Isifo seFelty

I-Felty syndrome sisifo esibandakanya i-rheumatoid arthritis, ukudumba, ukudumba kwenani lamaseli amhlophe, kunye nosulelo oluphindaphindiweyo. Inqabile.

Unobangela we-Felty syndrome awaziwa. Kuqheleke kakhulu kubantu abanesifo samathambo (RA) ixesha elide. Abantu abanesi sifo basemngciphekweni wosulelo kuba banenani eliphantsi leeseli ezimhlophe zegazi.

Iimpawu zibandakanya:

• Imvakalelo ngokubanzi yokungonwabi (malaise)
• Ukudinwa
• Ubuthathaka emlenzeni okanye engalweni
• Ukuphelelwa ngumdla wokutya
• Ukuphulukana nobunzima ngabom
• Izilonda eluswini
• Ukudumba ngokudibeneyo, ukuqina, iintlungu kunye nokukhubazeka
• Izifo ezenzeka rhoqo
• Iliso elibomvu ngokutshisa okanye ukukhupha

Uvavanyo lomzimba luya kubonisa:

• Udakada odumbileyo
• Amalungu abonisa iimpawu zeRA
• Isibindi sokudumba kunye ne-lymph node

Inani elipheleleyo legazi (CBC) umahluko liya kubonisa inani eliphantsi leeseli ezimhlophe zegazi ezibizwa ngokuba zii-neutrophils. Phantse bonke abantu abane-Felty syndrome banoluvavanyo oluqinisekileyo lwe-rheumatoid factor.

Isisu esisisu sinokuqinisekisa udakada odumbileyo.

Kwiimeko ezininzi, abantu abanesi sifo abafumani unyango olucetyiswayo lwe-RA. Banokufuna amanye amayeza ukucinezela amajoni abo omzimba kunye nokunciphisa umsebenzi weRA yabo.

I-Methotrexate inokuphucula inani eliphantsi le-neutrophil. I-rituximab yeziyobisi iphumelele kubantu abangaphenduliyo kwimethotrexate.

IGranulocyte-colony evuselelayo (G-CSF) inokuphakamisa ukubala kwe-neutrophil.

Abanye abantu baxhamla ekususweni kwepleen (splenectomy).

Ngaphandle konyango, usulelo lungaqhubeka nokuvela.

I-RA inokuba mandundu.

Ukunyanga i-RA, nangona kunjalo, kufuneka kuphuculwe isifo seFelty.

Unokuba nosulelo oluhlala lubuya.

Abanye abantu abane-Felty syndrome baye bonyusa inani lee-lymphocyte ezinkulu, ezibizwa ngokuba yi-LGL leukemia. Oku kuya kunyangwa nge-methotrexate kwiimeko ezininzi.

Tsalela umnxeba umboneleli wakho ukuba ukhulisa iimpawu zesi sifo.

Unyango olukhawulezileyo lweRA kunye namayeza acetyiswayo okwangoku anciphisa umngcipheko wokuba neFelty syndrome.

Isifo samathambo esisifo esifunyanwa emzimbeni (RA); Isifo sikaFelty

• Iintsholongwane

I-Bellistri JP, Muscarella P. Splenectomy yezifo zehematologic. Ku: UCameron JL, uCameron AM, ii-eds. Unyango lwangoku lonyango. Umhla we-12. IPhiladelphia, PA: Elsevier; Ngo-2017: 603-610.

U-Erickson AR, uCannella AC, uMikuls TR. Iimpawu zonyango lwe-rheumatoid arthritis. Ku: Firestein GS, Budd RC, Gabriel SE, McInnes IB, O'Dell JR, ii-eds. Incwadi kaKelley kunye neFirestein yeRheumatology. Ngomhla we-10. IPhiladelphia, PA: Elsevier; Ngo-2017: isahluko 70.

I-Gazitt T, Loughran TP Jr.I-neutropenia engapheliyo kwi-LGL leukemia kunye ne-rheumatoid arthritis. Inkqubo yeHematology Am Soc Hematol yeNkqubo yezeMfundo. Ngo-2017; 2017 (1): 181-186. IINKCUKACHA: 29222254 www.ncbi.nlm.nih.gov/pubmed/29222254.

UMyasoedova E, uTuresson C, uMatteson EL. Iimpawu ezongezelelweyo zesifo samathambo. Ku: Hochberg MC, Gravallese EM, Silman AJ, Smolen JS, Weinblatt ME, Weisman MH, ii-eds. Rheumatology. Umhla wesi-7. IPhiladelphia, PA: Elsevier; I-2019: isahluko 95.

USavola P, uBrück O, u-Olson T, et al. Somatic STAT3 Utshintsho kwisifo seFelty syndrome: intsingiselo yentsholongwane yesiqhelo ene-granular lymphocyte leukemia. I-Haematologica. 2018; 103 (2): 304-312. IINKCUKACHA: 29217783 www.ncbi.nlm.nih.gov/pubmed/29217783.

U-Wang CR, u-Chiu YC, u-Chen YC. Unyango oluyimpumelelo lwe-neutropenia ekhanyayo kwi-Felty's syndrome ene-rituximab. Scand J Rheumatol. 2018; 47 (4): 340-341. IINKCUKACHA: 28753121 www.ncbi.nlm.nih.gov/pubmed/28753121.