Uvavanyo lweGlucose-6-phosphate dehydrogenase

I-Glucose-6-phosphate dehydrogenase (G6PD) yiprotein enceda iiseli ezibomvu zegazi zisebenze ngokufanelekileyo. Uvavanyo lwe-G6PD lujonga isixa (umsebenzi) wale nto kwiiseli ezibomvu zegazi.

Isampulu yegazi iyafuneka.

Akukho lungiselelo lukhethekileyo ludla ngokufuneka.

Xa kufakwa inaliti ukutsala igazi, abanye abantu baziva iintlungu eziphakathi. Abanye baziva behlaba okanye behlaba kuphela. Emva koko, kunokubakho ukubetha okanye ukukrala kancinci. Oku kuya kuhamba kungekudala.

Umboneleli wakho wokhathalelo lwempilo unokucebisa olu vavanyo ukuba uneempawu zokusilela kwe-G6PD. Oku kuthetha ukuba awunayo imisebenzi eyaneleyo ye-G6PD.

Umsebenzi omncinci we-G6PD ukhokelela ekutshatyalalisweni kweeseli ezibomvu zegazi. Le nkqubo ibizwa ngokuba yi-hemolysis. Xa le nkqubo isenzeka, ibizwa ngokuba sisiqwengana sehemolytic.

Iziqendu zeHemolytic zinokubangelwa zizifo, ukutya okuthile (okunjengeembotyi ze-fava), kunye namayeza athile, kubandakanya:

• Iziyobisi ezisetyenziselwa ukunciphisa umkhuhlane
• INitrofurantoin
• Iphenacetin
• Intshayelelo
• Isulfonamides
• I-Thiazide yomchamo
• ITolbutamide
• Iquinidine

Iimpawu eziqhelekileyo ziyahluka kwaye zixhomekeke kwilabhoratri esetyenzisiweyo. Ezinye iilebhu zisebenzisa imilinganiselo eyahlukeneyo okanye ukuvavanya iisampulu ezahlukeneyo. Thetha nomboneleli wakho malunga nentsingiselo yeziphumo zakho zovavanyo.

Iziphumo ezingaqhelekanga zithetha ukuba unengxaki ye-G6PD. Oku kunokubangela i-hemolytic anemia kwiimeko ezithile.

Akukho mngcipheko ubandakanyekileyo ekuthatheni igazi lakho. Imithambo kunye nemithambo iyahluka ngobukhulu ukusuka komnye umntu ukuya komnye nakwelinye icala lomzimba liye kwelinye. Ukufumana isampulu yegazi kwabanye abantu kunokuba nzima ngakumbi kunabanye.

Eminye imingcipheko enxulumene nokutsalwa kwegazi incinci, kodwa inokubandakanya:

• Ukopha kakhulu
• Ukufa isiqaqa okanye ukuziva ungenantloko
• Ukugqobhoza okuninzi ukufumana imithambo
• I-Hematoma (igazi elakhiweyo phantsi kolusu)
• Usulelo (umngcipheko omncinci nangaliphi na ixesha ulusu lwaphukile)

Uvavanyo lwe-RBC G6PD; Isikrini seG6PD

IChernecky CC, iBerger BJ. Iswekile yegazi-6-phosphate dehydrogenase (G6PD, G-6-PD), ubungakanani-begazi. Ku: IChernecky CC, iBerger BJ, ii-eds. Iimvavanyo zaselebhu kunye neenkqubo zokuqonda isifo. Umhla wesi-6. ISt Louis, MO: Elsevier Saunders; Ngo-2013: 594-595.

IGallagher PG. I-hemolytic anemias: inwebu ebomvu yegazi kunye neziphene kwimetabolism. Ku: IGoldman L, iSchafer AI, ii-eds. Amayeza eGoldman-Cecil. Ngomhla wama-26. IPhiladelphia, PA: Elsevier; 2020: isahluko152.