Autosomal ephezulu

I-Autosomal ephezulu yenye yeendlela ezininzi apho uphawu okanye ukuphazamiseka kungadluliselwa kwiintsapho.

Kwisifo esine-autosomal esilawulayo, ukuba ufumana isifo esingaqhelekanga kumzali omnye kuphela, unokufumana isifo. Rhoqo, omnye wabazali usenokuba nesi sifo.

Ukufumana ilifa lesifo, imeko, okanye uphawu luxhomekeke kuhlobo lwechromosome echaphazelekayo (i-nonsex okanye i-chromosome yesini). Kuyaxhomekeka ekubeni uphawu lubalulekile okanye luluhle kakhulu.

Uhlobo olunye olungaqhelekanga kwinto yokuqala yama-22 nonsex (i-autosomal) chromosomes evela komnye umzali inokubangela isifo se-autosomal.

Ilifa elongamileyo lithetha ukuba ufuzo olungaqhelekanga oluvela kumzali omnye kunokubangela isifo. Oku kuyenzeka nokuba udidi oluhambelana nomnye umzali luqhelekile. Uhlobo olungaqhelekanga lilawula.

Esi sifo sinokubakho njengemeko entsha emntwaneni xa kungekho mzali une-gene engaqhelekanga.

Umzali onemeko ebalaseleyo ye-autosomal unethuba lama-50% lokuba nomntwana onale meko. Oku kuyinyani ukukhulelwa ngakunye.

Kuthetha ukuba umngcipheko womntwana ngamnye kwesi sifo awuxhomekekanga ekubeni umntakwabo unesi sifo.

Abantwana abangazuzi njengelifa ufuzo olungaqhelekanga abayi kukhula okanye basigqithise esi sifo.

Ukuba umntu ufunyenwe enesifo esihamba phambili kwi-autosomal, abazali babo kufuneka bavavanywe nofuzo olungaqhelekanga.

Imizekelo yokuphazamiseka okuphezulu kwe-autosomal ibandakanya iMarfan syndrome kunye nohlobo lwe-neurofibromatosis 1.

Ilifa - i-autosomal ephezulu; I-Genetics - i-autosomal ephezulu

• Uhlobo lwendalo oluphezulu kakhulu

INussbaum RL, iMcInnes RR, uWillard HF. Iipateni zelifa elinye lohlobo. Ku: Nussbaum RL, McInnes RR, Willard HF, ii-eds. Thompson & Thompson Genetics kwiyeza. Ngomhla we-8. IPhiladelphia, PA: Elsevier; 2016: isahluko 7.

UScott DA, uLee B. Iipatheni zosasazo lwemfuzo. Ku: Kliegman RM, St Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, ii-eds. Incwadi kaNelson yeNcwadi yePediatrics. I-21 ed .. iPhiladelphia, PA: Elsevier; 2020: isahl. 97.