Imembranoproliferative glomerulonephritis

I-Membranoproliferative glomerulonephritis sisifo sezintso esibandakanya ukudumba kunye notshintsho kwiiseli zezintso. Ingakhokelela ekusileleni kwezintso.

IGlomerulonephritis kukukrala kweglomeruli. I-glomeruli yezintso inceda ukuhluza inkunkuma kunye nolwelo olusuka egazini ukwenza umchamo.

I-Membranoproliferative glomerulonephritis (MPGN) luhlobo lwe-glomerulonephritis ebangelwa yimpendulo yomzimba engaqhelekanga. Iidipozithi ze-antibodies zakha kwinxalenye yezintso ezibizwa ngokuba yigalomerular kwigumbi elingaphantsi. Le nwebu inceda ukuhluza inkunkuma kunye nolwelo olongezelelweyo egazini.

Ukonakala kwale membrane kuchaphazela amandla wezintso okwenza umchamo ngesiqhelo. Inokuvumela igazi kunye neeprotein ukuba zivuze kumchamo. Ukuba iiprotheyini ezaneleyo ziyavuza kumchamo, ulwelo lunokuvuza kwimithambo yegazi iye kwizicubu zomzimba, oko kukhokelele ekudumbeni (i-edema). Iimveliso zenitrogen zinokwakha nasegazini (azotemia).

Iifom ze-2 zesi sifo yi-MPGN I kunye ne-MPGN II.

Uninzi lwabantu abanesifo banodidi I. I-MPGN II ayixhaphakanga kakhulu. Ikwathanda ukuba mandundu ngokukhawuleza kune-MPGN I.

Izizathu ze-MPGN zinokubandakanya:

• Izifo ezisebenza ngokuzenzekelayo (inkqubo ye lupus erythematosus, scleroderma, Sjögren syndrome, sarcoidosis)
• Umhlaza (leukemia, lymphoma)
• Usulelo (i-hepatitis B, i-hepatitis C, i-endocarditis, i-malaria)

Iimpawu zinokubandakanya nayiphi na kwezi zinto zilandelayo:

• Igazi kumchamo
• Utshintsho kwisimo sengqondo njengokuncipha kokuphapha okanye ukunciphisa uxinzelelo
• Kufike umchamo
• Umchamo omnyama (umsi, icola, okanye iti enemibala)
• Ukunciphisa ivolumu yomchamo
• Ukudumba kwalo naliphi na ilungu lomzimba

Umboneleli wezempilo uyakukuvavanya akubuze malunga neempawu zakho. Umboneleli unokufumanisa ukuba uneempawu zamanzi amaninzi emzimbeni, anje ngala:

• Ukudumba, rhoqo emilenzeni
• Izandi ezingaqhelekanga xa umamele intliziyo yakho kunye nemiphunga ngestethoscope
• Unokuba noxinzelelo lwegazi oluphezulu

Ezi mvavanyo zilandelayo zinceda ukuqinisekisa isifo:

• I-BUN kunye ne-creatinine yovavanyo lwegazi
• Amanqanaba okuncedisa igazi
• Uhlalutyo lomchamo
• Umchamo protein
• I-biopsy yezintso (ukuqinisekisa i-membranoproliferative GN I okanye II)

Unyango luxhomekeke kwiimpawu. Iinjongo zonyango kukunciphisa iimpawu, ukuthintela iingxaki, kunye nokucothisa ukuqhubela phambili kwesi sifo.

Unokufuna utshintsho kwindlela otya ngayo. Oku kunokubandakanya ukunciphisa isodiyam, ulwelo, okanye iproteni ukunceda ukulawula uxinzelelo lwegazi oluphezulu, ukudumba, kunye nokwakhiwa kweenkunkuma egazini.

Amayeza anokumiselwa abandakanya:

• Amayeza oxinzelelo lwegazi
• I-Dipyridamole, kunye okanye ngaphandle kwe-aspirin
• Womchamo
• Amayeza ukucinezela amajoni omzimba, ezifana cyclophosphamide
• IiSteroids

Unyango lusebenza ngakumbi ebantwaneni kunabantu abadala. I-Dialysis okanye ukufakelwa kwezintso ekugqibeleni kuya kufuneka ukulawula ukungaphumeleli kwezintso.

Esi sifo sihlala sisiba mandundu kancinci kancinci kwaye sikhokelela ekusileleni kwezintso okungapheliyo.

Isiqingatha sabantu abakule meko sikhula ukusilela kwezintso ixesha elide (ixesha elide) kwisithuba seminyaka elishumi. Oku kunokwenzeka ngakumbi kwabo banamanqanaba aphezulu eprotini kumchamo wabo.

Iingxaki ezinokubangelwa sesi sifo zibandakanya:

• Isifo se-nephritic
• Ukungasebenzi kakuhle kwezintso
• Isifo sezintso esinganyangekiyo

Biza ixesha lokubonana nomboneleli wakho ukuba:

• Unempawu zale meko
• Iimpawu zakho ziya zisiba mbi okanye azihambi
• Uphuhlisa iimpawu ezintsha, kubandakanya ukuncipha kwemveliso yomchamo

Ukukhusela izifo ezifana ne-hepatitis okanye ukulawula izifo ezifana ne-lupus kunokunceda ukukhusela i-MPGN.

Imemranoproliferative GN I; Imemranoproliferative GN II; Mesangiocapillary glomerulonephritis; Imembranoproliferative glomerulonephritis; ILobular GN; I-Glomerulonephritis - i-membranoproliferative; Uhlobo lweMPGN I; Uhlobo lwe-MPGN II

• I-anatomy yezintso

URoberts ISD. Izifo zezintso. Ku: Umnqamlezo we-SS, ed. Underwood's Pathology: Indlela yonyango. Umhla wesi-7. IPhiladelphia, PA: Elsevier; I-2019: isahluko 21.

USaha MK, iPendergraft WF, uJennette JC, uFalk RJ. Isifo esisisiseko se-glomerular. Ku: Yu ASL, Chertow GM, Luyckx VA, Marsden PA, Skorecki K, Taal MW, ii-eds. Brenner kunye noMphathi weZintso. Ngomhla we-11. IPhiladelphia, PA: Elsevier; 2020: isahl 31.

USethi S, uDe Vriese AS, uFervenza FC. I-Membranoproliferative glomerulonephritis kunye ne-cryoglobulinemic glomerulonephritis. Ku: Feehally J, Floege J, Tonelli M, Johnson RJ, ii-eds. I-Clinical Nephrology epheleleyo. Umhla wesi-6. IPhiladelphia, PA: Elsevier; I-2019: isahluko 21.