C1 esterase inhibitor

I-C1 esterase inhibitor (C1-INH) yiprotein efumaneka kwinxalenye yegazi lakho. Ilawula iprotein ebizwa ngokuba yi-C1, eyinxalenye yenkqubo yokuncedisa.

Inkqubo yokuncoma liqela leeprotein eziphantse zibe ngama-60 kwi-plasma yegazi okanye kumphezulu weeseli ezithile. Iiproteni ezizalisayo zisebenza kunye namajoni akho omzimba ukukhusela umzimba kwizifo. Ziyanceda nokususa iiseli ezifileyo kunye nezinto zangaphandle. Zilithoba iiprotheyini zokuncedisa. Babhalwe i-C1 nge-C9. Rhoqo, abantu banokufumana ilifa lokusilela kwezinye iiprotein ezincedisayo. Aba bantu bathambekele kusulelo oluthile okanye ukuphazamiseka komzimba.

Eli nqaku lixoxa ngovavanyo olwenziwe ukulinganisa isixa se-C1-INH egazini lakho.

Isampulu yegazi iyafuneka. Oku kuhlala kuthathwa ngemithambo. Inkqubo ibizwa ngokuba yi-venipuncture.

Akukho lungiselelo lukhethekileyo luyafuneka.

Xa kufakwa inaliti ukutsala igazi, abanye abantu baziva iintlungu eziphakathi. Abanye banokuziva ngathi batyhafile okanye batyhafile. Emva koko, kunokubakho ukuthotywa okuthile.

Unokulufuna olu vavanyo ukuba uneempawu zelifa okanye ufumene i-angioedema. Zombini ezi ntlobo ze-angioedema zibangelwa ngamanqanaba asezantsi e-C1-INH.

Izinto zokugcwalisa nazo zinokubaluleka kuvavanyo lwezifo ezisebenza gwenxa, ezinje nge-lupus erythematosus.

Amaxabiso esiqhelo ahluka kancinci phakathi kweelebhu ezahlukeneyo. Umboneleli wakho wezempilo uya kulinganisa inqanaba lomsebenzi we-C1 esterase inhibitor yakho. Thetha nomboneleli wakho malunga nentsingiselo yeziphumo zakho zovavanyo.

Amanqanaba asezantsi e-C1-INH anokubangela iintlobo ezithile ze-angioedema. I-Angioedema ibangela ukudumba ngokukhawuleza kwezihlunu zobuso, umqala ophezulu nolwimi. Inokubangela nobunzima bokuphefumla. Ukudumba emathunjini nakwiintlungu zesisu nako kunokwenzeka. Zimbini iintlobo ze-angioedema ezibangelwa kukuhla kwamanqanaba e-C1-INH. I-angioedema yelifa ichaphazela abantwana kunye nabantu abadala abangaphantsi kweminyaka engama-20. I-angioedema efumanekayo ibonakala kubantu abadala abadala kuneminyaka engama-40. Abantu abadala abane-angioedema efunyenweyo banamathuba okuba babe nezinye iimeko ezinje ngomhlaza okanye isifo se-autoimmune.

Iingozi ezinxulunyaniswa nokutsalwa kwegazi zincinci, kodwa zinokubandakanya:

• Ukopha kakhulu
• Ukufa isiqaqa okanye ukuziva ungenantloko
• I-Hematoma (igazi eliqokelela phantsi kwesikhumba)
• Usulelo (umngcipheko omncinci nangaliphi na ixesha ulusu lwaphukile)

I-C1 yokuthintela into; I-C1-INH

• Uvavanyo lwegazi

UCicardi M, Aberer W, Banerji A, et al. Isiseko Ukwahlulahlula, ukuxilonga, kunye nendlela yonyango lwe-angioedema: ingxelo yemvumelwano evela kwiQela lokuSebenza leLizwe le-Angioedema. Unyango. Ngo-2014; 69 (5): 602-616. IINKCUKACHA: 24673465 www.ncbi.nlm.nih.gov/pubmed/24673465.

I-Leslie TA, i-Greaves MW. I-angioedema yelifa. Ku: Lebwohl MG, Heymann WR, Berth-Jones J, Coulson IH, ii-eds. Unyango lwezifo zolusu: Amacandelo oBuchule oNyango. Umhla we-5. IPhiladelphia, PA: Elsevier; 2018: isahl. 101.

UZanichelli A, Azin GM, Wu MA, et al. Ukuchongwa, ikhosi, kunye nolawulo lwe-angioedema kwizigulana ezinesiphene se-C1-inhibitor. J Ikliniki ye-Allergy Pract Immun. Ngo-2017; 5 (5): 1307-1313. IINKCUKACHA: 28284781 www.ncbi.nlm.nih.gov/pubmed/28284781.