Uvavanyo lwe-anti-insulin antibody

Uvavanyo lwe-anti-insulin antibody luhlola ukubona ukuba umzimba wakho uvelise izilwa-buhlungu ezichasene ne-insulin.

Ii-antibodies ziiprotein eziveliswa ngumzimba ukuzikhusela xa zibhaqa nantoni na "yangaphandle," enjengentsholongwane okanye ilungu elifakelweyo.

Isampulu yegazi iyafuneka.

Akukho lungiselelo lukhethekileyo luyafuneka.

Xa kufakwa inaliti ukutsala igazi, abanye abantu baziva iintlungu eziphakathi. Abanye baziva behlaba okanye behlaba kuphela. Emva koko, kunokubakho ukubetha okanye ukukrala kancinci. Oku kuya kuhamba kungekudala.

Olu vavanyo lunokwenziwa ukuba:

• Unobungozi okanye usengozini yohlobo lweswekile 1.
• Kubonakala ngathi unempendulo ye-insulin.
• I-insulin ayisabonakali ukulawula isifo seswekile.
• Uthatha i-insulin ukulawula isifo sakho seswekile kwaye inqanaba leswekile esegazini lakho lahluka kakhulu, ngamanani aphezulu kunye asezantsi angenakuchazwa kukutya okutyayo xa kuthelekiswa nexesha lokufakwa kwenaliti ye-insulin.

Ngokwesiqhelo, akukho zintsholongwane ngokuchasene ne-insulin egazini lakho. Ama-antibodies anokufumaneka egazini labantu abaninzi abathatha i-insulin ukulawula isifo seswekile.

Amaxabiso esiqhelo ahluka kancinci phakathi kweelebhu ezahlukeneyo. Ezinye iilebhu zisebenzisa imilinganiselo eyahlukeneyo okanye ukuvavanya iisampulu ezahlukeneyo. Thetha nomboneleli wakho wezempilo malunga nentsingiselo yeziphumo zakho zovavanyo.

Ukuba uneentsholongwane ze-IgG kunye ne-IgM ngokuchasene ne-insulin, umzimba wakho uphendula ngokungathi i-insulin emzimbeni wakho yiprotein yelinye ilizwe efuna ukususwa. Esi siphumo sinokuba yinxalenye yovavanyo oluchonga ukuba une-autoimmune okanye uthayiphe isifo seswekile se-1.

Ukuba unesifo seswekile kwaye uvelisa ii-anti-insulin antibodies, oku kunokwenza ukuba i-insulin ingasebenzi kakuhle, okanye ingasebenzi kwaphela.

Kungenxa yokuba i-antibody ithintela i-insulin ekusebenzeni ngendlela eyiyo kwiiseli zakho. Ngenxa yoko, iswekile yegazi lakho inokuphakama ngokungaqhelekanga. Abantu abaninzi abathatha i-insulin ukunyanga isifo seswekile banee-antibodies. Nangona kunjalo, ezi ntsholongwane azibangeli zimpawu okanye zitshintshe ukusebenza kwe-insulin.

Amachiza omzimba anokukhulisa isiphumo se-insulin ngokukhupha i-insulin ixesha elide emva kokuba kufakwe ukutya kwakho. Oku kunokukubeka emngciphekweni weswekile esezantsi yegazi.

Ukuba uvavanyo lubonisa inqanaba eliphezulu le-IgE antibody ngokuchasene ne-insulin, umzimba wakho uvelise impendulo yokungavumi kwi-insulin. Oku kunokukubeka emngciphekweni wokuphendula kolusu apho utofa khona i-insulin. Unako kwakhona ukuphendula iimpendulo ezimandundu ngakumbi ezichaphazela uxinzelelo lwegazi okanye ukuphefumla.

Amanye amayeza, anje ngee-antihistamines okanye i-dose yedosi ephantsi enesitofu, anokunceda ukunciphisa impendulo. Ukuba iimpendulo bezinzima, unokufuna inkqubo yonyango ekuthiwa yi-desensitization okanye olunye unyango lokususa izilwa-buhlungu egazini lakho.

Akukho mngcipheko ubandakanyekileyo ekuthatheni igazi lakho. Imithambo kunye nemithambo iyahluka ngobukhulu ukusuka komnye umntu ukuya komnye nakwelinye icala lomzimba liye kwelinye. Ukufumana isampulu yegazi kwabanye abantu kunokuba nzima ngakumbi kunabanye.

Eminye imingcipheko yokutsalwa kwegazi incinci, kodwa inokubandakanya:

• Ukopha kakhulu
• Ukufa isiqaqa okanye ukuziva ungenantloko
• Ukugqobhoza okuninzi ukufumana imithambo
• I-Hematoma (ukwakha igazi phantsi kolusu)
• Usulelo (umngcipheko omncinci nangaliphi na ixesha ulusu lwaphukile)

Iintsholongwane ze-insulin - i-serum; Uvavanyo lwe-insulin Ab; Ukuxhathisa kwe-insulin - ii-antibodies ze-insulin; Seswekile - omzimba insulin

• Uvavanyo lwegazi

UAtkinson MA, uMcgill DE, uDassau E, uLaffel L. Uhlobo lwe-1 yeswekile. Ku: UMelmed S, uAuchus RJ, uGoldfine AB, uKoenig RJ, uRosen CJ, ii-eds. Incwadi ebhaliweyo kaWilliam ye-Endocrinology. Umhla we-14. IPhiladelphia, PA: Elsevier; 2020: isahluko 36.

IChernecky CC, iBerger BJ. I-insulin kunye ne-insulin antibodies - igazi. Ku: IChernecky CC, iBerger BJ, ii-eds. Iimvavanyo zaselebhu kunye neenkqubo zokuqonda isifo. Umhla wesi-6. IPhiladelphia, PA: Elsevier Saunders; Ngo-2013: 682-684.