Neutropenia - iintsana

I-Neutropenia linani elisezantsi ngokungaqhelekanga leeseli ezimhlophe zegazi. Ezi seli zibizwa ngokuba zii-neutrophils. Zinceda umzimba ukulwa usulelo. Eli nqaku lixoxa nge-neutropenia kwiintsana.

Iiseli ezimhlophe zegazi ziveliswa kumongo wethambo. Ziyakhululwa ziye egazini kwaye zihamba naphi na apho zifuneka khona. Amanqanaba asezantsi ee-neutrophil ayenzeka xa umongo wethambo ungenakukwazi ukuwutshintsha ngokukhawuleza njengoko kufuneka.

Kwiintsana, esona sizathu siqhelekileyo sisifo. Usulelo olubi kakhulu lunokubangela ukuba i-neutrophils isetyenziswe ngokukhawuleza. Inokuthintela umongo wethambo ekuveliseni ii-neutrophils ezingakumbi.

Ngamanye amaxesha, umntwana ongaguliyo uya kuba nenani eliphantsi le-neutrophil ngaphandle kwesizathu. Ezinye iingxaki kumama okhulelweyo, ezinje nge-preeclampsia, zinokukhokelela kwi-neutropenia kwiintsana.

Kwiimeko ezinqabileyo, oomama banokuba ne-antibodies ngokuchasene ne-neutrophils yosana lwabo. Ezi antibodies zinqumla i-placenta ngaphambi kokuzalwa kwaye zibangele ukuba iiseli zomntwana ziqhekeze (alloimmune neutropenia). Kwezinye iimeko ezinqabileyo, ingxaki yomongo wethambo lomntwana inokukhokelela ekunciphiseni imveliso yeeseli ezimhlophe.

Isampuli encinci yegazi lomntwana iya kuthunyelwa elabhoratri ngenani elipheleleyo legazi (CBC) kunye nokwahluka kwegazi. I-CBC ityhila inani nohlobo lweeseli ezisegazini. Umahluko unceda ukumisela inani leentlobo ezahlukeneyo zeeseli ezimhlophe zegazi kwisampulu yegazi.

Umthombo walo naluphi na usulelo kufuneka ufunyanwe kwaye unyangwe.

Kwiimeko ezininzi, i-neutropenia ihamba yodwa njengoko umongo wethambo uphinde uphinde uqalise ukuvelisa iiseli ezimhlophe zegazi ezaneleyo.

Kwiimeko ezinqabileyo xa inani le-neutrophil liphantsi ngokwaneleyo ukuba lisongele ubomi, unyango olulandelayo lunokucetyiswa:

• Amayeza okukhuthaza imveliso emhlophe yeeseli
• Ii-antibodies ezivela kwiisampulu zegazi (i-immune globulin efakwa ngaphakathi)

Ukujonga kosana kuxhomekeke kwisizathu se-neutropenia. Ezinye izifo kunye nezinye iimeko kwiintsana zingasongela ubomi. Nangona kunjalo, uninzi losulelo alubangeli iziphumo ebezingalindelekanga zexesha elide emva kokuba i-neutropenia ihambile okanye inyangwa.

I-Alloimmune neutropenia iya kuphinda ibengcono xa ii-antibody zikamama ziphumile kwigazi lomntwana.

• Neutrophils

UBenjamin JT, uTorres BA, Maheshwari A. Neonatal leukocyte physiology kunye nokuphazamiseka. Ku: Gleason CA, Juul SE, ii-eds. Izifo zika-Avery Zomntwana osandul 'ukuzalwa. Ngomhla we-10. IPhiladelphia, PA: Elsevier; I-2018: isahluko 83.

I-Koenig JM, i-Bliss JM, iMariscalco MM. Ngesiqhelo kunye nokungaqhelekanga komzimba we-neutrophil kwimveku. Ku: Polin RA, Abman SH, Rowitch DH, Benitz WE, Fox WW, ii-eds. I-Physology yoSana kunye neNzalo. Umhla we-5. IPhiladelphia, PA: Elsevier; Ngo-2017: isahluko 126.

I-Letterio J, i-Ahuja S. iingxaki zeHematologic. Ku: UFanaroff AA, uFanaroff JM, ii-eds. UKlaus kunye noKhathalelo lukaFanaroff lweNgozi ephezulu yomngcipheko. Umhla wesi-7. ISt Louis, MO: Elsevier; 2020: isahluko 16.