I-Soliqua 100/33 (i-insulin glargine / lixisenatide)

Umxholo

• Yintoni iSoliqua 100/33?
• Ukusebenza ngempumelelo
• I-Soliqua 100/33 generic
• Umthamo weSoliqua 100/33
• Iifom zamachiza kunye namandla
• Isisombululo seSoliqua 100/33
• Kuthekani ukuba ndiphose idosi?
• Ngaba kuya kufuneka ndisebenzise eli chiza ixesha elide?
• Iziphumo ebezingalindelekanga zeSoliqua 100/33
• Iziphumo eziqhelekileyo ezichaphazelekayo
• Iziphumo ebezingalindelekanga ezimandundu
• Iindleko zeSoliqua 100/33
• Uncedo lwezezimali kunye neinshurensi
• Uyithatha njani iSoliqua 100/33
• Ulawula njani
• Ixesha
• Ukuthatha iSoliqua 100/33 ngokutya
• Eminye indlela eya eSoliqua 100/33
• I-Soliqua 100/33 vs. Xultophy
• Sebenzisa
• Iifom zeziyobisi kunye nolawulo
• Iziphumo kunye neengozi
• Ukusebenza ngempumelelo
• Iindleko
• I-Soliqua 100/33 vs. nezinye iziyobisi
• I-Soliqua 100/33 vs.Lantus
• Soliqua 100/33 vs.Victoza
• I-Soliqua 100/33 vs. iToujeo
• I-Soliqua 100/33 vs.Adlyxin
• Ukusetyenziswa kweSoliqua 100/33
• Ukusetyenziswa kweSoliqua 100/33 kunye nezinye iziyobisi
• Soliqua 100/33 notywala
• Ukusebenzisana kweSoliqua 100/33
• Soliqua 100/33 kunye namanye amayeza
• I-Soliqua 100/33 kunye namayeza kunye nezongezo
• Isebenza njani iSoliqua 100/33
• I-insulin iyichaphazela njani iswekile yegazi
• Yintoni eyenziwa nguSoliqua 100/33
• Kuthatha ixesha elingakanani ukusebenza?
• Soliqua 100/33 kunye nokukhulelwa
• I-Soliqua 100/33 kunye nokuncancisa
• Imibuzo eqhelekileyo malunga neSoliqua 100/33
• Ngaba iSoliqua 100/33 ibangela ukutyeba?
• Ngaba i-Soliqua 100/33 insulin?
• Ngaba iSoliqua 100/33 isebenza ixesha elide?
• Ngaba iSoliqua 100/33 ingasetyenziselwa ukunyanga uhlobo lweswekile 1?
• Soliqua 100/33 izilumkiso
• Soliqua 100/33 libanda
• Iimpawu libanda
• Kufuneka wenze ntoni xa uthe wagqithisa?
• Ukuphela kunye nokugcinwa kweSoliqua 100/33
• Ulwazi lobungcali lweSoliqua 100/33
• Iimpawu
• Indlela yokusebenza
• I-Pharmacokinetics kunye ne-metabolism
• Ukungqinelana
• Ukugcina

Yintoni iSoliqua 100/33?

I-Soliqua 100/33 ligama lonyango elinegama lophawu. Isetyenziselwa ukutya kunye nokuzilolonga ukuphucula amanqanaba eswekile yegazi kubantu abadala abanesifo seswekile sesi-2.

I-Soliqua 100/33 inamachiza amabini:

• I-insulin glargine, esebenza ixesha elide njenge-insulin
• i-lixisenatide, eyeklasi yamachiza abizwa ngokuba yi-glucagon-like peptide 1 (GLP-1) receptor agonists

I-Soliqua 100/33 iza njengesiba senaliti esetyenziselwa ukuzitofa ngokwakho phantsi kolusu (subcutaneous). Ipeni nganye iqulethe i-3 mL yesisombululo seziyobisi, kunye neeyunithi ezili-100 ze-insulin glargine kunye ne-33 mcg ye-lixisenatide nge-mL yesisombululo. Iipeni zisetyenziswa ngeenaliti, ezingafakwanga neepeni.

Ukusebenza ngempumelelo

I-Soliqua 100/33 ifunyenwe isebenza kunyango lwe-2 yeswekile. Kwisifundo esinye seklinikhi, i-Soliqua 100/33 yavavanywa kubantu abanesifo seswekile sesi-2 ababephathwe i-insulins esebenza ixesha elide ubuncinci iinyanga ezintandathu. Emva kweeveki ezingama-30 zonyango kunye neSoliqua 100/33, aba bantu banciphise ihemoglobin A1c (HbA1c) ngepesenti eyi-1.1. Baye banciphisa amanqanaba eswekile yegazi nge-5.7 mg / dL.

Kwesinye isifundo seklinikhi, iSoliqua 100/33 yayisetyenziswa nge-metformin iiveki ezingama-30. Uphononongo lwalubandakanya abantu ababekhe baphathwa nge-metformin kuphela, okanye nge-metformin kunye nelinye ichiza leswekile. Unyango nge-Soliqua 100/33 kunye ne-metformin yehlise i-HbA1c ngeepesenti ze-1.6. Ikwanciphisile nokuzila amanqanaba eswekile yegazi ngama-59.1 mg / dL.

I-Soliqua 100/33 generic

I-Soliqua 100/33 ifumaneka kuphela njengeyeza elinegama lophawu. Okwangoku ayifumaneki ngendlela eqhelekileyo.

I-Soliqua 100/33 inamachiza amabini asebenzayo: i-insulin glargine kunye ne-lixisenatide. Akukho nalinye ichiza elifumanekayo ngohlobo oluqhelekileyo.

I-insulin glargine yi-insulin esebenza ixesha elide efumaneka ngokwayo njengeziyobisi ezinamagama anje ngeLantus, Toujeo, kunye neBasaglar. ILixisenatide yeyeklasi yamachiza abizwa ngokuba yi-glucagon-like peptide 1 (GLP-1) receptor agonists. Iyafumaneka njengegama lophawu lweziyobisi iAdlyxin.

Umthamo weSoliqua 100/33

Ngokwesiqhelo, ugqirha wakho uza kukuqala ngedosi esezantsi yeSoliqua 100/33 kwaye uyihlengahlengise ekuhambeni kwexesha ukufikelela kumthamo olungele wena. Le nkqubo yohlengahlengiso ibizwa ngokuba yi-titration. Ugqirha wakho uya kuthi ekugqibeleni anike idosi encinci enika isiphumo esifunayo.

Olu lwazi lulandelayo luchaza iidosi eziqhelekileyo ezisetyenziswayo okanye ezicetyiswayo. Nangona kunjalo, qiniseka ukuthatha idosi ekumisela ugqirha wakho. Ugqirha wakho uya kumisela eyona idosi ilungele iimfuno zakho.

Iifom zamachiza kunye namandla

Iphakheji nganye yeSoliqua 100/33 inezinto ezintlanu ezilahlwayo, ezikhethiweyo zeSoliqua 100/33. Iinaliti zepen azifakwanga neepeni. (Kwiimeko ezininzi, ungazithenga iinaliti kwiikhemesti. Ungalufuna iyeza.)

Ipeni nganye enesitofu iqulethe i-3 mL yesisombululo seziyobisi, iyonke iyunithi ye-insulin ye-insulin glargine kunye ne-100 mcg ye-lixisenatide.

Iipeni ezinesitofu zeSoliqua 100/33 nganye nganye ifuna ukusetyenziswa amaxesha amaninzi. Inani lamaxesha linokuvela kumaxesha ama-5 ukuya kuma-20, kuxhomekeke kumyinge wakho. Ipeni nganye inokusetyenziselwa ukuya kuthi ga kwiintsuku ezingama-28 emva kokusetyenziswa kokuqala. Emva kwelo xesha, kuya kufuneka ulahle usiba, nokuba lusenalo iyeza.

Iinaliti zokubhala kufuneka zisetyenziswe kube kanye kuphela.

Isisombululo seSoliqua 100/33

I-Soliqua 100/33 iqhele ukwenziwa ngenaliti enye yeeyunithi ezili-15 ukuya kwezi-60 inye. Igama elithi "iiyunithi" yindlela yokulinganisa esetyenziselwa i-insulin glargine equlethwe eSoliqua 100/33. Elona thamo liphezulu ngenaliti nganye ziiyunithi ezingama-60, nto leyo ethetha ukuba iiyunithi ezingama-60 ze-insulin glargine kunye ne-20 mcg lixisenatide.

Ukuqala idosi

Umthamo wokuqala ocetyiswayo weSoliqua 100/33 uxhomekeke kunyango lwangaphambili lweswekile.

PhawulaNgaphambi kokuba uqale i-Soliqua 100/33, kufuneka uyeke lonke olunye unyango nge-lixisenatide okanye i-insulin esebenza ixesha elide.

Umthamo wesondlo

Emva kokuqala i-Soliqua 100/33, ugqirha wakho uya kubeka esweni amanqanaba eswekile yegazi kwaye unokuhlengahlengisa idosi yakho ukufikelela kwinqanaba elifanelekileyo lakho. Umenzi weziyobisi ucebisa ukuba ubeke idosi phezulu okanye ezantsi ngeeyunithi ezi-2 ukuya kwezi-4 veki nganye njengoko kufuneka ukuhlangabezana neenjongo zeswekile yegazi.

Uhlengahlengiso lweedosi

Wena nogqirha wakho niza kusebenza kunye ukwenza isicwangciso sokuhlangabezana neenjongo zeswekile yegazi.

Apha ngezantsi ngumzekelo wohlengahlengiso lwethamo ugqirha anokucebisa ngalo. Ugqirha wakho uya kuthatha isigqibo sokuba ngaba ufuna olu hlengahlengiso. Qiniseka ukuba uthatha idosi ekhuthazwa ngugqirha wakho. (Sukutshintsha idosi yakho ngaphandle kwemvume kagqirha wakho.)

Kuthekani ukuba ndiphose idosi?

Ukuba uphosa idosi ye-Soliqua 100/33, yeqa idosi kwaye uqhubeke nedosi yakho ehleliweyo elandelayo. Ungazami ukubamba ngokuthatha idosi eyongezelelweyo okanye ukonyusa idosi elandelayo. Oku kunokubangela iziphumo ebezingalindelekanga eziyingozi.

Ngaba kuya kufuneka ndisebenzise eli chiza ixesha elide?

Ukuba i-Soliqua 100/33 iyasebenza kwaye ikhuselekile kuwe, uya kusebenzisa eli chiza ixesha elide. I-Soliqua 100/33 isetyenziswa ixesha elide ukunyanga isifo seswekile sesi-2.

Iziphumo ebezingalindelekanga zeSoliqua 100/33

I-Soliqua 100/33 inokubangela iziphumo ebezingalindelekanga ezinobulali okanye ezinobuzaza. Olu luhlu lulandelayo luqulathe ezinye zeziphumo ebezingalindelekanga ezinokubakho ngelixa uthatha iSoliqua 100/33. Olu luhlu alubandakanyi zonke iziphumo ebezingalindelekanga ezinokubakho.

Ngolwazi oluthe kratya malunga neziphumo ebezingalindelekanga ezinokubakho zeSoliqua 100/33, okanye iingcebiso ngendlela yokujongana nefuthe elibi, thetha nogqirha okanye usokhemesti.

Iziphumo eziqhelekileyo ezichaphazelekayo

Iziphumo eziqhelekileyo ezichaphazela uSoliqua 100/33 zinokubandakanya:

• isicaphucaphu
• izifo zokuphefumla ezinje ngengqele eqhelekileyo okanye umkhuhlane
• urhudo
• intloko ebuhlungu
• hypoglycemia (iswekile esezantsi yegazi)

Uninzi lweziphumo ebezingalindelekanga zinokuhamba zingaphelanga iintsuku okanye iiveki ezimbalwa. Ukuba zinzima kakhulu okanye azihambi, thetha nogqirha wakho okanye usokhemesti.

Iziphumo ebezingalindelekanga ezimandundu

Iziphumo ebezingalindelekanga ezimandundu ezivela eSoliqua 100/33 aziqhelekanga, kodwa zinokwenzeka. Shayela ugqirha wakho ngokukhawuleza ukuba unemiphumo emibi. Tsalela umnxeba ku-911 ukuba iimpawu zakho ziziva zisongela ubomi okanye ukuba ucinga ukuba unempilo kaxakeka.

Iziphumo ebezingalindelekanga ezimandundu kunye neempawu zazo zinokubandakanya oku kulandelayo:

• Impendulo enamandla kakhulu. Iimpawu zingabandakanya:
• irhashalala
• ukugungxula
• ukudumba
• ukurhawuzelela ulusu
• ingxaki yokuphefumla
• uxinzelelo lwegazi oluphantsi
• Ipancreatitis (ukudumba kwepancreas). Iimpawu zingabandakanya:
• intlungu okanye ukuthamba esiswini sakho
• umqolo obuhlungu
• isicaphucaphu
• ukugabha
• ifiva
• ukuhla ukusinda
• Ukonakala kwezintso. Iimpawu zingabandakanya:
• ukunciphisa ukuchama
• ukudumba emilenzeni, emaqatheni, okanye ezinyaweni
• ukudideka
• ukudinwa
• isicaphucaphu
• iintlungu esifubeni okanye uxinzelelo
• ukubetha kwentliziyo ngokungaqhelekanga
• ukuxhuzula
• Hypokalemia (potassium esezantsi). Iimpawu zingabandakanya:
• ubuthathaka
• ukudinwa
• ukuqhina
• ukuxhamla izihlunu
• ukubetha kwentliziyo ngokungaqhelekanga

Ukutyeba okanye ukunciphisa umzimba

Kwezilingo zeklinikhi, iSoliqua 100/33 ayifumanekanga ibangela utshintsho kubunzima. Nangona kunjalo, kwisifundo esinye seklinikhi, abantu abathathe i-Soliqua 100/33 kwiiveki ezingama-30 baphulukana neepawundi eziyi-1.5.

Ukongeza, iziyobisi ezizezinye eziqulethwe yiSoliqua 100/33 zidityaniswe notshintsho lobunzima. I-Soliqua 100/33 iqulethe i-insulin glargine, i-insulin esebenza ixesha elide. Iziyobisi eziqukethe i-insulin zinokubangela ukutyeba.

I-Soliqua 100/33 ikwanayo ne-lixisenatide, i-peptide efana ne-glucagon efana ne-1 (GLP-1) receptor agonist. Kwizifundo ezahlukeneyo zeklinikhi, amayeza kwiklasi ye-GLP-1 yeziyobisi abonise ukwehla kobunzima njengempembelelo yecala.

Ukuba ukhathazekile malunga notshintsho lobunzima ngelixa usebenzisa iSoliqua 100/33, thetha nogqirha wakho.

Hypoglycemia

I-insulin, elinye lamachiza eSoliqua 100/33, lisetyenziselwa ukunceda ukunciphisa amanqanaba eswekile yegazi. Nangona kunjalo, amanqanaba eswekile yegazi angathoba kude kakhulu, okukhokelela kwi-hypoglycemia. I-Hypoglycemia sesona sisiphumo secala siqhelekileyo sibangelwa sisiyobisi se-insulin, kubandakanya iSoliqua 100/33.

Kwizifundo zeklinikhi, i-hypoglycemia yenzeke kwi-8.1 ukuya kwi-17.8 yepesenti yabantu abathatha iSoliqua 100/33. Kwaye i-hypoglycemia eqatha yenzeka malunga neepesenti enye yabantu abathatha ichiza.

Zininzi izinto ezinokunyusa umngcipheko we-hypoglycemia. Oku kubandakanya ukuthatha idosi ephezulu yesifo seswekile kunye nokuthatha ngaphezulu kwesiyobisi esinye seswekile. Ezinye izinto ezinokuchaphazela umngcipheko wakho zibandakanya ukutya kunye nokuzilolonga, nokuba uthatha amanye amayeza.

Iimpawu zehypoglycemia zinokwenzeka ngesiquphe kwaye zinokubandakanya ukungcangcazela, ukudinwa, ukozela kunye nokudideka. Ukuqina kwehypoglycemia kunokukhokelela kwiziphumo ebezingalindelekanga ezinje ngokuxhuzula okanye nokufa. Thetha nogqirha wakho malunga nokuba kufuneka ujonge kangaphi amanqanaba eswekile yegazi ukukhusela i-hypoglycemia ngelixa uthatha iSoliqua 100/33.

Uxinzelelo okanye isikhumba esixineneyo

Uthatha i-Soliqua 100/33 ngenaliti engaphantsi, oko kuthetha ukuba uyayifaka phantsi kolusu lwakho. Inaliti engaphantsi inokubangela i-lipodystrophy (uxinzelelo okanye ukutyeba kolusu) kwindawo enenaliti.

Ukunciphisa umngcipheko we-lipodystrophy, tshintsha iisayithi apho utofa ichiza. Umzekelo, ngolunye usuku unokulifaka iyeza esiswini sakho, kwaye elilandelayo ungasebenzisa ithanga lakho langaphandle.

Ukuba unenkxalabo malunga neziphumo zolusu ezibangelwa kukujova iSoliqua 100/33, thetha nogqirha wakho.

Ukonakala kwezintso

Umonakalo wezintso awuzange ubonwe kwizifundo zeklinikhi zeSoliqua 100/33. Nangona kunjalo, kukho iingxelo zomonakalo wezintso kubantu abaphathwe nge-glucagon-njenge-peptide 1 (GLP-1) yeziyobisi. ILixisenatide, nelinye leziyobisi eSoliqua 100/33, sisiyobisi se-GLP-1.

Iimpawu zomonakalo wezintso zingabandakanya:

• ukudumba kwemilenze, amaqatha okanye iinyawo
• ukudinwa
• isicaphucaphu
• ukugabha

Umonakalo wezintso uqhele ukwenzeka kubantu ababephelelwe ngamanzi emzimbeni ngenxa yeziphumo ebezingalindelekanga zeSoliqua 100/33, ezinje ngesicaphucaphu, ukugabha kunye norhudo.

Ukuba uziphuhlisa ezi mpawu ngelixa uthatha iSoliqua 100/33, okanye ukhathazekile ngempilo yezintso, thetha nogqirha wakho.

Iindleko zeSoliqua 100/33

Njengawo onke amayeza, indleko zeSoliqua 100/33 ziyahluka.

Ixabiso lakho liya kuxhomekeka kwi-inshurensi yakho.

Uncedo lwezezimali kunye neinshurensi

Ukuba ufuna inkxaso yemali ukuhlawulela iSoliqua 100/33, uncedo luyafumaneka. USanofi Aventis, umenzi weSoliqua 100/33, unikezela ngeKhadi lokuGcina leSoliqua 100/33. Ngolwazi oluthe kratya, ndwendwela iwebhusayithi yenkqubo.

Uyithatha njani iSoliqua 100/33

Apha ngezantsi kukho imiyalelo esisiseko yendlela yokuzifaka ngenaliti usebenzisa ipeni eyiSoliqua 100/33. Njalo qiniseka ukuthatha iSoliqua 100/33 ngokwemigqirha yakho okanye imiyalelo yomboneleli wezempilo.

Ulawula njani

Inyathelo 1. Lungiselela ujonge usiba lwakho.

Ukuba oku kukusebenzisa kwakho okokuqala, thatha ipeni kwifriji kwaye uvumele usiba ukuba lufikelele kubushushu begumbi.

• Hlanganisa i-swabs yotywala, inaliti entsha, kunye nekhonteyina yakho yokulahla.
• Hlamba izandla zakho.
• Susa ipen cap uze uqiniseke ukuba iyeza licacile kwaye alinawo umbala. (Sukusebenzisa ukuba isisombululo asicacanga kwaye singenambala. Amaqamza omoya alungile.)
• Coca itywina yerabha ngeswabi yotywala.

Inyathelo 2. Fakela inaliti entsha.

Kwisitofu ngasinye, soloko usebenzisa inaliti entsha yokubhala. Qinisekisa ukuba inaliti yokubhala inokusetyenziswa kunye neSoliqua 100/33. Ukuba awazi ukuba zeziphi iinaliti oza kuzisebenzisa, buza ugqirha wakho okanye usokhemesti.

• Susa inaliti yosiba kwiphakheji yayo yokukhusela.
• Ukugcina inaliti yenaliti ithe tye, uyijike ebuhlanti.
• Susa ikepusi yenaliti yangaphandle uyibeke ecaleni. (Yigcine uyisebenzise emva kwenaliti.)
• Susa ikepusi yenaliti yangaphakathi uyilahle emgqomeni.

Inyathelo 3. Yenza uvavanyo lokhuseleko.

Ngalo lonke ixesha yenza uvavanyo lokhuselo ngaphambi kwento nganye yokufaka inaliti ukuqinisekisa ukuba usiba kunye nenaliti zisebenza ngokuchanekileyo.

• Lungisa i-counter counter ukuze ifunde iiyunithi ezi-2.
• Cinezela iqhosha lenaliti ngaphakathi kwaye ujonge isisombululo seziyobisi ukuze uphume kwincam yenaliti. Ukuba oku kuyenzeka, qhubeka inyathelo 4.
• Ukuba akukho siyobisi siphumayo, phinda uvavanyo lokhuseleko ukuya kuthi ga kumaxesha ama-3.
• Ukuba akukho chiza liphuma emva kovavanyo kathathu, buyisela inaliti kwaye uphinde iimvavanyo zokhuseleko.
• Ukuba akukho siyobisi siphumayo emva kokutshintsha inaliti, sukuyisebenzisa ipeni kuba inokonakala. Sebenzisa usiba olutsha.

Inyathelo 4. Khetha idosi yakho.

• Guqula ikhawuntari yethamo de ufike kwidosi yakho emiselweyo.

Inyathelo 5. Tofa idosi.

Kukho iindawo ezintathu emzimbeni wakho onokuzisebenzisa kwindawo enenaliti: isisu sakho (ngaphandle kweesentimitha ezi-2 zesisu sakho), umva wengalo yakho ephezulu (indawo enamanqatha), kunye nomlenze wakho wangaphandle.

• Khetha indawo yenaliti kwaye usule isikhumba kwindawo enotywala.
• Kwindawo yenaliti, faka inaliti kulusu lwakho kwinqanaba le-90-degree.
• Cinezela iqhosha lenaliti phantsi ngokupheleleyo kwaye ulibambe de ubone u "0" kwifestile yedosi.
• Emva kokuba ikhawuntara yethamo ijike ibe ngu “0,” ubale ukuya ku-10 ngaphambi kokukhulula iqhosha lenaliti kunye nokususa inaliti. Le nqumama inceda ekuqinisekiseni ukuba ufumana idosi epheleleyo.
• Khupha iqhosha lenaliti kwaye ususe inaliti kulusu lwakho.

Inyathelo 6. Lahla inaliti kwaye ugcine usiba.

• Beka ikepusi yenaliti yangaphakathi emva kwinaliti.
• Susa inaliti kwipeni enesitofu kwaye uyilahle kwangoko inaliti kwisitya esibukhali. (Yilahle kwangoko ukunqanda ukuyibhidanisa nenaliti entsha.)
• Beka usiba lusiba lwepen kubuya epen.
• Gcina usiba kubushushu begumbi emva kokusetyenziswa kokuqala.

Ixesha

Kuya kufuneka uthathe iSoliqua 100/33 ngaphakathi kweyure ngaphambi kwesidlo sakho sokuqala sosuku.

Ukuthatha iSoliqua 100/33 ngokutya

I-Soliqua 100/33 akufuneki ithathwe kunye nokutya. Kufuneka kuthathwe ngaphakathi kweyure ngaphambi kokutya kwakho kokuqala kosuku.

Eminye indlela eya eSoliqua 100/33

Amanye amachiza akhoyo anokunyanga udidi lwesibini lweswekile. Abanye banokukulungela ngcono kunabanye. Ukuba unomdla wokufumana enye indlela eya eSoliqua 100/33, thetha nogqirha wakho ukuze ufunde ngakumbi ngamanye amayeza anokukusebenzela.

I-Soliqua 100/33 inamachiza amabini: i-insulin esebenza ixesha elide ebizwa ngokuba yi-insulin glargine, kunye ne-glucagon-efana ne-peptide 1 (GLP-1) receptor agonist ebizwa ngokuba yi-lixisenatide.

Imizekelo yeziyobisi ezinokusetyenziswa njengezinye endaweni yeSoliqua 100/33 zibandakanya:

• ii-insulins ezisebenza ixesha elide, ezinje:
• I-insulin glargine (Lantus, Toujeo)
• Intshutshiso ye-insulin (Levemir)
• I-GLP-1 receptor agonists, enje nge:
• Ukunyaniseka (Bydureon, Byetta)
• iliraglutide (iVictoza, iSaxenda)
• Lixisenatide (Adlyxin)
• semaglutide (iOzempic)
• I-dipeptidyl peptidase-4 (DPP-4) inhibitors, enje:
• alogliptin (eNesina)
• linagliptin (I-Tradjenta)
• iSaxagliptin (iOnglyza)
• sitagliptin (Januwari)
• meglitinides, ezinje:
• repaglinide (Prandin)
• icandelo (Starlix)
• metformin (iGlucophage, iGlumetza, iRiomet)
• Isodium-glucose cotransporter 2 (SGLT2) inhibitors, ezinje nge:
• canagliflozin (Invokana)
• dapagliflozin (Farxiga)
• empagliflozin (Jardiance)
• sulfonylureas, ezinje:
• I-glimepiride (Amaryl)
• glipizide (Glucotrol)
• I-glyburide (iDiaBeta, iGlynase)
• thiazolidinediones, ezinje:
• pioglitazone (Actos)
• I-rosiglitazone (iAvandia)

I-Soliqua 100/33 vs. Xultophy

Usenokuzibuza ukuba iSoliqua 100/33 ithelekiswa njani namanye amayeza amiselweyo ukuze asetyenziswe ngokufanayo.Apha sijonga indlela iSoliqua 100/33 kunye neXultophy ezifanayo kunye ezahlukeneyo.

Sebenzisa

I-Soliqua 100/33 kunye ne-Xultophy zombini zivunyelwe yi-FDA ukuphucula amanqanaba eswekile yegazi kubantu abadala abanesifo seswekile sesi-2. Zombini zimiselwe ukusetyenziswa kunye notshintsho kwindlela yokutya kunye nokuzilolonga.

I-Soliqua 100/33 kunye neXultophy zombini zinamachiza amabini, kwaye la machiza akwiiklasi ezifanayo zamayeza. Oku kuthetha ukuba basebenza ngendlela efanayo emzimbeni.

I-Soliqua 100/33 iqulethe:

• I-insulin glargine (i-insulin esebenza ixesha elide)
• lixisenatide (i-peptide efana ne-glucagon-1 [GLP-1] receptor agonist)

Xultophy iqulethe:

• I-insulin degludec (i-insulin esebenza ixesha elide)
• i-liraglutide (i-GLP-1 receptor agonist)

Iifom zeziyobisi kunye nolawulo

I-Soliqua 100/33 kunye neXultophy zombini ziza njengesisombululo samanzi kwisibaya esilahlwayo. Zombini zizitofile phantsi kolusu (zangaphantsi) kanye ngemini.

Iziphumo kunye neengozi

I-Soliqua 100/33 kunye neXultophy baneziphumo ezifanayo emzimbeni kwaye ke zibangela iziphumo ezifanayo.

Iziphumo eziqhelekileyo ezichaphazelekayo

Olu luhlu lunemizekelo yeziphumo ebezingalindelekanga ezinokubakho ngamachiza omabini (xa ethathwe ngokwahlukeneyo).

• Inokwenzeka zombini iSoliqua 100/33 kunye neXultophy:
• izifo zokuphefumla ezinje ngengqele eqhelekileyo okanye umkhuhlane
• isicaphucaphu
• urhudo
• intloko ebuhlungu
• hypoglycemia (iswekile esezantsi yegazi)

Iziphumo ebezingalindelekanga ezimandundu

Olu luhlu lunemizekelo yeziphumo ebezingalindelekanga ezinokubakho ngeSoliqua 100/33, kunye neXultophy, okanye zombini iziyobisi (xa zithathwa ngokwahlukeneyo).

• Ngaba inokwenzeka ngeSoliqua 100/33:
• zimbalwa iziphumo ebezingalindelekanga ezimandundu
• Ngaba kunokwenzeka ngeXultophy:
• umhlaza wedlala lengqula
• isifo senyongo
• Inokwenzeka zombini iSoliqua 100/33 kunye neXultophy:
• negazi lakho kakhulu
• i-hypoglycemia enamandla (iswekile esezantsi yegazi)
• ukudumba kwenjeke (ukudumba kwepancreas)
• umonakalo kwizintso
• i-hypokalemia (amanqanaba asezantsi e-potassium)

I-Xultophy inesilumkiso esibhokisiweyo esivela kwi-FDA yomhlaza wedlala lengqula. Isilumkiso sebhokisi sisilumkiso esomeleleyo esifunwa yi-FDA. Yazisa oogqirha kunye nezigulana malunga neziphumo zeziyobisi ezinokuba yingozi.

Ukusebenza ngempumelelo

I-Soliqua 100/33 kunye ne-Xultophy azithelekiswanga ngokuthe ngqo kwizifundo zeklinikhi, kodwa zombini zifunyenwe zisebenza ngokunyanga uhlobo lwe-2 yeswekile.

Kwizifundo ezahlukileyo, i-Soliqua 100/33 kunye ne-Xultophy zombini zazisebenza ngokunciphisa i-HbA1c kunye nokuzila amanqanaba eswekile yegazi.

• Kwisifundo seklinikhi, i-Soliqua 100/33 inciphise i-hemoglobin A1c (HbA1c) nge-1.1 yepesenti kunye nokuzila amanqanaba eswekile yegazi nge-5.7 mg / dL emva kweeveki ezingama-30 zonyango.
• Kwizifundo zeklinikhi, iXultophy inciphise i-HbA1c nge-1.31 ukuya kwi-1.94 yeepesenti kunye nokuzila amanqanaba eswekile yegazi nge-49.9 mg / dL ukuya kwi-63.5 mg / dL emva kweeveki ezingama-26 zonyango. Abantu abasebenzisa iXultophy bafumene malunga neepawundi ezingama-4.4 ngaphezulu kweeveki ezingama-26 zonyango.

PhawulaKubalulekile ukugcina engqondweni ukuba nokuba la machiza anganciphisa njani i-HbA1c yakho okanye amanqanaba eswekile yegazi aya kuxhomekeka kwizinto ezininzi, kubandakanya:

• amanqanaba eswekile yegazi xa uqala ichiza
• ukutya kwakho kunye neerejimeni zokuzilolonga
• amanye amayeza eswekile owathathayo
• Ululandela ngokusondeleyo njani unyango lwakho

Iindleko

I-Soliqua 100/33 kunye neXultophy zombini zineziyobisi ezinamagama. Okwangoku azikho iifom zohlobo oluthile ezifumaneka nakweliphi na ichiza. Amayeza egama leBrand ahlala exabisa ngaphezu kwegeneric.

Ngokusekwe kuqikelelo oluvela kwi-GoodRx.com, iXultophy inokubiza ngaphezulu kweSoliqua 100/33. Elona xabiso ubuya kulihlawula ngalo naliphi na ichiza lixhomekeke kwidosi yakho, isicwangciso sakho seinshurensi, indawo okuyo, kunye nekhemesti oyisebenzisayo.

I-Soliqua 100/33 vs. nezinye iziyobisi

Zikhona ezinye iziyobisi ngaphandle kweSoliqua 100/33 kunye neXultophy (ngasentla) enokusetyenziselwa ukunyanga uhlobo lwesibini lweswekile. Apha ngezantsi kuthelekiswa phakathi kweSoliqua 100/33 kunye namanye amayeza.

I-Soliqua 100/33 vs.Lantus

I-Soliqua 100/33 inamachiza amabini:

• I-insulin glargine, esebenza ixesha elide njenge-insulin
• i-lixisenatide, eyeklasi yamachiza abizwa ngokuba yi-glucagon-like peptide 1 (GLP-1) receptor agonists

I-insulin glargine sisiyobisi esiqulathwe eLantus. Ngenxa yokuba iSoliqua 100/33 kunye neLantus babelana ngesithako esisebenzayo, basebenza ngeendlela ezifanayo emzimbeni.

Sebenzisa

I-Soliqua 100/33 ivunyiwe yi-FDA ukuba isetyenziswe kunye notshintsho kwindlela yokutya kunye nokuzilolonga ukuphucula amanqanaba eswekile yegazi kubantu abadala abanesifo seswekile sesi-2.

I-Lantus ivunyiwe yi-FDA ukuphucula amanqanaba eswekile yegazi kubantu abadala kunye nabantwana abanesifo seswekile sokuqala, kunye nabantu abadala abanesifo seswekile sesi-2.

Iifom zeziyobisi kunye nolawulo

I-Soliqua 100/33 iza njengesisombululo esingamanzi kwipeni enokutsalwa. I-Lantus iza njengesisombululo esingamanzi kwi-vial yedosi ezininzi okanye kwindawo yokubhala enokubulala. Omabini la machiza azitofile phantsi kolusu (subcutaneous) kanye ngemini.

Iziphumo kunye neengozi

I-Soliqua 100/33 kunye ne-Lantus zombini ziqulethe i-insulin esebenza ixesha elide, i-insulin glargine. Ke ngoko, omabini la machiza anokubangela iziphumo ezifanayo. Apha ngezantsi kunemizekelo yeziphumo ebezingalindelekanga.

Iziphumo eziqhelekileyo ezichaphazelekayo

Olu luhlu lunemizekelo yeziphumo ebezingalindelekanga ezinokubakho ngeSoliqua 100/33, kunye neLantus, okanye zombini iziyobisi (xa zithathwa ngokwahlukeneyo).

• Ngaba kunokwenzeka ngeSoliqua 100/33:
  • isicaphucaphu
  • izifo zokuphefumla ezinje ngengqele eqhelekileyo okanye umkhuhlane
  • intloko ebuhlungu
  • urhudo
• Inokwenzeka ngeLantus:
  • ukutyeba kwakho
  • I-lipodystrophy (induction okanye ukuqina kwesikhumba kwindawo yenaliti)
  • iimpendulo zesiza senaliti
• Inokwenzeka kunye neSoliqua 100/33 kunye neLantus:
  • hypoglycemia (iswekile esezantsi yegazi)

Iziphumo ebezingalindelekanga ezimandundu

Olu luhlu lunemizekelo yeziphumo ebezingalindelekanga ezinokubakho neSoliqua 100/33, kunye neLantus, okanye zombini iziyobisi (xa zithathwa ngokwahlukeneyo).

• Ngaba kunokwenzeka ngeSoliqua 100/33:
  • ukudumba kwenjeke (ukudumba kwepancreas)
  • umonakalo kwizintso
• Inokwenzeka ngeLantus:
  • zimbalwa iziphumo ebezingalindelekanga ezimandundu
• Inokwenzeka kunye neSoliqua 100/33 kunye neLantus:
  • negazi lakho kakhulu
  • i-hypoglycemia enamandla (iswekile esezantsi yegazi)
  • amanqanaba e-potassium asezantsi (hypokalemia)

Ukusebenza ngempumelelo

Ukusebenza kweSoliqua 100/33 kunye neLantus ngokuthelekiswe ngokuthe ngqo kwizifundo ezibini. Kwisifundo sokuqala, la mayeza mabini ayesetyenziswa yedwa. Kwesibini, zazisetyenziselwa nganye ngokudibanisa ne-metformin (ichiza leswekile yomlomo).

Sebenzisa wedwa

Isifundo sokuqala sigxile kubantu abadala abanesifo seswekile sesi-2 ababekhe baphathwa ngaphambili ngama-insulins asebenza ixesha elide. Ibonise ukuba iSoliqua 100/33 inokusebenza ngcono kancinci kuneLantus yokunciphisa ihemoglobin A1c (HbA1c), kodwa hayi nangokunciphisa amanqanaba eswekile yegazi.

Emva kweeveki ezingama-30 zonyango, i-Soliqua 100/33 yehlisa i-HbA1c ngepesenti eyi-1.1, kunye nokuzila amanqanaba eswekile yegazi nge-5.7 mg / dL. Ngexesha elifanayo, iLantus yanciphisa i-HbA1c ngeepesenti ze-0.6, kunye nokuzila ukutya amanqanaba eswekile nge-7.0 mg / dL.

Sebenzisa nge metformin

Isifundo sesibini kuvavanywe i-Soliqua 100/33 nge-metformin ngokuchasene ne-Lantus ene-metformin kubantu abadala abanesifo seswekile sesi-2. Aba bantu babekhe baphathwa nge-metformin kuphela, okanye nge-metformin kunye nelinye ichiza leswekile yomlomo.

Ngaphezulu kweeveki ezingama-30, iSoliqua 100/33 nge-metformin yayisebenza kancinci kuneLantus ene-metformin. I-Soliqua 100/33 ene-metformin inciphise i-HbA1c nge-1.6 yepesenti kunye nokuzila ukutya kwinqanaba leswekile nge-59.1 mg / dL. I-Lantus kunye ne-metformin, kwelinye icala, banciphisa i-HbA1c ngeepesenti ze-1.3 kunye nokuzila ukutya amanqanaba eswekile egazi ancitshiswe nge-55.8 mg / dL.

Phawula: Kubalulekile ukuba ugcine engqondweni ukuba nokuba la machiza anganciphisa njani i-HbA1c yakho okanye amanqanaba eswekile yegazi aya kuxhomekeka kwizinto ezininzi, kubandakanya:

• amanqanaba eswekile yegazi xa uqala ichiza
• ukutya kwakho kunye neerejimeni zokuzilolonga
• amanye amayeza eswekile owathathayo
• Ululandela ngokusondeleyo njani unyango lwakho

Iindleko

I-Soliqua 100/33 kunye neLantus zozibini iziyobisi ezinamagama. Okwangoku azikho iifom zohlobo oluthile ezifumaneka nakweliphi na ichiza. Amayeza egama leBrand ahlala exabisa ngaphezu kwegeneric.

Ngokwengqikelelo yeGoodRx.com, iLantus ngokubanzi ixabisa ngaphantsi kweSoliqua 100/33. Elona xabiso ubuya kulihlawula ngalo naliphi na ichiza lixhomekeke kwidosi yakho, isicwangciso sakho seinshurensi, indawo okuyo, kunye nekhemesti oyisebenzisayo.

Soliqua 100/33 vs.Victoza

I-Soliqua 100/33 inamachiza amabini:

• I-insulin glargine, esebenza ixesha elide njenge-insulin
• i-lixisenatide, eyeklasi yamachiza abizwa ngokuba yi-glucagon-like peptide 1 (GLP-1) receptor agonists

IVictoza iqulethe ichiza le-liraglutide, ekwayi-GLP-1 receptor agonist. Kuba iSoliqua 100/33 kunye neVictoza babelana ngesithako esisebenzayo kwiklasi enye yeziyobisi, basebenza ngeendlela ezifanayo emzimbeni.

Sebenzisa

I-Soliqua 100/33 ivunyiwe yi-FDA ukuphucula amanqanaba eswekile yegazi kubantu abadala abanesifo seswekile sesi-2. Imiselwe ukuba isetyenziswe notshintsho kwindlela yokutya kunye nokuzilolonga.

IVictoza ikwavunyiwe ukuphucula amanqanaba eswekile yegazi kubantu abadala abanesifo seswekile sesi-2 ngokudibeneyo kunye nokutya okuphuculweyo kunye nokuzilolonga. Ukongeza, kuyavunywa ukunciphisa umngcipheko weengxaki ezinkulu zentliziyo ezinje ngokuhlaselwa sisifo sentliziyo kunye nokubetha kubantu abane-2 yeswekile nesifo sentliziyo.

Iifom zeziyobisi kunye nolawulo

Zombini i-Soliqua 100/33 kunye ne-Victoza ziza njengesisombululo samanzi kwisibaya esilahlwayo. Omabini la machiza azitofile phantsi kolusu (subcutaneous) kanye ngemini.

Iziphumo kunye neengozi

Kuba iSoliqua 100/33 kunye neVictoza zombini ziqulathe iziyobisi ezikwiklasi yeziyobisi ye-GLP-1, omabini la machiza anokubangela iziphumo ezifanayo. Apha ngezantsi kunemizekelo yeziphumo ebezingalindelekanga.

Iziphumo eziqhelekileyo ezichaphazelekayo

Olu luhlu lunemizekelo yeziphumo ebezingalindelekanga ezinokubakho ngeSoliqua 100/33, kunye neVictoza, okanye zombini iziyobisi (xa zithathwa ngokwahlukeneyo).

• Ngaba kunokwenzeka ngeSoliqua 100/33:
  • hypoglycemia (iswekile esezantsi yegazi)
  • izifo zokuphefumla ezinje ngengqele eqhelekileyo okanye umkhuhlane
  • intloko ebuhlungu
• Inokwenzeka ngoVictoza:
  • ukunciphisa ukutya
  • ukugabha
  • ukuqhina
  • isisu esibuhlungu
• Inokwenzeka kunye neSoliqua 100/33 kunye neVictoza:
  • isicaphucaphu
  • urhudo

Iziphumo ebezingalindelekanga ezimandundu

Olu luhlu lunemizekelo yeziphumo ebezingalindelekanga ezinokubakho ngeSoliqua 100/33, kunye neVictoza, okanye zombini iziyobisi (xa zithathwa ngokwahlukeneyo).

• Ngaba inokwenzeka ngeSoliqua 100/33:
  • i-hypokalemia (amanqanaba asezantsi e-potassium)
• Inokwenzeka ngoVictoza:
  • umhlaza wedlala lengqula
  • isifo senyongo
• Inokwenzeka kunye neSoliqua 100/33 kunye neVictoza:
  • negazi lakho kakhulu
  • i-hypoglycemia enamandla (iswekile esezantsi yegazi)
  • ukudumba kwenjeke (ukudumba kwepancreas)
  • umonakalo kwizintso

UVictoza unesilumkiso esibhokisi esivela kwi-FDA somhlaza we-thyroid. Isilumkiso sebhokisi sisilumkiso esomeleleyo esifunwa yi-FDA. Yazisa oogqirha kunye nezigulana malunga neziphumo zeziyobisi ezinokuba yingozi.

Ukusebenza ngempumelelo

I-Soliqua 100/33 kunye ne-Victoza khange ithelekiswe ngokuthe ngqo kwizifundo zeklinikhi, kodwa zombini zifunyenwe zisebenza ngokunyanga uhlobo lwe-2 yeswekile.

Kwizifundo ezahlukileyo, zombini iSoliqua 100/33 kunye neVictoza zehlisa i-HbA1c kunye nokuzila amanqanaba eswekile yegazi kubantu abanesifo seswekile sesi-2.

• Kwisifundo seklinikhi, emva kweeveki ezingama-30 zonyango, i-Soliqua 100/33 inciphise i-hemoglobin A1c (HbA1c) nge-1.1 yeepesenti kunye nokuzila amanqanaba eswekile yegazi nge-5.7 mg / dL.
• Kwezinye izifundo zeklinikhi, ngaphezulu kweeveki ezingama-52 zonyango, uVictoza wanciphisa i-HbA1c malunga ne-0.8 ukuya kwi-1.1 yepesenti kunye nokuzila amanqanaba eswekile yegazi nge-15 ukuya kuma-26 mg / dL.

Uphononongo olwahlukileyo lweklinikhi lubonise ukuba uVictoza unciphise umngcipheko weengxaki zentliziyo ezinje ngokuhlaselwa sisifo sentliziyo kunye nokubetha ngepesenti ye-13. Esi siphumo asifundiswanga kuphando kwi-Soliqua 100/33.

PhawulaKubalulekile ukugcina engqondweni ukuba nokuba la machiza anganciphisa njani i-HbA1c yakho okanye amanqanaba eswekile yegazi aya kuxhomekeka kwizinto ezininzi, kubandakanya:

• amanqanaba eswekile yegazi xa uqala ichiza
• ukutya kwakho kunye neerejimeni zokuzilolonga
• amanye amayeza eswekile owathathayo
• Ululandela ngokusondeleyo njani unyango lwakho

Iindleko

I-Soliqua 100/33 kunye ne-Victoza zombini iziyobisi ezinamagama. Okwangoku azikho iifom zohlobo oluthile ezifumaneka nakweliphi na ichiza. Amayeza egama leBrand ahlala exabisa ngaphezu kwegeneric.

Ngokwengqikelelo yeGoodRx.com, iVictoza ngokubanzi ixabisa ngaphezulu kweSoliqua 100/33. Eyona ndleko uya kuhlawulela ngayo naliphi na ichiza kuya kuxhomekeka kumthamo wakho, isicwangciso sakho seinshurensi, indawo okuyo, kunye nekhemesti oyisebenzisayo.

I-Soliqua 100/33 vs. iToujeo

I-Soliqua 100/33 inamachiza amabini:

• I-insulin glargine, esebenza ixesha elide njenge-insulin
• i-lixisenatide, eyeklasi yamachiza abizwa ngokuba yi-glucagon-like peptide 1 (GLP-1) receptor agonists

I-insulin glargine sisiyobisi esikuToujeo. Ngenxa yokuba iSoliqua 100/33 kunye neToujeo babelana ngesithako esisebenzayo, basebenza ngeendlela ezifanayo emzimbeni.

Sebenzisa

I-Soliqua 100/33 ivunyiwe yi-FDA ukuphucula amanqanaba eswekile yegazi kubantu abadala abanesifo seswekile sesi-2. Kuvunyelwe ukusetyenziswa kunye neenguqu zokutya kunye nokuzilolonga.

I-Toujeo yamkelwe yi-FDA ukuphucula amanqanaba eswekile yegazi kubantu abadala abane-2 yeswekile, kunye nabantu abadala kunye nabantwana abanesifo seswekile sokuqala.

Iifom zeziyobisi kunye nolawulo

I-Soliqua 100/33 kunye neToujeo zombini ziza njengesisombululo samanzi kwisibaya esilahlwayo. Omabini la machiza azitofile phantsi kolusu (subcutaneous) kanye ngemini.

I-Soliqua 100/33 iza ngesixa esinye. Ipeni nganye ine-3 mL yesisombululo sesiyobisi, kunye neeyunithi ezingama-300 ze-insulin glargine kunye ne-100 mcg ye-lixisenatide. Elona thamo liphezulu ngenaliti nganye ziiyunithi ezingama-60, nto leyo ethetha ukuba iiyunithi ezingama-60 ze-insulin glargine kunye ne-20 mcg lixisenatide.

I-Toujeo iza ngamanani amabini ahlukeneyo:

• IToujeo SoloStar iqulethe iiyunithi ezingama-450 ze-insulin glargine kwi-1.5 ml yesisombululo, kunye nedosi ephezulu yeeyunithi ezingama-80 ngenaliti nganye.
• IToujeo Max SoloStar iqulethe iiyunithi ezingama-900 ze-insulin glargine kwi-3 ml yesisombululo, ngethamo eliphezulu leeyunithi ezili-160 ngenaliti nganye.

Iziphumo kunye neengozi

I-Soliqua 100/33 kunye neToujeo bobabini babelana nge-insulin esebenza ixesha elide, insulin glargine. Ke ngoko, omabini la machiza anokubangela iziphumo ezifanayo. Apha ngezantsi kunemizekelo yeziphumo ebezingalindelekanga.

Iziphumo eziqhelekileyo ezichaphazelekayo

Olu luhlu lunemizekelo yeziphumo ebezingalindelekanga ezinokubakho ngeSoliqua 100/33, kunye neToujeo, okanye zombini iziyobisi (xa zithathwa ngokwahlukeneyo).

• Ngaba inokwenzeka ngeSoliqua 100/33:
  • isicaphucaphu
  • urhudo
  • intloko ebuhlungu
• Inokwenzeka ngeToujeo:
  • ukutyeba kwakho
  • iimpendulo zesiza senaliti
  • I-lipodystrophy (induction okanye uxinzelelo kwindawo yenaliti)
  • ukucheba
  • irhashalala
  • ukudumba emilenzeni, emaqatheni, okanye ezinyaweni
• Inokwenzeka kunye neSoliqua 100/33 kunye neToujeo:
  • izifo zokuphefumla ezinje ngengqele eqhelekileyo okanye umkhuhlane
  • hypoglycemia (iswekile esezantsi yegazi)

Iziphumo ebezingalindelekanga ezimandundu

Olu luhlu lunemizekelo yeziphumo ebezingalindelekanga ezinokubakho ngeSoliqua 100/33, kunye neToujeo, okanye zombini iziyobisi (xa zithathwa ngokwahlukeneyo).

• Ngaba kunokwenzeka ngeSoliqua 100/33:
  • ukudumba kwenjeke (ukudumba kwepancreas)
  • umonakalo kwizintso
• Inokwenzeka ngeToujeo:
  • zimbalwa iziphumo ebezingalindelekanga ezimandundu
• Inokwenzeka kunye neSoliqua 100/33 kunye neToujeo:
  • negazi lakho kakhulu
  • i-hypoglycemia enamandla (iswekile esezantsi yegazi)
  • i-hypokalemia (amanqanaba asezantsi e-potassium)

Ukusebenza ngempumelelo

I-Soliqua 100/33 kunye neToujeo khange zithelekiswe ngokuthe ngqo kwizifundo zeklinikhi. Nangona kunjalo, izifundo ezizodwa zibonise ukuba zombini iToujeo kunye neSoliqua 100/33 zinokusebenza ngokunciphisa i-HbA1c kunye nokuzila amanqanaba eswekile yegazi.

• Kwisifundo seklinikhi, i-Soliqua 100/33 inciphise i-hemoglobin A1c (HbA1c) nge-1.1 yepesenti kunye nokuzila amanqanaba eswekile yegazi nge-5.7 mg / dL emva kweeveki ezingama-30 zonyango.
• Kwezinye izifundo zeklinikhi, uToujeo unciphise i-HbA1c malunga ne-0.73 ukuya kwi-1.42 yeepesenti kunye nokuzila amanqanaba eswekile yegazi nge-18 ukuya kuma-61 mg / dL ngaphezulu kweeveki ezingama-26 zonyango.

PhawulaKubalulekile ukugcina engqondweni ukuba nokuba la machiza anganciphisa njani i-HbA1c yakho okanye amanqanaba eswekile yegazi aya kuxhomekeka kwizinto ezininzi, kubandakanya:

• amanqanaba eswekile yegazi xa uqala ichiza
• ukutya kwakho kunye neerejimeni zokuzilolonga
• amanye amayeza eswekile owathathayo
• Ululandela ngokusondeleyo njani unyango lwakho

Iindleko

I-Soliqua 100/33 kunye neToujeo zozibini iziyobisi ezinamagama. Okwangoku azikho iifom zohlobo oluthile ezifumaneka nakweliphi na ichiza. Amayeza egama leBrand ahlala exabisa ngaphezu kwegeneric.

Ngokweqikelelo oluvela kwi-GoodRx.com, iToujeo ngokubanzi ixabisa ngaphezulu kweSoliqua 100/33. Elona xabiso ubuya kulihlawula ngalo naliphi na ichiza lixhomekeke kwidosi yakho, isicwangciso sakho seinshurensi, indawo okuyo, kunye nekhemesti oyisebenzisayo.

I-Soliqua 100/33 vs.Adlyxin

I-Soliqua 100/33 inamachiza amabini:

• I-insulin glargine, esebenza ixesha elide njenge-insulin
• i-lixisenatide, eyeklasi yamachiza abizwa ngokuba yi-glucagon-like peptide 1 (GLP-1) receptor agonists

I-Lixisenatide ikwachiza eliqulethwe yi-Adlyxin. Kuba iSoliqua 100/33 kunye neAdlyxin zabelana ngento esebenzayo, zisebenza ngendlela efanayo emzimbeni.

Sebenzisa

I-Soliqua 100/33 ivunyiwe yi-FDA ukuba isetyenziswe kunye notshintsho kwindlela yokutya kunye nokuzilolonga ukuphucula amanqanaba eswekile yegazi kubantu abadala abanesifo seswekile sesi-2.

I-Adlyxin ivunyiwe yi-FDA ukuba isetyenziswe kunye nokutya kunye nokuzilolonga ukuphucula amanqanaba eswekile yegazi kubantu abadala abanesifo seswekile sesi-2.

Iifom zeziyobisi kunye nolawulo

I-Soliqua 100/33 kunye ne-Adlyxin zombini ziza njengesisombululo samanzi kwisibaya esilahlwayo. Omabini la machiza azitofile phantsi kolusu (subcutaneous) kanye ngemini.

Ipeni yeSoliqua 100/33 iza kwisixa esinye. Ipeni nganye iqulethe i-3 mL yesisombululo sesiyobisi, kunye neeyunithi ezili-100 ze-insulin glargine kunye ne-33 mcg ye-lixisenatide nge-mL nganye. Elona thamo liphezulu ngenaliti nganye ziiyunithi ezingama-60, nto leyo ethetha ukuba iiyunithi ezingama-60 ze-insulin glargine kunye ne-20 mcg lixisenatide.

Ipeni ye-Adlyxin iza ngamanani amabini ahlukeneyo:

• Ipeni eluhlaza ye-Adlyxin iqulethe i-50 mcg / mL kwi-3 mL yesisombululo, kunye nedosi ye-10 mcg ngenaliti nganye.
• Ipeni ye-burgundy Adlyxin iqulethe i-100 mcg / mL kwi-3 mL yesisombululo, kunye nedosi ye-20 mcg ngenaliti nganye.

Iziphumo kunye neengozi

I-Soliqua 100/33 kunye ne-Adlyxin zombini ziqulethe ichiza le-lixisenatide. Ke ngoko, omabini la mayeza anokubangela iziphumo ezifanayo. Apha ngezantsi kunemizekelo yeziphumo ebezingalindelekanga.

Iziphumo eziqhelekileyo ezichaphazelekayo

Olu luhlu lunemizekelo yeziphumo ebezingalindelekanga ezinokubakho ngeSoliqua 100/33, kunye neAdlyxin, okanye zombini iziyobisi (xa zithathwa ngokwahlukeneyo).

• Ngaba kunokwenzeka ngeSoliqua 100/33:
  • izifo zokuphefumla ezinje ngengqele eqhelekileyo okanye umkhuhlane
• Ngaba kunokwenzeka ngeAdlyxin:
  • ukugabha
  • isiyezi
• Inokwenzeka kunye neSoliqua 100/33 kunye neAdlyxin:
  • isicaphucaphu
  • urhudo
  • intloko ebuhlungu
  • hypoglycemia (iswekile esezantsi yegazi)

Iziphumo ebezingalindelekanga ezimandundu

Olu luhlu lunemizekelo yeziphumo ebezingalindelekanga ezinokubakho ngeSoliqua 100/33, kunye neAdlyxin, okanye zombini iziyobisi (xa zithathwa ngokwahlukeneyo).

• Ngaba kunokwenzeka ngeSoliqua 100/33:
  • i-hypokalemia (amanqanaba asezantsi e-potassium)
• Ngaba kunokwenzeka ngeAdlyxin:
  • zimbalwa iziphumo ebezingalindelekanga ezimandundu
• Inokwenzeka kunye neSoliqua 100/33 kunye neAdlyxin:
  • negazi lakho kakhulu
  • i-hypoglycemia enamandla (iswekile esezantsi yegazi)
  • ukudumba kwenjeke (ukudumba kwepancreas)
  • umonakalo kwizintso

Ukusebenza ngempumelelo

Ukusetyenziswa kwe-Soliqua 100/33 okanye i-Adlyxin njengonyango lwamachiza ohlobo olunye lwesifo seswekile aluthelekiswanga ngqo kuphando lweklinikhi.Nangona kunjalo, ukusetyenziswa kwesiyobisi ngasinye ngokudibeneyo ne-metformin (ichiza leswekile yomlomo) kuthelekiswa ngokuthe ngqo.

Izifundo ezahlukileyo xa zisetyenziswa zodwa

Kwizifundo ezahlukileyo zeklinikhi, i-Soliqua 100/33 kunye ne-Adlyxin zombini zazisebenza zodwa ekunciphiseni ukutya iswekile yegazi kwabo bane-2 yeswekile.

• Kwisifundo seklinikhi, i-Soliqua 100/33 inciphise i-hemoglobin A1c (HbA1c) nge-1.1 yepesenti kunye nokuzila amanqanaba eswekile yegazi nge-5.7 mg / dL emva kweeveki ezingama-30 zonyango.
• Kwisifundo esahlukileyo seklinikhi, i-Adlyxin yanciphisa i-HbA1c nge-0.57 ukuya kwi-0.71 yeepesenti kunye nokuzila amanqanaba eswekile yegazi nge-4.48 ukuya kwi-24.56 mg / dL ngaphezulu kweeveki ezingama-24 zonyango.

Ukuthelekisa ngokuthe ngqo xa kusetyenziswa i-metformin

Olunye uphononongo luvavanye ukusetyenziswa kweSoliqua 100/33 nge-metformin ngqo ngokuchasene nokusetyenziswa kwe-Adlyxin kunye ne-metformin kubantu abadala abanesifo seswekile sesi-2. Abantu abakwisifundo babekhe baphathwa ngaphambili nge-metformin yodwa, okanye nge-metformin kunye nelinye ichiza lomlomo leswekile.

Emva kweeveki ezingama-30, iSoliqua 100/33 nge-metformin yayisebenza ngakumbi kune-Adlyxin ene-metformin. I-Soliqua 100/33 ene-metformin inciphise i-HbA1c nge-1.6 yepesenti kunye nokuzila ukutya kwinqanaba leswekile nge-59.1 mg / dL. I-Adlyxin kunye ne-metformin, kwelinye icala, inciphise i-HbA1c nge-0.9 yepesenti kunye nokuzila amanqanaba eswekile yegazi nge-27.2 mg / dL.

Phawula: Kubalulekile ukuba ugcine engqondweni ukuba nokuba la machiza anganciphisa njani i-HbA1c yakho okanye amanqanaba eswekile yegazi aya kuxhomekeka kwizinto ezininzi, kubandakanya:

• amanqanaba eswekile yegazi xa uqala ichiza
• ukutya kwakho kunye neerejimeni zokuzilolonga
• amanye amayeza eswekile owathathayo
• Ululandela ngokusondeleyo njani unyango lwakho

Iindleko

I-Soliqua 100/33 kunye ne-Adlyxin zombini ziziyobisi ezinamagama. Okwangoku azikho iifom zohlobo oluthile ezifumaneka nakweliphi na ichiza. Amayeza egama leBrand ahlala exabisa ngaphezu kwegeneric.

Ngokwengqikelelo evela kwi-GoodRx.com, i-Adlyxin ngokubanzi ixabisa ngaphezulu kweSoliqua 100/33. Elona xabiso ubuya kulihlawula ngalo naliphi na ichiza liya kuxhomekeka kumthamo wakho, isicwangciso sakho seinshurensi, indawo okuyo, kunye nekhemesti oyisebenzisayo.

Ngomhla ka-Meyi ka-2020, uLawulo lwezoKutya kunye noLawulo lweziyobisi (i-FDA) lwacebisa ukuba abanye abenzi be-metformin bandise ukukhutshwa kwezinye zeetafile zabo kwimakethi yase-US. Kungenxa yokuba inqanaba elingamkelekanga le-carcinogen enokubakho (iarhente ebangela umhlaza) yafunyanwa kwezinye iipilisi ze-metformin ezandisiweyo. Ukuba ngoku uthatha eli chiza, tsalela umnikezeli wakho wezempilo. Baza kukucebisa malunga nokuba kufuneka uqhubeke na ukuthatha amayeza akho okanye ukuba ufuna iphepha elitsha.

Ukusetyenziswa kweSoliqua 100/33

Ulawulo lokutya kunye neziyobisi (i-FDA) livuma amayeza amiselweyo anje ngeSoliqua 100/33 ukunyanga iimeko ezithile. I-Soliqua 100/33 ivunyiwe yi-FDA ukuba isetyenziswe kunye notshintsho kwindlela yokutya kunye nokuzilolonga ukuphucula amanqanaba eswekile yegazi kubantu abadala abanesifo seswekile sesi-2.

Kuphononongo lweklinikhi lweeveki ezingama-30 lwabantu ababephathwe ngohlobo lwe-basal insulin (efana ne-insulin glargine), uSoliqua 100/33 kwafunyaniswa ukuba iyasebenza. Iyanciphisa i-hemoglobin A1c (HbA1c) nge-1.1 yepesenti kunye nokuzila ukutya amanqanaba eswekile nge-5.7 mg / dL.

Uvavanyo lweklinikhi lweeveki ezingama-30 lujolise kubantu ababephathwe nge-metformin kuphela, okanye nge-metformin kunye nelinye iyeza leswekile lomlomo. Kubantu abakwisifundo, i-Soliqua 100/33 kunye ne-metformin zinciphise i-HbA1c yabo nge-1.6 yeepesenti kunye nokuzila amanqanaba eswekile yegazi nge-59.1 mg / dL.

Ukusetyenziswa kweSoliqua 100/33 kunye nezinye iziyobisi

I-Soliqua 100/33 inokusetyenziswa yodwa okanye ngokudibeneyo namanye amachiza ukuphucula amanqanaba eswekile yegazi kubantu abanesifo seswekile sesi-2. Unyango lweswekile, kuqhelekile ukuba amayeza angaphezu kwelinye asetyenziselwa ukulawula amanqanaba eswekile yegazi ukuba ichiza elinye kuphela alizange liphucule amanqanaba eswekile yegazi ngokwaneleyo.

Imizekelo yamachiza anokusetyenziswa kunye neSoliqua 100/33 ibandakanya:

• canagliflozin (Invokana)
• dapagliflozin (Farxiga)
• I-glimepiride (Amaryl)
• glipizide (Glucotrol)
• I-glyburide (iDiaBeta, iGlynase)
• metformin (iGlucophage, iGlumetza, iRiomet)
• pioglitazone (Actos)

Soliqua 100/33 notywala

Kunqabe ukusela kakhulu utywala ngelixa uthatha iSoliqua 100/33. Utywala bunokuwatshintsha amanqanaba eswekile yegazi kwaye wandise umngcipheko wehypoglycemia (iswekile esezantsi yegazi) kunye nepancreatitis (ukudumba okutsha kwepancreas).

Ukuba usela utywala, thetha nogqirha wakho malunga nokuba butywala kangakanani na obukhuselekileyo kuwe.

Ukusebenzisana kweSoliqua 100/33

I-Soliqua 100/33 inokusebenzisana namanye amayeza. Inokuphinda inxibelelane nezinye izongezo kunye nokutya okuthile.

Unxibelelwano olwahlukileyo kunokubangela iziphumo ezahlukeneyo. Umzekelo, ezinye zinokuphazamisa ukusebenza kakuhle kwesiyobisi, ngelixa ezinye zinokubangela ukwanda kweempembelelo.

Soliqua 100/33 kunye namanye amayeza

Apha ngezantsi luluhlu lwamayeza anokusebenzisana neSoliqua 100/33. Olu luhlu alunazo zonke iziyobisi ezinokuthi zinxibelelane neSoliqua 100/33.

Ngaphambi kokuba uthathe i-Soliqua 100/33, qiniseka ukuxelela ugqirha wakho kunye nosokhemesti ngayo yonke into emiselweyo, ekhawuntareni, kunye nezinye iziyobisi ozithathayo. Baxelele malunga nazo naziphi na iivithamini, amayeza esintu kunye nezixhasi ozisebenzisayo. Ukwabelana ngolu lwazi kunokukunceda uphephe unxibelelwano olunokubakho.

Ukuba unemibuzo malunga nokunxibelelana kweziyobisi okunokuchaphazela, buza ugqirha wakho okanye usokhemesti.

Amanye amayeza eswekile

Ukuthatha i-Soliqua 100/33 kunye namanye amayeza eswekile kunokukhokelela kumanqanaba eswekile esezantsi kunye nokunyusa umngcipheko we-hypoglycemia (iswekile esezantsi yegazi). Ukuba uthatha naliphi na kula mayeza, kusenokufuneka ujonge amanqanaba eswekile yegazi rhoqo. Kwakhona, ugqirha wakho unokufuna ukutshintsha idosi yakho yeSoliqua 100/33.

Imizekelo yesifo seswekile ibandakanya:

• canagliflozin (Invokana)
• dapagliflozin (Farxiga)
• empagliflozin (Jardiance)
• I-glyburide (iDiaBeta, iGlynase, iMicronase)
• I-glimepiride (Amaryl)
• glipizide (Glucotrol)
• ii-insulins zexesha lesidlo (uHumalog, Novolog)
• i-metformin (iGlucophage)
• icandelo (Starlix)
• repaglinide (Prandin)

Ukongeza, ukusebenzisa i-Soliqua 100/33 enesifo seswekile esibizwa ngokuba yi-thiazolidinediones (TZDs) kunokubangela ukugcinwa kolwelo. Inokonyusa umngcipheko wokungaphumeleli kwentliziyo okanye ibonakalise iimpawu zentliziyo (jonga isilumkiso esingezantsi). Imizekelo yala machiza ibandakanya:

• pioglitazone (Actos)
• I-rosiglitazone (iAvandia)

Ukuba uthatha i-TZD, thetha nogqirha wakho ngaphambi kokuqala iSoliqua 100/33. Ukuba ugqirha wakho uyavuma ukuba usebenzisa i-TZD ngelixa usebenzisa i-Soliqua 100/33, qiniseka ukuba ujonge iimpawu zokwehluleka kwentliziyo. Ukuba uhlakulela ukungaphumeleli kwentliziyo, ugqirha wakho unokunciphisa umthamo we-TZD yakho okanye uyeke ukuyithatha.

Iimpawu zokusilela kwentliziyo zingabandakanya:

• ingxaki yokuphefumla
• ukudumba emilenzeni, emaqatheni nasezinyaweni
• ukukhawuleza kwentliziyo okanye okungaqhelekanga
• iintlungu esifubeni

Unyango lwegazi oluphezulu

Ukuthatha i-Soliqua 100/33 ngamayeza athile oxinzelelo lwegazi kunokukhokelela kumanqanaba eswekile egazi asezantsi kwaye wandise umngcipheko wehypoglycemia (iswekile esezantsi yegazi). Ukuba uthatha naliphi na kula mayeza, kusenokufuneka ujonge amanqanaba eswekile yegazi rhoqo. Kwakhona, ugqirha wakho unokufuna ukutshintsha idosi yakho yeSoliqua 100/33.

Imizekelo yoxinzelelo lwegazi oluphezulu olunokunyusa umngcipheko wehypoglycemia xa ithathwa kunye neSoliqua 100/33 ibandakanya:

• i-angiotensin-converting enzyme (ACE) inhibitors, enje nge:
• Ibenazepril (iLotensin)
• captopril
• enalapril (Vasotec)
• I-lisinopril (iZestril)
• ii-angiotensin II receptor blockers (ARBs), ezinje:
• valsartan (uDiovan)
• ikhandlela (iAtacand)
• Irbesartan (Avapro)
• losartan (uCozaar)
• olmesartan (iBenicar)

Amanye amayeza oxinzelelo lwegazi anokuzifihla iimpawu zamanqanaba eswekile egazi asezantsi. La machiza anokunyusa okanye anciphise indlela iSoliqua eyi-100/33 esebenza ngayo ekwehliseni amanqanaba eswekile yegazi. Ukuba uthatha la mayeza kunye neSoliqua 100/33, kusenokufuneka ujonge amanqanaba eswekile yegazi rhoqo. Kwakhona, ugqirha wakho unokufuna ukutshintsha idosi yakho yeSoliqua 100/33.

Imizekelo yonyango loxinzelelo lwegazi olunokufihla imiqondiso yoxinzelelo lwegazi okanye ichaphazele indlela esebenza ngayo iSoliqua 100/33 isebenza ibandakanya:

• iclonidine (iCatapres)
• iMetoprolol (iLopressor, iTrolrol-XL)
• i-atenolol (Tenormin)

Amanye amachiza anokufihla iimpawu zehypoglycemia

Amanye amayeza anokuzifihla iimpawu kunye neempawu zamanqanaba eswekile egazi asezantsi. Ukuba uthatha la mayeza, kusenokufuneka ujonge amanqanaba eswekile yegazi rhoqo. Kwakhona, ugqirha wakho unokufuna ukutshintsha idosi yakho yeSoliqua 100/33.

Imizekelo yala mayeza ibandakanya:

• albuterol (ProAir, Proventil, Ventolin)
• guanethidine
• gcwalisa

Amanye amayeza anokunciphisa amanqanaba eswekile yegazi

Ukuthatha i-Soliqua 100/33 ngamanye amayeza kunokukhokelela kumanqanaba eswekile esezantsi yegazi kunye nokunyusa umngcipheko wehypoglycemia (iswekile esezantsi yegazi). Ukuba uthatha naliphi na kula mayeza, kusenokufuneka ujonge amanqanaba eswekile yegazi rhoqo. Kwakhona, ugqirha wakho unokufuna ukutshintsha idosi yakho yeSoliqua 100/33.

Imizekelo yala mayeza ibandakanya:

• iDisopyramide (iNorpace)
• amayeza athile e-cholesterol, afana ne-fenofibrate (iTricor, Triglide) kunye ne-gemfibrozil (Lopid)
• ezinye izidambisi zengqondo, ezinje nge-fluoxetine (Prozac, Sarafem) kunye ne-selegiline (Emsam, Zelapar)
• i-octreotide (iSandostatin)
• Isulfamethoxazole-trimethoprim (iBactrim, Septra)

Olunye unyango olonyusa amanqanaba eswekile yegazi

Amanye amayeza anokunyusa amanqanaba eswekile yegazi emzimbeni wakho. Ukuba uthatha la mayeza, kusenokufuneka ujonge amanqanaba eswekile yegazi rhoqo ukukhusela i-hyperglycemia (iswekile ephezulu yegazi). Kwakhona, ugqirha wakho unokufuna ukutshintsha idosi yakho yeSoliqua 100/33.

Imizekelo yala mayeza ibandakanya:

• albuterol (ProAir, Proventil, Ventolin)
• ezinye ii-antivirals, ezinje nge-atazanavir (Reyataz) kunye ne-lopinavir / ritonavir (Kaletra)
• ii-steroids ezithile, ezinjenge-budesonide (i-Entocort EC, iPulmicort, i-Uceris), i-prednisone, kunye ne-fluticasone (i-Flonase, i-Flovent)
• i-diuretics ethile, enje nge-chlorothiazide (Diuril) kunye nehydrochlorothiazide (Microzide)
• ezinye i-antipsychotic, ezinje nge-clozapine (Clozaril, Fazaclo) kunye ne-olanzapine (Zyprexa)
• iihormoni ezithile, ezinje nge-danazol (iDanazol), levothyroxine (Levoxyl, Synthroid) kunye ne-somatropin (Genotropin)
• iglucagon (GlucaGen)
• niacin (Niaspan, Slo-Niacin, abanye)
• izinto zokucwangcisa ngomlomo (iipilisi zolawulo lokuzalwa)

Iziyobisi ezonyusa okanye zinciphisa iziphumo zeSoliqua 100/33

Amanye amayeza anokuchaphazela indlela iSoliqua 100/33 esebenza ngayo emzimbeni wakho. Ukuba uthatha la mayeza, kusenokufuneka ujonge amanqanaba eswekile yegazi rhoqo. Kwakhona, ugqirha wakho unokufuna ukutshintsha idosi yakho yeSoliqua 100/33.

Imizekelo yala mayeza ibandakanya:

• albuterol (ProAir, Proventil, Ventolin)
• lithium

I-Soliqua 100/33 kunye namayeza kunye nezongezo

Ukuthatha i-Soliqua 100/33 ngamayeza athile okanye izongezo kunokunyusa umngcipheko wehypoglycemia (amanqanaba eswekile esezantsi). Imizekelo yoku ibandakanya:

• i-alpha-lipoic acid
• banaba
• ivatala ekrakra
• chromium
• umthambo
• cactus enqabileyo
• ibhombu emhlophe

Isebenza njani iSoliqua 100/33

I-Soliqua 100/33 inceda ukuphucula amanqanaba eswekile yegazi kubantu abane-2 yeswekile.

I-insulin iyichaphazela njani iswekile yegazi

Ngokwesiqhelo, xa usitya ukutya, umzimba wakho ukhupha ihomoni ebizwa ngokuba yi-insulin. Iswekile (iswekile) evela ekutyeni ihamba iye kwigazi lakho, kwaye i-insulin iyanceda ukuyihambisa iye kwiiseli zomzimba wakho. Iiseli emva koko ziguqula iswekile ibe ngamandla.

Abantu abanesifo seswekile sesi-2 bahlala benokunganyangeki kwi-insulin. Oku kuthetha ukuba umzimba wabo awuphenduli kwi-insulin ngendlela efanele. Ixesha elingaphezulu, abantu abanesifo seswekile sesi-2 banokuyeka ukuvelisa i-insulin eyaneleyo.

Xa umzimba wakho ungaphenduli kwi-insulin ngendlela ekufanele ukuba uyenze, okanye ukuba awuyivelisi ngokwaneleyo i-insulin, oku kubangela iingxaki. Iiseli zomzimba wakho zinokungayifumani iglucose ekufuneka zisebenza ngokuchanekileyo.

Kwakhona, unokufumana iswekile eninzi egazini lakho. Oku kubizwa ngokuba yi-hyperglycemia (iswekile ephezulu yegazi). Ukuba ne-glucose eninzi egazini lakho kungonakalisa umzimba kunye namalungu omzimba, kubandakanya amehlo, intliziyo, imithambo-luvo kunye nezintso.

Yintoni eyenziwa nguSoliqua 100/33

I-Soliqua 100/33 iqulethe iziyobisi ezibini. Ezi yi-insulin glargine, eyi-insulin esebenza ixesha elide, kunye ne-lixisenatide, eyi-peptide 1 (GLP-1) ye-glucagon efana ne-receptor agonist.

I-insulin glargine isebenza ngendlela enye: yehlisa amanqanaba eswekile yegazi ngokuhambisa iswekile kwigazi lakho liye kwiiseli zakho.

ILixisenatide isebenza ngeendlela ezintathu. Okokuqala, yonyusa inani le-insulin eyenziwa ngumzimba wakho. Oku kwanda kwe-insulin kunceda ukuhambisa iswekile eninzi egazini lakho nakwiiseli zakho. Okwesibini, ibangela ukuba isisu sakho sikhuphe kancinci emva kwesidlo, sikwenze uzive ugcwele ixesha elide. Okwesithathu, ixelela isibindi sakho ukuba sikhuphe iswekile encinci egazini lakho.

Kuthatha ixesha elingakanani ukusebenza?

I-Soliqua 100/33 iqala ukusebenza kanye emva kokuba uyifakile. Nangona kunjalo, ifikelela kwisona siphumo siphezulu malunga neeyure eziyi-2.5 ukuya kwezi-3 emva kwenaliti nganye.

Soliqua 100/33 kunye nokukhulelwa

Idatha yokufunda inikwe umda ekusetyenzisweni kweSoliqua 100/33 ngexesha lokukhulelwa ebantwini. Nangona kunjalo, uphononongo lwezilwanyana lubonisa ukuba kunokubakho umngcipheko weziphene zokuzalwa kunye nokusetyenziswa kwe-lixisenatide ngexesha lokukhulelwa. ILixisenatide yenye yeziyobisi ezifumaneka eSoliqua 100/33. Ke ngoko, iSoliqua 100/33 kufuneka isetyenziswe kuphela ngexesha lokukhulelwa ukuba isibonelelo esinokubakho singaphezulu kobungozi obunokubakho.

Ukuba ukhulelwe okanye uceba ukukhulelwa, thetha nogqirha wakho malunga nobungozi kunye nezibonelelo zokusebenzisa iSoliqua 100/33 ngexesha lokukhulelwa.

I-Soliqua 100/33 kunye nokuncancisa

Ayaziwa ukuba i-Soliqua 100/33 idlula kubisi lwebele. Ngaphambi kokuncancisa, kuya kufuneka uxoxe nogqirha wakho ngomngcipheko kunye nezibonelelo zokuthatha eli chiza ngelixa uncancisa.

Imibuzo eqhelekileyo malunga neSoliqua 100/33

Nazi iimpendulo kwimibuzo ebuzwa rhoqo malunga neSoliqua 100/33.

Ngaba iSoliqua 100/33 ibangela ukutyeba?

Kuvavanyo lweklinikhi, iSoliqua 100/33 ayifumanekanga ibangela ukutyeba. Ngapha koko, kolunye uvavanyo lweklinikhi, abantu abathathe i-Soliqua 100/33 iiveki ezingama-30 baphulukana neepawundi eziyi-1.5.

Kuyathakazelisa ukuqaphela ukuba iziyobisi ezizodwa eziqulethwe yiSoliqua 100/33 zibonakala ngathi zineziphumo ezahlukeneyo kubunzima. Elinye lamachiza yi-insulin glargine, eyi-insulin esebenza ixesha elide. Ngokwesiqhelo, iziyobisi ezine-insulin zinxulunyaniswe nokuzuza ubunzima.

Nangona kunjalo, elinye ichiza elikwiSoliqua 100/33 libizwa ngokuba yi-lixisenatide, eyi-peptide 1 (GLP-1) yeglucagon receptor agonist. Amayeza kwiklasi ye-GLP-1 yeziyobisi ibonakalise ukunciphisa umzimba njengempembelelo yecala kwizifundo ezahlukeneyo zeklinikhi.

Ukuba unenkxalabo malunga nefuthe elinokuthi libe nalo uSoliqua 100/33 kubunzima bakho, thetha nogqirha wakho.

Ngaba i-Soliqua 100/33 insulin?

Ewe, iSoliqua 100/33 ine-insulin. I-Soliqua 100/33 yenziwe ngamachiza amabini, elinye lawo yi-insulin glargine, i-insulin esebenza ixesha elide.

Iyeza lesibini yi-lixisenatide, eyi-peptide 1 (GLP-1) ye-receptor agonist.

Ngaba iSoliqua 100/33 isebenza ixesha elide?

Ewe. I-Soliqua 100/33 iqulethe iziyobisi ezibini ezisebenzayo. Enye yazo yi-insulin glargine, eyi-insulin esebenza ixesha elide.

Ngaba iSoliqua 100/33 ingasetyenziselwa ukunyanga uhlobo lweswekile 1?

Hayi, iSoliqua 100/33 akufuneki isetyenziselwe ukunyanga isifo seswekile sokuqala. I-Soliqua 100/33 khange ifundwe okanye ivunywe nguLawulo lokutya kunye noLawulo lweziyobisi ukunyanga loo meko. Kuvunyiwe kuphela ukunyanga uhlobo lwe-2 yeswekile.

Soliqua 100/33 izilumkiso

Ngaphambi kokuba uthathe i-Soliqua 100/33, thetha nogqirha wakho malunga nembali yakho yezempilo. I-Soliqua 100/33 isenokungakulungeli ukuba uneemeko ezithile zonyango. Oku kubandakanya:

• Isifo sezintso. Ukuba unesifo sezintso, ukuthatha iSoliqua 100/33 kunokuba mandundu imeko yakho. Ukuba imeko yakho iya isiba mandundu, kungafuneka uyeke ukuthatha iSoliqua 100/33. Sukuthatha la mayeza ukuba unesifo sezintso.
• Ukucotha isisu. ILixisenatide, elinye lamachiza eSoliqua 100/33, licothisa isenzo semisipha yesisu sakho. Ukuba une-gastroparesis, oko kuthetha ukuba umzimba wakho uyetyisa ukutya kancinci, ukuthatha i-Soliqua 100/33 kunokuba mandundu imeko yakho. Abantu abane-gastroparesis enzima akufuneki bathathe la mayeza.
• Iipancreas okanye iingxaki ze-gallbladder, okanye ingxaki yokusebenzisa utywala. I-Soliqua 100/33 inokunyusa umngcipheko wepancreatitis. Unokuba semngciphekweni omkhulu wokuba nepancreatitis ukuba unembali ye-pancreatitis, amatye e-gallbladder, okanye utywala. Ukuba unembali yezi ngxaki, thetha nogqirha wakho malunga nokuba iSoliqua 100/33 ikulungele na.

Soliqua 100/33 libanda

Ukuthatha kakhulu la mayeza kunokunyusa umngcipheko weziphumo ebezingalindelekanga ezibi.

Iimpawu libanda

Iimpawu zokudlula ngaphezulu zinokubandakanya:

• i-hypoglycemia enamandla (iswekile esezantsi yegazi), enokubangela ukuba ungcangcazele, unxunguphalo kunye nokudideka
• i-hypokalemia (amanqanaba asezantsi e-potassium), anokubangela ubuthathaka, ukuqhina, kunye necramps
• iingxaki zesisu, ezinokubangela urhudo, isicaphucaphu kunye nokugabha

Kufuneka wenze ntoni xa uthe wagqithisa?

Ukuba ucinga ukuba uthathe kakhulu eli chiza, biza ugqirha wakho okanye ufune isikhokelo kuMbutho waseMelika wamaZiko oLawulo lweTyhefu e800-222-1222 okanye ngesixhobo sabo se-Intanethi. Kodwa ukuba iimpawu zakho zinzima, tsalela umnxeba ku-911 okanye uye kwigumbi likaxakeka elikufutshane ngoko nangoko.

Ukuphela kunye nokugcinwa kweSoliqua 100/33

Xa iSoliqua 100/33 ikhutshwa ekhemesti, usokhemesti uya kongeza umhla wokuphelelwa kwileyibhile kwisitya. Lo mhla uqhele ukuba ngunyaka omnye ukusukela kumhla wokukhutshwa kwamayeza.

Injongo yale mihla yokuphelelwa lixesha kukuqinisekisa ukusebenza kweyeza ngeli xesha. Isimo sangoku soLawulo lwezoKutya kunye noLawulo lweziyobisi (i-FDA) kukuphepha ukusebenzisa amayeza aphelelwe lixesha.

Kuhlala ixesha elingakanani iyeza lihlala lilungile kunokuxhomekeka kwizinto ezininzi, kubandakanya nokuba ligcinwa njani kwaye liphi iyeza. Gcina iipali zakho zeSoliqua 100/33 kwifriji yakho, kubushushu obuphakathi ko-36 ° F kunye no-46 ° F (2 ° C no-8 ° C). Ungaze ubambe ngci iintlanti zakho.

Emva kokusetyenziswa kokuqala kwepen nganye, ungayigcina kubushushu begumbi (77 ° F / 25 ° C), kodwa qiniseka ukuyikhusela ekukhanyeni. Lahla ipeni nganye emva kweentsuku ezingama-28 ekusebenziseni kwayo okokuqala.

Ukuba awusebenzisanga iyeza elidlulileyo kumhla wokuphelelwa kwalo, thetha nosokhemesti wakho malunga nokuba unganako na ukuyisebenzisa.

Ulwazi lobungcali lweSoliqua 100/33

Olu lwazi lulandelayo lubonelelwe ngoochwephesha kunye nabanye abaqeqeshi bezempilo.

Iimpawu

I-Soliqua 100/33 ivunyiwe yi-FDA ukuba isetyenziswe kunye nokutya kunye nokuzilolonga ukuphucula ulawulo lwe-glycemic kubantu abadala abanesifo seswekile sesifo seswekile.

Indlela yokusebenza

I-Soliqua 100/33 yindibaniselwano ye-insulin glargine (i-basal insulin analog) kunye ne-lixisenatide (i-peptide efana ne-glucagon-1 [GLP-1] receptor agonist).

I-insulin glargine yehlisa iswekile yegazi ngokwandisa ukuthathwa kweglucose kunye nokunciphisa imveliso yeswekile kwisibindi. I-Lixisenatide inciphisa i-glucose yegazi ngokwandisa ukufihlwa kwe-insulin, ukunciphisa ukugcinwa kweglucagon, kunye nokucothisa ukuphuma kwesisu.

I-Pharmacokinetics kunye ne-metabolism

Umlinganiselo we-insulin glargine-to-lixisenatide awunampembelelo kwi-pharmacokinetics yelinye icandelo.

I-insulin glargine ayinayo incopho kwaye i-metabolism ngokuyinxenye kwi-carboxyl terminus yetyathanga le-B kwindawo yokugcina izinto engaphantsi.

Ixesha lokufumana uxinzelelo oluphezulu lwe-lixisenatide ziiyure ezingama-2.5 ukuya kwezi-3. ILixisenatide ineepesenti ezingama-55 zokubopha iiproteyini kwaye iyasuswa ngomchamo kunye nokuhla komgangatho weproteolytic. Kuthetha isiqingatha sobomi malunga neeyure ezi-3.

Ukungqinelana

I-Soliqua 100/33 iyaphikiswa kwizigulana:

• Ngexesha leziqendu zehypoglycemic
• kunye nembali ye-hypersensitivity eqatha kwi-insulin glargine okanye i-lixisenatide

Ukugcina

Iipeni zeSoliqua 100/33 kufuneka zigcinwe kwisikhenkcisi, kubushushu obuphakathi kwama-36 ° F kunye nama-46 ° F (2 ° C kunye no-8 ° C), kodwa ungaze ube ngumkhenkce. Emva kokusetyenziswa kokuqala, iipenki zingagcinwa kwiqondo lokushisa lama-77 ° F (25 ° C). Zifanele zikhuselwe ekukhanyeni. Lahla ipeni emva kweentsuku ezingama-28 ukusuka kusetyenziso lokuqala.

Ukuziphendulela: I-MedicalNewsToday yenze yonke imizamo yokuqinisekisa ukuba yonke ingcaciso ichanekile, ibanzi kwaye ihlaziyiwe. Nangona kunjalo, eli nqaku akufuneki lisetyenziswe endaweni yolwazi kunye nobuchule bengcali yezempilo enelayisensi. Kuya kufuneka usoloko uqhagamshelana nogqirha wakho okanye nolunye uqeqesho kwezonyango ngaphambi kokuba uthathe nawaphi na amayeza. Ulwazi lweziyobisi oluqulethwe apha luyakwazi ukutshintsha kwaye alujoliswanga ekusetyenzisweni konke okunokwenzeka, imikhombandlela, izilumkiso, izilumkiso, ukuhlangana kweziyobisi, ukungahambelani komzimba, okanye iziphumo ezibi. Ukungabikho kwezilumkiso okanye olunye ulwazi ngesiyobisi esinikiweyo akubonisi ukuba indibaniselwano yeziyobisi ikhuselekile, iyasebenza, okanye ifanelekile kuzo zonke izigulana okanye konke ukusetyenziswa okuthile.