I-IgA nephropathy

I-nephropathy ye-IgA sisifo sezintso apho ii-antibodies ezibizwa ngokuba yi-IgA zakha kwizicubu zezintso. I-Nephropathy ngumonakalo, isifo, okanye ezinye iingxaki zezintso.

I-nephropathy ye-IgA ikwabizwa ngokuba sisifo seBerger.

I-IgA yiprotein, ebizwa ngokuba yi-antibody, enceda umzimba ukulwa usulelo. I-nephropathy ye-IgA yenzeka xa uninzi lwale proteni lubekwe kwizintso. I-IgA iyakha ngaphakathi kwimithambo yegazi encinci yezintso. Izakhiwo kwizintso ezibizwa ngokuba yi-glomeruli ziyavutha kwaye zonakaliswe.

Esi sifo sinokuvela ngesiquphe (sibukhali), okanye siqhubeke kancinci kancinci kwiminyaka emininzi (glomerulonephritis).

Izinto zomngcipheko zibandakanya:

• Imbali yobuqu okanye yosapho ye-IgA nephropathy okanye iHenoch-Schönlein purpura, uhlobo lwe-vasculitis echaphazela amalungu amaninzi omzimba
• Ubuhlanga obuMhlophe okanye obaseAsia

I-nephropathy ye-IgA inokwenzeka kubantu bayo yonke iminyaka, kodwa ihlala ichaphazela abesilisa abakwishumi elivisayo ukuya kwiminyaka engama-30.

Kungangabikho mpawu iminyaka emininzi.

Xa kukho iimpawu, zinokubandakanya:

• Umchamo wegazi oqala ngexesha okanye ngokukhawuleza emva kosulelo lokuphefumla
• Iziqendu eziphindaphindwayo zomchamo omnyama okanye onegazi
• Ukudumba kwezandla neenyawo
• Iimpawu zesifo sezintso ezingapheliyo

I-nephropathy ye-IgA ihlala ifunyanwa xa umntu engenazo ezinye iimpawu zeengxaki zezintso enesinye okanye iziqendu zomchamo omnyama okanye onegazi.

Akukho lutshintsho lubonakalayo ngexesha lovavanyo lomzimba. Ngamanye amaxesha, uxinzelelo lwegazi lunokuba phezulu okanye kunokubakho nokudumba komzimba.

Uvavanyo lubandakanya:

• Uvavanyo lwegazi urea nitrogen (BUN) ukulinganisa ukusebenza kwezintso
• Ukudala uvavanyo lwegazi ukulinganisa ukusebenza kwezintso
• I-biopsy yezintso ukuqinisekisa ukuxilongwa
• Uhlalutyo lomchamo
• Umchamo immunoelectrophoresis

Injongo yonyango kukhulula iimpawu kunye nokuthintela okanye ukulibazisa ukusilela okungapheliyo kwezintso.

Unyango lunokubandakanya:

• I-Angiotensin-converting enzyme (ACE) inhibitors kunye ne-angiotensin receptor blockers (ARBs) yokulawula uxinzelelo lwegazi kunye nokudumba (edema)
• ICorticosteroids, amanye amayeza acinezela amajoni omzimba
• Ioli yeentlanzi
• Amayeza okunciphisa i-cholesterol

Ityuwa kunye nolwelo lunokuthintelwa ukulawula ukudumba. Ukutya okuneeprotein ezisezantsi ukuya kumodareyitha kunokucetyiswa kwezinye iimeko.

Ekugqibeleni, abantu abaninzi kufuneka banyangwe isifo sezintso esinganyangekiyo kwaye banokufuna i-dialysis.

I-nephropathy ye-IgA iba mandundu ngokuthe ngcembe. Kwiimeko ezininzi, ayibi mbi kwaphela. Imeko yakho inokuba mandundu ukuba unayo:

• Igazi elonyukayo
• Inani elikhulu leprotheni kumchamo
• Ukunyuka kwe-BUN okanye amanqanaba e-creatinine

Tsalela umnxeba umboneleli wakho ukuba unegazi elinegazi okanye ukuba uvelisa umchamo omncinci kunesiqhelo.

I-Nephropathy -IgA; Isifo seBerger

• I-anatomy yezintso

UFeehally J, uFloege J. Immunoglobulin I-nephropathy kunye ne-IgA vasculitis (Henoch-Schönlein purpura). Ku: Feehally J, Floege J, Tonelli M, Johnson RJ, ii-eds. I-Clinical Nephrology epheleleyo. Umhla wesi-6. IPhiladelphia, PA: Elsevier; I-2019: isahluko 23.

USaha MK, iPendergraft WF, uJennette JC, uFalk RJ. Isifo esisisiseko se-glomerular. Ku: Yu ASL, Chertow GM, Luyckx VA, Marsden PA, Skorecki K, Taal MW, ii-eds. Brenner kunye noMphathi weZintso. Ngomhla we-11. IPhiladelphia, PA: Elsevier; 2020: isahl 31.