Inkqubo yokuhlela kaGleason

Umhlaza wedlala lobudoda ufunyaniswe emva kokuvavanywa. Isampulu enye okanye ezingaphezulu zeethishu zithathwa kwiprostate kwaye zivavanywa phantsi kwemicroscope.

Inkqubo yokuhlelwa kweGleason ibhekisa kwindlela ekungaqhelekanga ngayo iiseli zomhlaza wesibeletho kunye nendlela onokuthi umhlaza uqhubeke kwaye usasaze ngayo. Inqanaba eliphantsi leGleason lithetha ukuba umhlaza ukhula kancinci kwaye awunaburhalarhume.

Isinyathelo sokuqala sokumisela ibakala leGleason kukufumanisa amanqaku eGleason.

1. Xa ujonga iiseli phantsi kwemicroscope, ugqirha wabela inombolo (okanye inqanaba) kwiiseli zomhlaza wedlala lobudoda phakathi kwe-1 kunye ne-5.
2. Eli banga lisekwe kwindlela ezingaqhelekanga ngayo iiseli ezivela. IBakala 1 lithetha ukuba iiseli zikhangeleka phantse njengeeseli zeprostate eziqhelekileyo. IBakala 5 lithetha ukuba iiseli zikhangeleka zahluke kakhulu kwiiseli zeprostate eziqhelekileyo.
3. Uninzi lwee-cancer zomhlaza wesinyi ziqulathe iiseli ezikumanqanaba ahlukeneyo. Ke la mabakala mabini aqhelekileyo asetyenziswa.
4. Amanqaku eGleason amiselwe ngokudibanisa amabakala amabini aqhelekileyo. Umzekelo, elona banga liqhelekileyo leeseli kwisampulu yethishu inokuba ziiseli ze-3, zilandelwa ziiseli zebanga lesi-4 Amanqaku eGleason ale sampulu angangama-7.

Amanani aphezulu abonisa umhlaza okhula ngokukhawuleza onokuthi usasazeke.

Okwangoku awona manqaku asezantsi anikwe ithumba libanga lesi-3. Uninzi lomhlaza lunamanqaku eGleason (isibalo samabakala amabini aqhelekileyo) phakathi kwe-6 (amanqaku eGleason ka-3 + 3) kunye no-7 (amanqaku eGleason ka-3 + 4 okanye 4 + 3).

Ngamanye amaxesha, kunokuba nzima ukuqikelela ukuba abantu baya kwenza njani ngokusekwe kumanqaku abo eGleason kuphela.

• Ngokomzekelo, i-tumor yakho inokunikezelwa ngamanqaku e-Gleason angama-7 ukuba amabakala amabini aqhelekileyo angama-3 no-4. I-7 inokuza ngenxa yokongeza u-3 + 4 okanye ukongeza u-4 + 3.
• Ngokubanzi, umntu onamanqaku ka-Gleason ka-7 avela ekongezeni u-3 + 4 uziva ngathi unomdlavuza ongekho krakra kunomntu onenqaku le-Gleason eli-7 eliza ngokudibanisa u-4 + 3. Kungenxa yokuba umntu one-4 + 3 = Ibanga lesi-7 lineeseli ezingaphezulu kwebanga lesi-4 kuneeseli ezi-3. Iiseli zeBakala 4 aziqhelekanga kwaye kunokwenzeka ukuba zisasazeke kuneeseli ze-3.

Inkqubo entsha yamaBakala ama-5 isandula ukwenziwa. Le nkqubo yindlela ebhetele yokuchaza ukuba umhlaza uza kuziphatha njani kwaye uphendule njani kunyango.

• Iqela leBakala 1: Amanqaku eGleason 6 okanye asezantsi (umhlaza webanga eliphantsi)
• Iqela leBakala 2: Amanqaku eGleason 3 + 4 = 7 (umhlaza okumgangatho ophakathi)
• Iqela leBakala 3: Amanqaku eGleason 4 + 3 = 7 (umhlaza webanga eliphakathi)
• Iqela leBakala 4: Amanqaku eGleason 8 (umhlaza webanga eliphezulu)
• Iqela leBakala 5: Amanqaku eGleason 9 ukuya kwi-10 (umhlaza webanga eliphezulu)

Iqela elisezantsi libonisa ithuba elingcono lonyango olunempumelelo kuneqela eliphezulu. Iqela eliphezulu lithetha ukuba uninzi lweeseli zomhlaza zibonakala zahlukile kwiiseli eziqhelekileyo. Iqela eliphezulu likwathetha ukuba kunokwenzeka ukuba eli thumba lisasazeke ngamandla.

Ukubekwa kwinqanaba kukunceda wena nogqirha wakho ukuba ukhethe iindlela zonyango onokuthi uzikhethe, kunye:

• Inqanaba lomhlaza, elibonisa ukuba umhlaza usasazeke kangakanani
• Iziphumo zovavanyo lwePSA
• Impilo yakho iyonke
• Umnqweno wakho wotyando, imitha, okanye amayeza e-hormone, okanye akukho nyango kwaphela

Umhlaza wedlala lesinyi - Gleason; Iadenocarcinoma prostate - Gleason; Ibanga leGleason; Amanqaku kaGleason; Iqela leGleason; Umhlaza webala lobudoda - iqela leBanga lesi-5

I-Bostwick DG, i-Cheng L. Neoplasms yeprostate. Ku: Cheng L, MacLennan GT, Bostwick DG, ii-eds. I-Urology yokuNyanga iPathology. Ngomhla we-4. IPhiladelphia, PA: Elsevier; 2020: isahl 9.

U-Epstein JI. I-Pathology ye-Prostatic neoplasia.Ku: UPartin AW, uDmochowski RR, uKavoussi LR, uPeter CA, ii-eds. ICampbell-Walsh-Wein Urology. Umhla we-12. IPhiladelphia, PA: Elsevier; 2021: isahl. 151.

Kwiwebhusayithi yeZiko loMhlaza weSizwe. Unyango lweprostate lomhlaza (PDQ) -uhlobo lobungcali kwezempilo. www.cancer.gov/types/prostate/hp/prostate- unyango-pdq#_2097_toc. Ukuhlaziywa ngoJulayi 22, 2020. Ifikeleleke ngo-Agasti 10, 2020.

• Umhlaza wedlala lobudoda