Yintoni iKallmann Syndrome

Umxholo

• Ziintoni iimpawu
• Izizathu ezinokubangela
• Uxilongo lwenziwa njani
• Yintoni unyango

Isifo sikaKallman sisifo esinqabileyo semfuza esibonakaliswa kukulibaziseka ekufikiseni kunye nokunciphisa okanye ukungabikho kwevumba, ngenxa yokusilela kwimveliso yehomoni ekhupha i-gonadotropin.

Unyango lubandakanya ukulawulwa kwee-gonadotropins kunye neehomoni zesini kwaye kufuneka zenziwe kwangexesha ngokukhawuleza ukuthintela iziphumo zomzimba nezengqondo.

Ziintoni iimpawu

Iimpawu zixhomekeke kwimfuza ehamba notshintsho, eyona ixhaphakileyo kukungabikho okanye ukunciphisa ivumba kulibaziseko lokufikisa.

Nangona kunjalo, ezinye iimpawu zinokubakho, ezinje ngombala wobumfama, utshintsho olubonakalayo, ubuthulu, inkalakahla ecandekileyo, ukuphazamiseka kwentliziyo kunye nokungaqheleki kwemithambo-luvo kunye nokungabikho kwamasende kumatyhalarha.

Izizathu ezinokubangela

Isifo sikaKallmann sibaleka ngenxa yotshintsho kwiijeni ezifaka iiproteni ezinoxanduva lophuhliso lwe-neuronal, ezibangela utshintsho kuphuhliso lwe-bulb ye-olfactory kunye notshintsho olulandelayo kumanqanaba e-gonadotropin-ekhulula i-hormone (GnRH).

Ukusilela kweConital GnRH kuthetha ukuba iihomoni ze-LH kunye ne-FSH aziveliswanga ngokwaneleyo ukuze zikhuthaze amalungu esini ukuba avelise i-testosterone kunye ne-estradiol, umzekelo, ukulibazisa ukufikisa. Jonga ukuba loluphi utshintsho olwenzeka emzimbeni xa ufikisa.

Uxilongo lwenziwa njani

Abantwana abangaqali ukukhula ngokwesondo xa beneminyaka eli-13 ubudala kumantombazana nakwiminyaka eli-14 kumakhwenkwe, okanye abantwana abangaqhubekiyo ngokwesiqhelo ngexesha lokufikisa, kufuneka bavavanywe ngugqirha.

Ugqirha kufuneka ahlalutye imbali yonyango lomntu, enze uvavanyo lomzimba kwaye acele umlinganiso wamanqanaba eplasma gonadotropin.

Uxilongo kufuneka lwenziwe ngexesha ukuqala unyango lwehomoni kunye nokuthintela iziphumo zomzimba nezengqondo zokulibazisa ukufikisa

Yintoni unyango

Unyango emadodeni kufuneka lwenziwe ixesha elide, ngokulawulwa kwe-chorionic gonadotropin okanye i-testosterone nakwabasetyhini abane-cyclic estrogen kunye neprogesterone.

Ukuchuma kunokuphinda kubuyiswe ngokulawula i-gonadotropins okanye ukusebenzisa impompo yokufaka ngaphakathi ukuhambisa i-pulned subcutaneous GnRH.