Iiarhente zeprokinetic

Umxholo

• Iindidi zeProkinetics
• IBethanechol
• ICisapride
• Imetoclopramide

Kwi-esophagus esempilweni yabantu, ukuginya kukhuthaza i-peristalsis ephambili. Ezi zizishunqulelo ezihambisa ukutya kwakho ezantsi kwesisu kunye nayo yonke inkqubo yokugaya ukutya. Kwelinye icala, i-reflux ye-gastroesophageal icaphukisa isandi sesibini sokuphazamiseka kwemisipha okususa isophagus, ukutyhala ukutya ezantsi nge-esophageal sphincter (LES) nakwisisu.

Nangona kunjalo, kwabanye abantu, i-LES iphinda ivule okanye ivule ngokuzenzekelayo, ivumela iziqulatho zesisu, kubandakanya iiasidi, ukuba ziphinde zingene kwisophagus. Oku kubizwa ngokuba yi-acid reflux kwaye kungakhokelela kwiimpawu ezinje ngokutshiswa sisilonda.

Iiarhente zeprokinetic, okanye iprokinetics, ngamayeza anceda ukulawula i-acid reflux. Iprokinetics inceda ukomeleza i-esophageal sphincter (LES) kwaye ibangele ukuba imixholo yesisu ikhuphe ngokukhawuleza. Oku kuvumela ixesha elincinci lokuba i-acid reflux yenzeke.

Namhlanje, ii-prokinetics zihlala zisetyenziswa nezinye izifo ze-gastroesophageal reflux (GERD) okanye amayeza okutsha, njengeproton pump inhibitors (PPIs) okanye i-H2 receptor blockers. Ngokungafaniyo namanye amayeza e-acid reflux, ahlala ekhuselekile, iprokinetics inokuba neziphumo ebezingalindelekanga ezinobungozi, okanye ezinobungozi. Ziye zisetyenziswe kuphela kwiimeko ezinzima kakhulu ze-GERD.

Umzekelo, iprokinetics inokusetyenziselwa ukunyanga abantu abane-insulin exhomekeke kwisifo seswekile, okanye kwiintsana kunye nabantwana abanesifo sokukhupha amathumbu okanye ukuqhina okunzima okungaphenduliyo kwezinye iindlela zonyango.

Iindidi zeProkinetics

IBethanechol

IBethanechol (Urecholine) lunyango olunyusa isinyi kwaye lukunceda udlulise umchamo ukuba unengxaki yokukhupha isinyi. Inceda ukomeleza i-LES, kwaye yenza isisu singabinanto ngokukhawuleza. Inceda ekuthinteleni isicaphucaphu kunye nokugabha. Iyafumaneka kwifom yethebhulethi.

Nangona kunjalo, ukusebenziseka kwayo kunokugqwesa kwiziphumo ebezingalindelekanga rhoqo. Iziphumo zalo zinokubandakanya:

• ixhala
• ukudakumba
• ukozela
• ukudinwa
• iingxaki zomzimba ezinjengeentshukumo ezingazibandakanyiyo kunye nokudumba kwemisipha

ICisapride

I-Cisapride (Propulsid) isebenza kwii-serotonin receptors esiswini. Yayisetyenziselwa ikakhulu ukuphucula ithoni yemisipha kwi-LES. Nangona kunjalo, ngenxa yeziphumo zayo ebezingalindelekanga, ezinje ngokubetha kwentliziyo okungaqhelekanga, isusiwe kwimarike kumazwe aliqela, kubandakanya iUnited States. Yakhe yathathelwa ingqalelo njengeyisebenzayo ekunyangeni i-GERD njenge-H2 receptor blocker efana ne-famotidine (Pepcid). I-Cisapride isasetyenziswa rhoqo kunyango lwezilwanyana.

Imetoclopramide

I-Metoclopramide (Reglan) yiarhente yeprokinetic esetyenzisiweyo ukunyanga i-GERD ngokuphucula isenzo semisipha kwithumbu lesisu. Iyafumaneka kuzo zombini iipilisi kunye neefom zelwelo. Njengamanye ama-prokinetics, ukusebenza kwe-metoclopramide kuthintelwa yimiphumo emibi.

Iziphumo ebezingalindelekanga zinokubandakanya ukwanda komngcipheko weemeko zemithambo-luvo ezinje nge-tardive dyskinesia, ebangela ukuphindaphindeka kokungahambelani nokuziphatha. Ezi ziphumo bezingalindelekanga ziye zaziwa ukuba zenzeka ebantwini abahlala kwichiza ngaphezulu kweenyanga ezintathu. Abantu abathatha i-metoclopramide kufuneka balumke kakhulu ngelixa beqhuba okanye besebenzisa oomatshini abakhulu okanye izixhobo.

Sebenza nogqirha wakho ukufumana ukuba loluphi na unyango olukufaneleyo. Qinisekisa ukuba ulandela ulwalathiso olunikwa ngugqirha wakho. Biza ugqirha wakho ukuba uziva ngathi amayeza akho abangele iziphumo ebezingalindelekanga.