Yonke into obufuna ukuyazi malunga ne-SGLT2 Inhibitors

Umxholo

• Zeziphi iintlobo ezahlukeneyo ze-SGLT2 inhibitors?
• Amayeza athathwe njani?
• Zeziphi izibonelelo ezinokubakho ngokuthatha i-SGLT2 inhibitor?
• Yeyiphi imingcipheko enokubakho kunye neziphumo ebezingalindelekanga zokuthatha eli yeza?
• Ngaba kukhuselekile ukudibanisa olu hlobo lonyango kunye nezinye iziyobisi?
• Ukuthatha

Ushwankathelo

I-SGLT2 inhibitors ludidi lwamayeza asetyenziselwa ukunyanga isifo seswekile sesi-2. Zikwabizwa ngokuba yiprotein zothutho lwesodium-glucose 2 inhibitors okanye ii-gliflozins.

I-SGLT2 inhibitors zithintela ukubuyiselwa kweglucose egazini elihluzwe ngezintso zakho, ke ngoko kuququzelela ukukhutshwa kweglucose kumchamo. Oku kunceda ukunciphisa amanqanaba eswekile yegazi.

Funda ukuze ufunde ngakumbi malunga neendidi ezahlukeneyo ze-SGLT2 inhibitors, kunye nezibonelelo ezinokubakho kunye nomngcipheko wokongeza olu hlobo lwamayeza kwisicwangciso sakho sonyango.

Zeziphi iintlobo ezahlukeneyo ze-SGLT2 inhibitors?

Ukuza kuthi ga ngoku, iU.S.Ukutya noLawulo lweeDrug (i-FDA) sele ivume iindidi ezine ze-SGLT2 inhibitors ukunyanga isifo seswekile sesi-2:

• canagliflozin (Invokana)
• dapagliflozin (Farxiga)
• empagliflozin (Jardiance)
• ertugliflozin (Steglatro)

Ezinye iintlobo ze-SGLT2 inhibitors ziyaphuhliswa kwaye zavavanywa kuvavanyo lweklinikhi.

Amayeza athathwe njani?

I-SGLT2 inhibitors ngamayeza onyango. Ziyafumaneka kwifom yeepilisi.

Ukuba ugqirha wakho wongeza i-SGLT2 inhibitor kwisicwangciso sakho sonyango, baya kukucebisa ukuba uyithathe kanye okanye kabini ngemini.

Ngamanye amaxesha, ugqirha wakho unokumisela i-SGLT2 inhibitor kunye namanye amayeza eswekile. Umzekelo, olu didi lwamayeza lunokudityaniswa ne-metformin.

Ukudityaniswa kwamayeza eswekile kunokukunceda ugcine inqanaba leswekile esegazini kuluhlu ekujoliswe kulo. Kubalulekile ukuthatha idosi efanelekileyo yeyeza ngalinye ukuyeka inqanaba leswekile yegazi lakho ukuba lihle kakhulu.

Zeziphi izibonelelo ezinokubakho ngokuthatha i-SGLT2 inhibitor?

Xa uthathwe wedwa okanye kunye namanye amayeza eswekile, i-SGLT2 inhibitors inokunceda ukuthoba amanqanaba eswekile yegazi. Oku kunciphisa amathuba akho okuphuhlisa iingxaki kuhlobo lwesibini lweswekile.

Ngokophando lwango-2018 olupapashwe kwiphephancwadi Isifo seswekile, izazinzulu zinika ingxelo yokuba i-SGLT2 inhibitors inokukhuthaza ukwehla kobunzima kunye nokuphucuka okutofileyo kuxinzelelo lwegazi kunye namanqanaba e-cholesterol egazini.

Uphononongo lwango-2019 lufumanise ukuba ii-inhibitors ze-SGLT2 zinxulunyaniswe nomngcipheko ophantsi wokubetha, isifo sentliziyo, kunye nokufa kwesifo sentliziyo kubantu abanesifo seswekile sesi-2 kunye nemithambo eqinileyo.

Ukuphononongwa okufanayo kufumanise ukuba i-SGLT2 inhibitors inokucothisa ukuqhubela phambili kwesifo sezintso.

Gcina ukhumbula, izibonelelo ezinokubakho ze-SGLT2 inhibitors ziyahluka ukusuka komnye umntu ukuya komnye, kuxhomekeke kwimbali yabo yonyango.

Ukuze ufunde okungakumbi malunga nolu hlobo lonyango, nokuba ingaba ilungile na isicwangciso sakho sonyango, thetha nogqirha wakho.

Yeyiphi imingcipheko enokubakho kunye neziphumo ebezingalindelekanga zokuthatha eli yeza?

I-SGLT2 inhibitors zithathwa njengezikhuselekileyo, kodwa kwezinye iimeko, zinokubangela iziphumo ebezingalindelekanga.

Umzekelo, ukuthatha olu hlobo lonyango kunokuphakamisa umngcipheko wokuphuhlisa:

• usulelo lomchamo
• izifo ezosulela ngokwabelana ngesondo, ezifana nosulelo lwegwele
• I-ketoacidosis yeswekile, ebangela ukuba igazi lakho libe ne-asidi
• hypoglycemia, okanye iswekile esezantsi yegazi

Kwiimeko ezinqabileyo, usulelo olunzima lwamalungu omzimba lubekhona kubantu abathatha i-SGLT2 inhibitors. Olu hlobo losulelo lwaziwa njenge-necrotizing fasciitis okanye i-Fournier's gangrene.

Olunye uphando lubonisa ukuba i-canagliflozin inokunyusa umngcipheko wokuqhekeka kwethambo. Ezi ziphumo zingakhange zidityaniswe nezinye i-SGLT2 inhibitors.

Ugqirha wakho unokukwazisa ngakumbi malunga nomngcipheko onokubakho wokuthatha i-SGLT2 inhibitors. Banokukunceda ukuba ufunde indlela yokuqonda kunye nokulawula naziphi na iziphumo ebezingalindelekanga ezinokubakho.

Ukuba ucinga ukuba unokufumana iziphumo ebezingalindelekanga kunyango, nxibelelana nogqirha wakho ngoko nangoko.

Ngaba kukhuselekile ukudibanisa olu hlobo lonyango kunye nezinye iziyobisi?

Nanini na xa usongeza iyeza elitsha kwisicwangciso sakho sonyango, kubalulekile ukuba uqwalasele indlela enokusebenzisana ngayo namayeza osele uwathatha.

Ukuba uthatha amanye amayeza eswekile ukunciphisa amanqanaba eswekile yegazi, ukongeza i-SGLT2 inhibitor yonyusa umngcipheko wokukhula kweswekile esezantsi yegazi.

Ukongeza, ukuba uthatha iintlobo ezithile ze-diuretics, i-SGLT2 inhibitors inokunyusa isiphumo sokuchama kuloo mayeza, ikwenza uchame rhoqo. Oko kunokuphakamisa umngcipheko wokuphelelwa ngamanzi emzimbeni kunye noxinzelelo lwegazi olusezantsi.

Ngaphambi kokuba uqale ukuthatha iyeza elitsha okanye uncedise, cela ugqirha wakho ukuba angadibana nantoni na kwisicwangciso sakho sonyango esele sikhona.

Ngamanye amaxesha, ugqirha wakho unokwenza utshintsho kunyango lwakho olumiselweyo ukunciphisa umngcipheko wokudibana kweziyobisi.

Ukuthatha

I-SGLT2 inhibitors ziyilelwe ukunceda ukulawula iswekile yegazi kubantu abaphila nohlobo lwesibini lweswekile.

Ukongeza ekunciphiseni amanqanaba eswekile yegazi, olu didi lwamayeza lufunyenwe lunezibonelelo zentliziyo kunye nezintso. Nangona ngokubanzi kuthathwa njengokukhuselekileyo, i-SGLT2 inhibitors ngamanye amaxesha ibangela iziphumo ebezingalindelekanga okanye ukuhlangana okungalunganga kunye neziyobisi ezithile.

Ugqirha wakho unokukuxelela ngakumbi malunga nezibonelelo ezinokubakho kunye nomngcipheko wokongeza olu hlobo lonyango kwisicwangciso sakho sonyango.