Yintoni umntu wonke oneePsoriasis ekufuneka azi ngayo nge-PDE4 Inhibitors

Umxholo

• Ushwankathelo
• Zithini ii-PDE4 inhibitors?
• Bayisebenzela njani ukhwekhwe?
• Unyango lwe-PDE4 inhibitor ngokuchasene nolunye unyango lwepsoriasis
• Izibonelelo ezinokubakho
• Iziphumo ebezingalindelekanga kunye nezilumkiso
• Ukuthatha

Ushwankathelo

I-plaque psoriasis yimeko engapheliyo yokuzimela. Oko kukuthi, amajoni omzimba ahlasela ngempazamo umzimba. Yenza amabala abomvu, anamaxolo ukuba akhule eluswini. Ezi patches ngamanye amaxesha zinokuziva zirhawuzelela kakhulu okanye zibuhlungu.

Unyango lukhetho lokunciphisa ezi mpawu. Ngenxa yokuba ukudumba yingcambu ye-plaque psoriasis, injongo yamayeza amaninzi kukunciphisa le mpendulo yenkqubo yomzimba yokuzikhusela kunye nokwenza ibhalansi eqhelekileyo.

Ukuba uhlala ne-plaque psoriasis ephakathi, i-PDE4 inhibitor inokuba sisixhobo esisebenzayo ekulawuleni iimpawu.

Nangona kunjalo, amayeza ayinguye wonke umntu. Kuya kufuneka uxoxe ngonyango lwakho ngeendlela zokhetho.

Zithini ii-PDE4 inhibitors?

I-PDE4 inhibitors lunyango olutsha. Basebenza ukucinezela amajoni omzimba, anciphisa ukudumba. Benza kwinqanaba leselula ukumisa ukuveliswa kwe-enzyme egqithisileyo ebizwa ngokuba yi-PDE4.

Abaphandi bayazi ukuba i-phosphodiesterases (PDEs) ihlaziya i-cyclic adenosine monophosphate (cAMP). I-cAMP inegalelo elibonakalayo ekuboniseni umendo phakathi kweeseli.

Ngokumisa ii-PDE4s, i-cAMP inyuka.

Ngokophando luka-2016, eli zinga liphezulu le-CAMP linokuba neziphumo ezichasayo, ngakumbi kubantu abaphila ne-psoriasis kunye ne-atopic dermatitis.

Bayisebenzela njani ukhwekhwe?

I-PDE4 inhibitors, njenge-apremilast (Otezla), sebenza ngaphakathi komzimba ukuthintela ukudumba.

Njengenyathelo lokuthintela, kunokuba luncedo kubantu abane-psoriasis ukulawula ukudumba. Ukunciphisa ukudumba kunokubangela ukuba uqhambuko lungabikho rhoqo kwaye lungabi qatha.

Inokuthi ibambe okanye ithintele ukuqhubela phambili kwesifo ukukhokelela kwi-psoriatic arthritis (PsA).

Kulawo aphilayo nangaluphi na uhlobo lwe-psoriasis, malunga neepesenti ezingama-30 ekugqibeleni ziyaphuhlisa i-PsA, ebangela ukuba iintlungu zidibane. I-PsA inokunciphisa ubomi bakho.

Unyango lwe-PDE4 inhibitor ngokuchasene nolunye unyango lwepsoriasis

I-Apremilast, PDE4 inhibitor, ithathwa ngomlomo. Ikwasebenza kwindlela ebalulekileyo ngokunqamla impendulo yokuvuvukala enegalelo kwiimpawu zeplagi psoriasis.

Unyango lwe-Biologic njenge-adalimumab (Humira), etanercept (Enbrel), kunye ne-infliximab (Remicade) zijojowe emzimbeni.

Olunye unyango olunokutofa inaliti lubandakanya:

• Ustekinumab (IL-12/23 inhibitor)
• secukinumab (IL-17A inhibitor)
• ixekizumab (IL-17A inhibitor)
• guselkumab (IL-23 inhibitor)
• I-risankizumab (IL-23 inhibitor)

I-Tofacitinib yi-Janus kinase (JAK) inhibitor evunyiweyo njengonyango lomlomo.

I-Abatacept yi-T-cell activation inhibitor enikwa njenge-intravenous (IV) infusion okanye inaliti.

Izibonelelo ezinokubakho

I-apremilast iyacetyiswa kubantu abaphila ngokulingeneyo ukuya kwi-plaque psoriasis ekwangabagqatswa kunyango lwenkqubo okanye i-phototherapy.

Ku, inani elikhulu labantu abathatha i-apremilast bafumene amanqaku amahle kuVavanyo lweGqirha lweHlabathi (sPGA) kunye neNdawo yePsoriasis kunye ne-Index ye-Severity (PASI) xa kuthelekiswa nabo bathatha indawo ye-placebo.

Iziphumo ebezingalindelekanga kunye nezilumkiso

Nangona ii-PDE4 inhibitors zibonisa isithembiso esikhulu, ayingabo bonke abantu. I-Apremilast ayikavavanywa kwabasetyhini abakhulelweyo okanye abancancisayo. Okwangoku, yamkelwe kuphela kubantu abadala.

Kukwabalulekile ukulinganisa ubungozi obunokubakho kunye nezibonelelo ze-PDE4 inhibitors.

I-Apremilast iza nomngcipheko owaziwayo.

Abantu abathatha i-apremilast banokufumana iimpendulo ezinje:

• isicaphucaphu
• urhudo
• usulelo lwephepha lokuphefumla
• intloko ebuhlungu

Abanye abantu banamava okuphulukana nobunzima.

I-apremilast inokunyusa iimvakalelo zokudakumba kunye neengcinga zokuzibulala.

Kubantu abanembali yoxinzelelo okanye indlela yokuziphatha yokuzibulala, kuyacetyiswa ukuba bathethe nogqirha wabo ukubanceda ngononophelo ukulinganisa izibonelelo ezinokubakho zechiza ngokuchasene nomngcipheko.

Ukuba uneziphumo ebezingalindelekanga, ugqirha unokucebisa ukuba uyeke amayeza.

Ukuthatha

I-Psoriasis sisifo esinganyangekiyo-kodwa esilawulekayo. Indima edlalwa kukudumba kukugxila kunyango kunye nophando.

Ukuba ugqirha wakho ugqiba ukuba i-plaque psoriasis yakho ithambile okanye ilawulwe kakuhle, banokucebisa iziyobisi ezingezizo ezokulwa nokudumba (i-NSAID). Banokucebisa nangonyango.

Baza kuzama zombini ezi ngcebiso ngaphambi kokujonga ukusetyenziswa kwe-PDE4 inhibitor okanye ezinye iimodyuli zomzimba.

Abaphandi bafumanise ngakumbi malunga neendlela zomzimba ezibangela ukudumba. Olu lwazi lincedisile kuphuhliso lwamayeza amatsha anokubonelela ngoncedo kwabo baphila ngepsoriasis.

I-PDE4 inhibitors yinto entsha, kodwa iza nomngcipheko. Wena kunye nogqirha wakho kufuneka niqwalasele ngenyameko le miba ngaphambi kokuqala uhlobo olutsha lonyango.