Ukusilela kweProthrombin

Ukusilela kwe-Prothrombin sisifo esibangelwa kukuswela kweprotein egazini elibizwa ngokuba yi-prothrombin. Kukhokelela kwiingxaki ze-clotting yegazi (i-coagulation). IProthrombin ikwabizwa ngokuba yinto yesibini (into yesibini).

Xa usopha, uthotho lweempendulo zenzeka emzimbeni onceda amahlwili egazi. Le nkqubo ibizwa ngokuba yi-coagulation cascade. Ibandakanya iiproteni ezikhethekileyo ezibizwa ngokuba yi-coagulation, okanye i-clotting, factor. Unokuba namathuba aphezulu okuphuma egazini ngokugqithisileyo ukuba enye okanye ezingakumbi zezi zinto zilahlekile okanye azisebenzi ngendlela ebekufanele ukuba zisebenza ngayo.

Iprothrombin, okanye factor II, yenye yezinto ezinje ngokujiya. Ukusilela kwe-Prothrombin kuqhutywa kwiintsapho (ezizuze ilifa) kwaye kunqabile kakhulu. Bobabini abazali kufuneka babe nemfuza yokudlulisela ingxaki kubantwana babo. Imbali yosapho yokuphazamiseka kwegazi inokuba ngumngcipheko.

Ukusilela kwe-Prothrombin nako kunokubangelwa yenye imeko okanye ukusetyenziswa kwamayeza athile. Oku kubizwa ngokuba kukusilela kweprothrombin. Ingabangelwa ngu:

• Ukungabikho kwe-vitamin K (abanye abantwana bazalwa benesifo se-vitamin K)
• Isifo esibi sesibindi
• Ukusetyenziswa kwamayeza athintela i-clotting (ii-anticoagulants ezifana ne-warfarin)

Iimpawu zinokubandakanya nayiphi na kwezi zinto zilandelayo:

• Ukopha ngokungaqhelekanga emva kokubeleka
• Ukopha okuninzi kokuya exesheni
• Ukopha emva kotyando
• Ukopha emva komothuko
• Ukukrala ngokulula
• Ukuphuma kweempumlo okungayeki ngokulula
• Umtya we-umbilical ukopha emva kokuzalwa

Uvavanyo olunokwenziwa lunokubandakanya:

• Into II kulingwa
• Ixesha le-thromboplastin ngexesha
• Ixesha leprothrombin (PT)
• Ukuxubusha isifundo (uvavanyo olukhethekileyo lwe-PTT ukuqinisekisa ukusilela kweprothrombin)

Ukopha kunokulawulwa ngokufumana infravenous (IV) infusions zeplasma okanye imixube yezinto ezijiyisayo. Ukuba awunayo i-vitamin K, ungayithatha le vithamini ngomlomo, ngokusebenzisa inaliti phantsi kolusu, okanye ngomthambo (ngaphakathi).

Ukuba unale ngxaki yokuphuma kwegazi, qiniseka ukuba:

• Xelela ababoneleli bakho bezempilo ngaphambi kokuba ube naluphi na uhlobo lwenkqubo, kubandakanya utyando kunye nomsebenzi wamazinyo.
• Xelela amalungu osapho lwakho kuba banokuba nengxaki efanayo kodwa abayazi okwangoku.

Ezi zixhobo zinokubonelela ngolwazi ngakumbi malunga nokusilela kweFactor VII:

• Isiseko seSizwe seHemophilia Foundation: Okunye ukusilela kweFactor- www.hemophilia.org/Bleeding-Disorder/Iindidi-ukukhupha igazi-Iingxaki/Okunye-Ifactor-Ukusilela
• IZiko loLwazi lweZifo zeMvelo zeNiH kunye neRare-rarediseases.info.nih.gov/diseases/2926/prothrombin-deficiency

Iziphumo zilungile ngonyango olululo.

Ukusilela kwilifa leprothrombin yimeko yobomi bonke.

Imbonakalo yokunqongophala kweprothrombin efunyenweyo ixhomekeke kwisizathu. Ukuba sibangelwa sisifo sesibindi, iziphumo zixhomekeke ekubeni isifo sakho sesibindi singanyangwa njani. Ukuthatha izongezo ze vithamin K kuya kunyanga ukusilela kwe vithamin K

Ukopha kakhulu kumalungu kunokwenzeka.

Fumana unyango olukhawulezileyo kwangoko ukuba uphulukene negazi ngokungachazwanga okanye ixesha elide, okanye ukuba awukwazi ukulawula ukopha.

Akukho kuthintelwa kwaziwayo kusweleka kweprothrombin. Xa ukunqongophala kukavithamini K kungunobangela, ukusebenzisa ivithamin K kunokunceda.

Hypoprothrombinemia; Ukusilela kweFactor II; Dysprothrombinemia

• Ukubumba kwegazi
• Amahlwili egazi

UGailani D, Wheeler AP, Neff AT. Ukunqongophala kwezinto ezinqabileyo. Ku: Hoffman R, Benz EJ, Silberstein LE, et al, ii-eds. I-Hematology: Imigaqo esisiseko kunye nokuziqhelanisa. Umhla wesi-7. IPhiladelphia, PA: Elsevier; I-2018: isahluko 137.

Iholo JE. I-Hemostasis kunye nokuqina kwegazi. Ku: Iholo JE, ed. Incwadi kaGuyton kunye neHolo yePhysical Physiology. Umhla we-13. IPhiladelphia, PA: Elsevier Saunders; 2016: isahluko 37.

Ragni MV. Ukuphazamiseka kwento eyophayo: ukungabikho kwento ekunqandeni. Ku: IGoldman L, iSchafer AI, ii-eds. Amayeza eGoldman-Cecil. Umhla wama-25. IPhiladelphia, PA: Elsevier Saunders; Ngo-2016: isahluko 174.