Ukunyanga

I-virilization yimeko apho umntu obhinqileyo ekhulisa khona iimpawu ezinxulunyaniswa neehomoni zesilisa (i-androgens), okanye xa usana olusandul 'ukuzalwa luneempawu zokuvezwa kwehomoni eyindoda xa izalwa.

Intsholongwane inokubangelwa ngu:

• Ukuveliswa kwe testosterone
• Ukusetyenziswa kwe-anabolic steroids (ukuphucula ukusebenza) okanye ukunxulumana nokwabiwa kwesini kwakhona)

Kumakhwenkwe okanye amantombazana asandul 'ukuzalwa, imeko inokubangelwa:

• Amayeza athile athathwe ngumama ngexa lokukhulelwa
• I-hyperplasia ye-adrenal ye-congenital kusana okanye kunina
• Ezinye iimeko zonyango kumama (njengamathumba ama-ovari okanye i-adrenal gland ekhupha iihomoni zesilisa)

Kumantombazana ahamba ngexesha lokufikisa, imeko inokubangelwa:

• Isifo sePolycystic ovary
• Amayeza athile, okanye ii-anabolic steroids
• I-hyperplasia yokuzalwa ye-adrenal
• Izidumbu zama-ovari, okanye i-adrenal gland ekhupha iihomoni zesilisa (androgens)

Kwabasetyhini abadala, imeko inokubangelwa:

• Amayeza athile, okanye ii-anabolic steroids
• Ukudumba kwama-ovari okanye amadlala eadrenal akhupha iihomoni zesilisa

Iimpawu zokuphucula imeko yabasetyhini zihlala zixhomekeke kwinqanaba le testosterone emzimbeni.

Inqanaba eliphantsi (eliqhelekileyo):

• Izinwele ezijiyileyo, ezimnyama ebusweni kwiindevu okanye kumadevu
• Ukwanda kweenwele zomzimba
• Ulusu olunamafutha okanye amabala
• Amaxesha okuya exesheni ngokungaqhelekanga

Inqanaba eliphakathi (engaqhelekanga):

• Impandla yomntu
• Ukuphulukana nokuhanjiswa kwamafutha ababhinqileyo
• Ukunciphisa ubungakanani besifuba

Inqanaba eliphezulu (kunqabile):

• Ukwandiswa kwe-clitoris
• Ukujula kwelizwi
• Ipateni yemisipha yamadoda

Uvavanyo lunokubandakanya:

• Uvavanyo lwegazi ukufumana i-testosterone egqithileyo kubantu basetyhini
• Ukuskena i-CT, iMRI, okanye i-ultrasound ukulawula amathumba ama-ovari kunye namadlala eadrenal

Ukuba i-virilization ibangelwa kukuvezwa kwe-androgens (iihomoni zesilisa) kubantu abadala ababhinqileyo, uninzi lweempawu luyaphela xa iihomoni zimisiwe. Nangona kunjalo, ukujula kwelizwi sisiphumo esisigxina sokuvezwa kwe-androgens.

• Imveliso yehypothalamus hormone

UGooren LJ. I-endocrinology yokuziphatha ngokwesondo kunye nokuzazisa ngokwesini. Ku: Jameson JL, De Groot LJ, de Kretser DM, et al, ii-eds. Endocrinology: Abantu abadala kunye nabantwana. Umhla wesi-7. IPhiladelphia, PA: Elsevier Saunders; I-2016: isahluko 124.

I-Styne DM, iGrumbach MM. I-Physiology kunye nokuphazamiseka kokufikisa. Ku: Melmed S, Polonsky KS, Larsen PR, Kronenberg HM, ii-eds. Incwadi ebhaliweyo kaWilliam ye-Endocrinology. Umhla we-13. IPhiladelphia, PA: Elsevier; 2016: isahluko 25.