Isiseko kunye nesekondari hyperaldosteronism

I-Hyperaldosteronism sisifo apho i-adrenal gland ikhupha i-hormone aldosterone egazini.

I-Hyperaldosteronism inokuba yiprayimari okanye yesibini.

I-hyperaldosteronism yaseprayimari ingenxa yengxaki yeengqungquthela ze-adrenal ngokwazo, ezibangela ukuba zikhulule kakhulu i-aldosterone.

Ngokwahlukileyo, kunye ne-hyperaldosteronism yesibini, ingxaki kwenye indawo emzimbeni ibangela ukuba iadrenal gland ikhuphe i-aldosterone eninzi. Ezi ngxaki zinokuba kwimfuza, ukutya, okanye ukuphazamiseka kwezonyango okufana nentliziyo, isibindi, izintso, okanye uxinzelelo lwegazi.

Uninzi lweziganeko eziphambili ze-hyperaldosteronism zibangelwa yi-noncancerous (benign) tumor of the adrenal gland. Imeko ikakhulu ichaphazela abantu abaneminyaka engama-30 ukuya kwengama-50 ubudala kwaye ingunobangela oqhelekileyo woxinzelelo lwegazi oluphezulu kwiminyaka yobudala.

I-hyperaldosteronism yaseprayimari neyesibini ineempawu eziqhelekileyo, kubandakanya:

• Igazi elonyukayo
• Inqanaba eliphantsi le potassium egazini
• Ndiziva ndidiniwe ngalo lonke ixesha
• Intloko ebuhlungu
• Ubuthathaka bemisipha
• Ubumdaka

Umboneleli wezempilo uya kwenza uvavanyo lomzimba kwaye abuze malunga neempawu zakho.

Uvavanyo olunokuyalelwa ukuba lufumanise ukuba i-hyperaldosteronism ibandakanya:

• Ukuskena kwe-CT esiswini
• ECG
• Inqanaba lealdosterone yegazi
• Umsebenzi wegazi
• Inqanaba le potassium yegazi
• I-aldosterone yomchamo
• Isifo sezintso

Inkqubo yokufaka i-catheter kwimithambo yamadlala eadrenal inokufuna ukwenziwa. Oku kunceda ukujonga ukuba yeyiphi kwezi ndlala zimbini zenza i-aldosterone eninzi kakhulu. Olu vavanyo lubalulekile kuba abantu abaninzi banezilonda ezincinci ezinobungozi kwiidrenal gland ezingafaki naziphi na iihomoni. Ukuthembela kuphela kwi-CT scan kunokubangela ukuba i-adrenal gland isuswe.

I-hyperaldosteronism yaseprayimari ebangelwa yi-adrenal gland tumor ihlala inyangwa ngotyando. Ngamanye amaxesha inokunyangwa ngamayeza. Ukususa ithumba le-adrenal kunokulawula iimpawu. Kwanasemva koqhaqho, abanye abantu basenoxinzelelo oluphezulu lwegazi kwaye kufuneka bathathe amayeza. Kodwa rhoqo, inani lamayeza okanye idosi linokwehliswa.

Ukunciphisa ukutya kunye nokusela amayeza kunokulawula iimpawu ngaphandle kotyando. Amayeza okunyanga i-hyperaldosteronism abandakanya:

• Iziyobisi ezithintela isenzo se-aldosterone
• I-diuretics (iipilisi zamanzi), ezinceda ukulawula ulwakhiwo lwamanzi emzimbeni

I-hyperaldosteronism yesibini inyangwa ngamayeza (njengoko kuchaziwe apha ngasentla) kunye nokunciphisa ityuwa. Uqheliso alusetyenziswa.

Imbonakalo ye-hyperaldosteronism ephambili ilungile ngokuxilongwa kwangoko kunye nonyango.

Imbonakalo ye-hyperaldosteronism yesibini ixhomekeke kwisizathu sale meko.

I-hyperaldosteronism yaseprayimari inokubangela uxinzelelo lwegazi oluphezulu, olunokonakalisa amalungu amaninzi, kubandakanya amehlo, izintso, intliziyo nengqondo.

Iingxaki zokwakhiwa kunye ne-gynecomastia (eyandisiweyo amabele emadodeni) inokwenzeka ngokusetyenziswa kwamayeza ixesha elide ukuthintela ukusebenza kwehyperaldosteronism.

Tsalela umnxeba kwindibano kunye nomnikezeli wakho ukuba uphuhlisa iimpawu zehyperaldosteronism.

Isifo seConn; Ukumbiwa kweMineralocorticoid

• Amadlala endocrine
• Ukukhutshwa kwe-adrenal gland secretion

Unonophelo RM, uPadia SH. Ukuphazamiseka okungaphezulu kwemaminerocorticoid kunye noxinzelelo lwegazi. Ku: Jameson JL, De Groot LJ, de Kretser DM, et al, ii-eds. Endocrinology: Abantu abadala kunye nabantwana. Umhla wesi-7. IPhiladelphia, PA: Elsevier Saunders; 2016: isahluko 108.

UNieman LK. I-adrenal cortex. Ku: IGoldman L, iSchafer AI, ii-eds. Amayeza eGoldman-Cecil. Ngomhla wama-26. IPhiladelphia, PA: Elsevier; 2020: isahluko 214.