Unyango loMhlaza wamabele osele luqhubekile kunye noPhando: Yintoni e-Horizon?

Umxholo

• Unyango ekujoliswe kulo
• Unyango lweziyobisi kufutshane
• Iziyobisi ezichasene ne-angiogenesis
• Iziyobisi zeBiosimilar
• Unyango lwe-Immunotherapy
• PI3 kinase inhibitors
• Uqikelelo oluphuculweyo kunye nokubeka iliso
• Ukuzibandakanya kuvavanyo lweklinikhi

Umhlaza webele we-Metastatic unganyangeka, kodwa amaxesha ngamaxesha awunakuphiliswa. Okwangoku, iinjongo zonyango zibandakanya ukunciphisa iimpawu zakho, ukuphucula umgangatho wobomi, kunye nokwandisa ubomi bakho.

Unyango lubandakanya unyango lwehomoni, ichemotherapy, unyango ekujoliswe kulo, okanye indibaniselwano yezi.

Nazi ezinye zonyango lwangoku nolwexesha elizayo onokulindela ukukuva malunga nokuba ufumene isifo somhlaza wamabele esihambele phambili.

Unyango ekujoliswe kulo

Abaphandi baye bavelisa amayeza amatsha athile ajolise kwiinguqu ezithile zeseli. Olu tshintsho lubangela ukuba iiseli zomhlaza zikhule ngokukhawuleza kwaye zisasazeke. Oku kwahlukile kunokhemotherapy, ejolise kuzo zonke iiseli ezikhula ngokukhawuleza, kubandakanya iiseli zomhlaza kunye neeseli ezisempilweni.

Uninzi lwezi ziyobisi zijolise ekunyangeni umhlaza webele we-metastatic. Abanye bafundwa kuvavanyo lweklinikhi, kwaye uninzi lwabo lusekuvavanyweni kwangaphambili.

Eminye imizekelo yonyango ekujoliswe kulo ibandakanya:

• ILapatinib (iTykerb). Eli chiza yi-tyrosine kinase inhibitor. Isebenza ngokuthintela ii-enzymes ezikhuthaza ukukhula kweseli. Iyafumaneka njengepilisi oyisela yonke imihla ukunyanga umhlaza webele we-metastatic. Inokudityaniswa namachiza athile e-chemotherapy okanye unyango lwehomoni.
• INeratinib (iNerlynx). Eli chiza livunyiwe ukuba liphathe umhlaza webele we-HER2-positive. Olunye uphononongo lubonisa ukuba inokusebenza ekunyangeni abantu abanesifo somhlaza webele.
• I-Olaparib (iLynparza). Olu nyango luvunyiwe kwi-HER2-negative metastatic cancer cancer kubantu abane I-BRCA Ukutshintsha kwemfuza. Iyafumaneka njenge pilisi yemihla ngemihla.

I-CDK4 / 6 inhibitors lolunye udidi lweziyobisi ekujoliswe kuzo. La machiza athintela iiproteni ezithile ezenza ukuba iiseli zomhlaza zikhule. I-Abemaciclib (Verzenio), palbociclib (Ibrance), kunye ne-ribociclib (Kisqali) zii-CDK4 / 6 inhibitors ezivunyiweyo yi-Food and Drug Administration (FDA) kunyango lomhlaza wamabele. Zisetyenziswe ngokudibeneyo nonyango lwehomoni ukunyanga i-HR-positive kunye ne-HER2-negative metastatic cancer cancer.

Unyango lweziyobisi kufutshane

Zininzi iindlela zonyango ezikhoyo zokunyanga umhlaza webele we-metastatic, kodwa kusaqhutywa izifundo ukuze kufumaneke okungakumbi malunga nokuba iiseli zomhlaza kunye nokutshintsha kwemfuza kusebenza njani. Apha ngezantsi ezinye zonyango zisaphandwa.

Iziyobisi ezichasene ne-angiogenesis

I-Angiogenesis yinkqubo apho kwenziwa khona imithambo yegazi emitsha. Amachiza e-anti-angiogenesis enzelwe ukunciphisa ukunikezelwa kwegazi kwimithambo. Oku kuthintela iiseli zomhlaza zegazi elifunekayo ukukhula.

Iyeza elichasene ne-angiogenesis bevacizumab (Avastin) kungoku nje livunyiwe yi-FDA ukunyanga eminye imihlaza. Eli chiza libonakalise ukusebenza kakuhle kwabasetyhini abanomhlaza wamabele ophucukileyo, kodwa i-FDA irhoxile ekuvumeleni oko kusetyenziswa ngo-2011.

Iziyobisi zeBiosimilar

Amachiza e-Biosimilar ayafana negama lophawu lweziyobisi, kodwa angabiza imali encinci. Ziyindlela efanelekileyo yokwenza unyango.

Amachiza amaninzi afanayo omhlaza webele afundwa. Uhlobo lwe-biosimilar lwe-trastuzumab (i-Herceptin), ichiza le-chemotherapy, kuphela kwe-biosimilar evunyiweyo kunyango lomhlaza webele we-HER2-positive. Ibizwa ngokuba yi-trastuzumab-dkst (Ogivri).

Unyango lwe-Immunotherapy

I-Immunotherapy yindlela yonyango encedisa amajoni omzimba ekutshabalaliseni iiseli zomhlaza.

Iklasi enye yamachiza e-immunotherapy yi-PD1 / PD-L1 inhibitors. IPembrolizumab (Keytruda) yamkelwe ukunyanga umhlaza wemiphunga. Kuyenziwa kuvavanyo lweklinikhi ukuvavanya ukusebenza kwayo kwizigulana ezinomhlaza webele we-metastatic webele.

PI3 kinase inhibitors

Inkqubo ye- PIK3CA Imfuza inceda ukulawula i-PI3 kinase, i-enzyme ebangela ukukhula kwamathumba. I-PI3 kinase inhibitors ziyilelwe ukuphazamisa nokumisa ukukhula kwe-enzyme ye-P13. Ezi zifundelwa unyango lomhlaza webele we-metastatic.

Uqikelelo oluphuculweyo kunye nokubeka iliso

Ngelishwa, abantu banokuphuhlisa ukunganyangeki kunyango oluthile lomhlaza. Oku kubangela ukuba unyango luyeke ukusebenza ngokufanelekileyo. Abaphandi baphuhlisa iindlela ezintsha zokujonga ukuba izigulana zisabela njani kunyango.

Uhlalutyo lokujikeleza kwe-tumor ye-DNA (ekwabizwa ngokuba yi-biopsy ye-liquid) ifundwa njengendlela yokukhokela unyango. Abaphandi bazama ukufumanisa ukuba ingaba olu vavanyo luyanceda na ekubekeni iliso kwizigulana ezinomhlaza webele we-metastatic kunye nokuqikelela ukuba ziya kuphendula njani kunyango.

Ukuzibandakanya kuvavanyo lweklinikhi

Ukuthatha inxaxheba kuvavanyo lweklinikhi kunokunceda abaphandi bafumane ukuba ingaba unyango olutsha luzakusebenza na. Ukuba unomdla wokujoyina enye, indawo elungileyo yokuqala yeClinicalTrials.gov, indawo yogcino-zincwadi yophando lwezifundo ezikhoyo ngoku kwihlabathi liphela. Jonga amanyathelo anje ngeProjekthi yeMhlaza webele yeMastastatic. Eli qonga lisekwe kwi-intanethi lidibanisa abantu abanesifo somhlaza webele kunye nososayensi abasebenzisa itekhnoloji yokufunda izizathu zomhlaza.

Thetha nomboneleli wakho wezempilo ukuze ubone ukuba ukujoyina uvavanyo lweklinikhi kukulungele.Banokukunceda ubone ukuba uyafaneleka kwaye bakuncede ubhalise.