Ukusilela okukhethiweyo kwe-IgA

Ukusilela kokukhetha i-IgA sesona sifo sixhaphakileyo sokuzikhusela kwizifo. Abantu abanale ngxaki banezinga eliphantsi okanye elingekhoyo kwiproteni yegazi ebizwa ngokuba yi-immunoglobulin A.

Ukusilela kwe-IgA kuhlala kuzuzwa njengelifa, oko kuthetha ukuba kudluliswa kwiintsapho. Nangona kunjalo, kukwakho neemeko zokusilela kweziyobisi okubangelwa sisiyobisi i-IgA.

Ingafunyanwa njengelifa njengeyona nto iphambili kwi-autosomal okanye kwi-autosomal. Ihlala ifunyanwa kubantu abanemvelaphi yaseYurophu. Akuqhelekanga kubantu bezinye iintlanga.

Uninzi lwabantu abanesiphene sokukhetha i-IgA abanazimpawu.

Ukuba umntu uneempawu, zinokubandakanya iziqendu eziqhelekileyo ze:

• I-bronchitis (usulelo lwomoya)
• Urhudo olunganyangekiyo
• Ukudibana (usulelo lwamehlo)
• Ukudumba kwamathumbu, kubandakanya ulcerative colitis, isifo seCrohn, kunye nesifo esifana nesiporo
• Usulelo lomlomo
• I-otitis media (usulelo lwendlebe oluphakathi)
• I-pneumonia (usulelo lwemiphunga)
• Sinusitis (usulelo lwesono)
• Usulelo lolusu
• Usulelo oluphezulu lokuphefumula

Ezinye iimpawu zibandakanya:

• I-Bronchiectasis (isifo apho iisaka ezincinci zomoya emiphungeni zonakala kwaye zandiswe)
• Isifo sombefu ngaphandle kwesizathu esaziwayo

Kunokubakho imbali yosapho yokusilela kwe-IgA. Uvavanyo olunokwenziwa lunokubandakanya:

• Imilinganiselo yeklasi ye-IgG
• Ubungakanani beemunoglobulin
• I-Serum immunoelectrophoresis

Akukho lunyango lukhoyo lukhoyo. Abanye abantu ngokuthe ngcembe bakhulisa amanqanaba aqhelekileyo e-IgA ngaphandle konyango.

Unyango lubandakanya ukuthatha amanyathelo okunciphisa inani kunye nobukhali bosulelo. Amayeza okubulala iintsholongwane ahlala efuneka ukunyanga usulelo lwebacteria.

Ii-Immunoglobulins zinikwa ngomthambo okanye ngenaliti ukonyusa amajoni omzimba.

Unyango lwezifo ezizimeleyo lusekwe kwingxaki ethile.

Qaphela: Abantu abanokusilela okupheleleyo kwe-IgA banokuphuhlisa ii-anti-IgA antibodies ukuba banikwe iimveliso zegazi kunye nee-immunoglobulins. Oku kunokukhokelela kwizifo ezithile okanye ukusongela ubomi be-anaphylactic shock. Nangona kunjalo, banokunikwa ngokukhuselekileyo ii-immunoglobulins ze-IgA.

Ukunqongophala kokukhetha i-IgA kuyingozi kunezinye izifo ezininzi zokungasebenzi komzimba.

Abanye abantu abanesiphene se-IgA baya kuphila ngokwabo kwaye bavelise i-IgA ngesixa esikhulu kwisithuba seminyaka.

Ukuphazamiseka okuzenzekelayo okunje nge-rheumatoid arthritis, inkquboic lupus erythematosus, kunye ne-celiac sprue inokukhula.

Abantu abanesiphene se-IgA banokuphuhlisa ii-antibodies kwi-IgA. Ngenxa yoko, banokuba neempembelelo ezinzima, ezinokusongela ubomi kutofelo-gazi kunye nemveliso yegazi.

Ukuba unengxaki ye-IgA, qiniseka ukuyithetha kumboneleli wakho wokhathalelo lwempilo ukuba ngaba i-immunoglobulin okanye olunye utofelo-gazi lucetyiswa njengonyango kuyo nayiphi na imeko.

Ukucebisa ngemfuza kunokuba lixabiso kubazali abanokubakho abanembali yosapho ekukhetheni i-IgA.

Ukusilela kwe-IgA; Ukungabikho koxinzelelo - i-IgA ukusilela; Uxinzelelo lwe-immune-ukusilela kwe-IgA; Hypogammaglobulinemia - ukuswela kwe-IgA; Ukusilela kwe-Agammaglobulinemia -IgA

• Iintsholongwane

ICunningham-Rundles C. Izifo zokuqala zokungasebenzi komzimba. Ku: IGoldman L, iSchafer AI, ii-eds. Amayeza eGoldman-Cecil. Ngomhla wama-26. IPhiladelphia, PA: Elsevier; 2020: isahl 236.

USullivan KE, uBuckley RH. Iziphene eziphambili zemveliso yentsholongwane. Ku: Kliegman RM, St Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, ii-eds. Incwadi kaNelson yeNcwadi yePediatrics. Umhla wama-21. IPhiladelphia, PA: Elsevier; 2020: isahluko 150.