Uvavanyo lwe-CPK isoenzymes

I-creatine phosphokinase (CPK) isoenzymes yovavanyo lokulinganisa iindlela ezahlukeneyo ze-CPK egazini. I-CPK yi-enzyme efumaneka ikakhulu entliziyweni, kwingqondo nakwisipha samathambo.

Isampulu yegazi iyafuneka. Oku kungathathwa kumthambo. Uvavanyo lubizwa ngokuba yi-venipuncture.

Ukuba usesibhedlele, olu vavanyo lunokuphindwa kwiintsuku ezi-2 okanye ezi-3. Ukunyuka okuphawulekayo okanye ukuhla kwi-isoenzymes epheleleyo ye-CPK okanye ye-CPK inokunceda umboneleli wakho wezempilo ukuba afumane imeko ezithile.

Akukho lungiselelo lukhethekileyo luyafuneka kwiimeko ezininzi.

Xelela umboneleli wakho ngawo onke amayeza owasebenzisayo. Amanye amachiza anokuphazamisa iziphumo zovavanyo. Iziyobisi ezinokunyusa imilinganiselo ye-CPK zibandakanya oku kulandelayo:

• Utywala
• Amphotericin B
• Ezinye iintlungu
• Cocaine
• Ukuhambisa iziyobisi
• Iingxelo
• IiSteroids, ezinjenge-dexamethasone

Olu luhlu alubandakanyi konke.

Unokuva iintlungu kancinci xa kufakwa inaliti ukutsala igazi. Abanye abantu baziva ngathi batyhafile okanye batyhafile. Emva koko, kunokubakho ukuthotywa okuthile.

Olu vavanyo lwenziwa ukuba uvavanyo lwe-CPK lubonisa ukuba inqanaba elipheleleyo le-CPK liphakanyisiwe. Uvavanyo lwe-CPK isoenzyme lunokunceda ekufumaneni owona mthombo wezicubu ezonakeleyo.

I-CPK yenziwe ngezinto ezintathu ezahlukeneyo:

• I-CPK-1 (ekwabizwa ngokuba yi-CPK-BB) ifumaneka ikakhulu kwingqondo nasemiphungeni
• I-CPK-2 (ekwabizwa ngokuba yi-CPK-MB) ifumaneka ikakhulu entliziyweni
• I-CPK-3 (ekwabizwa ngokuba yi-CPK-MM) ifunyanwa ikakhulu kwisisipha samathambo

Amanqanaba aphezulu kune-CPK-1 aqhelekileyo:

Ngenxa yokuba i-CPK-1 ifumaneka ikakhulu kwingqondo nasemiphungeni, ukwenzakala kwezi ndawo kunganyusa amanqanaba e-CPK-1. Ukunyuswa kwamanqanaba e-CPK-1 kunokubangelwa:

• Umhlaza wobuchopho
• Ukulimala kwengqondo (ngenxa yalo naluphi na uhlobo lokulimala kubandakanya, ukubetha, okanye ukopha kwingqondo)
• Unyango lwe-Electroconvulsive
• Isifo sepulmonary infarction
• Ukuhlutha

Amanqanaba aphezulu kune-CPK-2 aqhelekileyo:

Amanqanaba e-CPK-2 anyuka i-3 ukuya kwiiyure ze-6 emva kokuhlaselwa sisifo sentliziyo. Ukuba akukho monakalo wumbi wemisipha yentliziyo, inqanaba linyuka ngeeyure ezili-12 ukuya kwezi-24 kwaye libuyele kwesiqhelo emva kweeyure ezili-12 ukuya kweziyi-48 emva kokubhubha kwezicubu.

Ukunyuswa kwamanqanaba e-CPK-2 kusenokwenzeka ukuba:

• Ukulimala kombane
• Intsingiselo yentliziyo (eyothusayo ngenjongo yentliziyo ngabasebenzi bezonyango)
• Ukulimala kwentliziyo (umzekelo, kwingozi yemoto)
• Ukudumba kwentliziyo yemisipha ngesiqhelo ngenxa yentsholongwane (myocarditis)
• Utyando lwentliziyo oluvulekileyo

Amanqanaba aphezulu kune-CPK-3 aqhelekileyo ahlala eluphawu lokonzakala kwemisipha okanye uxinzelelo lwemisipha. Zingakho ngenxa:

• Ukulimala
• Ukulimala kwemisipha ngenxa yeziyobisi okanye ukungahambi ixesha elide (rhabdomyolysis)
• Isihlunu semisipha
• I-Myositis (ukuvuvukala kwemisipha)
• Ukufumana inaliti ezininzi zangaphakathi
• Uvavanyo lwamva nje kunye nokusebenza kwemisipha (i-electromyography)
• Uhlaselo lwamva nje
• Utyando lwamva nje
• Ukuzilolonga kakhulu

Izinto ezinokuchaphazela iziphumo zovavanyo zibandakanya i-catheterization yentliziyo, inaliti ye-intramuscular, utyando lwamva nje, kunye nokuzilolonga okunamandla kunye nexesha elide okanye ukungasebenzi.

Uvavanyo lwe-Isoenzyme lweemeko ezithile lumalunga ne-90% ichanekile.

Ukudala i-phosphokinase - isoenzymes; Yenza i-kinase-isoenzymes; CK - isoenzymes; Ukuhlaselwa yintliziyo - CPK; Ukutyunyuzwa-CPK

• Uvavanyo lwegazi

UAnderson JL. Icandelo lokuphakama kwinqanaba eliphakamileyo le-myocardial infarction kunye neengxaki ze-myocardial infarction. Ku: IGoldman L, iSchafer AI, ii-eds. Amayeza eGoldman-Cecil. Umhla wama-25. IPhiladelphia, PA: Elsevier Saunders; Ngo-2016: isahluko 73.

UMarshall WJ, uSuku A, uLapsley M.Iiproteni zePlasma kunye nee-enzymes. Ku: UMarshall WJ, uSuku A, uLapsley M, ii-eds. Ikhemistry yezonyango. Ngomhla we-8. IPhiladelphia, PA: Elsevier; I-2017: isahluko 16.

INagaraju K, Gladue HS, iLundberg IE. Izifo ezivuthayo zemisipha kunye nezinye i-myopathies. Ku: Firestein GS, Budd RC, Gabriel SE, McInnes IB, O'Dell JR, ii-eds. Incwadi kaKelley kunye neFirestein yeRheumatology. Ngomhla we-10. IPhiladelphia, PA: Elsevier Saunders; Ngo-2017: isahluko 85.

USelcen D. Izifo zemisipha. Ku: IGoldman L, iSchafer AI, ii-eds. Amayeza eGoldman-Cecil. Umhla wama-25. IPhiladelphia, PA: Elsevier Saunders; Ngo-2016: isahluko 421.