I-Cannabidiol oyile (i-CBD): yintoni kunye nezibonelelo ezinokwenzeka

Umxholo

• Isebenza njani i-Cannabidiol yeoyile
• Izibonelelo zempilo ezinokwenzeka
• Iziphumo ebezingalindelekanga ezinokwenzeka

Ioli yeCannabidiol, ekwabizwa ngokuba yi-CBD yeoyile, yinto efumaneka kwisityalo I-Cannabis sativa, eyaziwa ngokuba yi-marijuana, ekwaziyo ukunciphisa iimpawu zoxinzelelo, ukunceda kunyango lokungalali kwaye ube nezibonelelo kunyango lwesifo sokuwa.

Ngokungafaniyo nezinye iziyobisi ezisekwe kwentsangu, ioyile ye-cannabidiol ayinayo i-THC, eyinto yentsangu ejongene nefuthe le-psychotropic, njengokulahleka kwengqondo kunye nokugqwetha ngexesha nendawo, umzekelo. Ke ngoko, ioyile ye-cannabidiol kunokwenzeka ukuba isetyenziswe kunyango. Funda ngezinye iziphumo zentsangu.

Nangona kunjalo, ezinye izifundo ziyafuneka ukucacisa izibonelelo zeoyile ye-CBD kwingxaki nganye, kunye noxinzelelo olufanelekileyo.

Isebenza njani i-Cannabidiol yeoyile

Isenzo seoyile ye-cannabidiol ikakhulu ngenxa yomsebenzi wayo kwii-receptors ezimbini ezikhoyo emzimbeni, ezaziwa njenge-CB1 kunye ne-CB2. I-CB1 ibekwe ebuchotsheni kwaye inxulumene nokulawulwa kokukhutshwa kwe-neurotransmitter kunye nomsebenzi we-neuronal, ngelixa i-CB2 ikhoyo kumalungu e-lymphoid, anoxanduva lweempendulo ezitshisayo nezosulelayo.

Ngokusebenza kwi-CB1 receptor, i-cannabidiol iyakwazi ukuthintela umsebenzi ogqithisileyo we-neuronal, ukunceda ukuphumla kunye nokunciphisa iimpawu ezinxulumene noxinzelelo, kunye nokulawula ukuqonda kwentlungu, inkumbulo, ulungelelwaniso kunye nokukwazi ukuqonda. Xa usebenza kwi-CB2 receptor, i-cannabidiol inceda kwinkqubo yokukhupha ii-cytokines ngeeseli zomzimba, ezinceda ukunciphisa iintlungu kunye nokudumba.

Izibonelelo zempilo ezinokwenzeka

Ngenxa yendlela ioyile ye-CBD esebenza ngayo emzimbeni, ukusetyenziswa kwayo kunokuzisa izibonelelo zempilo kwaye kungaqwalaselwa kunyango lwezifo ezithile:

• Ukuxhuzula: Olunye uphononongo lubonakalisile ukuba ioyile ye-cannabidiol iyakwazi ukunciphisa ukuphindaphindeka kokuxhuzula ngenxa yokunxibelelana kwale nto kunye ne-CB1 uhlobo lwee-receptors kwingqondo, kunye nezinye ii-receptors ezingabalulekanga ze-cannabidiol;
• Uxinzelelo lwasemva koxinzelelo: uphononongo olwenziwe nabantu abafunyaniswe benengxaki yoxinzelelo lwasemva koxinzelelo bafumanisa ukuba ukusetyenziswa kwe-cannabidiol kubangele ukuphucuka kweempawu zoxinzelelo kunye nokuphazamiseka kwengqondo, xa kuthelekiswa neqela elanyangwa nge-placebo, apho ukwanda kweempawu kwaqwalaselwa;
• Ukuphuthelwa: Ngokusebenza kummiselo we-neuronal kunye nokukhululwa kwee-neurotransmitters, ioyile ye-cannabidiol inokukhuthaza ukuphumla kwaye, ke, kuncede kunyango lokungalali. Kwaye kwabonwa kwimeko yokufunda ukuba ukusetyenziswa kwe-25 mg yeoyile ye-cannabidiol ikwazile ukuphucula umgangatho wokulala;
• Ukudumba: Uphononongo olwenziwe ngeempuku lubonise ukuba i-cannabidiol yayisebenza ekunciphiseni iintlungu ezinxulumene nokuvuvukala, njengoko kubonakala ngathi kuyasebenzisana nee-receptors ezinxulumene nemvakalelo yentlungu.

Jonga izibonelelo ze-cannabidiol kule vidiyo ilandelayo:

Ngaphandle kwezikhombisi, indlela yokusebenza, iipropathi kunye nokungabikho koxinaniso lwe-THC, olunokwenza ioyile ye-cannabidiol yamkelwe ngakumbi kwezonyango nakwezenzululwazi, iimpembelelo zokusebenzisa le oyile kwixesha elide azikaqinisekiswa, kwaye zisaqhubeka izifundo ziyafuneka ukunceda ukubonisa iziphumo zeoyile ye-CBD kubantu abaninzi.

Ngo-2018, i Ulawulo lweziyobisi (FDA) ukuvumile ukusetyenziswa kwesiyobisi, i-Epidiolex, equlathe kuphela i-cannabidiol kunyango lwesifo sokuwa, nangona kunjalo i-ANVISA ukuza kuthi ga ngoku ayikazibeki ngokunxulumene nokuthengisa iyeza eBrazil.

Kude kube ngoku, i-ANVISA igunyazise ukuthengiswa kwe-Mevatyl, esisisiyobisi esisekwe kwi-cannabidiol kunye ne-THC eboniswe ikakhulu ukunyanga ukungqinelana kwezihlunu okungazibandakanyi okwenzeka kwi-multiple sclerosis kwaye nokusetyenziswa kwayo kufuneka kuboniswe ngugqirha. Bona ngakumbi malunga neMevatyl kunye neempawu zayo.

Iziphumo ebezingalindelekanga ezinokwenzeka

Olunye uphononongo lufumanise ukuba iziphumo ebezingalindelekanga zeoyile ye-cannabidiol zinxulumene nokusetyenziswa gwenxa kwemveliso, ikakhulu ngaphandle kokuboniswa ngugqirha okanye ukonyuka koxinzelelo, ngokudinwa kunye nokulala kakhulu, urhudo, utshintsho kumdla wokutya kunye nobunzima, ukucaphuka, urhudo, ukugabha nokuphefumla. Ukongeza, kufunyenwe ukuba iidosi kubantwana ngaphezulu kwe-200 mg ye-cannabidiol inokuzenza mandundu iimpawu ezinxulumene noxinzelelo, ukongeza ekunyuseni isingqi sentliziyo kunye nokutshintsha kwemozulu.

Kwafunyaniswa ukuba i-cannabidiol inokuphazamisa umsebenzi we-enzyme eveliswa sisibindi, i-cytochrome P450, ethi, phakathi kweminye imisebenzi, inoxanduva lokuyekisa ezinye iziyobisi kunye neetyhefu. Ke, i-CBD inokuchaphazela iziphumo zamachiza athile, kunye nokunciphisa amandla kwesibindi sokwaphula kunye nokuphelisa i-toxins, enokonyusa umngcipheko wetyhefu yesibindi.

Ukongeza, ukusetyenziswa kweoyile ye-cannabidiol ayiboniswanga kwabasetyhini abakhulelweyo, abacwangcisa ukukhulelwa okanye abancancisayo, kuba kwafunyaniswa ukuba i-CBD inokufumaneka kubisi lwebele, ukongeza ekubeni inokudluliselwa kwimveku ngexesha lokukhulelwa .