Ukuqhubela phambili kwesifo senyukliya

Progressive supranuclear palsy (PSP) sisifo sokuhamba esenzeka kumonakalo kwiiseli ezithile zemithambo-luvo kwingqondo.

I-PSP yimeko ebangela iimpawu ezifanayo nezo zesifo se-Parkinson.

Kubandakanya ukonakala kwiiseli ezininzi zobuchopho. Iindawo ezininzi zichaphazelekayo, kubandakanya nenxalenye yenkqubo yengqondo apho iiseli ezilawula ukuhamba kwamehlo zibakhona. Indawo yengqondo elawula ukuzinza xa uhamba nayo iyachaphazeleka. I-lobes yangaphambili yengqondo iyachaphazeleka, ekhokelela kutshintsho lobuntu.

Unobangela womonakalo kwiiseli zobuchopho awaziwa. I-PSP iya isiba mandundu ngokuhamba kwexesha.

Abantu abane-PSP bane-deposits kwizicubu zobuchopho ezibonakala ngathi zifumaneka kubantu abanesifo se-Alzheimer. Kukho ukulahleka kwezicubu kwiindawo ezininzi zobuchopho nakwezinye iindawo zomqolo womqolo.

Esi sifo sihlala sibonwa ebantwini ngaphezulu kweminyaka engama-60, kwaye siqhelekile emadodeni.

Iimpawu zinokubandakanya nayiphi na kwezi zinto zilandelayo:

• Ukuphulukana nokulingana, ukuwa okuphindaphindiweyo
• Ukuqhubela phambili xa ushukuma, okanye ukuhamba ngokukhawuleza
• Ukungqubeka kwizinto okanye ebantwini
• Utshintsho kwinkangeleko yobuso
• Ubuso obunemigca ebanzi
• Iingxaki zamehlo kunye nemibono njengabafundi abahlukeneyo, ubunzima bokuhambisa amehlo (supranuclear ophthalmoplegia), ukungabikho kolawulo kwamehlo, iingxaki zokugcina amehlo evulekile
• Kunzima ukugwinya
• Iinyikima, imihlathi okanye ijerks yobuso okanye i-spasms
• Isifo sengqondo esixhalabisayo
• Ubuntu buyatshintsha
• Ukuhamba kancinci okanye ukuqina
• Ubunzima bokuthetha, njengevolumu yelizwi esezantsi, akakwazi ukuthetha amagama ngokucacileyo, intetho ecothayo
• Ukuqina kunye nentshukumo eqinileyo entanyeni, embindini womzimba, iingalo kunye nemilenze

Uvavanyo lwenkqubo yemithambo-luvo (uviwo lwe-neurologic) lunokubonisa:

• Isifo sengqondo esiyingozi esiya sisiba mandundu
• Kunzima ukuhamba
• Ukuhamba kwamehlo okulinganiselweyo, ngakumbi ukunyuka nokuhla
• Umbono oqhelekileyo, ukuva, ukuziva, kunye nolawulo lokuhamba
• Ukuqina kunye nokungahambelani okungahambelaniyo nesifo seParkinson

Umboneleli wezempilo unokwenza ezi mvavanyo zilandelayo ukukhusela ezinye izifo:

• Imagnetic resonance imaging (MRI) inokubonisa ukuncipha kwenkqubo yobuchopho (uphawu lwe-hummingbird)
• Ukuvavanywa kwePET kwengqondo kuya kubonisa utshintsho ngaphambili kwengqondo

Injongo yonyango kukulawula iimpawu. Akukho lunyango lwePSP lwaziwayo.

Amayeza afana nelevodopa anokuzama. La machiza aphakamisa inqanaba lekhemikhali yobuchopho ebizwa ngokuba yidopamine. I-Dopamine ibandakanyeka kulawulo lwentshukumo. Amayeza anokunciphisa ezinye iimpawu, ezinje ngamalungu omzimba aqinileyo okanye ukuhamba kancinci okwexeshana. Kodwa zihlala zingasebenzi njengoko zinjalo isifo seParkinson.

Abantu abaninzi abane-PSP ekugqibeleni baya kufuna ukunakekelwa kwexesha kunye nokubeka iliso njengoko belahlekelwa yimisebenzi yengqondo.

Unyango ngamanye amaxesha lunokunciphisa iimpawu okwexeshana, kodwa imeko iya isiba mandundu. Umsebenzi weBongo uya kuncipha ngokuhamba kwexesha. Ukufa kuhlala kwenzeka kwiminyaka emi-5 ukuya kwesi-7.

Amachiza amatsha afundwa ukunyanga le meko.

Iingxaki zePSP zibandakanya:

• Igazi elixineneyo kwimithambo (i-vein thrombosis enzulu) ngenxa yentshukumo encinci
• Ukwenzakala kukuwa
• Ukusilela kolawulo kumbono
• Ukuphulukana nokusebenza kwengqondo ngexesha
• I-pneumonia ngenxa yengxaki yokuginya
• Isondlo esibi (ukungondleki)
• Iziphumo ebezingalindelekanga ezivela kumayeza

Fowunela umnikezeli wakho ukuba uhlala uwa, kwaye ukuba unentamo eqinileyo / umzimba, kunye neengxaki zombono.

Kwakhona, tsalela umnxeba ukuba umntu omthandayo ufumene ukuba une-PSP kwaye imeko iye yehla kakhulu kangangokuba awusenakukwazi ukukhathalela umntu ekhaya.

Isifo sengqondo esiyingozi - dystonia nuchal; Isifo sikaRichardson-Steele-Olszewski; Ukukhubazeka - inkqubela phambili yenyukliya

• Inkqubo ye-nervous central kunye ne-peripheral system

Isifo sikaJankovic J. Parkinson kunye nezinye iingxaki zokuhamba. Ku: Daroff RB, Jankovic J, Mazziotta JC, Pomeroy SL, ii-eds. I-Neurology kaBradley kwiKlinikhi yokuziqhelanisa. Umhla wesi-7. IPhiladelphia, PA: Elsevier; 2016: isahluko 96.

U-Ling H. Indlela yonyango yokuqhubela phambili ukukhubazeka kwesifo senyukliya. J Mov Disord. Ngo-2016; 9 (1): 3-13. IINKCUKACHA: 26828211 pubmed.ncbi.nlm.nih.gov/26828211/.

IZiko leSizwe leNzululwazi yeengxaki ze-Neurological. Inkqubela phambili yenyani yesiphene yenyukliya. www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Fact-Sheets/Progressive-Supranuclear-Palsy-Fact-Sheet. Ukuhlaziywa ngo-Matshi 17, 2020. Ifikeleleke ngo-Agasti 19, 2020.