Inaliti ye-Acid ye-Zoledronic

Umxholo

• Phambi kokufumana inaliti ye-asidi ye-zoledronic,
• I-Zoledronic acid inokubangela iziphumo ebezingalindelekanga. Xelela ugqirha wakho ukuba ngaba kukho enye yezi mpawu, okanye ezo zidweliswe KUMANQAKU okanye AMANYATHELO, zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu zilandelayo, tsalela umnxeba kwangoko:
• Iimpawu libanda kungaquka oku kulandelayo:

I-Zoledronic acid (Reclast) isetyenziselwa ukuthintela okanye ukunyanga i-osteoporosis (imeko apho amathambo esiba buthathaka kwaye abuthathaka kwaye aphule ngokulula) kwabasetyhini abaye baphuma exesheni ('utshintsho lobomi,' ukuphela kwexesha lokuya exesheni rhoqo). I-Zoledronic acid (Reclast) ikwasetyenziselwa ukunyanga i-osteoporosis emadodeni, kunye nokukhusela okanye ukunyanga i-osteoporosis emadodeni nakwabasetyhini abathatha i-glucocorticoids (uhlobo lonyango lwe-corticosteroid olunokubangela i-osteoporosis). I-Zoledronic acid (Reclast) ikwasetyenziselwa ukunyanga isifo sikaPaget samathambo (imeko apho amathambo ethambile kwaye ebuthathaka kwaye angakhubazeka, abebuhlungu, okanye aphuke lula). I-Zoledronic acid (iZometa) isetyenziselwa ukunyanga amanqanaba aphezulu e-calcium egazini enokubangelwa ziindidi ezithile zomhlaza. I-Zoledronic acid (iZometa) ikwasetyenziswa kunye nomhlaza chemotherapy ukunyanga umonakalo wethambo obangelwa zii-myeloma ezininzi [umhlaza oqala kwiiseli ze-plasma (iiseli ezimhlophe zegazi ezivelisa izinto ezifunekayo ukulwa usulelo)] okanye ngumhlaza oqale kwenye indawo umzimba kodwa usasazekile waya emathanjeni. I-Zoledronic acid (iZometa) ayisiyi-chemotherapy yomhlaza, kwaye ayizukucothisa okanye iyeke ukusasazeka komhlaza. Nangona kunjalo, inokusetyenziselwa ukunyanga isifo samathambo kwizigulana ezinomhlaza. I-Zoledronic acid ikudidi lwamayeza abizwa ngokuba yi-bisphosphonates. Isebenza ngokunciphisa ukophuka kwethambo, ukonyusa ukuxinana kwethambo (ubukhulu), kunye nokunciphisa inani lecalcium ekhutshwe emathanjeni egazini.

I-Zoledronic acid iza njengesisombululo (ulwelo) ukujova emthanjeni ngaphezulu kwemizuzu eli-15. Ihlala itofwe ngumboneleli wezempilo kwiofisi kagqirha, esibhedlele, okanye ekliniki. Xa i-zoledronic acid injection isetyenziselwa ukunyanga amanqanaba aphezulu egazi e-calcium abangelwa ngumhlaza ihlala inikwa idosi enye. Idosi yesibini inokunikwa ubuncinci kwiintsuku ezisi-7 emva kwethamo lokuqala ukuba i-calcium yegazi ayiweli kumanqanaba aqhelekileyo okanye ayihlali kumanqanaba aqhelekileyo. Xa i-zoledronic acid injection isetyenziselwa ukunyanga umonakalo wethambo obangelwa yi-myeloma emininzi okanye umhlaza osasazeke emathanjeni, ihlala inikwa kube kanye kwiiveki ezi-3 ukuya kwezi-4. Xa i-zoledronic acid injection isetyenziselwa ukunyanga i-osteoporosis kubafazi abaye bayeka ukuya exesheni, okanye emadodeni, okanye ukunyanga okanye ukuthintela i-osteoporosis kubantu abathatha i-glucocorticoids, ihlala inikwa kube kanye ngonyaka. Xa i-zoledronic acid isetyenziselwa ukuthintela i-osteoporosis kubafazi abaye bayeka ukuya exesheni, ihlala inikwa kanye kwiminyaka emibini. Xa i-zoledronic acid isetyenziselwa ukunyanga isifo sePaget samathambo, sihlala sinikwa njengedosi enye, kodwa iidosi ezongezelelweyo zinokunikwa emva kwexesha elidlulileyo.

Qiniseka ukuba usele ubuncinci iiglasi ezimbini zamanzi okanye enye into engamanzi ngaphakathi kweeyure ezimbalwa ngaphambi kokuba ufumane i-zoledronic acid.

Ugqirha wakho unokumisela okanye acebise isongezo se calcium kunye nemultivitamin equkethe ivithamin D oza kuyithatha ngexesha lonyango lwakho. Kuya kufuneka uthathe la machiza mihla le njengoko ugqirha wakho ekuyalela. Xelela ugqirha wakho ukuba ngaba kukho nasiphi na isizathu sokuba ungazukukwazi ukuthatha ezi zongezo ngexesha lonyango lwakho.

Unokufumana impendulo ngeentsuku zokuqala emva kokufumana idosi ye-zoledronic acid injection. Iimpawu zempendulo zingabandakanya iimpawu ezinje ngomkhuhlane, umkhuhlane, intloko ebuhlungu, ukugodola, kunye nethambo, ukudibana okanye iintlungu zemisipha. Ezi mpawu zinokuqala ngeentsuku ezintathu zokuqala emva kokuba ufumane idosi yenaliti ye-zoledronic acid kwaye inokuhlala iintsuku ezi-3 ukuya kwezi-14. Ugqirha wakho unokukuxelela ukuba uthathe i-reliever ye-non-prescription pain / reducer fever emva kokuba ufumane inaliti ye-zoledronic acid ukukhusela okanye ukunyanga ezi mpawu.

Ukuba ufumana i-zoledronic acid injection ukukhusela okanye ukunyanga i-osteoporosis, kufuneka uqhubeke nokufumana amayeza njengoko kucwangcisiwe nokuba uziva uphilile. Kuya kufuneka uthethe nogqirha wakho amaxesha ngamaxesha malunga nokuba usafuna na ukunyangwa ngala mayeza.

Ugqirha wakho okanye usokhemesti uya kukunika uxwebhu lolwazi lwesigulana lomenzi (Isikhokelo seMithi) xa uqala unyango ngenaliti ye-zoledronic acid kwaye ngalo lonke ixesha ufumana idosi. Funda ulwazi ngononophelo kwaye ubuze ugqirha okanye usokhemesti ukuba unayo nayiphi na imibuzo. Ungandwendwela noLawulo lwezoKutya noLawulo lweziyobisi (FDA) iwebhusayithi (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) okanye kwiwebhusayithi yomenzi} ukufumana isiKhokelo seyeza.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Phambi kokufumana inaliti ye-asidi ye-zoledronic,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabisa i-zoledronic acid okanye naliphi na iyeza, okanye nasiphi na isithako kwi-zoledronic acid injection. Buza usokhemesti wakho okanye ujonge isiKhokelo seyeza ukuze ufumane uluhlu lwezithako.
• Kuya kufuneka uyazi ukuba inaliti ye-zoledronic acid iyafumaneka phantsi kwegama lophawu iZometa kunye neReclast. Kuya kufuneka uphathwe enye yezi mveliso ngexesha.
• xelela ugqirha wakho kunye nosokhemesti ukuba yeyiphi na amayeza kagqirha kunye nalawo angabhaliswanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: aminoglycoside antibiotics ezinje nge-amikacin (Amikin), gentamicin (Garamycin), kanamycin (Kantrex), neomycin (Neo-Rx, Neo-Fradin), paromomycin (Humatin), streptomycin, kunye ne-tobramycin (Tobi , Nebcin); i-aspirin kunye nezinye iziyobisi ezichasayo (i-NSAIDs) ezifana ne-ibuprofen (Advil, Motrin) kunye ne-naproxen (Aleve, Naprosyn); umhlaza chemotherapy amayeza; i-digoxin (iLanoxin, kwiDigitek); i-diuretics (‘iipilisi zamanzi’) ezifana ne-bumetanide (Bumex), i-ethacrynic acid (i-Edecrin), kunye ne-furosemide (Lasix); kunye nee-steroids zomlomo ezinje nge-dexamethasone (i-Decadron, i-Dexone), i-methylprednisolone (Medrol), kunye ne-prednisone (Deltasone). Uninzi lwamanye amayeza anokusebenzisana ne-zoledronic acid, ke xelela ugqirha wakho malunga nawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu. Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga.
• xelela ugqirha wakho ukuba ukhe unesifo sezintso okanye unomlomo owomileyo, umchamo omnyama, ukubila kunciphile, ulusu olomileyo, kunye neminye imiqondiso yokuphelelwa ngamanzi emzimbeni okanye kutshanje, ukugabha, umkhuhlane, usulelo, ukubila kakhulu, okanye khange bakwazi ukusela ulwelo olwaneleyo. Ugqirha wakho uya kulinda de ungabi nakuphelelwa ngamanzi emzimbeni ngaphambi kokuba akunike inaliti ye-zoledronic acid okanye ukuba uneentlobo ezithile zesifo sezintso akunakukuyalela olu nyango. Xelela ugqirha wakho ukuba wakhe wanayo inqanaba eliphantsi le-calcium egazini lakho. Ugqirha wakho uya kujonga inqanaba le-calcium egazini lakho ngaphambi kokuba uqale unyango kwaye ngekhe amisele eli nyango ukuba inqanaba liphantsi kakhulu.
• xelela ugqirha wakho ukuba uphathwe i-zoledronic acid okanye ezinye i-bisphosphonates (Actonel, Actonel + Ca, Aredia, Boniva, Didronel, Fosamax, Fosamax + D, Reclast, Skelid, kunye neZometa) ngaphambili; ukuba ukhe wenza utyando kwi-parathyroid gland yakho (incindi encinci entanyeni) okanye idlala lengqula okanye utyando lokususa amacandelo emathumbu akho amancinci; kwaye ukuba ukhe wasilela kwentliziyo (imeko apho intliziyo ingakwazi ukumpompa igazi elaneleyo kwamanye amalungu omzimba); i-anemia (imeko apho iiseli ezibomvu zegazi zingenakho ukuzisa ioksijini eyaneleyo kwamanye amalungu omzimba); nayiphi na imeko emisa igazi lakho ekunqandeni ngesiqhelo; amanqanaba asezantsi e-calcium, i-magnesium, okanye i-potassium egazini lakho; nayiphi na imeko ethintela umzimba wakho ekufunxeni izakhamzimba ekutyeni; okanye iingxaki ngomlomo, ngamazinyo, okanye ngeentsini; usulelo, ngakumbi emlonyeni wakho; i-asthma okanye ukuphefumula, ngakumbi ukuba yenziwa mandundu ngokuthatha i-aspirin; okanye parathyroid okanye isifo sesibindi.
• xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye uncancisa. Kuya kufuneka usebenzise indlela ethembekileyo yolawulo lokuzalwa ukukhusela ukukhulelwa ngelixa ufumana i-zoledronic acid. Ukuba ukhulelwa ngelixa ufumana i-zoledronic acid, tsalela ugqirha wakho. I-Zoledronic acid inokulimaza umbungu. Thetha nogqirha wakho ukuba ucwangcisa ukukhulelwa nanini na kwixa elizayo kuba i-zoledronic acid inokuhlala emzimbeni wakho kangangeminyaka emva kokuba uyekile ukuyifumana.
• Kuya kufuneka uyazi ukuba inaliti ye-asidi ye-zoledronic inokubangela ukuba ithambo eliqatha, izihlunu, okanye iintlungu ezidibeneyo. Ungaqala ukuziva le ntlungu ngaphakathi kweentsuku okanye kwiinyanga emva kokuba ufumane okokuqala inaliti ye-zoledronic acid. Nangona olu hlobo lweentlungu lungaqala emva kokuba ufumene inaliti ye-zoledronic acid kangangexesha elithile, kubalulekile kuwe nogqirha ukuba uqaphele ukuba kunokubangelwa yi-zoledronic acid. Biza ugqirha wakho ngoko nangoko ukuba ufumana iintlungu ezibuhlungu nangaliphi na ixesha ngexesha lonyango lwakho ngenaliti ye-zoledronic acid. Ugqirha wakho angayeka ukukunika inaliti ye-asidi ye-zoledronic kwaye iintlungu zakho zinokuhamba emva kokuba uyekile unyango ngala mayeza.
• Kuya kufuneka uyazi ukuba i-zoledronic acid inokubangela i-osteonecrosis yomhlathi (ONJ, imeko enzima yethambo lomhlathi), ngakumbi ukuba uqhaqho lwamazinyo okanye unyango ngelixa usebenzisa amayeza. Ugqirha wamazinyo kufuneka ahlolisise amazinyo akho kwaye enze naluphi na unyango olufunekayo, kubandakanya nokucoca, ngaphambi kokuba uqale ukusebenzisa i-zoledronic acid. Qiniseka ukuba uhlamba amazinyo kwaye ucoce umlomo kakuhle ngelixa usebenzisa i-zoledronic acid. Thetha nogqirha wakho ngaphambi kokuba ufumane unyango lwamazinyo ngelixa usebenzisa le mayeza.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Ukuba uphosa ixesha lokufumana i-zoledronic acid infusion, tsalela ugqirha ngokukhawuleza.

I-Zoledronic acid inokubangela iziphumo ebezingalindelekanga. Xelela ugqirha wakho ukuba ngaba kukho enye yezi mpawu, okanye ezo zidweliswe KUMANQAKU okanye AMANYATHELO, zinzima okanye azihambi:

• ukurhawuzelela, ukuba bomvu, iintlungu, okanye ukudumba kwindawo ofumene kuyo inaliti
• bomvu, ukudumba, ukurhawuzelela, okanye amehlo aneenyembezi okanye ukudumba ujikeleze amehlo
• ukuqhina
• isicaphucaphu
• ukugabha
• urhudo
• isisu esibuhlungu
• Ukuphelelwa ngumdla wokutya
• ukuhla ukusinda
• isilungulela
• izilonda zomlomo
• ukukhathazeka ngokweqile
• ukuphazamiseka
• ukudakumba
• ubunzima bokulala okanye ukulala
• umkhuhlane, ukugodola, ukukhohlela, kunye neminye imiqondiso yosulelo
• amabala amhlophe emlonyeni
• ukudumba, ukuba bomvu, ukurhawuzelela, ukutshisa, okanye ukurhawuzelela kwilungu lobufazi
• ukukhutshwa okumhlophe kwilungu lobufazi
• ukuba ndindisholo okanye ukurhawuzelela umlomo okanye iminwe okanye iinzwane
• ukulahleka kweenwele

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu zilandelayo, tsalela umnxeba kwangoko:

• irhashalala
• urhwebo
• ukurhawuzelela
• ukudumba kwamehlo, ubuso, imilebe, ulwimi, umqala, izandla, iingalo, iinyawo, amaqatha okanye imilenze esezantsi
• ukudinwa
• ubunzima bokuphefumla okanye ukugwinya
• iintlungu zesifuba
• ukubetha kwentliziyo ngendlela engaqhelekanga
• ukuxhamla izihlunu, ukujija, okanye iicampu
• ukugruzuka okanye ukopha okungaqhelekanga
• iintsini ezibuhlungu okanye ezidumbileyo
• ukukhululeka kwamazinyo
• ukuba ndindisholo okanye ukuziva unzima emhlathini
• Ubuhlungu emlonyeni okanye umhlathi ongaphilisi

I-Zoledronic acid inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukunyangwa ngamayeza e-bisphosphonate afana ne-zoledronic acid injection ye-osteoporosis inokunyusa umngcipheko wokuba wophule amathambo akho. Unokuziva utyhafile, iintlungu zibuhlungu esinqeni, emithanjeni, okanye emathangeni kangangeeveki okanye iinyanga ngaphambi kokuba amathambo aqhekeke, kwaye ungafumanisa ukuba elinye okanye omabini amathambo amathambo akho aphukile nangona ungakhange uwe olunye umothuko. Akuqhelekanga ukuba ithambo lethanga liphule kubantu abasempilweni, kodwa abantu abane-osteoporosis banokulophula eli thambo nokuba abafumani ngenaliti ye-zoledronic acid. Thetha nogqirha wakho malunga nemingcipheko yokufumana inaliti ye-zoledronic acid.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Ugqirha wakho uya kuligcina eli yeza eofisini yakhe kwaye akunike njengoko kufuneka.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Iimpawu libanda kungaquka oku kulandelayo:

• ifiva
• ubuthathaka
• Ukuqinisa ngesiquphe kwezihlunu okanye izihlunu zovalo
• ukukhawuleza, ukubetha, okanye ukubetha kwentliziyo ngokungafaniyo
• isiyezi
• iintshukumo zamehlo ezingalawulekiyo
• umbono kabini
• ukudakumba
• ubunzima bokuhamba
• ukushukuma okungalawulekiyo kwilungu lomzimba wakho
• ukuxhuzula
• ukudideka
• ukuqhawukelwa ngumphefumlo
• iintlungu, ukutshisa, ukuba ndindisholo okanye ukubetha ezandleni okanye ezinyaweni
• kunzima ukuthetha
• kunzima ukugwinya
• ukuncipha kokuchama

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile zelebhu ukujonga impendulo yomzimba wakho kwi-zoledronic acid.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Ukuhlaziywa kwakhona^®
• Zometa^®