Ipancreatic islet cell tumor

I-pancreatic islet cell tumor ithumba elinqabileyo le-pancreas eliqala kuhlobo lweseli ebizwa ngokuba yi-islet cell.

Kwipancreas esempilweni, iiseli ezibizwa ngokuba ziislet zeslet zivelisa iihomoni ezilawula imisebenzi eliqela yomzimba. Oku kubandakanya inqanaba leswekile yegazi kunye nokuveliswa kwesisu esiswini.

Izidumba ezivela kwiislet zeseleke zepancreas zinokuvelisa iintlobo ezahlukeneyo zehomoni, ezinokukhokelela kwiimpawu ezithile.

Iipancreatic islet cell tumors zingenakuba ngumhlaza (ezinobungozi) okanye ezinomhlaza (ezinobungozi).

Islet cell tumors zibandakanya:

• I-Gastrinoma (iZollinger-Ellison syndrome)
• Glucagonoma
• Insulinoma
• Somatostatinoma
  
• I-VIPoma (isifo seVerner-Morrison)

Imbali yosapho ye-endocrine neoplasia, yohlobo lwe-I (MEN I) yinto ebeka umngcipheko kuphuhliso lwezidumbu zeselflet.

Iimpawu zixhomekeke ekubeni yeyiphi na ihomoni eyenziwe lithumba.

Umzekelo, ii-insulinomas zivelisa i-insulin, eyehlisa izinga leswekile esegazini. Iimpawu zingabandakanya:

• Ndiziva ndidiniwe okanye ndibuthathaka
• Ukungcangcazela okanye ukubila
• Intloko ebuhlungu
• Indlala
• Uvalo, unxunguphalo, okanye iimvakalelo zomsindo
• Ukucinga okungacacanga okanye ukuziva ungakhululekanga
• Umbono ophindwe kabini okanye ongacacanga
• Ukukhawuleza okanye ukubetha kwentliziyo

Ukuba inqanaba leswekile esegazini lakho liba sezantsi kakhulu, usenokufa isiqaqa, uxhuzule, okanye ude ube isiqaqa.

I-Gastrinomas yenza i-hormone gastrin, exelela umzimba ukuba wenze isisu esiswini. Iimpawu zingabandakanya:

• Intlungu zesisu
• Urhudo
• Izilonda esiswini kunye namathumbu amancinci
• Ukuphalaza igazi (ngamanye amaxesha)

Iiglucagonomas zenza i-hormone yeglucagon, enceda umzimba uphakamise inqanaba leswekile yegazi. Iimpawu zingabandakanya:

• Seswekile
• Olubomvu, ukuqhuma kweblister kwi-groin okanye ezinqeni
• Ukuhla ukusinda
• Ukuchama rhoqo nokunxanwa

I-Somatostatinomas yenza i-hormone somatostatin. Iimpawu zingabandakanya:

• Iswekile yegazi ephezulu
• Amatye egall
• Imbonakalo etyheli kulusu, namehlo
• Ukuhla ukusinda
• Urhudo ngezitulo ezinukayo

I-VIPomas yenza i-hormone vasoactive intestinal peptide (VIP) ebandakanyekayo ekugcineni ulungelelwaniso lweetyiwa, isodiyam, i-potassium kunye nezinye izimbiwa kwiphecana le-GI. I-VIPomas inokubangela:

• Urhudo olomeleleyo olukhokelela ekuphelelweni ngumzimba
• Amanqanaba e-potassium ephantsi egazini, kunye namanqanaba aphezulu e-calcium
• Iintlanzi zesisu
• Ukuhla ukusinda

Umboneleli wakho wezempilo uya kuthatha imbali yakho yezonyango kwaye enze uvavanyo lomzimba.

Uvavanyo lwegazi lungahluka, kuxhomekeka kwiimpawu, kodwa zinokubandakanya:

• Ukuzila ukutya kwenqanaba leswekile
• Inqanaba leGastrin
• Uvavanyo lokunyamezelwa kweglucose
• Uvavanyo lwe-Secretin lokukhuthaza iipancreas
• Inqanaba legazi le-glucagon
• I-insulin yegazi C-peptide
• Inqanaba le-insulin yegazi
• Ukuzila ukutya kwinqanaba le-somatostatin
• Inqanaba le-serum vasoactive intestinal peptide (VIP)

Ukujonga iimvavanyo kunokwenziwa:

• Ukuskena kwe-CT esiswini
• I-ultrasound yesisu
• I-endoscopic ultrasound
• I-MRI yesisu

Isampulu yegazi nayo ingathatyathwa kumthambo kwipancreas kuvavanywa.

Ngamanye amaxesha, utyando luyafuneka ukufumanisa nokunyanga le meko. Ngexesha lale nkqubo, ugqirha uvavanya i-pancreas ngesandla kunye ne-ultrasound.

Unyango luxhomekeke kuhlobo lwethumba kwaye ukuba lungumhlaza.

Izidumba ezinomhlaza zingakhula ngokukhawuleza kwaye zinwenwele kwamanye amalungu. Basenokunganyangeki. Izidumba zihlala zisuswa ngotyando, ukuba kunokwenzeka.

Ukuba iiseli zomhlaza zisasazeka esibindini, inxenye yesibindi inokususwa nayo, ukuba kunokwenzeka. Ukuba umhlaza usasazekile, ichemotherapy inokusetyenziselwa ukuzama ukunciphisa amathumba.

Ukuba ukuveliswa okungaqhelekanga kwamahomoni kubangela iimpawu, unokufumana amayeza okuthintela iziphumo zawo. Umzekelo, nge-gastrinomas, ukuveliswa kakhulu kwe-gastrin kukhokelela kwi-asidi eninzi esiswini. Amayeza athintela ukukhutshwa kweasidi esiswini anokunciphisa iimpawu.

Ungaluphelisa uxinzelelo lokugula ngokujoyina iqela lokuxhasa umhlaza. Ukwabelana nabanye abanamava afanayo kunye neengxaki kunokukunceda ungaziva ulilolo.

Unyangeke ukuba amathumba asuswe ngotyando ngaphambi kokuba asasazeke kwamanye amalungu. Ukuba amathumba anomhlaza, i-chemotherapy inokusetyenziswa, kodwa ihlala ingenako ukunyanga abantu.

Iingxaki ezisongela ubomi (ezinje ngeswekile esezantsi yegazi) zinokwenzeka ngenxa yemveliso engaphezulu kwehomoni, okanye ukuba umhlaza usasazeka emzimbeni wonke.

Iingxaki zala mathumba zibandakanya:

• Seswekile
• Iingxaki zeHormone (ukuba ithumba likhupha iintlobo ezithile zehomoni)
• Iswekile esezantsi yegazi (ukusuka kwi-insulinomas)
• Izilonda ezinzima esiswini kunye namathumbu amancinci (ukusuka kwi-gastrinomas)
• Ukusasazeka kwethumba kwisibindi

Fowunela umboneleli wakho ukuba uphuhlisa iimpawu zala mathumba, ngakumbi ukuba unembali yosapho ye-MEN I.

Akukho sithintelo saziwayo kwezi tumors.

Umhlaza - injeke; Umhlaza - pancreatic; Umhlaza wepancreatic; Islet cell amathumba; Islet of Langerhans ithumba; Amathumba e-neuroendocrine; Peptic ulcer - islet cell ithumba; Hypoglycemia - iqokobhe islet; Isifo seZollinger-Ellison; Isifo seVerner-Morrison; Gastrinoma; Insulinoma; VIPoma; Somatostatinoma; Glucagonoma

• Amadlala endocrine
• Iipancreas

Foster DS, Norton JA. Ulawulo lwee-pancreatic islet cell tumors ngaphandle kwe-gastrinoma. Ku: ICameron AM, uCameron JL, ii-eds. Unyango lwangoku lonyango. Umhla we-13. IPhiladelphia, PA: Elsevier; Ngo-2020: 581-584.

Kwiwebhusayithi yeZiko loMhlaza weSizwe. Unyango lomhlaza wepancreatic (PDQ) -uhlobo lobungcali kwezempilo. www.cancer.gov/types/pancreatic/hp/pnet-kunyanga-pdq. Ukuhlaziywa ngoJanuwari 2, 2020. Ifikeleleke ngoFebruwari 25, 2020.

Iwebhusayithi yeNethiwekhi yeCancer epheleleyo yoMhlaza. Isikhokelo sonyango se-NCCN kwi-oncology (izikhokelo ze-NCCN). Neuroendocrine kunye ne-adrenal tumors. Inguqulelo 1.2019. www.nccn.org/professionals/physician_gls/pdf/neuroendocrine.pdf. Ukuhlaziywa ngo-Matshi 5, 2019. Ifikeleleke ngoFebruwari 25, 2020.

Iwebhusayithi yeNethiwekhi yeCancer epheleleyo yoMhlaza. Izikhokelo ze-NCCN zezigulana. Amathumba e-Neuroendocrine. 2018. www.nccn.org/patients/guidelines/content/PDF/neuroendocrine-patient.pdf.