IBosentan

Umxholo

• Ngaphambi kokuba uthathe i-bosentan,
• IBosentan inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ezi mpawu zilandelayo aziqhelekanga, kodwa ukuba ufumana enye yazo okanye ezo zidweliswe kwicandelo LESILumkiso ESIBALULEKILEYO, tsalela ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:
• Iimpawu libanda kungaquka oku kulandelayo:

Kwizigulana ezingamadoda nabasetyhini:

IBosentan inokubangela ukonakala kwesibindi. Xelela ugqirha wakho ukuba ukhe unesifo sesibindi. Ugqirha wakho uya kuyalela uvavanyo lwegazi ukuze aqiniseke ukuba isibindi sakho sisebenza ngesiqhelo phambi kokuba uqale ukuthatha i-bosentan kunye nenyanga nganye ngexesha lonyango lwakho. Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. IBosentan inokonakalisa isibindi ngaphambi kokubangela iimpawu. Ukuvavanywa kwegazi rhoqo kuphela kwendlela yokufumana ukonakala kwesibindi ngaphambi kokuba kusisigxina kwaye kube nzima. Ukuba unazo naziphi na kwezi mpawu zilandelayo, tsalela umnxeba kwangoko: isicaphucaphu, ukugabha, umkhuhlane, iintlungu zesisu, ubumthubi besikhumba okanye amehlo, okanye ukudinwa kakhulu. Ugqirha wakho angayinciphisa idosi, okanye ayeke unyango lwakho okwethutyana okanye ngokusisigxina ukuba uneziphumo ebezingalindelekanga okanye uneziphumo ezingaqhelekanga zebhu.

Kwabaguli ababhinqileyo:

Musa ukuthatha i-bosentan ukuba ukhulelwe okanye ucwangcise ukukhulelwa. IBosentan inokulimaza umbungu. Ukuba uyakwazi ukukhulelwa, kuyakufuneka uthathe uvavanyo lokukhulelwa ngaphambi kokuqala unyango, inyanga nenyanga ngexesha lonyango, kunye nenyanga e-1 emva konyango lwakho ukubonisa ukuba awukhulelwe. Ugqirha wakho uya kuku-odola iimvavanyo zokukhulelwa. Kuya kufuneka usebenzise indlela ethembekileyo yolawulo lokuzalwa ngexesha lonyango lwakho kunye nenyanga e-1 emva konyango lwakho. Izinto zokucwangcisa zeHormonal (iipilisi zolawulo lokuzalwa, iipatches, iiringi, ukudubula, ukufakelwa, kunye nezixhobo zangaphakathi) zinokungasebenzi kakuhle xa zisetyenziswa ne-bosentan kwaye akufuneki zisetyenziswe njengeyona ndlela yakho yolawulo lokuzalwa. Thetha nogqirha wakho malunga neendlela zokulawula ukuzalwa eziza kukusebenzela. Kwiimeko ezininzi kuya kufuneka usebenzise iindlela ezimbini zolawulo lokuzalwa.

Fowunela ugqirha wakho kwangoko ukuba ubelana ngesondo ngokungakhuselekanga, cinga ukuba ulawulo lwakho lokuzalwa aluphumelelanga, uphoswe lixesha okanye ucinga ukuba ungakhulelwa ngelixa uthatha i-bosentan. Musa ukulinda de kuqeshwe ixesha elizayo ukuze uxoxe ngale nto nogqirha wakho.

Ukuba ungumzali okanye umgcini wesigulana esingumfazi esingekafiki kwinqanaba lokufikisa, jonga umntwana wakho rhoqo ukuze abone ukuba ngaba ukhula na naziphi na iimpawu zokufikisa (amabele, amabele, kunye neenwele zasesidlangalaleni) kwaye wazise ugqirha wakhe ngalo naluphi na utshintsho.

Ngenxa yemingcipheko yokonakala kwesibindi kunye neziphene zokuzalwa, i-bosentan ifumaneka kuphela ngenkqubo ethintelweyo ebizwa ngokuba yiTracleer Risk Evaluation and Mitigation Strategy Programme (Tracleer REMS). Ukuze ufumane i-bosentan wena kunye nogqirha wakho kufuneka nibhaliswe kwi-Tracleer REMS, kwaye nilandele iimfuno zeenkqubo ezinje kanye ngenyanga ukusebenza kwesibindi kunye nokuvavanywa kokukhulelwa. Ugqirha wakho uya kukubhalisa kwinkqubo. IBosentan ifumaneka kuphela kwiikhemesti ezithile ezibhaliswe kwiTracleer REMS. Buza ugqirha wakho okanye usokhemesti ukuba unayo nayiphi na imibuzo malunga nendlela onokugcwalisa ngayo amayeza akho.

Uya kufumana iphepha lolwazi lomguli lomenzi (Isikhokelo seMithi) xa uqala unyango nge-bosentan kwaye ngalo lonke ixesha ugcwalisa amayeza. Funda ulwazi ngononophelo ngalo lonke ixesha kwaye ubuze ugqirha wakho okanye usokhemesti ukuba unayo nayiphi na imibuzo. Unokufumana nesikhokelo samayeza kwiwebhusayithi ye-FDA: http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm.

Thetha nogqirha wakho malunga nemingcipheko yokuthatha i-bosentan.

IBosentan isetyenziselwa ukunyanga uxinzelelo lwegazi kwimiphunga (PAH, uxinzelelo lwegazi oluphezulu kwimithambo ephethe igazi ukuya emiphungeni) kubantu abadala nakubantwana abaneminyaka emi-3 ubudala nangaphezulu. IBosentan inokuphucula ukubanakho ukuzilolonga kunye nokucotha ukwanda kweempawu kwizigulana ezine-PAH. IBosentan ikudidi lwamayeza abizwa ngokuba zi-endothelin receptor antagonists. Isebenza ngokumisa isenzo se-endothelin, into yendalo ebangela ukuba imithambo yegazi icuthe kwaye ithintele ukuhamba kwegazi okuqhelekileyo kubantu abane-PAH.

IBosentan iza njengecwecwe kwaye njengethebhulethi esasazekayo (ithebhulethi enokuthi inyibilike kulwelo) ukuyithatha ngomlomo. Ihlala ithathwa kunye okanye ngaphandle kokutya kabini ngemini kusasa nangokuhlwa. Ukukunceda ukhumbule ukuthatha i-bosentan, yithathe ngamaxesha afanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-bosentan ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ukuba uthatha ithebhulethi esasazekayo, beka ithebhulethi kwindawo encinci yolwelo ngaphambi kokuba uyithathe. Ukuba ugqirha wakho ukuxelele ukuba uthabathe isiqingatha sethebhulethi, yaphule ithebhulethi esasazekayo ngononophelo emgceni. Thatha isiqingatha sethebhulethi njengoko kuyalelwe, kwaye esinye isiqingatha usibuyisele kwiblister evulekileyo kwiphakheji. Sebenzisa esinye isiqingatha sethebhulethi ngaphakathi kweentsuku ezisi-7. Musa ukuphula i-tablet esasazekayo kwiindawo zokuhlala.

Ugqirha wakho uya kukuqala ngedosi esezantsi ye-bosentan kwaye andise idosi yakho emva kweeveki ezi-4.

IBosentan ilawula iimpawu zePAH kodwa ayiyinyangi. Inokuthatha i-1 ukuya kwiinyanga ezi-2 okanye ngaphezulu ngaphambi kokuba uve isibonelelo esipheleleyo se-bosentan. Qhubeka uthatha i-bosentan nokuba uziva uphilile. Sukuyeka ukuthatha i-bosentan ungakhange uthethe nogqirha wakho. Ukuba ngequbuliso uyeka ukuthatha i-bosentan, iimpawu zakho zinokuya zisiba mandundu. Ugqirha wakho unokunciphisa umthamo wakho ngokuthe ngcembe.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-bosentan,

• xelela ugqirha wakho kunye nosokhemisti ukuba ngaba uxabisa i-bosentan, nawaphi na amanye amayeza, okanye ezinye izithako ezikwiipilisi ze-bosentan okanye iipilisi ezisasazekayo.
• sukuthatha i-cyclosporine (Gengraf, Neoral, Sandimmune) okanye glyburide (DiaBeta, Glynase) ngelixa uthatha i-bosentan.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo nalawo angabhaliswanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo. Qinisekisa ukukhankanya nayiphi na kwezi zilandelayo: amiodarone (Nexterone, Pacerone); cholesterol-ukunciphisa amayeza (ii-statins) ezinjenge-atorvastatin (Lipitor, eCaduet), lovastatin (Altoprev), kunye ne-simvastatin (Flolopid, Zocor, eVytorin); diltiazem (Cardizem, Cartia, Diltzac, nabanye); i-erythromycin (i-EES, i-Eryc, i-PCE); i-fluconazole (iDiflucan); gemfibrozil (iLopid); itraconazole (Onmel, Sporanox); ketoconazole; irifampin (Rifadin, Rimactane, eRifater, Rifamate); i-ritonavir (iNorvir, eKaletra, eViekira Pak, eTechnivie); voriconazole (Vfend); kunye ne-warfarin (Coumadin, Jantoven). Amanye amayeza amaninzi anokusebenzisana ne-bosentan, ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu. Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga.
• xelela ugqirha wakho ukuba ukhe wasilela kwentliziyo (imeko apho intliziyo ingakwazi ukumpompa igazi elaneleyo kwamanye amalungu omzimba).
• xelela ugqirha wakho ukuba uncelisa okanye ucwangcisa ukuncancisa. Ugqirha wakho unokukuxelela ukuba ungancancisi ngelixa uthatha i-bosentan.
• ukuba une-phenylketonuria (PKU, imeko ekuyo njengelifa apho ukutya okukhethekileyo kufuneka kulandelwe ukuthintela ukudodobala kwengqondo), kuya kufuneka wazi ukuba iipilisi ezisasazekayo zinencasa kunye ne-aspartame, umthombo we-phenylalanine.

Thetha nogqirha wakho malunga nokusela ijusi yamagilebhisi ngelixa uthatha eli yeza.

Thatha idosi ephosiweyo ngokukhawuleza nje ukuba uyikhumbule. Nangona kunjalo, ukuba phantse lixesha ledosi elandelayo, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yethamo eqhelekileyo. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

IBosentan inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• intloko ebuhlungu
• ukugungxula
• ukuphuma kwempumlo, umqala obuhlungu, kunye nezinye iimpawu ezibandayo
• intlungu edibeneyo

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ezi mpawu zilandelayo aziqhelekanga, kodwa ukuba ufumana enye yazo okanye ezo zidweliswe kwicandelo LESILumkiso ESIBALULEKILEYO, tsalela ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:

• imihlathi irhashalala; ukurhawuzelela; ubunzima bokuphefumla okanye ukugwinya; ukudumba kobuso, umqala, ulwimi, imilebe namehlo; ukudakumba; ifiva; ukudumba kwamalungu enkovu; ukudinwa
• ukudumba kweenyawo, amaqatha, okanye imilenze esezantsi, ukuzuza ubunzima ngesiquphe, ingxaki engakumbi ngokuphefumla kunesiqhelo
• okutsha okanye okuba mandundu kokuphefumla; isikhohlela esitsha okanye esiba mandundu okanye ngaphandle kwegazi; iintlungu zesifuba; ngokukhawuleza, ukubetha, okanye ukubetha kwentliziyo okungaqhelekanga
• isiqaqa
• isiyezi; ulusu oluthuthu; ukuqhawukelwa ngumphefumlo; ubuthathaka; ngokukhawuleza, ukubetha, okanye ukubetha kwentliziyo okungaqhelekanga

Izilwanyana zaselabhoratri ezinikwe amayeza afana ne-bosentan ziye zaphuhlisa iingxaki ngamasende azo kwaye zavelisa isidoda esincinci (iiseli zokuzala) kunesiqhelo. Ayaziwa ukuba i-bosentan iya konakalisa amasende okanye inciphise inani lesidoda esiveliswe emadodeni. Thetha nogqirha wakho malunga nemingcipheko yokuthatha i-bosentan ukuba ungathanda ukuba nabantwana kwixa elizayo.

IBosentan inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Iimpawu libanda kungaquka oku kulandelayo:

• intloko ebuhlungu
• isicaphucaphu
• ukugabha
• ukubetha kwentliziyo ngokukhawuleza
• isiqaqa
• ukubila
• isiyezi
• ukungaboni kakuhle

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza ugqirha wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Umqhubi^®