Inkqubo yesibini ye-amyloidosis

Inkqubo yesibini ye-amyloidosis sisifo apho iiproteni ezingaqhelekanga zakha izicwili kunye namalungu. Ukuvutha kweeproteni ezingaqhelekanga kuthiwa ziidipozithi zeamyloid.

Okwesibini kuthetha ukuba kwenzeka ngenxa yesinye isifo okanye imeko. Umzekelo, le meko ihlala isenzeka ngenxa yosulelo lwexesha elide (elingapheliyo) okanye ukudumba. Ngokwahlukileyo, i-amyloidosis yokuqala ithetha ukuba akukho esinye isifo esibangela imeko.

Inkqubo ithetha ukuba isifo sichaphazela umzimba wonke.

Oyena nobangela wesystemid amyloidosis awaziwa. Kungenzeka ukuba uphuhlise inkqubo yesibini ye-amyloidosis ukuba unosulelo lwexesha elide okanye ukudumba.

Le meko inokwenzeka nge:

• I-Ankylosing spondylitis -ifom ye-arthritis echaphazela kakhulu amathambo kunye namalungu omqolo
• I-Bronchiectasis - isifo apho iindlela ezinkulu zomoya emiphungeni zonakaliswa sisifo esingapheliyo
• I-osteomyelitis engapheliyo - usulelo lwethambo
• I-cystic fibrosis - isifo esibangela ukungcola, incangathi ekwakheni imiphunga, indlela yokugaya ukutya, kunye nezinye iindawo zomzimba, ezikhokelela kusulelo olungapheliyo lwemiphunga.
• Umkhuhlane owaziwayo waseMeditera- njengelifa lokuphindaphindeka kwemfiva kunye nokudumba okuhlala kuchaphazela ulusu lwesisu, isifuba, okanye amalungu.
• I-leukemia yeseli yeenwele - uhlobo lomhlaza wegazi
• Isifo se-Hodgkin - umhlaza wesikhumba se-lymph
• I-juvenile idiopathic arthritis - isifo samathambo esichaphazela abantwana
• Multiple myeloma - uhlobo lomhlaza wegazi
• I-Reiter syndrome-liqela leemeko ezibangela ukudumba kunye nokudumba kwamalungu, amehlo, kunye neenkqubo zokuchama kunye nezomzimba)
• Irheumatoid Arthritis
• Inkqubo ye-lupus erythematosus -ingxaki yokuzimela
• Isifo sephepha

Iimpawu zesekondari yenkqubo ye-amyloidosis ixhomekeke ekubeni zeziphi izicwili zomzimba ezichaphazeleka kwiipositi. Ezi dipozithi zonakalisa izicwili eziqhelekileyo. Oku kunokukhokelela kwiimpawu okanye iimpawu zesi sifo, kubandakanya:

• Ukopha kulusu
• Ukudinwa
• Ukubetha kwentliziyo ngokungaqhelekanga
• Ubungqongqo bezandla neenyawo
• Irhashalala
• Ukuqhawukelwa ngumphefumlo
• Ukuginya ubunzima
• Ukudumba kweengalo okanye imilenze
• Ukudumba ulwimi
• Ukubambelela kwesandla esibuthathaka
• Ukuhla ukusinda

Umboneleli wezempilo uya kwenza uvavanyo lomzimba kwaye abuze malunga neempawu zakho.

Uvavanyo olunokwenziwa lunokubandakanya:

• Isisu esiswini (sinokubonisa ukudumba kwesibindi okanye udakada)
• I-Biopsy okanye i-aspiration ye-fat nje ngaphantsi kwesikhumba (i-fatcutcut fat)
• I-Biopsy ye-rectum
• I-Biopsy yolusu
• I-Biopsy yomongo wethambo
• Uvavanyo lwegazi, kubandakanya i-creatinine kunye ne-BUN
• Echocardiogram
• I-Electrocardiogram (ECG)
• Isantya sokuqhuba kwemithambo
• Uhlalutyo lomchamo

Imeko ebangela i-amyloidosis kufuneka inyangwe. Kwezinye iimeko, ichiza colchicine okanye ibhayoloji (amayeza aphatha amajoni omzimba) emiselweyo.

Ukusebenza kakuhle komntu kuxhomekeke kumalungu achaphazelekayo. Kuxhomekeke ekubeni, nokuba isifo esisibangela sinokulawulwa. Ukuba esi sifo sibandakanya intliziyo kunye nezintso, sinokubangela ukusilela kwamalungu nokufa.

Iingxaki zempilo ezinokubangelwa yinkqubo yesibini ye-amyloidosis ibandakanya:

• Ukusilela kwe-Endocrine
• Ukumelwa yintliziyo
• Ukungaphumeleli kwezintso
• Ukusilela kokuphefumla

Fowunela umboneleli wakho ukuba uneempawu zeli meko. Ezi zilandelayo zimpawu ezinzima ezifuna unyango ngokukhawuleza:

• Ukopha
• Ukubetha kwentliziyo ngokungaqhelekanga
• Ubumdaka
• Ukuqhawukelwa ngumphefumlo
• Ukudumba
• Ukubambelela kubuthathaka

Ukuba unesifo esaziwayo sonyusa umngcipheko wale meko, qiniseka ukuba uyasinyanga. Oku kunokunceda ukukhusela i-amyloidosis.

IAmyloidosis - inkqubo yesibini; I-AA amyloidosis

• I-Amyloidosis yeminwe
• Amyloidosis ebusweni
• Iintsholongwane

UGertz MA. Amyloidosis. Ku: IGoldman L, iSchafer AI, ii-eds. Amayeza eGoldman-Cecil. Umhla wama-25. IPhiladelphia, PA: Elsevier Saunders; 2016: isahl. 188.

Utata R, uLachmann HJ. Kwimfundo yesibini, iAA, iAmyloidosis. Ikliniki yaseRheum Dis eMantla Am. 2018; 44 (4): 585-603. IINKCUKACHA: 30274625 www.ncbi.nlm.nih.gov/pubmed/30274625.