Yintoni i-Lynch syndrome, izizathu kunye nendlela yokuchonga

Umxholo

• Uyichonga njani i-Lynch syndrome
• Yintoni ebangela isifo
• Yeyiphi ingozi yokufumana isifo
• Unyango lwenziwa njani

I-Lynch syndrome yimeko enqabileyo yemfuza eyonyusa umngcipheko womntu wokuba nomhlaza wamathumbu ngaphambi kweminyaka engama-50. Ngokwesiqhelo iintsapho ezine-Lynch syndrome zinamanani aphezulu kakhulu omhlaza wamathumbu, anokunceda ugqirha enze uxilongo.

Nangona kungekho ndlela ilula yokunciphisa umngcipheko womhlaza, ukuba nendlela yokuphila esempilweni kunye nokugcina ixesha lokuqeshwa kunye ne-gastroenterologist kunokunciphisa amathuba eengxaki, nokuba umhlaza uyavela, njengoko unyango lunokuqaliswa ngokukhawuleza.

Uyichonga njani i-Lynch syndrome

I-Lynch syndrome yimfuza, imeko yelifa engakhokeleli ekubonakaleni kweempawu okanye iimpawu, ke ngoko, ukuchongwa kolu tshintsho kwenziwa kuvavanyo lukagqirha weendlela ezithile, ezinje:

• Ukuba nomhlaza wamathumbu ngaphambi kweminyaka engama-50;
• Imbali yosapho yomhlaza wamathumbu kubantu abancinci;
• Imbali yosapho yamatyala aliqela omhlaza wesibeleko;

Ukongeza, iintsapho ezinamatyala amaninzi eminye imihlaza enxulumene, njenge-ovari, isinyi, okanye umhlaza wamatyhalarha, nazo zinokuba neLynch syndrome. Ukongeza ekuchongeni ukuba kuvavanywa iikhrayitheriya, isiqinisekiso sinokwenziwa kuvavanyo lweemolekyuli ezijolise ekuchongeni utshintsho kwiijeni ezinxulumene nesi sifo.

Yintoni ebangela isifo

I-Lynch syndrome yenzeka xa kukho ukungalunganga kolunye uhlobo olunoxanduva lokuphelisa utshintsho kwi-DNA, ukuthintela ukubonakala komhlaza. Ezi zofuzo zinokubandakanya i-MLH1, i-MSH2, i-MSH6, i-PMS2 kunye ne-EPCAM kwaye, ke ngoko, iimvavanyo zegazi zaselebhu zihlala zisenziwa ukuqinisekisa olu tshintsho.

Nangona kunjalo, kukho iimeko zeentsapho ezibonisa i-syndrome ngaphandle kokutshintsha kule mizila yesi-5.

Yeyiphi ingozi yokufumana isifo

Ukongeza kumngcipheko okhulayo wokuba nomhlaza wamathumbu ngaphambi kweminyaka engama-50 ubudala, i-Lynch syndrome inokuthanda ukukhula kwezinye iintlobo zomhlaza, ezinje:

• Umhlaza wesisu;
• Umhlaza wesibindi okanye imibhobho yenyongo;
• Umhlaza wokuhambisa umchamo;
• Umhlaza wezintso;
• Umhlaza wolusu;
• Umhlaza wesibeleko okanye amaqanda, kwimeko yabasetyhini;
• Ithumba lobuchopho.

Ngenxa yomngcipheko owandileyo weentlobo ezahlukeneyo zomhlaza, kuyacetyiswa ukuba kuboniswane rhoqo kwizonyango ezahlukeneyo ukuze kwenziwe iimviwo kwaye kuchongwe naluphi na utshintsho kwangethuba. Uvavanyo oluqhele ukwenziwa kula matyala kukucebisa ngemfuza, apho umngcipheko wokuba nomhlaza kunye nethuba lokuhambisa ufuzo ebantwaneni, umzekelo, ziyaqinisekiswa. Qonda ukuba yintoni na ingcebiso ngemfuzo kwaye yenziwa njani.

Unyango lwenziwa njani

Akukho lunyango lonyango lwe-Lynch syndrome, nangona kunjalo, ezinye iindlela zokuthintela kunokunceda ukunciphisa umngcipheko womhlaza njengokutya okunempilo kunye nokutya okunesondlo, ukwenza imithambo rhoqo kunye nokuphepha ukutshaya nokusela, njengoko ezi zinto zinokuthi zithande ukukhula ezinye iintlobo zomhlaza.

Ukongeza, ukonyusa ukusetyenziswa kokutya okunotye kwii-antioxidants kunokunceda ukunciphisa umngcipheko womhlaza. Jonga iresiphi yeencindi ezi-4 ezilula ezikunceda ukukhusela umhlaza.