Luthini unyango lweRegenokine kwaye luyasebenza?

Umxholo

• Yintoni iRegenokine?
• Inkqubo yeRegenokine ibandakanya ntoni?
• Igazi lakho liya kutsalwa
• Igazi lakho liza kwenziwa
• Igazi lakho liza kuphinda lifakwe kwilungu elichaphazelekayo
• Akukho xesha lokuphumla kufuneka
• Usebenza njani Regenokine?
• Ngaba iRegenokine iyasebenza?
• Kutheni le nto iRegenokine ingasebenzi kuye wonke umntu?
• Zithini izifundo
• Bangaphi abantu abaye baphathwa?
• Kuthiwani ngokuzalwa kwakhona kwe-cartilage?
• Uthini umahluko phakathi kwonyango lweRegenokine kunye ne-PRP?
• I-Regenokine isebenzisa irejimeni yokulungisa esemgangathweni
• I-Regenokine isusa iiseli zegazi kunye nezinye izinto ezinokubangela ukudumba
• Ngaba iRegenokine ikhuselekile?
• Ixabisa malini iRegenokine?
• Ayigutyungelwanga yi-inshurensi eMelika
• Luthabatha ixesha elingakanani unyango lweRegenokine?
• Ndingamfumana phi umboneleli ofanelekileyo?
• Yise kude

I-Regenokine lunyango lokuchasana nentlungu yokudibana kunye nokudumba. Inkqubo itofa iiproteni eziluncedo eziqokelelwe kwigazi lakho ukuya kumalungu akho achaphazelekayo.

Unyango lwaphuhliswa nguGqirha Peter Wehling, ugqirha waseJamani ongumqolo, kwaye luvunyiwe ukuba lusetyenziswe eJamani. Iimbaleki ezininzi ezibalaseleyo, kubandakanya u-Alex Rodriguez no-Kobe Bryant, baye eJamani ukuya kunyango lwe-Regenokine kwaye baxela ukuba iyazithomalalisa iintlungu.

Nangona i-Regenokine ingekavunywa yi-Food and Drug Administration (i-FDA), isetyenzisiwe ngaphandle kwelebheli kwiindawo ezintathu e-United States ezinelayisensi yi-Wehling.

I-Regenokine iyafana nonyango lweplasma (PRP) olutyebileyo, olusebenzisa iimveliso zegazi ukunceda ukuvuselela izicwili kwindawo eyenzakeleyo.

Kule nqaku, siza kuphinda sihlolisise ukuba inkqubo yeRegenokine injani, yahluke njani kwi-PRP, kwaye isebenza njani ekuncedeni iintlungu.

Yintoni iRegenokine?

Ekukhuleni kwakhe kwangoko kukaRegenokine, u-Wehling waphatha ngempumelelo amahashe aseArabia awayefumana ukonzakala ngokudibeneyo. Emva kokuqhubeka nophando lwakhe nabantu, ukwenziwa kuka-Wehling kwavunywa ukuba kusetyenziswe abantu ngo-2003 yiJamani efana ne-FDA.

Inkqubo igxila kwiiproteni ezisegazini lakho ezilwa nokudumba kunye nokukhuthaza ukuhlaziywa. I-serum eqhutyiweyo emva koko ifakwe ngaphakathi kwilungu elichaphazelekayo. I-serum ayinazo iiseli ezibomvu zegazi okanye iiseli ezimhlophe zegazi ezinokubangela ukucaphuka.

I-serum inokubizwa ngokuba yi-autologous conditioned serum, okanye i-ACS.

Inkqubo yeRegenokine ibandakanya ntoni?

Ngaphambi kwenkqubo, ingcali yeRegenokine iya kusebenza kunye nomboneleli wakho wezempilo wokuqala ukumisela ukuba ngaba ululungeleyo olu nyango. Baza kwenza isigqibo sabo ngokuvavanya umsebenzi wakho wegazi kunye nemifanekiso yokujonga ukwenzakala kwakho.

Ukuba ufumana ukuqhubela phambili, nantsi into onokuyilindela ngexesha lenkqubo:

Igazi lakho liya kutsalwa

Ugqirha uza kutsala malunga nee-ounces ezimbini zegazi engalweni yakho. Oku kuthatha imizuzu eliqela.

Igazi lakho liza kwenziwa

Iqondo lobushushu besampulu yegazi lakho liya kuphakanyiswa kancinci ukuya kuthi ga kwiiyure ezingama-28 kwindawo engenabungozi. Iya kuthi emva koko ibekwe kwi-centrifuge ukuya:

• Zahlule iimveliso zegazi
• gxila kwiiproteni ezichasayo
• yenza i-serum engenaselfowuni

Kuxhomekeka kwimeko yakho, ezinye iiproteni zinokongezwa kwi-serum.

Ngokutsho kukaGqirha Jana Wehling, ingcali yamathambo neyenzakeleyo esebenza notata wakhe kwiklinikhi yaseRegenokine eDusseldorf, eJamani, “Ukongezwa kule serum kubandakanya iiproteni ezinokuphinda zenziwe njenge-IL-1 Ra, i-anesthetics yendawo, okanye i-cortisone yedosi ephantsi.”

Isampuli ephathwayo iyabanda kwaye ifakwe kwiisirinji zenaliti.

Igazi lakho liza kuphinda lifakwe kwilungu elichaphazelekayo

Inkqubo yokubuyisela kwakhona ithatha imizuzu embalwa. UPeter Wehling usandula ukwazisa ubuchwephesha besitofu esinye (iRegenokine® One Shot), endaweni yenaliti enye suku ngalunye iintsuku ezi-4 okanye ezi-5.

Ugqirha unokusebenzisa i-ultrasound njengoncedo lokucinga ukubeka indawo yenaliti ngokuchanekileyo.

Ukuba i-serum ishiywe ngaphezulu, inokumiswa ngumkhenkce ukuze isetyenziswe kwixesha elizayo.

Akukho xesha lokuphumla kufuneka

Akukho xesha lokuphumla lilandela inkqubo. Uyakwazi ukuphinda uqalise imisebenzi yakho kwangoko emva kokufakwa kwakhona.

Ixesha elithathayo lokuba uzive ukhululekile kwiintlungu kunye nokudumba kuyahluka ngokwahlukeneyo.

Usebenza njani Regenokine?

Ngokuka-Peter Wehling, i-Regenokine serum ephathwayo inamaxesha angamawaka ayi-10 000 yoxinaniso oluqhelekileyo lweprotein echasayo. Le protein, eyaziwa ngokuba yi-interleukin-1 receptor antagonist (IL-1 Ra), ibhloka umlingani wayo odala ukudumba, i-interleukin 1.

UGqr. Christopher Evans, umlawuli weRehabilitation Medicine Research Centre eMayo Clinic, wayicacisa ngale ndlela: “I-‘dleleukin embi,’ i-interleukin 1, idityaniswa nesamkeli esithile kumphezulu weseli esiphendula kuso. Ima apho. Emva koko, zonke iintlobo zobubi ziyenzeka. ”

U-Evans uqhubeke wathi: "I-interleukin elungileyo, yinto ye-interleukin-1 receptor antagonist. Oku kuthintela i (cell's) receptor. … Iseli ayiyiboni i-interleukin-1, kuba ivaliwe, yiyo ke loo nto izinto ezimbi azenzeki. "

Kucingelwa ukuba i-IL-1 Ra inokuphikisana nezinto ezikhokelela kwintlala kunye nokuqhekeka kwezicubu kunye ne-osteoarthritis.

Ngaba iRegenokine iyasebenza?

Izifundo zeRegenokine zibonisa ukuba iyasebenza kubantu abaninzi, kodwa ayingabo bonke.

Izinto zeklinikhi ye-Wehling zithi luthathelwa ingqalelo unyango lweRegenokine lube yimpumelelo xa iintlungu zesigulana okanye ukusebenza kuphucula ngama-50 epesenti. Basebenzisa iikhweshine eziqhelekileyo kubantu abanonyango ukunyanga isiphumo salo.

Iklinikhi iqikelela ukuba malunga neepesenti ezingama-75 zabantu abane-osteoarthritis yamadolo aphakathi kunye nentlungu baya kuba nempumelelo kunyango.

Oogqirha baseMelika abanelayisensi yokusebenzisa iRegenokine banempumelelo efanayo. Kubonakalisiwe ukuhlehlisa isidingo sokudityaniswa ngokudibeneyo, okanye ukunqanda isidingo sokudityaniswa ngokudibeneyo kwabanye abantu.

Kutheni le nto iRegenokine ingasebenzi kuye wonke umntu?

Sibuze uEvans, owayesebenza noPeter Wehling kwangoko kuphando lwakhe, ukuba kutheni uRegenokine esebenzela uninzi lwabantu kodwa engasebenzeli wonke umntu. Nantsi into ayithethileyo:

“I-Osteoarthritis ayisosifo esinye esifana neso. Iza ngeendlela ezininzi kwaye kunokwenzeka ukuba kukho iindidi ezahlukeneyo, ezinye zazo ziya kuphendula, kwaye ezinye zingabinjalo. UGqr. Wehling uphuhlise ialgorithm yoku kusetyenziswa izixhobo ezahlukeneyo ze-DNA yesigulana. Abantu abanezinto ezithile ezilandelelana ngokulandelelana kweDNA kwaxelwa kwangaphambili ukuba bazokuphendula ngcono. ”

Ugqirha Thomas Buchheit, MD, CIPS, umlawuli we-Regenerative Pain Therapies kwiYunivesithi yaseDuke - enye yeendawo ezintathu e-United States ezinelayisensi yokusebenzisa i-serum ephuhliswe ngu-Wehling- ukwaqaphele, "Sibona ezona ziphumo zibalaseleyo kubantu abathi unesifo samathambo esiphakathi, nesingamathambo. ”

Zithini izifundo

Izifundo ezincinci zijonge unyango lwe-Regenokine, ekwabizwa ngokuba yi-autologous conditioned serum (ACS), yeentlungu ezidibeneyo. Abanye bayithelekisa nolunye unyango. Ezinye izifundo zijonga kumalungu athile.

Nazi izifundo ezimbalwa zakutshanje:

• Isifundo se-2020 sabantu abali-123 abane-osteoarthritis xa kuthelekiswa ne-ACS kunyango lwe-PRP. Uphononongo lufumanise ukuba unyango lwe-ACS lwalusebenza kwaye "luphezulu ngokwebhayoloji kune-PRP." Abantu abafumene i-ACS babenokuncitshiswa okungcono kweentlungu kunye nokuphuculwa komsebenzi kunabo babene-PRP.
• Abantu abangama-28 abaneedolo okanye i-hip osteoarthritis bafumanisa ukuba unyango lwe-ACS luvelise "ukwehla okukhawulezayo kwintlungu" kunye nokonyuka kokuhamba.
• Unyango lwonyango oluhlaziya kwakhona luthelekisa i-Regenokine kunye nolunye unyango oluhlaziya. Inika ingxelo yokuba i-ACS "inciphisa iintlungu kunye nomonakalo odibeneyo kwisifo samathambo."
• Abantu abangama-47 abanezilonda ze-meniscus baphathwe bafumanisa ukuba i-ACS ivelise uphuculo olubonakalayo emva kweenyanga ezi-6. Ngenxa yoko, utyando lwaluphetshwa kuma-83 eepesenti zamatyala.
• A ye-118 yamadolo aphathwe nge-ACS ifumene ukuphuculwa ngokukhawuleza kwintlungu egcinwe kwiminyaka emi-2 yesifundo. Mnye kuphela umntu ofumene ukutshintshwa kwedolo ngexesha lofundo.

Bangaphi abantu abaye baphathwa?

Ngokuka-Jana Wehling, "Inkqubo ye-Regenokine ibisetyenziswa kwiklinikhi kangangeminyaka elishumi kwaye izigulana eziqikelelwa kuma-20 000 ziye zanyangwa kwihlabathi liphela."

Isizukulwana sokuqala seRegenokine, iOrthokine, sasetyenziselwa ukunyanga ngaphezulu kwe-100,000 yezigulana, utshilo.

Kuthiwani ngokuzalwa kwakhona kwe-cartilage?

Njengoko u-Evans ebeka, ukuhlaziywa kwe-cartilage yi-grail engcwele kubantu abasebenza ne-osteoarthritis. Ngaba inokuphinda ihlaziye intlala? Ngumbuzo ophantsi kophando lukaPeter Wehling kunye nelebhu yakhe.

Xa ebuzwa malunga nokuzalwa ngokutsha kwe-cartilage, uJana Wehling waphendula wathi: “Eneneni, sinobungqina obucacileyo benzululwazi bokwakha izihlunu neetoni phantsi kwe-ACS. Kukho iimpawu zokukhuselwa kwe-cartilage kunye nokuvuselelwa kwakhona kwizilingo zezilwanyana kunye nokusetyenziswa kweklinikhi yabantu, "watsho.

"Kodwa ukuvuselelwa kwe-cartilage kunzima kakhulu ukungqina kwizifundo zeklinikhi."

Uthini umahluko phakathi kwonyango lweRegenokine kunye ne-PRP?

Unyango lwe-PRP lutsala igazi lakho, liyiqhubele phambili ukonyusa uxinzelelo lweeplatelets, emva koko iphinde iphinde iphinde iphinde iphinde iphinde iphinde ichaphazele indawo echaphazelekayo.

Igazi lakho liqhutywa nge-centrifuge ukugxila kwiiplatelets, kodwa ayicocwanga. Kucingelwa ukuba uxinzelelo oluphezulu lweeplatelet lunceda ukukhawulezisa ukuphilisa kwendawo ngokukhupha izinto eziyimfuneko ekukhuleni.

I-PRP ayikavunywa yi-FDA, kwaye ihlala ingagutyungelwanga yi-inshurensi. Iindleko zonyango lwe-PRP ziyahluka ukusuka kwi- $ 500 ukuya kwi-2,000 yeedola ngenaliti nganye. Nangona kunjalo, isetyenziswa ngokufanelekileyo ekunyangeni iimeko ze-musculoskeal.

. IArthritis Foundation ithi i-PRP inokuhlala iinyanga ezintathu ukuya kwezi-6. "Ugqithile kwaye ngamanye amaxesha ukhuphe i-hyaluronic acid okanye inaliti ye-corticosteroid," watsho isiseko.

Ugqirha wamathambo uGqirha Laura Timmerman ukubeka ngale ndlela: I-PRP “yinto elungileyo ukuzama kuqala… kodwa uRegenokine unethuba elingcono lokunyanga isigulana.”

I-Regenokine isebenzisa irejimeni yokulungisa esemgangathweni

NjengoRegenokine, i-PRP lunyango lwebhayoloji. Kodwa iRegenokine inerejimeni yokuqhubekeka ngokusesikweni, ngaphandle kokungangqinelani kulwakhiwo, utsho uJana Wehling.

Ngokwahlukileyo, i-PRP ilungiselelwe ngokwahlukeneyo kunye. Oku kwenza ukuba kube nzima ukuthelekisa unyango kwizifundo zesayensi kuba ukwenziwa kwePRP kuyahluka.

I-Regenokine isusa iiseli zegazi kunye nezinye izinto ezinokubangela ukudumba

Ngokungafaniyo neRegenokine, i-PRP ayinaselfowuni. Iqulethe iiseli ezimhlophe zegazi kunye nezinye iinxalenye zegazi ezinokubangela ukudumba kunye nentlungu xa itofwe, ngokukaGqirha Thomas Buchheit, kwiziko iYunivesithi yaseDuke kwiziko eliguqulela amayeza obuhlungu.

Ngokwahlukileyo, iRegenokine iyacocwa.

Ngaba iRegenokine ikhuselekile?

Ukhuseleko lweRegenokine alukho kumbuzo, ngokweengcali ezininzi. Kunjengokuba i-Evans Clinic kaMayo yathi: “Into yokuqala yokwazi kukuba kukhuselekile. Oko kunokuchazwa ngokuthe gabalala. ”

Akukho ngxelo zeziphumo ezibi kwizifundo zeRegenokine.

Ukuvunywa kwe-FDA kuyafuneka ukuze kusetyenziswe iRegenokine eUnited States kuba ukuphinda kufakwe isampulu yegazi ephathwayo kuthathwa njengesiyobisi.

Ukuvunywa kwe-FDA kufuna uluhlu olubanzi lwezifundo kunye nezigidi zeedola ukuxhasa uphando.

Ixabisa malini iRegenokine?

Unyango lwe-Regenokine lubiza kakhulu, malunga ne- $ 1,000 ukuya kwi- $ 3,000 ngenaliti, ngokukaJana Wehling.

Uthotho olupheleleyo ngokomndilili lunezitofu ezine ukuya kwezintlanu. Ixabiso liyahluka ngokwommandla womzimba ophathweyo kunye nobunzima bawo. Umzekelo, uJana Wehling uthe, emqolo "singena kumalungu amaninzi nakwimithambo-luvo ejikelezileyo ngexesha elinye."

Ayigutyungelwanga yi-inshurensi eMelika

E-United States, i-Regenokine isetyenziswa ngaphandle kwelebheli ngamagosa anelayisensi kaPeter Wehling. Amaxabiso alandela oko kwenziwa ngu-Wehling eDusseldorf, eJamani, kwaye unyango alugutyungelwanga yi-inshurensi.

Ugqirha wamathambo uTimmerman uthi ubiza i-10, 000 yeedola kuthungelwano lwelungu lokuqala, kodwa isiqingatha lelo kwilungu lesibini okanye elilandelayo. Ukwaphawula ukuba ukutsalelwa kwegazi elinye kunokukunika iibhotile ezininzi ze-serum ezinokumiswa ngumkhenkce ukuze zisetyenziswe kamva.

Isicwangciso ngasinye sonyango "senziwe ngokwezifiso" kwiimfuno zomntu, ngokukaJana Wehling. Ezinye izinto zinokuchaphazela indleko, ezinje "ngohlobo kunye nobukrakra besifo, imeko yentlungu nganye, izikhalazo zeklinikhi, kunye nokudodobala (izigulo esele zikho)."

Ucacisile ukuba injongo yabo kukuzisa ixabiso.

Luthabatha ixesha elingakanani unyango lweRegenokine?

Nokuba i-Regenokine ifuna ukuphindaphindwa iyahluka ngokwahlukeneyo nangobukrakra bemeko yakho. UPeter Wehling uqikelela ukuba isiqabu samadolo nesinqe samathambo sinokuhlala phakathi konyaka omnye ukuya kwemihlanu.

Abantu abasabela kakuhle kunyango bahlala beyiphinda rhoqo kwiminyaka emi-2 ukuya kwemi-4, utshilo uPeter Wehling.

Ndingamfumana phi umboneleli ofanelekileyo?

Iofisi kaPeter Wehling eDusseldorf, eJamani, ilayisenisi kwaye ihlola rhoqo iilebhu zoogqirha abalawula unyango lweRegenokine. Bafuna ukuqinisekisa ukuba unyango lwenziwa ngokuchanekileyo kwaye ngendlela esemgangathweni.

Nalu ulwazi lonxibelelwano kwiklinikhi eseDusseldorf kunye neendawo ezintathu zase-US ezinelayisensi yokusebenzisa unyango:

UGqirha Wehling kunye neQabane
Dusseldorf, eJamani
UPeter Wehling, MD, PhD
Imeyile: [email protected]
Indawo yewebhu: https://drwehlingandpartner.com/en/
Ifowuni: 49-211-602550

Inkqubo yeDuke yokuHlaziya iintlungu
IRaleigh, North Carolina
UTomas Buchheit, MD
I-imeyile: [email protected]
Indawo yewebhu: dukerptp.org
Ifowuni: 919-576-8518

Ubomi beLifeSpan
ISanta Monica, eCarlifonia
UChris Renna, NGABA
I-imeyile: [email protected]
Indawo yewebhu: https://www.lifespanmedicine.com
Ifowuni: 310-453-2335

ULaura Timmerman, MD
IWalnut Creek, eCarlifonia
I-imeyile: [email protected]
Indawo yewebhu: http://lauratimmermanmd.com/-regenokinereg-program.html
Ifowuni: 925- 952-4080

Yise kude

I-Regenokine lunyango lwentlungu edibeneyo kunye nokudumba. Inkqubo iqhubekeka negazi lakho ukugxila kwiiproteni eziluncedo kwaye emva koko utofe igazi elinyangiweyo kwindawo echaphazelekayo.

I-Regenokine yindlela eyomeleleyo yokunyanga kune-platelet-rich plasma (PRP), kwaye isebenza ngcono kwaye ixesha elide kune-PRP.

I-Regenokine ivunyiwe ukuba isetyenziswe eJamani, apho yaphuhliswa nguGqirha Peter Wehling, kodwa ayinayo imvume ye-FDA e-United States. Isetyenziswa ngaphandle kwelebheli kwiindawo ezintathu eMelika ezinelayisensi ngu-Wehling.

Izifundo ezingaphezulu ziyafuneka ukuqinisekisa ukusebenza kweRegenokine kunye nokufumana ukuvunywa kwe-FDA.

Unyango lukhuselekile kwaye luyasebenza, ngokwezifundo zeklinikhi kunye neengcali zonyango. Ingxaki kukuba iRegenokine lonyango olubizayo ekufuneka luhlawulwe epokothweni eMelika.