Indlela i-Short-Chain ye-Fatty Acids iyichaphazela njani impilo kunye nobunzima

Umxholo

• Yintoni i-Short-Chain ye-Fatty Acids?
• Imithombo yokutya yeeTyhefu eziMfutshane zaManqatha
• Amanqatha amaTyhefu amaFutshane kunye neZiphazamiso eDigestive
• Urhudo
• Isifo seThumbu lesifo
• I-Short-Chain ye-Fatty Acids kunye neCancer Colon
• Amanqatha amfutshane ama-Acids kunye neswekile
• Amanqatha amaTyhefu amaFutshane kunye nokuNcipha
• I-Short-Chain ye-Fatty Acids kunye neMpilo yeNtliziyo
• Ngaba kufuneka uthathe iSongezelelo?
• Thatha uMyalezo waseKhaya

I-fatty-chain chain fatty iveliswa yintsholongwane enobubele emathunjini akho.

Ngapha koko, zezona zinto zingumthombo wesondlo kwiiseli ezikwikholoni yakho.

Amanqatha e-asidi amancinci angadlala indima ebalulekileyo kwimpilo nakwizifo.

Banokunciphisa umngcipheko wezifo ezikruthayo, uhlobo lwesibini lweswekile, ukutyeba kakhulu, isifo sentliziyo kunye nezinye iimeko ().

Eli nqaku liphonononga indlela ii-acids ezinamafutha amafutshane ezichaphazela ngayo impilo.

Yintoni i-Short-Chain ye-Fatty Acids?

Amanqatha amafutshane e-asidi anamafutha acid anee-athomu ezingaphantsi kwe-6 zekhabhoni (C) ().

Ziveliswa xa ulusu olunobubele lwegciwane lubola ifayibha kwikholoni yakho, kwaye lolona mthombo wamandla kwiiseli ezingqonge ikholoni yakho.

Ngesi sizathu, badlala indima ebalulekileyo kwimpilo yekolon ().

Amanqatha e-asidi efutshane asetyenzisiweyo asetyenziselwa eminye imisebenzi emzimbeni. Umzekelo, banokubonelela malunga ne-10% yeemfuno zakho zekhalori yemihla ngemihla ().

I-fatty-chain chain fatty acids nazo zibandakanyeka kwi-metabolism yezondlo ezibalulekileyo ezifana ne-carbs kunye namafutha ().

Malunga ne-95% ye-fatty-chain chain fatty emzimbeni wakho zezi:

• I-acetate (C2).
• Ukuchazwa (C3).
• I-Butyrate (C4).

Ipropionate ibandakanyeka ikakhulu ekuveliseni iswekile esibindini, ngelixa i-acetate kunye ne-butyrate zibandakanyiwe kwezinye ii-acid kunye ne-cholesterol ().

Zininzi izinto ezichaphazela isixa se-fatty-chain fatty acids kwikholoni yakho, kubandakanya nokuba zingaphi ii-microorganisms ezikhoyo, umthombo wokutya kunye nexesha elithathayo ukutya ukuhamba kwinkqubo yakho yokwetyisa ().

I-fatty-chain chain fatty iveliswa xa ifayibha ibila kwikholoni. Zisebenza njengomthombo wamandla kwiiseli ezingqonge ikholoni.

Imithombo yokutya yeeTyhefu eziMfutshane zaManqatha

Ukutya ukutya okuninzi okunefayibha, okufana neziqhamo, imifuno kunye nembotyi, kunxulunyaniswa nokwanda kwee-acids ezinamafutha amancinci ().

Olunye uphononongo lwabantu abali-153 bafumene unxibelelwano oluqinisekileyo phakathi kokutya okuphezulu kokutya kwezityalo kunye namanqanaba anyukayo e-fatty-chain fatty acids kwizitulo (7).

Nangona kunjalo, isixa kunye nohlobo lwefayibha oyityayo ichaphazela ukwakheka kweebhaktiriya emathunjini akho, ezichaphazela yeyiphi i-fatty chain fatty eveliswayo ().

Umzekelo, uphononongo lubonakalisile ukuba ukutya ifibre ngakumbi kuyonyusa imveliso ye-butyrate, ngelixa ukunciphisa ukutya kwakho kwefayibha kunciphisa imveliso ().

Ezi ndidi zilandelayo zefayibha zezona zilungileyo kwimveliso yee-acids ezinamafutha amancinci kwikholoni (,):

• Inulin: Unokufumana i-inulin kwii-artichokes, igalikhi, iilike, amatswele, ingqolowa, irye kunye ne-asparagus.
• IFructooligosaccharides (FOS): I-FOS ifumaneka kwiziqhamo kunye nemifuno eyahlukeneyo, kubandakanya iibhanana, amatswele, igalikhi kunye neasparagus.
• Isitatshi esixhathisayo: Ungasifumana isitatshi esingaxhathisiyo kwiinkozo, irhasi, irayisi, iimbotyi, iibhanana eziluhlaza, iimbotyi kunye neetapile esele ziphekiwe zaze zaphola.
• IPectin: Imithombo elungileyo yepectin ibandakanya ii-apile, iiapilkosi, iminqathe, iiorenji kunye nezinye.
• IArabinoxylan: IArabinoxylan ifumaneka kwiinkozo zesiriyeli. Umzekelo, yeyona fiber ixhaphakileyo kwingqolowa yengqolowa, eyenza malunga ne-70% yomxholo opheleleyo wefayibha.
• Intsimbi yentsimbi: Intsimbi inokukhishwa kwiimbotyi zeguar, eziyimbotyi.

Ezinye iintlobo zeshizi, ibhotolo kunye nobisi lwenkomo nazo ziqulathe isixa esincinci se-butyrate.

Ukutya okunesinga eliphezulu, ezifana neziqhamo, imifuno, iimbotyi kunye neenkozo ezipheleleyo, kukhuthaza ukuveliswa kwee-asidi ezinamafutha amancinci.

Amanqatha amaTyhefu amaFutshane kunye neZiphazamiso eDigestive

Amanqatha e-asidi amancinci anokuba luncedo ngokuchasene nokuphazamiseka kokugaya.

Umzekelo, i-butyrate ineziphumo ezichasene nokudumba emathunjini ().

Urhudo

Iibacteria zakho zesisu ziguqula isitatshi esinganyangekiyo kunye ne-pectin zibe zii-fatty chain fatty, kwaye ukuzitya kubonisiwe ukunciphisa urhudo ebantwaneni (,).

Isifo seThumbu lesifo

I-ulcerative colitis kunye nesifo sikaCrohn zezi zimbini iintlobo eziphambili zesifo sokukrala kwamathumbu (IBD). Zombini zibonakaliswa kukudumba okungapheliyo kwamathumbu.

Ngenxa yeempawu zayo ezichasayo, i-butyrate isetyenziselwe ukunyanga zombini ezi meko.

Izifundo kwiimpuku zibonise ukuba izongezo ze-butyrate zinciphisa ukudumba kwamathumbu, kunye nezongezo ze-acetate zinezibonelelo ezifanayo. Ukongeza, amanqanaba asezantsi e-fatty-chain fatty acids adityaniswa ne-ulcerative colitis (,).

Izifundo zoluntu zikwacebisa ukuba ii-acids ezinama-short-chain, ngakumbi i-butyrate, zinokuphucula iimpawu zesifo sezilonda kunye nesifo sikaCrohn (,,,).

Uphononongo olubandakanya abaguli abangama-22 abane-ulcerative colitis bafumanisa ukuba ukusebenzisa i-60 yeigram ye-oat bran yonke imihla iinyanga ezi-3 ziphucule iimpawu ().

Olunye uphando oluncinci lufumanise ukuba izongezo ze-butyrate zikhokelele kuphuculo lweklinikhi kunye nokuxolelwa kwi-53% yezigulana zesifo sikaCrohn ().

Kwizigulana ezinesifo sokudumba okwenziwa sisilonda sikabhobhosi, i-enema ye-fatty-chain chain fatty, kabini ngemini kwiiveki ezi-6, incede ukunciphisa iimpawu nge-13% ().

Amanqatha e-asidi amancinci anokunciphisa urhudo kwaye ancede ukunyanga izifo zesisu ezivuthayo.

I-Short-Chain ye-Fatty Acids kunye neCancer Colon

Amanqatha e-asidi amancinci angadlala indima ephambili kuthintelo kunye nonyango lwee-cancer ezithile, ikakhulu umhlaza wekolon (,,).

Izifundo zeLebhu zibonisa ukuba i-butyrate inceda ukugcina iiseli zekholoni zisempilweni, kuthintela ukukhula kweeseli zethumba kwaye kukhuthaza ukutshabalalisa iiseli zomhlaza kwikholoni (,,,).

Nangona kunjalo, indlela esebenza ngayo ayiqondakali kakuhle (,,).

Izifundo ezininzi zokujonga zibonisa ukuba unxibelelwano phakathi kokutya okuphezulu kunye nokunciphisa umngcipheko womhlaza wekolon. Iingcali ezininzi zicebisa ukuba ukuveliswa kwee-acids ezinamafutha amancinci kunokuba luxanduva lwalo (,).

Olunye uphononongo lwezilwanyana lukwachaza unxibelelwano oluqinisekileyo phakathi kokutya okune-fiber ephezulu kunye nokwehla komngcipheko womhlaza wekolon (,).

Kwisifundo esinye, iimpuku kukutya okune-fiber ephezulu, amathumbu ayo aqulathe ibutterate evelisa ibhakteriya, yafumana i-75% yamathumba ambalwa kuneempuku ezingenayo ibacteria ().

Into enomdla kukuba, ukutya okunefayibha ephezulu kuphela-ngaphandle kwebhaktiriya yokwenza i-butyrate- khange kube neziphumo zokhuselo kumhlaza wekolon. Ukutya okune-fiber encinci-nokuba ibacteria evelisa i-butyrate- nako bekungasebenzi ().

Oku kuphakamisa ukuba izibonelelo ezichasene nomhlaza zibakho kuphela xa ukutya okunesondlo esikhulu kudityaniswa neebhaktiriya ezichanekileyo emathunjini.

Nangona kunjalo, izifundo zabantu zibonelela ngeziphumo ezixubeneyo. Abanye babonisa unxibelelwano phakathi kokutya okuphezulu kwefayibha kunye nokunciphisa umngcipheko womhlaza, ngelixa abanye bengafumani khonkco (,,,).

Ukanti ezi zifundo azikhange zijonge emathunjini ebacteria, kwaye umahluko ngamnye emathunjini ebacteria angadlala indima.

I-fatty-chain chain fatty acids ibonakalise ukukhusela kumhlaza wekolon kwizifundo zezilwanyana neelebhu. Nangona kunjalo, uphando oluthe kratya luyafuneka.

Amanqatha amfutshane ama-Acids kunye neswekile

Ukuphononongwa kobungqina buchaze ukuba i-butyrate inokuba neziphumo ezilungileyo kwizilwanyana nakubantu abanesifo seswekile sesi-2 ().

Ukuphononongwa okufanayo kukwaqaqambise ukuba kubonakala ngathi kukho ukungalingani kwizisu ezincinci kubantu abanesifo seswekile (,).

I-fatty-chain fatty acids ibonakalise ukwandisa umsebenzi we-enzyme kwisibindi nakwizihlunu zemisipha, okukhokelela kulawulo lweswekile yegazi olungcono (,,).

Kwizifundo zezilwanyana, i-acetate kunye nepropionate supplements ziphucule amanqanaba eswekile yegazi kwiimpuku zeswekile kunye neempuku eziqhelekileyo (,,).

Nangona kunjalo zimbalwa izifundo ezibandakanya abantu, kwaye iziphumo zixubekile.

Olunye uphononongo lufumanise ukuba izongezo zepropionate zinciphise amanqanaba eswekile yegazi, kodwa olunye uphononongo lufumanise ukuba ii-acid ezinamafutha amancinci azichaphazelekanga kulawulo lweswekile yegazi kubantu abasempilweni (,).

Inani lezifundo zoluntu likwanike nengxelo yemanyano phakathi kwefayibha enokubila kunye nokuphuculwa kolawulo lweswekile yegazi kunye nokuzwela kwe-insulin (,).

Nangona kunjalo esi siphumo ngokubanzi sibonwa kuphela kubantu abatyebe kakhulu okanye abanganyangekiyo kwi-insulin, hayi kubantu abasempilweni (,,).

I-acid-chain fatty acids ibonakala ngathi iyanceda ekulawuleni amanqanaba eswekile yegazi, ngakumbi kubantu abanesifo seswekile okanye i-insulin enganyangekiyo.

Amanqatha amaTyhefu amaFutshane kunye nokuNcipha

Ukwenziwa kwezinto ezincinci emathunjini kunokuchaphazela ukufunxeka kwezondlo kunye nolawulo lwamandla, ngaloo ndlela kuchaphazela ukukhula kokutyeba kakhulu (,).

Izifundo zibonise ukuba ii-acids ezinamafutha amancinci zilawula imetabolism yamafutha ngokwandisa ukutshiswa kwamafutha kunye nokunciphisa ukugcinwa kwamafutha ().

Xa oku kusenzeka, inani lamafutha easidi asimahla egazini ancitshisiwe, kwaye inokunceda ekukhuseleni nasekuzuzeni ubunzima (,,,).

Izifundo ezininzi zezilwanyana ziye zavavanya oku. Emva konyango lweeveki ezi-5 nge-butyrate, iimpuku ezityebe kakhulu zalahleka i-10.2% yesisindo sokuqala somzimba, kwaye amanqatha omzimba ancitshiswa nge-10%. Kwiigundane, izongezo ze-acetate zinciphise ukugcinwa kwamafutha (,).

Nangona kunjalo, ubungqina obudibanisa i-fatty chain fatty acids ekulahlekeni kwesisindo busekwe ikakhulu kwizifundo zezilwanyana kunye neetyhubhu zovavanyo.

Izifundo zezilwanyana kunye neetyhubhu zovavanyo zibonisa ukuba ii-acids ezinamafutha amancinci anokunceda ukuthintela nokunyanga ukutyeba. Nangona kunjalo, izifundo zabantu ziyafuneka.

I-Short-Chain ye-Fatty Acids kunye neMpilo yeNtliziyo

Izifundo ezininzi zokujonga zinxibelelanise ukutya okuphezulu kwefayibha kumngcipheko wesifo sentliziyo.

Nangona kunjalo, amandla alo mbutho uhlala exhomekeke kudidi lwefayibha kunye nomthombo ().

Ebantwini, ukungeniswa kwefayibha kukwanxulunyaniswa nokunciphisa ukudumba ().

Esinye sezizathu zokuba ifayibha inciphise umngcipheko wesifo sentliziyo kunokuba ngenxa yemveliso yee-acids ezinamafutha amancinci kwi-colon (,,).

Izifundo kwizilwanyana nakubantu zixele ukuba ii-acids ezinamafutha amancinci anciphise amanqanaba e-cholesterol (,,,,).

I-Butyrate icingelwa ukuba inxibelelane nezakhi zofuzo eziphambili ezenza i-cholesterol, ngokunokwenzeka inciphise imveliso ye-cholesterol ().

Umzekelo, ukuveliswa kwe-cholesterol kuye kwehla kwizibonda zeempuku ezinikwe izongezo zepropionate. I-Acetic acid ikwanciphisile amanqanaba e-cholesterol kwiigundane (,,).

Esi siphumo sinye sibonwe kubantu abatyebe kakhulu, njengoko i-acetate kwiviniga inciphise inani le-cholesterol engaphezulu kwegazi ().

Amanqatha e-asidi amancinci anokunciphisa umngcipheko wesifo sentliziyo ngokunciphisa ukudumba kunye nokuvimba imveliso ye-cholesterol.

Ngaba kufuneka uthathe iSongezelelo?

Amanqatha amancinci e-acid amancinci afunyanwa njenge-butyric acid salts.

Ezi zihlala zibizwa ngokuba yi-sodium, potassium, calcium okanye i-magnesium butyrate. Zifumaneka ngokulula kwi-intanethi okanye kwi-counter.

Nangona kunjalo, izongezo zisenokungabi yeyona ndlela ilungileyo yokunyusa amanqanaba akho e-acid-chain fatty. Izongezo ze-Butyrate zifunxwe ngaphambi kokuba zifike kwikholoni, zihlala zisemathunjini amancinci, oko kuthetha ukuba zonke izibonelelo zeeseli zekholoni ziya kulahleka.

Ukongeza, kukho ubungqina obuncinci kakhulu besayensi malunga nokusebenza kokuncitshiswa kwe-acid enamafutha.

I-Butyrate ifikelela kwi-colon engcono xa ibila ukusuka kwifayibha. Ke ngoko, ukonyusa inani lokutya okuphezulu kwifayibha kwindlela otya ngayo yeyona ndlela ingcono yokuphucula amanqanaba e-asidi enamafutha.

Ukutya ukutya okune-fiber ephezulu yeyona ndlela yokunyusa amanqanaba e-asidi enamafutha, njengoko izongezo zithathwa ngaphambi kokufika kwikholoni.

Thatha uMyalezo waseKhaya

Ngenxa yeepropathi zabo ezichasayo kunye nokuchasana nomhlaza, kusenokwenzeka ukuba ii-acid ezinama-short-chain zinoluhlu olubanzi lweziphumo eziluncedo emzimbeni wakho.

Inye kuphela into eqinisekileyo: ukujonga ulusu lwakho lwebacteria olunobuhlobo kunokukhokelela kwinkqubela phambili yezempilo.

Eyona ndlela yokondla iintsholongwane ezilungileyo emathunjini akho kukutya ukutya okuninzi okuphezulu kwifayibha enokubiliswa.