kokuba ne-HCT.

Abaphandi bathelekisa iziphumo zaba bantu neziphumo zabantu abafumene i-filgrastim ngaphambili. Oku kuthetha ukuba bekungekho liqela le-placebo (unyango ngaphandle kwesiyobisi esisebenzayo).

Abaphandi bafumanise ukuba kuthathe umndilili weentsuku ezili-11 ukuze i-neutrophils ibuyele kumanqanaba akhuselekileyo kubantu abafumene i-Neulasta. Xa kuthelekiswa, kuthathe umndilili weentsuku ezili-14 zabantu abathathe i-filgrastim ngaphambili.

Ukuba unemibuzo malunga nokuthatha i-Neulasta emva kwe-HCT, thetha nogqirha wakho.

Neulasta kunye nabantwana

I-Neulasta yamkelwe ukunceda ukuthintela usulelo kubantwana abafumana ichemotherapy. Iyeza livunyiwe ukuba lisetyenziswe kubantwana abanesifo semitha. Akukho zithintelo zisusela kubudala bokusebenzisa i-Neulasta.

Ukusetyenziswa kwe-Neulasta nezinye iziyobisi

I-Neulasta isetyenziswa ngamanye amayeza. Kungenxa yokuba iNeulasta yinxalenye enye kuphela yerejimeni yonyango lomhlaza (icebo).

I-Neulasta isetyenziswa rhoqo kwi-chemotherapy kuba i-Neulasta inceda ukuthintela okanye ukunyanga iziphumo ebezingalunganga ze-chemotherapy.

Ukusetyenziswa kwesiyobisi ngamayeza aquka:

  • Yimalini
  • icarboplatin
  • cyclophosphamide
  • I-docetaxel (iTaxotere)
  • doxorubicin (Doxil)
  • gemcitabine (iGemzar)
  • zibelka

Gcina ukhumbule ukuba oku akulona uluhlu olupheleleyo lweyeza zonyango. Thetha nogqirha wakho ukuba unemibuzo malunga naziphi na iziyobisi ze-chemotherapy kwaye nokuba i-Neulasta inokukunceda.

Eminye indlela eya eNeulasta

Amanye amachiza akhoyo anokuyinyanga imeko yakho. Ezinye zinokukulungela ngcono kunabanye. Ukuba unomdla wokufumana enye indlela eya kwi-Neulasta, thetha nogqirha wakho. Banokukuxelela ngamanye amayeza anokukusebenzela.

Phawula: Amanye amachiza adweliswe apha ngezantsi asetyenziswa ngaphandle kwelebheli ukunyanga le miqathango. Ukusetyenziswa kwelebula engekho xa kusebenze iyeza elamkelweyo ukunyanga imeko enye lisetyenziselwa ukunyanga imeko eyahlukileyo.

Ezinye iindlela zokuthintela usulelo ngexesha lekhemotherapy

Imizekelo yezinye iziyobisi ezingasetyenziselwa ukukhusela izifo ngexesha le-chemotherapy ziquka:

  • I-tbo-filgrastim (iGranix)
  • pegfilgrastim (iFulphila)
  • sargramostim (Leukine)
  • Iifilastrimu (Neupogen)
  • Ifilgrastim-aafi (iNivestym)
  • pegfilgrastim-cbqv (Udenyca)
  • Ifilgrastim-sndz (iZarxio)
  • pegfilgrastim-bmez (iZiextenzo)

Ezinye iindlela zokugula ngemitha

Imizekelo yezinye iziyobisi ezinokusetyenziselwa ukunyanga ukugula kwemitha zibandakanya:

  • I-tbo-filgrastim (iGranix)
  • ipotassium
  • I-Prussian eluhlaza okwesibhakabhaka
  • pegfilgrastim (iFulphila)
  • Iifilastrimu (Neupogen)
  • Ifilgrastim-aafi (iNivestym)
  • pegfilgrastim-cbqv (Udenyca)
  • Ifilgrastim-sndz (iZarxio)
  • pegfilgrastim-bmez (iZiextenzo)

I-Neulasta vs IGranx

Unokuzibuza ukuba i-Neulasta ithelekiswa njani namanye amayeza amiselwe ukusetyenziswa okufanayo. Apha sijonga indlela iNeulasta kunye neGranix ezifanayo kunye ezahlukeneyo.

Izithako

I-Neulasta iqulethe ichiza elisebenzayo i-pegfilgrastim. I-Granix iqulethe isiyobisi esisebenzayo se-tbo-filgrastim.

Zombini i-pegfilgrastim kunye ne-tbo-filgrastim zezodidi lwamayeza abizwa ngokuba zii-granulocyte-colony izinto ezikhuthazayo (G-CSFs). Iklasi yonyango liqela leziyobisi ezisebenza ngendlela efanayo.

I-G-CSF lunyango olubangela ukuba i-neutrophils (uhlobo lweseli emhlophe yegazi) ikhule kumongo wakho wethambo. Umongo wethambo sisicubu sangaphakathi samathambo esenza iiseli zegazi. Ii-G-CSF ziikopi ezenziwe ngabantu zehomoni ye-G-CSF eyenziwa ngumzimba wakho ngokwendalo.

Sebenzisa

Zombini i-Neulasta kunye ne-Granix zivunyiwe yi-Food and Drug Administration (i-FDA) ukunciphisa umngcipheko wosulelo ngenxa yemeko ebizwa ngokuba yi-febrile neutropenia kubantu abane-cancer ezingasebenziyo. * Ukuze usebenzise la mayeza, kufuneka uthathe iziyobisi zomhlaza ezinokubangela i-neutropenia efebrile.

I-Neulasta ikwavunyiwe yi-FDA ukunyanga ukugula kwemitha. * Uhlobo lokugula kwemitha okusetyenziselwa i-Neulasta kuthiwa yi-hematopoietic subsyndrome.

Iifom zeziyobisi kunye nolawulo

Nalu ulwazi malunga neefom ze-Neulasta kunye neGranix kunye nendlela abanikwa ngayo.

Iifom zeNeulasta

I-Neulasta iza ngeendlela ezimbini. Inye yethamo elinye lesirinji ekhethiweyo. Le fomu inikwa usuku emva kokuba une-chemotherapy njengenaliti engaphantsi (inaliti ngqo phantsi kolusu lwakho).

Umboneleli wezempilo uya kukunika inaliti ye-Neulasta, okanye usenokukwazi ukukunika inaliti ekhaya emva kokuba uqeqeshiwe.

Ifom yesibini ibizwa ngokuba yiNeulasta Onpro, eyinto yokufaka umzimba emzimbeni (OBI). Umboneleli wezempilo uya kuyifaka esiswini sakho okanye ngasemva kwengalo yakho ngalo mini ufumana ichemotherapy.

I-Neulasta Onpro ihambisa idosi yeziyobisi malunga nosuku emva kokuba kufakwe i-OBI. Oku kuthetha ukuba akukho mfuneko yokuba ubuyele kwi-ofisi kagqirha wakho ngenaliti.

Phawula: I-Neulasta Onpro ayisetyenziselwa ukunyanga ukugula kwemitha.

Iifom zeGranix

I-Granix iza ngeendlela ezimbini: idosi enye yesirinji ekhethiweyo kunye nedosi enye yedosi yesisombululo esingamanzi. Zombini ezi fom zinokunikwa ngumboneleli ngenkathalo yezempilo njengenaliti ngaphantsi, ngqo phantsi kolusu lwakho. Kodwa ngoqeqesho oluthile, unokukwazi ukuzifaka inaliti ekhaya.

Ukulinganisa rhoqo

Umahluko obalulekileyo phakathi kweNeulasta kunye neGranix kukunikwa iziyobisi amaxesha amaninzi ukunciphisa umngcipheko wosulelo ngexesha lokunyanga ngamayeza.

I-Neulasta inikwa kube kanye kuphela kumjikelo ngamnye we-chemotherapy. I-Granix, kwelinye icala, inikwa yonke imihla de amanqanaba ee-neutrophils egazini lakho abuyele esiqhelweni.

Iziphumo kunye neengozi

I-Neulasta kunye neGranix zombini zisetyenziselwa ukunceda ukuthintela usulelo ngexesha le-chemotherapy. Ke ngoko, la mayeza anokubangela iziphumo ebezingalindelekanga ezifanayo, kodwa ezinye zahlukile ngokunjalo. Apha ngezantsi kunemizekelo yeziphumo ebezingalindelekanga.

Iziphumo ebezingalindelekanga ezinobulali

Olu luhlu lunemizekelo yeziphumo ebezingalindelekanga ezinobulali ezinokuthi zenzeke ngeNeulasta, kunye neGranix, okanye zombini iziyobisi (xa zithathwa ngokwahlukeneyo).

  • Inokwenzeka ngeNeulasta:
    • iziphumo ebezingalindelekanga ezimbalwa ezizodwa
  • Ngaba kunokwenzeka ngeGranix:
    • intloko ebuhlungu
    • iintlungu zemisipha
    • ukugabha
  • Inokwenzeka kunye neNeulasta kunye neGranix:
    • iintlungu zethambo
    • iintlungu ezingalweni okanye emilenzeni

Iziphumo ebezingalindelekanga ezimandundu

Olu luhlu lunemizekelo yeziphumo ebezingalindelekanga ezinokubakho ngeNeulasta, kunye neGranix, okanye zombini iziyobisi (xa zithathwa ngokwahlukeneyo).

  • Inokwenzeka ngeNeulasta:
    • iziphumo ebezingalindelekanga ezimbalwa ezizodwa
  • Ngaba kunokwenzeka ngeGranix:
    • i-vasculitis (ukudumba kwemithambo yegazi yesikhumba)
    • thrombocytopenia (amanqanaba asezantsi eplatelet)
    • ukuphazamiseka kweseli yesigulana (iqela leziphazamiso ezichaphazela iiseli ezibomvu zegazi, ngakumbi ihemoglobin)
  • Inokwenzeka kunye neNeulasta kunye neGranix:
    • negazi lakho
    • leukocytosis (ukwanda kwenqanaba leeseli ezimhlophe zegazi)
    • i-spleen ephukile (ukuvulwa komzimba obizwa ngokuba yi-spleen)
    • isifo sokuphefumula (uhlobo lwemeko yemiphunga)
    • glomerulonephritis (iqela leemeko zezintso)
    • I-capillary leak syndrome (imeko apho imithambo yegazi encinci ivuza khona)
    • i-aortitis (ukudumba kwe-aorta, owona mthambo uphambili wentliziyo)

Ukusebenza ngempumelelo

Ukusetyenziswa okuphela kokubini i-Neulasta kunye ne-Granix zivunyiwe ukunciphisa umngcipheko wosulelo ngenxa yemeko ebizwa ngokuba yi-febrile neutropenia kubantu abanomhlaza ongenguye we-myeloid.

Izifundo ezahlukileyo zamachiza amabini zithelekiswa kuphononongo olukhulu lwezifundo ezibizwa ngokuba kukuphononongwa kwenkqubo. Abaphandi bajonga idatha kwizifundo ezili-18.

Abantu babefumene i-pegfilgrastim (ichiza elisebenzayo kwi-Neulasta), i-filgrastim, okanye ichiza elifanayo, kubandakanya i-Granix. Iqela le-pegfilgrastim lalingenamathuba okuba nefebrile neutropenia kwaye kunqabile ukuba lifune ukuhlala esibhedlele ngenxa ye-febrile neutropenia. Oku kuthelekiswa namanye amaqela eziyobisi.

Iindleko

I-Neulasta kunye neGranix zombini zinegama lophawu lweziyobisi.

INeulasta ineenguqulelo ezintathu zebiosimilar: UFulphila, Udenyca, kunye noZiextenzo.

I-Granix ayithathwa njengobuchwephesha njenge-biosimilar, ngokwe-FDA.

I-biosimilar sisiyobisi esifana nonyango lwegama lophawu. Ichiza elenza lafana nalawo aveliswe ngumenzi, kwelinye icala, liyikopi ngqo yesithako esisebenzayo kwiyeza elinegama lophawu.

I-Biosimilars isekelwe kumachiza e-biologic, adalwe kwiindawo zezinto eziphilayo. Iijenerikhi zisekwe kunyango oluqhelekileyo olwenziwe kwiikhemikhali. I-Biosimilars kunye ne-genics nazo zihlala zibiza ixabiso elingaphantsi kuneziyobisi ezinamagama.

Ngokwengqikelelo yeGoodRx.com, amaxabiso e-Neulasta kunye neGranix aya kwahluka ngokuxhomekeka kwidosi emiselweyo. Elona xabiso uzakuhlawula ngalo naliphi na ichiza liya kuxhomekeka kwisicwangciso sakho seinshurensi, indawo okuyo, kunye nekhemesti oyisebenzisayo.

INeulasta vs.Fulphila

NjengoGranix (exoxwe ngasentla), ichiza uFulphila asebenzise ngokufanayo nelaseNeulasta. Nalu uthelekiso lwendlela uNeulasta noFulphila abafana ngayo nabangafani ngayo.

Izithako

INeulasta kunye neFulphila ziqulethe ichiza elifanayo elisebenzayo, ipegfilgrastim.

Ngokobuchwephesha, iFulphila iqulethe isithako esisebenzayo pegfilgrastim-jmdb. Kungenxa yokuba uFulphila luhlobo lweziyobisi olubizwa ngokuba yi-biosimilar. I-biosimilar sisiyobisi esifana nonyango lwegama lophawu. I-Biosimilars isekelwe kumachiza e-biologic, adalwe kwiindawo zezinto eziphilayo.

Kule meko, i-Neulasta sisiyobisi se-biologic, kwaye uFulphila yi-biosimilar yayo. I-Pegfilgrastim kunye ne-pegfilgrastim-jmdb zombini zisebenza ngendlela efanayo.

I-Pegfilgrastim yeyodidi lwamayeza abizwa ngokuba zii-granulocyte-colony izinto ezikhuthazayo (G-CSFs). Udidi lwamayeza liqela leziyobisi ezisebenza ngendlela efanayo.

I-G-CSF lunyango olubangela ukuba i-neutrophils (uhlobo lweseli emhlophe yegazi) ikhule kumongo wakho wethambo. Umongo wethambo sisicubu sangaphakathi samathambo esenza iiseli zegazi. Kwaye ii-G-CSF ziikopi ezenziwe ngumntu zehomoni ye-G-CSF eyenziwa ngumzimba wakho ngokwendalo.

Sebenzisa

Zombini i-Neulasta kunye neFulphila zivunyiwe yi-Food and Drug Administration (i-FDA) ukunciphisa umngcipheko wosulelo ngenxa yemeko ebizwa ngokuba yi-febrile neutropenia kubantu abanomhlaza ongasebenzisiyo. * Ukuze usebenzise la mayeza, kufuneka uthathe iziyobisi zomhlaza ezinokubangela i-neutropenia efebrile.

I-Neulasta ikwavunyiwe yi-FDA ukunyanga ukugula kwemitha. * Uhlobo lwesifo semitha esetyenziselwa sona i-Neulasta kuthiwa yi-hematopoietic subsyndrome.

I-Fulphila ayivunyelwanga ukunceda ukuhambisa iiseli zegazi ukusuka kumongo wethambo uye egazini kufakelo lweseli yehematopoietic (HCT).

Iifom zeziyobisi kunye nolawulo

Zombini i-Neulasta kunye neFulphila ziza njengethamo elinye lesirinji elikhethiweyo. Le fomu inikwa usuku emva kokuba une-chemotherapy njengenaliti engaphantsi (inaliti ngqo phantsi kolusu lwakho).

Umboneleli wezempilo uya kukunika inaliti ye-Neulasta, okanye usenokukwazi ukukunika inaliti ekhaya emva kokuba uqeqeshiwe.

I-Neulasta iza nakwenye indlela ebizwa ngokuba yi-Neulasta Onpro, eyi-injector esemzimbeni (OBI). Umboneleli wezempilo uya kuyifaka esiswini sakho okanye ngasemva kwengalo yakho ngalo mini ufumana ichemotherapy.

I-Neulasta Onpro ihambisa idosi yeziyobisi malunga nosuku emva kokuba kufakwe i-OBI. Oku kuthetha ukuba akukho mfuneko yokuba ubuyele kwi-ofisi kagqirha wakho ngenaliti.

Phawula: I-Neulasta Onpro ayisetyenziselwa ukunyanga ukugula kwemitha.

Iziphumo kunye neengozi

I-Neulasta kunye neFulphila zombini ziqulathe i-pegfilgrastim. Ke ngoko, la mayeza anokubangela iziphumo ezifanayo. Apha ngezantsi kunemizekelo yeziphumo ebezingalindelekanga.

Iziphumo ebezingalindelekanga ezinobulali

Olu luhlu luqulathe imizekelo yeziphumo ebezingalindelekanga ezinobumnene ezinokwenzeka ngeNeulasta kunye neFulphila (xa zithathwa ngokwahlukeneyo):

  • iintlungu zethambo
  • iintlungu ezingalweni okanye emilenzeni

Iziphumo ebezingalindelekanga ezimandundu

Olu luhlu lunemizekelo yeziphumo ebezingalindelekanga ezinokubakho ngeNeulasta kunye neFulphila (xa zithathwa ngokwahlukeneyo):

  • negazi lakho
  • isifo sokuphefumula (uhlobo lwemeko yemiphunga)
  • i-aortitis (ukudumba kwe-aorta, owona mthambo uphambili wentliziyo)
  • I-capillary leak syndrome (imeko apho imithambo yegazi encinci ivuza khona)
  • glomerulonephritis (iqela leemeko zezintso)
  • leukocytosis (ukwanda kwenqanaba leeseli ezimhlophe zegazi)
  • i-spleen ephukile (ukuvulwa komzimba obizwa ngokuba yi-spleen)

Ukusebenza ngempumelelo

Ukusetyenziswa okuphela kweNeulasta kunye neFulphila kuvunyiwe ukunciphisa umngcipheko wosulelo ngenxa yemeko ebizwa ngokuba yi-febrile neutropenia kubantu abanomhlaza ongafakwanga i-myeloid.

La machiza awakhange athelekiswe ngokuthe ngqo kwizifundo zeklinikhi, kodwa izifundo zifumanise ukuba zombini i-Neulasta kunye neFulphila ziyasebenza ekunciphiseni umngcipheko wosulelo ngenxa yemeko ebizwa ngokuba yi-febrile neutropenia kubantu abanomhlaza ongena-myeloid.

Iindleko

Ngokwengqikelelo yeGoodRx.com, iNeulasta ixabisa kakhulu kuneFulphila. Elona xabiso uzakuhlawula ngalo naliphi na ichiza liya kuxhomekeka kwisicwangciso sakho seinshurensi, indawo okuyo, kunye nekhemesti oyisebenzisayo.

Iijenerikhi okanye ii-biosimilars

Amachiza amaninzi aqhelekileyo enziwe ngeekhemikhali aneenguqulelo eziqhelekileyo. Ichiza elenza lafana nalawo aveliswe ngumenzi yikopi ngqo yesithako esisebenzayo kwiyeza elinegama lophawu. Ihlala ixabisa ngaphantsi kohlobo lwegama lophawu.

Nangona kunjalo, i-Neulasta kunye neFulphila zombini zinegama lophawu lwebhayiloji, ezenziwa zivela kwizinto eziphilayo. Esikhundleni se-generic, iziyobisi ze-biologic zinee-biosimilars. I-biosimilar sisiyobisi esifana nesiyobisi se-biologic.

Njengama-generic, ii-biosimilars zihlala zibiza imali encinci kunegama lophawu lwebhayiloji ezisekwe kuyo.

INeulasta ineenguqulelo ezintathu zebiosimilar: UFulphila, Udenyca, kunye noZiextenzo. Ke uFulphila uyi-biosimilar yeNeulasta. Ukuba ungathanda ukufunda ngakumbi malunga neenguqulelo ze-biosimilar ze-Neulasta, kubandakanya iFulphila, thetha nogqirha wakho okanye usokhemesti.

Isebenza njani iNeulasta

Nazi ezinye iinkcukacha malunga nento eyenziwa nguNeulasta kunye nendlela ichiza elisebenza ngayo.

Ifrile neutropenia

I-Neulasta inceda ukunciphisa umngcipheko wosulelo ngenxa yemeko ebizwa ngokuba yi-febrile neutropenia kubantu abanomhlaza ongenguye we-myeloid.

I-Neutropenia yimeko yegazi apho amanqanaba e-neutrophil ephantsi. I-neutrophils luhlobo lweeseli ezimhlophe zegazi ezikhusela umzimba wakho kusulelo. Ukuba amanqanaba akho e-neutrophil aphantsi, umzimba wakho awuyi kukwazi ukulwa ngokufanelekileyo neebhaktheriya. Ke ukuba i-neutropenia yonyusa umngcipheko wosulelo.

I-neutropenia ye-Febrile yenzeka xa une-neutropenia kwaye uvelisa umkhuhlane, onokuba luphawu losulelo. Kwaye ukuba ne-neutropenia kuthetha ukuba awukwazi ukulwa nosulelo njengesiqhelo. Ke i-febrile neutropenia yimeko encomekayo ekufuneka ugqirha ayiqwalasele kwangoko.

I-Cancer engeyiyo i-myeloid yimihlaza engabandakanyi umongo wethambo, eziyizicubu ngaphakathi kwamathambo ezenza iiseli zegazi. Umzekelo womhlaza ongena-myeloid ngumhlaza webele.

Ukugula ngemitha

I-Neulasta ikwasetyenziselwa ukunyanga ukugula kwemitha, imeko eyenzeka xa usiva amanqanaba aphezulu emitha. Inokuthi ibhekiswe njenge-radiation syndrome.

Uhlobo lokugula kwemitha okusetyenziselwa i-Neulasta lubizwa ngokuba yi-hematopoietic subsyndrome. Ixabiso lokuvezwa kwemitha ebangela ukuba le syndrome ichazwe njenge-myelosuppressive, oko kuthetha ukuba bakhokelela kumongo wethambo lakho ukwenza iiseli zegazi ezimbalwa.

Isebenza njani iNeulasta

IGranulocyte-colony evuselelayo (G-CSF) yincindi yedlala ebangela ukuba i-neutrophils ikhule kumongo wethambo lakho.

Iyeza elisebenzayo eNeulasta, pegfilgrastim, yikopi eyenziwe ngumntu yehomoni ye-G-CSF eyenziwa ngumzimba wakho ngokwendalo. I-Pegfilgrastim isebenza ngendlela efanayo ne-G-CSF yendalo.

I-Neulasta ikunceda ekudaleni i-neutrophils kunye nezinye iiseli ezimhlophe zegazi. Oku kunceda umzimba wakho ukuba ukulungele ngakumbi ukulwa nosulelo, uthintele i-neutropenia ene-febrile, kwaye unciphise ukuba une-neutropenia ixesha elingakanani.

Kwi-hematopoietic subsyndrome ngenxa yokugula kwemitha, i-Neulasta inceda umzimba wakho ukuba ubuyisele iiseli ezimhlophe zegazi ezatshatyalaliswa kumongo wethambo ngokubonakaliswa yimitha.

Kuthatha ixesha elingakanani ukusebenza?

I-Neulasta iqala ukusebenza kungekudala emva kokuba ifakwe ngaphakathi emzimbeni wakho. Nangona kunjalo, izifundo zeklinikhi zibonisa ukuba kungathatha iiveki ezi-1 ukuya kwezi-2 kumanqanaba e-neutrophil ukubuyela esiqhelweni emva kokuba ufumene idosi ye-Neulasta kulandela umjikelo we-chemotherapy.

Neulasta kunye notywala

Okwangoku, akukho kunxibelelana kwaziwayo phakathi kweNeulasta kunye notywala.

Nangona kunjalo, utywala bunokuphazamisa amanye amachiza e-chemotherapy okanye benze ukuba iziphumo ebezingalindelekanga zibe mbi.

Thetha nogqirha wakho malunga nokuba utywala kukhuselekile ukuba ubusele ngexesha lonyango lwe-chemotherapy. (I-Neulasta inikwa emva kwethamo le-chemotherapy.)

Unxibelelwano lweNeulasta

Akukho kunxibelelana kwaziwayo phakathi kweNeulasta kunye namanye amayeza, amayeza kunye nokuncedisa, kunye nokutya.

Neulasta kunye namanye amayeza

Ayaziwa nokuba ngaba kukho ukusebenzisana kweziyobisi phakathi kwe-Neulasta kunye namanye amayeza. Kungenxa yokuba akukho zifundo zasesikweni zenziweyo ukufumanisa ukuhlangana kweziyobisi. Ngokusekwe kwindlela elisebenza ngayo ichiza, ukuhlangana namanye amayeza akunakulindeleka.

Ukuba unemibuzo malunga nokunxibelelana kweziyobisi okunokuchaphazela, buza ugqirha wakho okanye usokhemesti.

I-Neulasta kunye nemifuno kunye nezongezelelo

Akukho zityalo okanye izongezo ezichazwe ngokukodwa ukuba zisebenzisane neNeulasta. Nangona kunjalo, kuya kufuneka ujonge nogqirha wakho okanye usokhemesti ngaphambi kokusebenzisa nayiphi na kwezi mveliso ngelixa uthatha i-Neulasta.

I-Neulasta kunye nokutya

Akukho nakuphi na ukutya okuxelwe ngokukodwa ukuba kunxibelelane neNeulasta. Ukuba unemibuzo malunga nokutya ukutya okuthile ngelixa uthatha i-Neulasta, thetha nogqirha wakho.

Iindleko zeNeulasta

Njengawo onke amayeza, iindleko ze-Neulasta ziyahluka.

Elona xabiso uza kulihlawula liya kuxhomekeka kwisicwangciso sakho seinshurensi, indawo okuyo, kunye nekhemesti oyisebenzisayo.

Kubalulekile ukuba uqaphele ukuba kuya kufuneka ufumane i-Neulasta kwikhemesti ekhethekileyo. Olu hlobo lwekhemesti ligunyazisiwe ukuba liphathe amayeza awodwa. La ngamachiza anokubiza kakhulu okanye anokufuna uncedo kubaqeqeshi bezempilo ukuba basetyenziswe ngokukhuselekileyo nangempumelelo.

Isicwangciso sakho seinshurensi sinokufuna ukuba ufumane isigunyaziso ngaphambi kokuba bavume ukugubungela iNeulasta. Oku kuthetha ukuba ugqirha wakho kunye nenkampani yeinshurensi iya kudinga ukunxibelelana malunga nemiyalelo yakho phambi kokuba inkampani yeinshurensi iyigubungele iyeza. Inkampani yeinshurensi iyakusijonga kwakhona isicelo kwaye ikwazise wena nogqirha wakho ukuba ngaba isicwangciso sakho siza kuyigubungela iNeulasta.

Ukuba awuqinisekanga ukuba uyakufuna ukufumana imvume kwangaphambili ye-Neulasta, nxibelelana nesicwangciso sakho seinshurensi.

Uncedo lwezezimali kunye neinshurensi

Ukuba ufuna inkxaso yemali ukuhlawula i-Neulasta, okanye ukuba ufuna uncedo lokuqonda i-inshurensi yakho, uncedo luyafumaneka.

I-Amgen Inc., umvelisi we-Neulasta, unikezela ngeenkqubo ezibizwa ngokuba yi-Amgen FIRST STEP kunye ne-Amgen Assist 360. Ngolwazi oluthe kratya kunye nokufumanisa ukuba uyakufanelekela na ukufumana inkxaso, tsalela umnxeba ku-888-657-8371 okanye undwendwele iwebhusayithi.

Inguqulelo yeBiosimilar

I-Neulasta iyafumaneka kwiinguqulelo ezintathu zebiosimilar: UFulphila, Udenyca, kunye noZiextenzo.

I-biosimilar sisiyobisi esifana nonyango lwegama lophawu. Ichiza elenza lafana nalawo aveliswe ngumenzi, kwelinye icala, liyikopi ngqo yesithako esisebenzayo kwiyeza elinegama lophawu.

I-Biosimilars isekelwe kumachiza e-biologic, adalwe kwiindawo zezinto eziphilayo. Iijenerikhi zisekwe kunyango oluqhelekileyo olwenziwe ngeekhemikhali. I-Biosimilars kunye ne-genics nazo zihlala zibiza ixabiso elingaphantsi kuneziyobisi ezinamagama.

Ukufumanisa ukuba iindleko zeFulphila, Udenyca kunye neZiextenzo zithelekiswa njani nexabiso le-Neulasta, ndwendwela iGoodRx.com. Kwakhona, iindleko ozifumanayo kwi-GoodRx.com yinto onokuyihlawula ngaphandle kwe-inshurensi. Elona xabiso uza kulihlawula liya kuxhomekeka kwisicwangciso sakho seinshurensi, indawo okuyo, kunye nekhemesti oyisebenzisayo.

Ukuba ugqirha wakho umisele uNeulasta kwaye unomdla wokusebenzisa uFulphila, Udenyca, kunye noZiextenzo endaweni yoko, thetha nogqirha wakho. Banokukhetha uhlobo olunye okanye olunye. Kuya kufuneka ujonge isicwangciso sakho seinshurensi, njengoko inokugubungela enye okanye enye.

Indlela yokuthatha i-Neulasta

Kuya kufuneka uthathe i-Neulasta ngokwemiyalelo kagqirha wakho okanye yezempilo.

Nini ukuthatha

I-Neulasta iza ngeendlela ezimbini. Inye yethamo elinye lesirinji ekhethiweyo. Le fomu inikwa usuku emva kokuba une-chemotherapy njengenaliti engaphantsi (inaliti ngqo phantsi kolusu lwakho). Umboneleli wezempilo uya kukunika inaliti ye-Neulasta, okanye usenokukwazi ukukunika inaliti ekhaya emva kokuba uqeqeshiwe.

Ifom yesibini ibizwa ngokuba yiNeulasta Onpro. Yinto yokufaka umzimba emzimbeni (i-OBI) ukuba umboneleli wezempilo uya kuyifaka esiswini sakho okanye ngasemva kwengalo yakho. Bayakwenza oku ngemini enye ofumana ngayo ichemotherapy.

Emva koko i-OBI izakuhambisa ngokuzenzekelayo idosi yakho yeNeulasta malunga neeyure ezingama-27 emva kokuncanyathiselwa. Oku kuthetha ukuba awudingi ukubuyela eofisini kagqirha wakho ngenaliti.

Kubalulekile ukuba uqaphele ukuba i-Neulasta Onpro ayisetyenziselwa ukunyanga ukugula kwemitha.

Neulasta kunye nokukhulelwa

Ayaziwa ukuba i-Neulasta ikhuselekile ukuthatha ngexesha lokukhulelwa.

Izifundo zenziwe kwizilwanyana ezikhulelweyo ezanikwa i-filgrastim (ichiza elifana neNeulasta). Abaphandi abafumani bungozi bokwanda kweziphene zokuzalwa, ukuphuma kwesisu, okanye iingxaki zempilo kusana okanye kunina.

Nangona kunjalo, izifundo zezilwanyana azisoloko zibonisa okwenzekayo ebantwini. Olunye uphando malunga neNeulasta kunye nokukhulelwa kuyafuneka.

Ukuba ukhulelwe okanye uceba ukukhulelwa, thetha nogqirha wakho ngaphambi kokusebenzisa i-Neulasta. Banokuchaza ubungozi kunye nezibonelelo zamachiza kunye nezinye iindlela zonyango.

I-Neulasta kunye nolawulo lokuzalwa

Ayaziwa ukuba i-Neulasta ikhuselekile ukuthatha ngexesha lokukhulelwa. (Jonga icandelo le- "Neulasta kunye nokukhulelwa" apha ngasentla ukuze ufunde okungakumbi.) Ukuba uyabelana ngesondo kwaye wena okanye iqabane lakho ninokukhulelwa, thetha nogqirha wakho malunga neemfuno zakho zolawulo lokuzalwa ngelixa usebenzisa i-Neulasta.

Neulasta kunye nokuncancisa

Ayaziwa nokuba kukhuselekile na ukuthatha i-Neulasta ngelixa uncancisa.

Asazi ukuba ichiza elisebenzayo eNeulasta, pegfilgrastim, likho kubisi lwebele lomntu.

Ukuba uthatha i-Neulasta kwaye ucinga ngokuncancisa, thetha nogqirha wakho.

Izilumkiso ze-Neulasta

Eli chiza liza neendlela ezininzi zokukhusela. Ngaphambi kokuba uthathe i-Neulasta, thetha nogqirha wakho malunga nembali yakho yezempilo. I-Neulasta isenokungakulungeli ukuba uneemeko ezithile zonyango okanye ezinye izinto ezichaphazela impilo yakho. Oku kubandakanya:

  • Eminye imihlaza yomhlaza. Ukuba unomdlavuza we-myeloid (umhlaza obandakanya umongo wethambo), akufanele usebenzise i-Neulasta. Iyeza linokubangela ukukhula kwethumba kubantu abanomhlaza othile wegazi, ngakumbi umhlaza we-myeloid. Amathumba ngamathumbu omhlaza. Buza ugqirha wakho ukuba zeziphi ezinye iindlela zonyango ezinokukhetha ngcono kuwe.
  • Ukuphazamiseka kwesisele sokugula. Ukuthatha i-Neulasta xa unesifo se-sickle cell kungabangela ingxaki yeseli, enokubulala. (Esi sifo sichaphazela ihemoglobin, efumaneka kwiiseli ezibomvu zegazi.) Ukuba unengxaki yeseli yesigulo, thetha nogqirha wakho ngaphambi kokusebenzisa iNeulasta. Banokucebisa olona nyango lubalaseleyo lwakho.
  • Ukunyuka komzimba kwii-acrylics. Ukuba uxabisa i-acrylic adhesives, akufanele usebenzise i-Neulasta Onpro, i-Neulasta emzimbeni. Isixhobo sisebenzisa i-acrylic adhesive. Buza ugqirha wakho ukuba isirinji ekhethiweyo yeNeulasta lukhetho olufanelekileyo kuwe.
  • Ukungezwani komzimba ukuya kwi-latex. Ukuba une-latex allergies, akufuneki usebenzise iisirinji ezifakwe ngaphambili zeNeulasta. Ikepusi yenaliti kwiisirinji iqulethe irabha yendalo evela kwilatex. Buza ugqirha wakho ukuba ngaba i-Neulasta Onpro on-body injector lukhetho olufanelekileyo kuwe.
  • Ukungezwani komzimba kwi-Neulasta. Ukuba uxabisa i-Neulasta okanye nayiphi na izithako zayo, akufanele usebenzise iziyobisi. Buza ugqirha wakho ngezinye iindlela zonyango.
  • Ukukhulelwa. Ayaziwa ukuba i-Neulasta ikhuselekile ukusebenzisa ngexesha lokukhulelwa. Ngolwazi oluthe kratya, nceda ubone icandelo "Neulasta kunye nokukhulelwa" apha ngasentla.
  • Ukuncancisa. Ayaziwa nokuba kukhuselekile na ukuthatha i-Neulasta ngelixa uncancisa. Ngolwazi oluthe kratya, nceda ubone icandelo le- "Neulasta kunye nokuncancisa" apha ngasentla.

Phawula: Ngolwazi oluthe kratya malunga neziphumo ezibi ezinokubakho zeNeulasta, jonga icandelo leziphumo ebezingalindelekanga zeNeulasta.

Ukugqithisa kwe-Neulasta

Sebenzisa ngaphezulu komthamo ocetyiswayo weNeulasta kunokukhokelela kwiziphumo ebezingalindelekanga ezibi.

Iimpawu libanda

Iimpawu zokudlula ngaphezulu zinokubandakanya:

  • ukuvuvukala kunye nokugcinwa kwamanzi
  • iintlungu zethambo
  • ukuqhawukelwa ngumphefumlo
  • ukuxutywa kwamanzi (ukwakha amanzi malunga nemiphunga)

Kufuneka wenze ntoni xa uthe wagqithisa?

Ukuba ucinga ukuba uthathe kakhulu eli chiza, tsalela ugqirha wakho. Ungabiza uMbutho waseMelika wamaZiko oLawulo lweTyhefu ku-800-222-1222 okanye usebenzise isixhobo esikwi-Intanethi. Kodwa ukuba iimpawu zakho zinzima, tsalela umnxeba ku-911 okanye uye kwigumbi likaxakeka elikufutshane ngoko nangoko.

Ukuphelelwa lixesha, ukugcinwa kunye nokulahlwa kweNeulasta

Xa ufumana i-Neulasta ekhemesti, usokhemisti uya kongeza umhla wokuphelelwa kwileyibhile esebhokisini okanye ebhokisini. Lo mhla uqhele ukuba ngunyaka omnye ukusukela kumhla wokuhambisa kwabo amayeza.

Umhla wokuphelelwa unceda ekuqinisekiseni ukuba iyeza liyasebenza ngeli xesha. Isimo sangoku soLawulo lwezoKutya kunye noLawulo lweziyobisi (i-FDA) kukuphepha ukusebenzisa amayeza aphelelwe lixesha.

Ukuba awusebenzisanga iyeza elidlulileyo kumhla wokuphelelwa kwalo, thetha nosokhemesti wakho malunga nokuba unganako na ukuyisebenzisa.

Ukugcina

Ukuhlala ixesha elingakanani iyeza lihlala lilungile kunokuxhomekeka kwizinto ezininzi, kubandakanya ukuba uligcina phi kwaye phi na iyeza.

Kuya kufuneka ugcine iisirinji ezikhethiweyo zeNeulasta kwifriji (36 ° F kuye kwi-46 ° F / 2 ° C ukuya kwi-8 ° C). Musa ukuziqinisa. Kodwa ukuba ziye zaqina, vumela iisirinji zikhawuleze kwifriji ngaphambi kokuba uzisebenzise. Ukuba isirinji ifriziwe ngaphezulu kwexesha elinye, yilahle.

Kuya kufuneka ulahle naziphi na iisirinji ozigcine kubushushu begumbi ngaphezulu kweeyure ezingama-48. Okokugqibela, ungaze ugungqise iisirinji zeNeulasta.

Ukulahla

Nalu ulwazi malunga nendlela yokulahla iisirinji ze-Neulasta kunye ne-Neulasta Onpro.

Neulasta iisirinji ezizalisiweyo

Kanye emva kokuba usebenzise isirinji ekhethiweyo ye-Neulasta, yilahle kwisikhongozeli esivunyiweyo se-FDA. Oku kunceda ukuthintela abanye, kubandakanya abantwana kunye nezilwanyana zasekhaya, ekubeni bathathe iyeza ngengozi okanye bazenzakalise ngenaliti.

Ungathenga isikhongozeli esibukhali kwi-Intanethi, okanye ubuze ugqirha wakho, usokhemesti, okanye inkampani yeinshurensi yezempilo ukuba ungayifumana phi.

Eli nqaku libonelela ngamacebiso aluncedo ngokulahla amayeza. Unokuphinda ubuze usokhemesti wakho ngolwazi malunga nendlela yokulahla iisirinji zakho.

I-Neulasta Onpro

Ukuba usebenzisa i-Neulasta Onpro, kukho imiyalelo ekhethekileyo yokulahla. Emva kokufumana idosi yakho epheleleyo, kuya kufuneka ubeke iNeulasta Onpro kwisitya esibukhali.

Umvelisi weNeulasta Onpro uneNkqubo yokuThintela ukuChithwa kweSharps ukukunceda ulahle ngokukhuselekileyo iNeulasta Onpro. Oku kunikezelwa ngaphandle kweendleko ezongezelelweyo kuwe. Ungacofa apha ukuze ubhalisele le nkqubo, okanye utsalele umnxeba ku-844-696-3852.

Ulwazi lobungcali lweNeulasta

Olu lwazi lulandelayo lubonelelwe ngoochwephesha kunye nabanye abaqeqeshi bezempilo.

Iimpawu

I-Neulasta ibonakalisiwe ukunciphisa umngcipheko wosulelo kwizigulana ezinama-non-myeloid malignancies anyangwa ngonyango lwe-myelosuppressive anti-cancer unyango olwenza i-febrile neutropenia.

I-Neulasta ikwavunyiwe ngokwanda kokusinda kubantu abane-hematopoietic subsyndrome ye-acute radiation syndrome (ukugula kwemitha).

Indlela yokusebenza

Isithako esisebenzayo kwi-Neulasta, i-pegfilgrastim, yinto yokwenziwa yikholoni. Ibopha kwii-receptors kubuso beeseli zehematopoietic, ezibangela ukwanda kwazo, umahluko kunye nokusebenza. Oku kubangela ukwanda kwenani elipheleleyo le-neutrophil (ANC).

I-Pharmacokinetics kunye ne-metabolism

Isigamu-sobomi se-Neulasta emva kolawulo langaphantsi kwesikhumba ukusuka kwi-15 ukuya kwiiyure ezingama-80.

Izigulana ezinobunzima obuphezulu bomzimba ezinamava okuvezwa kwenkqubo ephezulu kwi-Neulasta kuvavanyo lweklinikhi, eqaqambisa ukubaluleka kokulandela iingcebiso zokulinganisa ezisekwe kubunzima ezinikezwe ngumenzi.

Nangona umenzi enganikezeli ngolwazi oluthile lwe-pharmacokinetic ngokubhekisele kubude bexesha lesiphumo, izifundo zeklinikhi zibonise ukuba i-ANC ithatha malunga neentsuku ezili-10 ukuya kwezili-14 ukusukela kumhla wolawulo lwe-chemotherapy ukubuyela kumanqanaba aqhelekileyo xa i-Neulasta yenziwa ngosuku olulandelayo olulandelayo lwe-chemotherapy.

Uxinzelelo lwe-Neulasta

Emva kolawulo olungaphantsi, ubuninzi be-Neulasta yokugxila kwenzeka nge-16 ukuya kwi-120 leeyure zedosi yasemva kwethamo.

Ukungqinelana

I-Neulasta iyaphikiswa kwizigulana ezinembali yokungaziphathi kakuhle kwi-pegfilgrastim okanye kwi-filgrastim.

Ukugcina

Iisirinji ezikhethwe ngaphambili zeNeulasta kufuneka zifrijiwe phakathi kwe-36 ° F kunye ne-46 ° F (2 ° C kunye ne-8 ° C). Iisirinji kufuneka zigcinwe kwikhathoni yoqobo ukukhusela ekukhanyeni. Iisirinji ezishiye ubushushu begumbi ngaphezulu kweeyure ezingama-48 kufuneka zilahlwe.

Musa ukuyiqanda iisirinji. Kodwa ukuba iisirinji ziba ngumkhenkce, zibeke efrijini ngaphambi kokuzisebenzisa. Lahla naziphi na iisirinji ebezingumkhenkce ngaphezu kwexesha elinye.

Iikiti ze-Neulasta Onpro kufuneka zifrijiwe phakathi kwe-36 ° F kunye ne-46 ° F (2 ° C kunye ne-8 ° C) kude kube yimizuzu engama-30 ngaphambi kokuyisebenzisa. Musa ukugcina iikhithi kubushushu begumbi ngaphezulu kweeyure ezili-12 ngaphambi kokuzisebenzisa. Ukuba iikiti zigcinwe kubushushu begumbi ngaphezulu kweeyure ezili-12, zilahle.

Iphepha elichazayo ukuba awusenanto oyifunayo: Iindaba zezoNyango namhlanje zenze zonke iinzame zokuqinisekisa ukuba zonke iinkcukacha zichanekile, zibanzi kwaye zihlaziyiwe. Nangona kunjalo, eli nqaku akufuneki lisetyenziswe endaweni yolwazi kunye nobuchule bengcali yezempilo enelayisensi. Kuya kufuneka usoloko uqhagamshelana nogqirha wakho okanye nolunye uqeqesho kwezonyango ngaphambi kokuba uthathe nawaphi na amayeza. Ulwazi lweziyobisi oluqulethwe apha luyakwazi ukutshintsha kwaye alujoliswanga ekusetyenzisweni konke okunokwenzeka, imikhombandlela, izilumkiso, izilumkiso, ukuhlangana kweziyobisi, ukungahambelani komzimba, okanye iziphumo ezibi. Ukungabikho kwezilumkiso okanye olunye ulwazi ngesiyobisi esinikiweyo akubonisi ukuba indibaniselwano yeziyobisi ikhuselekile, iyasebenza, okanye ifanelekile kuzo zonke izigulana okanye konke ukusetyenziswa okuthile.

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