HLA-B27 antigen

I-HLA-B27 luvavanyo lwegazi ukukhangela iprotheni efumaneka kumphezulu weeseli ezimhlophe zegazi. Iprotein ibizwa ngokuba yi-leukocyte yabantu i-antigen B27 (HLA-B27).

Ii-antigen ze-leukocyte yabantu (HLAs) ziiproteni ezinceda amajoni omzimba axelele umahluko phakathi kweeseli zawo nezinto zangaphandle, eziyingozi. Zenziwe ngemiyalelo yemfuza.

Isampulu yegazi iyafuneka. Uninzi lwexesha, igazi litsalwa kumthambo ngaphakathi kwengqiniba okanye ngasemva kwesandla.

Kwiimeko ezininzi, akukho manyathelo akhethekileyo afunekayo ukulungiselela uvavanyo.

Xa inaliti ifakwa ukutsala igazi, unokuziva iintlungu eziphakathi, okanye ukubetha okanye ukuhlaba. Emva koko, kunokubakho ukuthotywa okuthile.

Umboneleli wakho wezempilo unokuyalela olu vavanyo ukunceda ukumisela unobangela weentlungu ezidibeneyo, ukuqina, okanye ukudumba. Uvavanyo lunokwenziwa kunye nolunye uvavanyo, kubandakanya:

• Iprotheyini esebenzayo yeC
• Izinga le-sedimentation ye-Erythrocyte (ESR)
• Into yeRheumatoid
• X-reyi

Uvavanyo lwe-HLA lukwasetyenziselwa ukutshatisa izicwili ezinikelweyo kunye nethishu lomntu ofumana ukufakelwa komzimba. Umzekelo, inokwenziwa xa umntu efuna ukufakelwa izintso okanye ukufakelwa umongo wethambo.

Iziphumo eziqhelekileyo (ezingalunganga) zithetha ukuba i-HLA-B27 ayikho.

Uvavanyo oluqinisekileyo luthetha ukuba i-HLA-B27 ikho. Icebisa umngcipheko ongaphezulu komndilili wokuphuhlisa okanye ukuphazamiseka okuthile okuzenzekelayo. Ukuphazamiseka komzimba yimeko eyenzekayo xa amajoni omzimba ehlasela ngempazamo kwaye etshabalalisa izicwili zomzimba ezisempilweni.

Iziphumo ezintle zinokunceda umboneleli wakho ukuba enze uxilongo lwendlela yesifo samathambo ebizwa ngokuba sispondyloarthritis. Olu hlobo lwe-arthritis lubandakanya ezi ngxaki zilandelayo:

• I-Ankylosing spondylitis
• Isifo samathambo esihambelana nesifo sikaCrohn okanye isifo sezilonda
• I-Psoriatic arthritis (isifo samathambo esidityaniswa ne-psoriasis)
• Isifo samathambo esisebenzayo
• Sacroiliitis (ukudumba kwenxalenye ye-sacroiliac)
• Uveitis

Ukuba uneempawu okanye iimpawu zespondyloarthritis, uvavanyo oluqinisekileyo lwe-HLA-B27 lunokunceda ukuqinisekisa isifo. Nangona kunjalo, i-HLA-B27 ifunyanwa kubantu abaqhelekileyo kwaye ayisoloko ithetha ukuba unesifo.

Iingozi zokutsalwa kwegazi zincinci, kodwa zinokubandakanya:

• Ukopha kakhulu
• Ukufa isiqaqa okanye ukuziva ungenantloko
• I-Hematoma (igazi eliqokelela phantsi kwesikhumba)
• Usulelo (umngcipheko omncinci nangaliphi na ixesha ulusu lwaphukile)

I-antigen leukocyte antigen B27; I-Ankylosing spondylitis-HLA; I-Psoriatic arthritis-HLA; Isifo samathambo esisebenzayo-HLA

• Uvavanyo lwegazi

IChernecky CC, iBerger BJ. Leukocyte Antigen (HLA) B-27 - igazi. Ku: IChernecky CC, iBerger BJ, ii-eds. Iimvavanyo zaselebhu kunye neenkqubo zokuqonda isifo. Umhla wesi-6. ISt Louis, MO: Elsevier Saunders; Ngo-2013: 654-655.

Fagoaga OKANYE. I-antigen ye-leukocyte yabantu: eyona nto inzima kakhulu kukungalingani komntu. Ku: McPherson RA, Pincus MR, ii-eds. Ukuchongwa kweKlinikhi kaHenry kunye noLawulo ngeendlela zeLebhu. Umhla we-23. ISt Louis, MO: Elsevier; Ngo-2017: isahluko 49.

Inman RD. I-spondyloarthropathies. Ku: IGoldman L, iSchafer AI, ii-eds. Amayeza eGoldman-Cecil. Umhla wama-25. IPhiladelphia, PA: Elsevier Saunders; 2016: isahluko 265.

IMcPherson RA, iMassey HD. Amagqabantshintshi omzimba kunye nokuphazamiseka komzimba. Ku: McPherson RA, Pincus MR, ii-eds. Ukuchongwa kweKlinikhi kaHenry kunye noLawulo ngeendlela zeLebhu. Umhla we-23. ISt Louis, MO: Elsevier; Ngo-2017: isahluko 43.

Utyhile uJD. I-Spondyloarthritis. Ku: Rich RR, Fleisher TA, Shearer WT, Schroeder HW, Ambalwa AJ, Weyand CM, ii-eds. I-Clinical Immunology: Imigaqo kunye nokuziqhelanisa. Umhla we-5. IPhiladelphia, PA: Elsevier; I-2019: isahluko 57.