I-Nicotinamide Riboside: Izibonelelo, Iziphumo ebezingalindelekanga kunye nedosi

Umxholo

• Yintoni iNicotinamide Riboside?
• Izibonelelo ezinokubakho
• Uguqulwe ngokulula kwi-NAD +
• Yenza ii-Enzymes ezinokuthi zikhuthaze ukuguga okusempilweni
• Ngamana unokunceda ukukhusela iiseli zobuchopho
• Ngamana uMngcipheko weSifo seNtliziyo osezantsi
• Ezinye izibonelelo ezinokubakho
• Imingcipheko enokubakho kunye neziphumo ebezingalindelekanga
• Isisombululo kunye neengcebiso
• Umgca osezantsi

Unyaka nonyaka, abantu baseMelika bachitha iibhiliyoni zeedola kwiimveliso ezichasene nokwaluphala.

Ngelixa uninzi lweemveliso ezichasene nokwaluphala zizama ukubuyisela umva iimpawu zokwaluphala eluswini lwakho, i-nicotinamide riboside - ekwabizwa ngokuba yi-niagen- ijolise ekubuyiseleni umva iimpawu zokwaluphala emzimbeni wakho.

Ngaphakathi komzimba wakho, i-nicotinamide riboside iguqulwa ibe yi-NAD +, imolekyuli encedisayo ekhoyo ngaphakathi kweeseli zakho nganye kwaye ixhasa izinto ezininzi zokuguga okusempilweni.

Eli nqaku lichaza yonke into oyifunayo malunga nenicotinamide riboside, kubandakanya izibonelelo zayo, iziphumo ebezingalindelekanga kunye nedosi.

Yintoni iNicotinamide Riboside?

I-Nicotinamide riboside, okanye i-niagen, yenye indlela ye-vitamin B3, ekwabizwa ngokuba yi-niacin.

Njengezinye iintlobo zevithamini B3, inicotinamide riboside iguqulwa ngumzimba wakho ube yi-nicotinamide adenine dinucleotide (NAD +), i-coenzyme okanye i-molecule yomncedisi.

I-NAD + isebenza njengombane kwiinkqubo ezininzi eziphambili zebhayoloji, ezinje (,):

• Ukuguqula ukutya kube ngamandla
• Ukulungiswa kweDNA eyonakalisiweyo
• Ukuqinisa iiseli 'iinkqubo zokuzikhusela
• Ukuseta iwotshi yangaphakathi yomzimba wakho okanye isingqisho se-circadian

Nangona kunjalo, inani le-NAD + emzimbeni wakho ngokwendalo liwa kunye nobudala ().

Amanqanaba asezantsi e-NAD + enxulunyaniswa neenkxalabo zempilo ezinje ngokuguga kunye nezifo ezingapheliyo, ezinje ngeswekile, isifo sentliziyo, isifo se-Alzheimer kunye nelahleko lombono ().

Into enomdla kukuba, uphando lwezilwanyana lufumanise ukuba ukuphakamisa amanqanaba e-NAD + kunokunceda ukubuyisela umva iimpawu zokuguga kunye nokunciphisa umngcipheko wezifo ezingapheliyo (,,).

Izongezelelo zeNicotinamide riboside-ezinjenge-niagen-ziye zaduma ngokukhawuleza kuba zibonakala zisebenza ngokukodwa ekukhuliseni amanqanaba e-NAD +).

Inicotinamide riboside ikwafumaneka kwimilinganiselo yokulandelwa kobisi lweenkomo, igwele kunye nebhiya ().

INicotinamide riboside, okanye i-niagen, lolunye uhlobo lwevithamini B3. Iyakhuthazwa njengesongezelelo sokuguga ngenxa yokuba inyusa amanqanaba omzimba wakho we-NAD +, esebenza njengamafutha kwiinkqubo ezininzi zebhayiloji.

Izibonelelo ezinokubakho

Ngenxa yokuba uninzi lophando malunga ne-nicotinamide riboside kunye ne-NAD + zivela kwizifundo zezilwanyana, akukho zigqibo zicace gca zinokwenziwa malunga nokusebenza kwayo ebantwini.

Oko kwathiwa, Nazi izibonelelo ezinokubakho zempilo ze-nicotinamide riboside.

Uguqulwe ngokulula kwi-NAD +

I-NAD + yi-coenzyme, okanye i-molecule yomncedisi, ethatha inxaxheba kwiimpendulo ezininzi zebhayoloji.

Ngelixa kubalulekile kwimpilo efanelekileyo, uphando lubonisa ukuba amanqanaba e-NAD + aqhubeka nokuhla kunye nobudala. Amanqanaba asezantsi e-NAD + adityaniswa nokuguga okungalunganga kunye nezifo ezahlukeneyo eziyingozi (,).

Enye indlela yokunyusa amanqanaba e-NAD + kukusebenzisa i-NAD + eyandulelayo-iibhloko zokwakha ze-NAD + -njenge-nicotinamide riboside.

Izifundo zezilwanyana zibonisa ukuba i-nicotinamide riboside iphakamisa amanqanaba egazi le-NAD + ukuya kuthi ga kumaxesha e-2.7. Ngaphezulu, isetyenziswe ngokulula ngumzimba wakho kunezinye i-NAD + precursors ().

Yenza ii-Enzymes ezinokuthi zikhuthaze ukuguga okusempilweni

INicotinamide riboside inceda ukunyusa amanqanaba e-NAD + emzimbeni wakho.

Ukuphendula, i-NAD + isebenzisa ii-enzymes ezithile ezinokukhuthaza ukwaluphala okunempilo.

Elinye iqela zii-sirtuins, ezibonakala ngathi ziphucula ubomi kunye nempilo ngokubanzi kwizilwanyana. Izifundo zibonisa ukuba i-sirtuins inokulungisa i-DNA eyonakeleyo, inyuse uxinzelelo kuxinzelelo, inciphise ukudumba kwaye inikezele ngezinye izibonelelo ezikhuthaza ukwaluphala okunempilo (,,).

I-Sirtuins ikwanoxanduva lokuqhubeka nokwandisa ixesha lokufumana izithintelo zekhalori ().

Elinye iqela yiPoly (ADP-Ribose) polymerases (PARPs), ezilungisa iDNA eyonakeleyo. Izifundo zidibanisa imisebenzi ephezulu ye-PARP kumonakalo omncinci we-DNA kunye nexesha elide lobomi (,).

Ngamana unokunceda ukukhusela iiseli zobuchopho

I-NAD + idlala indima ephambili ekuncedeni iiseli zobuchopho bakho kakuhle.

Ngaphakathi kweeseli zobuchopho, i-NAD + inceda ukulawula imveliso ye-PGC-1-alpha, iprotein ebonakala ngathi iyanceda ukukhusela iiseli ngokuchasene noxinzelelo lwe-oxidative kunye nomsebenzi we-mitochondrial ().

Abaphandi bakholelwa ukuba zombini uxinzelelo lwe-oxidative kunye nokungasebenzi kakuhle kwe-mitochondrial kunxulunyaniswa nokuphazamiseka kwengqondo okuhambelana nobudala njenge-Alzheimer's kunye nesifo sika-Parkinson (,,).

Kwiimpuku ezinesifo se-Alzheimer, i-nicotinamide riboside iphakamise amanqanaba obuchopho be-NAD + kunye nemveliso ye-PGC-1-alpha ukuya kuthi ga kwi-70% kunye ne-50%, ngokwahlukeneyo. Ukuphela kwesifundo, iimpuku zenze ngcono kakhulu kwimisebenzi esekwe kwimemori ().

Kwisifundo setyhubhu yovavanyo, i-nicotinamide riboside iphakamise amanqanaba e-NAD + kwaye yaphucula ngokubonakalayo ukusebenza kwe-mitochondrial kwiiseli ezinqamlezileyo ezithathwe kwisigulana sesifo sikaParkinson ().

Nangona kunjalo, akukacaci ukuba kuluncedo kangakanani ukuphakamisa amanqanaba e-NAD + kubantu abaneengxaki zobuchopho ezinxulumene nobudala. Izifundo ezingakumbi zabantu ziyafuneka.

Ngamana uMngcipheko weSifo seNtliziyo osezantsi

Ukwaluphala yeyona nto iphambili kwisifo sentliziyo, esingunobangela wokufa wehlabathi ().

Inokubangela ukuba imithambo yegazi efana ne-aorta yakho iqine, iqine kwaye ingabi bhetyebhetye.

Olo tshintsho lunokunyusa amanqanaba oxinzelelo lwegazi kwaye lwenze ukuba intliziyo yakho isebenze nzima.

Kwizilwanyana, ukuphakamisa i-NAD + kuncede ukutshintsha utshintsho olunxulumene nobudala kwimithambo ().

Ebantwini, i-nicotinamide riboside iphakamise amanqanaba e-NAD, yanceda ukunciphisa ukuqina kwi-aorta kunye nokunciphisa uxinzelelo lwegazi kubantu abadala abasemngciphekweni woxinzelelo lwegazi (22).

Oko kwathiwa, uphando olungakumbi lomntu luyafuneka.

Ezinye izibonelelo ezinokubakho

Ukongeza, i-nicotinamide riboside inokubonelela ngezinye izibonelelo:

• Ngamana unganceda ukunciphisa umzimba: I-Nicotinamide riboside incede ukukhawulezisa imetabolism yeempuku. Nangona kunjalo, akucaci nokuba ingaba nefuthe elifanayo ebantwini kwaye lomelele kangakanani esi siphumo ().
• Ngamana unganciphisa umngcipheko womhlaza: Amanqanaba aphezulu eNAD + anceda ukukhusela kumonakalo we-DNA kunye noxinzelelo lwe-oxidative, ezinxulunyaniswa nophuhliso lomhlaza (,).
• Ngamana unokunceda ukuphatha i-jet lag: I-NAD + inceda ukulawula iwotshi yangaphakathi yomzimba wakho, ke ukuthatha i-niagen kunokunceda ukunyanga i-jet lag okanye ezinye iingxaki zesingqi sokujikeleza ngokuseta iwotshi yangaphakathi yomzimba wakho).
• Ngamana unokukhuthaza ukuguga kwemisipha esempilweni: Ukuphakamisa amanqanaba e-NAD + kuncede ukuphucula ukusebenza kwemisipha, ukomelela kunye nokunyamezeleka kwiimpuku ezindala (,).

I-Nicotinamide riboside inyusa amanqanaba e-NAD +, enxulunyaniswa nezibonelelo zempilo ezinokubakho malunga nokuguga, impilo yengqondo, umngcipheko wesifo sentliziyo nokunye.

Imingcipheko enokubakho kunye neziphumo ebezingalindelekanga

I-Nicotinamide riboside inokukhuseleka kunye neziphumo ebezingalindelekanga ezimbalwa.

Kwizifundo zabantu, ukuthatha i-1,000-2,000 mg ngosuku akukho ziphumo zibi (,).

Nangona kunjalo, uninzi lwezifundo zabantu lufutshane ngexesha kwaye bambalwa abathathi-nxaxheba. Ukufumana umbono ochanekileyo wokukhuseleka kwayo, kufuneka kwenziwe izifundo zabantu ezomeleleyo.

Abanye abantu baye baxela iziphumo ebezingalindelekanga ezinobulali, ezinjengezicaphucaphu, ukudinwa, intloko ebuhlungu, urhudo, ukungonwabi esiswini kunye nokugaya ().

Kwizilwanyana, ukuthatha i-300 mg ngekg yesisindo somzimba (i-136 mg ngeponti) yonke imihla kwiintsuku ezingama-90 kwakungekho ziphumo zibi ().

Ngaphezu koko, ngokungafaniyo nezongezelelo ze vithamin B3 (niacin), nicotinamide riboside akufuneki ibangele ukugungxula ebusweni ().

INicotinamide riboside ibonakala ikhuselekile kuneziphumo ebezingalindelekanga ezimbalwa. Nangona kunjalo, iziphumo zalo zexesha elide ebantwini azikaziwa nangoku.

Isisombululo kunye neengcebiso

I-Nicotinamide riboside ifumaneka kwithebhulethi okanye kwifomsule kwaye ibizwa ngokuba yi-niagen.

Iyafumaneka kwiivenkile ezikhethiweyo zokutya, kwiAmazon okanye kubathengisi abakwi-Intanethi.

Izongezo ze-Niagen zihlala ziqukethe i-nicotinamide riboside, kodwa abanye abavelisi bayayidibanisa nezinye izinto ezinje ngePterostilbene, eyi-polyphenol -i-antioxidant efana ne-resveratrol ().

Uninzi lweemveliso zokuncedisa i-niagen zincomela ukuthatha i-250-300 mg ngosuku, ilingana ne-1-2 yeepilisi njengeentsuku ngosuku kuxhomekeke kwibhrendi.

Uninzi lwabavelisi be-niagen bacebisa ukuthatha i-250-300 mg ye-nicotinamide riboside ngosuku.

Umgca osezantsi

INicotinamide riboside yenye yeevithamini B3 ezineziphumo ebezingalindelekanga ezimbalwa. Ihlala ithengiswa njengemveliso echasene nokwaluphala.

Umzimba wakho uwuguqula ube yi-NAD, evuselela zonke iiseli zakho. Ngelixa amanqanaba e-NAD + ewela ngokwendalo kunye nobudala, ukonyusa amanqanaba e-NAD + anokuguqula imiqondiso emininzi yokuguga.

Nangona kunjalo, uninzi lophando kwi-nicotinamide riboside kunye ne-NAD + kwizilwanyana. Izifundo zabantu ezikumgangatho ophezulu ziyafuneka ngaphambi kokucebisa njengonyango.