Ukusilela kweepoprotein lipase

Ukusilela kweepoprotein lipase eliqhelekileyo liqela leengxaki ezinqabileyo zemfuza apho umntu engenayo iprotein efunekayo yokwaphula iimolekyuli ezinamafutha. Ukuphazamiseka kubangela inani elikhulu lamafutha ukuba akhe egazini.

Ukusilela kwe-lipoprotein lipase ukusilela kubangelwa yimfuza enesiphene edluliswa kwiintsapho.

Abantu abanale meko abanayo i-enzyme ebizwa ngokuba yi-lipoprotein lipase. Ngaphandle kwale enzayim, umzimba awukwazi ukwahlula amanqatha kukutya okwetyisiweyo. Amasuntswana amanqatha abizwa ngokuba ziichylomicrons akha egazini.

Imiba yomngcipheko ibandakanya imbali yosapho yokusilela kwe-lipoprotein lipase.

Imeko ihlala iqala ukubonwa ngexa lobusana okanye ebuntwaneni.

Iimpawu zinokubandakanya nayiphi na kwezi zinto zilandelayo:

• Intlungu zesisu (zinokubonakala njenge-colic kwiintsana)
• Ukuphelelwa ngumdla wokutya
• Isicaphucaphu, ukugabha
• Ubuhlungu kwiimisipha kunye namathambo
• Ukwandiswa kwesibindi kunye ne-spleen
• Ukusilela ukuphumelela kwiintsana
• Amanqatha afakwa eluswini (xanthomas)
• Amanqanaba aphezulu e-triglyceride egazini
• Iipale retina kunye nemithambo yegazi enemibala emhlophe kwii-retina
• Ukudumba okunganyangekiyo kwepancreas
• Ukuthungwa kwamehlo kunye nolusu (i-jaundice)

Umboneleli wezempilo uya kwenza uvavanyo lomzimba kwaye abuze malunga neempawu.

Uvavanyo lwegazi luya kwenziwa ukujonga amanqanaba e-cholesterol kunye ne-triglyceride. Ngamanye amaxesha, uvavanyo lwegazi olukhethekileyo lwenziwa emva kokuba unikwe abacoci begazi ngomthambo. Olu vavanyo lujonga imisebenzi yelopoprotein lipase egazini lakho.

Uvavanyo lwemfuzo lunokwenziwa.

Unyango lujolise ekulawuleni iimpawu kunye nenqanaba legazi le-triglyceride ngokutya okunamafutha asezantsi kakhulu. Umboneleli wakho uya kuncoma ukuba ungadli ngaphezulu kwe-20 gram yeoli ngosuku ukukhusela iimpawu ukuba zingabuyi.

Iigram ezingamashumi amabini zamafutha zilingana nenye yezi zinto zilandelayo:

• Iiglasi ezimbini ze-8-ounce (240 milliliters) zeglasi yobisi olupheleleyo
• Iitisipuni ezi-4 (9.5 iigrem) zeargarine
• Ii-ounces (i-113 gram) zenyama

Ukutya okuphakathi kwaseMelika kunamafutha afikelela kwiipesenti ezingama-45 zeekhalori zizonke. Iivithamini ezinyibilika ngamanqatha A, D, E, kunye no-K kunye nezongezo zezimbiwa ziyacetyiswa kubantu abatya ukutya okunamafutha asezantsi kakhulu. Unokufuna ukuxoxa ngeemfuno zakho zokutya kunye nomboneleli wakho kunye nesidlo sokutya esibhalisiweyo.

I-Pancreatitis enxulumene nokusilela kwe-lipoprotein lipase iyaphendula kunyango lweso sifo.

Ezi zibonelelo zinokubonelela ngolwazi oluthe kratya malunga nokusilela kwe-lipoprotein lipase:

• Umbutho weSizwe woNxunguphalo oluNqabileyo- rarediseases.org/rare-diseases/familial-lipoprotein-lipase-deficiency
• Isalathiso seKhaya le-NIH yemfuzo- ghr.nlm.nih.gov/condition/familial-lipoprotein-lipase-deficiency

Abantu abakule meko balandela ukutya okunamafutha asezantsi kakhulu banokuhlala ebudaleni.

I-Pancreatitis kunye neziqendu eziphindaphindayo zentlungu esiswini zinokukhula.

AmaXanthomas aqhele ukuba buhlungu ngaphandle kokuba atyabukile kakhulu.

Tsalela umnikezeli wakho ukuba akuvavanye ukuba umntu othile kusapho lwakho une-lipoprotein lipase. Ukucetyiswa ngemfuzo kuyacetyiswa kuye nakubani na onembali yosapho yesi sifo.

Akukho kuthintelwa kwaziwayo kwesi sifo sinqabileyo, esivela kwilifa. Ukwaziswa kwemingcipheko kunokuvumela ukufunyanwa kwangoko. Ukulandela ukutya okunamafutha asezantsi kakhulu kunokuziphucula iimpawu zesi sifo.

Chwetheza I hyperlipoproteinemia; Chylomicronemia eqhelekileyo; Ukusilela kweLPL

• Imithambo yegazi

UGenest J, uLibby P.Lipoprotein ukuphazamiseka kunye nesifo sentliziyo. Ku: Zipes DP, Libby P, Bonow RO, Mann DL, Tomaselli GF, Braunwald E, ii-eds. Isifo sentliziyo seBraunwald: Incwadi yesifundo seMpilo yeNtliziyo. Ngomhla we-11. IPhiladelphia, PA: Elsevier; I-2019: isahluko 48.

Semenkovich CF, Goldberg AC, Goldberg IJ. Ukuphazamiseka kwemetabolism yelipid. Ku: Melmed S, Polonsky KS, Larsen PR, Kronenberg HM, ii-eds. Incwadi ebhaliweyo kaWilliam ye-Endocrinology. Umhla we-13. IPhiladelphia, PA: Elsevier; 2016: isahluko 37.