IDarunavir

Umxholo

• Ngaphambi kokuba uthathe i-darunavir,
• IDarunavir inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu, yeka ukuthatha i-darunavir kwaye ubize ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:

IDarunavir isetyenziswa ne-ritonavir (i-Norvir) kunye namanye amayeza ukunyanga usulelo lwe-immunodeficiency virus (HIV) kubantu abadala nakubantwana abaneminyaka emi-3 ubudala nangaphezulu. UDarunavir ukwiklasi yamayeza abizwa ngokuba zii-protease inhibitors. Isebenza ngokunciphisa inani le-HIV egazini. Nangona i-darunavir ingayinyangi i-HIV, inokuwanciphisa amathuba akho okuba ne-immunodeficiency syndrome (i-AIDS) kunye nezifo ezinxulumene ne-HIV ezinje ngezifo ezomeleleyo okanye umhlaza. Ukuthatha la mayeza kunye nokwabelana ngesondo okukhuselekileyo nokwenza olunye utshintsho kwindlela yokuphila kunokunciphisa umngcipheko wokudlulisela intsholongwane kagawulayo kwabanye abantu.

IDarunavir iza njengecwecwe kunye nokumiswa ngomlomo (ulwelo) ukuthatha ngomlomo. Ihlala ithathwa ngokutya kunye ne-ritonavir kanye okanye kabini ngemini. Thatha i-darunavir malunga nexesha elifanayo (ii) yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-darunavir ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Musa ukuthatha i-darunavir ngaphandle kwe-ritonavir.

Ginya zonke iipilisi ngesiselo esifana namanzi okanye ubisi. Musa ukuhlafuna iipilisi.

Hlanganisa ukunqunyanyiswa kakuhle phambi kokusetyenziswa ngakunye ukuxuba amayeza ngokulinganayo. Sebenzisa isirinji yomlomo yedosi eyeza nonyango ukurhoxisa inani elifanelekileyo lokumiswa kwibhotile. Ungaginya ukumiswa ngokuthe ngqo kwisirinji. Hlamba isirinji ngamanzi kwaye uyivumele yome kakuhle emva kokusetyenziswa.

IDarunavir ilawula i-HIV kodwa ayiyinyangi. Qhubeka nokuthatha i-darunavir nokuba uziva uphilile. Sukuyeka ukuthatha i-darunavir ungakhange uthethe nogqirha wakho. Ukuba uyeka ukuthatha i-darunavir okanye weqe amathamo, imeko yakho kunokuba nzima ukuyinyanga. Xa unikezelo lwakho lwe-darunavir luqala ukuba phantsi, fumana ngakumbi kugqirha wakho okanye kwikhemesti.

Buza usokhemesti okanye ugqirha wakho ngekopi yolwazi lomenzi wesigulana.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-darunavir,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabana ne-darunavir, i-ritonavir, i-sulfa iyeza, nawaphi na amanye amayeza, okanye nasiphi na isithako esikwipilisi zedarunavir okanye ukunqunyanyiswa. Buza usokhemesti wakho uluhlu lwezinto ezenziwayo okanye ukuba awuqinisekanga ukuba iyeza olichasayo lelonyango lwe-sulfa.
• xelela ugqirha wakho ukuba uthatha nawaphi na amayeza alandelayo: alfuzosin (Uroxatral); i-cisapride (Propulsid) (ayifumaneki e-U.S.); idronarone (iMultaq); i-elbasvir / grazoprevir (iZepatier); amayeza ohlobo lwe-ergot anjenge-dihydroergotamine (i-DHE 45, iMigranal), i-ergotamine (i-Ergomar, eCafergot, eMigergot), kunye ne-methylergonovine (Methergine); lomitapide (Juxtapid); i-lovastatin (Mevacor, kwiGqwetha); i-lurasidone (Latuda), midazolam (enikwe ngomlomo); ipimozide (Orap); I-ranolazine (iRanexa); irifampin (Rifadin, Rimactane, eRifamate, eRifater); sildenafil (kuphela uphawu lweRevatio olusetyenziselwa isifo semiphunga); isimvastatin (iZocor, eVytorin); I-wort yaseSt. okanye i-triazolam (Halcion). Ugqirha wakho uya kukuxelela ukuba ungathathi i-darunavir. Kwakhona, ukuba unesifo sezintso okanye sesibindi kwaye uthatha i-colchicine (Colcrys, Mitigare, kwi-Col-Probenecid), ugqirha wakho uya kukuxelela ukuba ungathathi i-darunavir.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo nolungabhaliswanga, iivithamini, kunye nezongezelelo zesondlo ozithathayo okanye oceba ukuzithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: ii-anticoagulants ('blood thinner') ezinje ngeapixaban (Eliquis), rivaroxaban powder (Xarelto), kunye warfarin (Coumadin, Jantoven); izinto zokubulala ezinje nge-itraconazole (Onmel, Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), kunye ne-voriconazole (Vfend); artemether / lumefantrine (Coartem); ii-beta blockers ezinje nge-carvedilol (Coreg), metoprolol (Lopressor, Toprol XL, in Dutoprol, in Lopressor HCT), kunye ne timolol (Betimol, Istalol, e Combigan, e Cosopt, ezinye); betamethasone; i-boceprevir (ayisafumaneki e-US; iVictrelis); i-bosentan (iTracleer); budesonide (Entocort, Pulmicort, Uceris, nabanye); buprenorphine (Belbuca, Buprenex, Butrans, eSuboxone, abanye); i-buprenorphine / naloxone (iBunavail, iSuboxone, iZubsolv); buspirone; iicalcium-channel blocker ezinje nge-amlodipine (Norvasc, eCaduet), diltiazem (Cardizem CD, Cartia, XT, Diltzac, others), felodipine (Plendil), nicardipine (Cardene), nifedipine (Adalat CC, Afebitab CR, Procardia), kunye i-verapamil (Calan, Covera, Verelan, eTarka); amayeza athile e-chemotherapy anje nge-dasatinib (Sprycel), nilotinib (Tasigna), vinblastine, kunye ne-vincristine (Marqibo Kit); ukunciphisa amayeza e-cholesterol (ii-statins) ezinjenge-atorvastatin (Lipitor, eCaduet), pravastatin (Pravachol), kunye ne-rosuvastatin (Crestor); iciclesonide (Alvesco); i-clarithromycin (i-Biaxin, kwi-Prevpac); amayeza athile oxinzelelo anje nge-amitriptyline, desipramine (Norpramin), imipramine, nortriptyline, paroxetine (Brisdelle, Paxil, Pexeva), sertraline (Zoloft), kunye ne-trazodone; dexamethasone; diazepam (Diastat, Valium); estazolam; fentanyl (Abstral, iDuragesic, Subsys); i-fluticasone (iFlonase, iFlovent, eAdvair); amayeza athile kwintsholongwane ye-hepatitis C (HCV) efana ne-glecaprevir / pibrentasvir (Mavyret) kunye ne-simeprevir (engasekhoyo e-U.S. Olysio); amanye amayeza e-HIV kubandakanya indinavir (Crixivan), lopinavir / ritonavir (Kaletra), maraviroc (Selzentry), kunye ne-saquinavir (Invirase); izinto zokucwangcisa zehormonal (estrogen) (iipilisi zolawulo lokuzalwa, iipatches, iiringi, ukufakelwa, okanye inaliti); amayeza okubetha kwentliziyo ngokungaqhelekanga kubandakanya i-amiodarone (Nexterone, Pacerone), bepridil (engasafumaneki e-US), digoxin (Lanoxin), disopyramide (Norpace), flecainide, lidocaine (Xylocaine), mexiletine, propafenone (Rythmol), kunye nequinidine (kwiNuedexta ); amayeza athile okubanjwa njenge-carbamazepine (Carbatrol, Equetro, Tegretol, abanye), clonazepam (Klonopin), phenobarbital, kunye ne phenytoin (Dilantin, Phenytek); amayeza athile acinezela amajoni omzimba njenge-cyclosporine (Gengraf, Neoral, Sandimmune), everolimus (Afinitor, Zortress), sirolimus (Rapamune), kunye ne-tacrolimus (Astagraf XL, Prograf); imethadone (iDolophine, iMethadose); imethylprednisolone; mometasone (Asmanex); omeprazole (Prilosec); Oxycodone (Xtampza); ezithile ze-phosphodiesterase inhibitors (PDE-5 inhibitors) ezisetyenziselwa ukungasebenzi kakuhle kwe-erectile njenge-avanafil (Stendra), sildenafil (Viagra), tadalafil (Cialis), kunye ne-vardenafil (Levitra, Staxyn); iperphenazine; uqikelelo (iRayos); iquetiapine (iSeroquel); irifabutin (Mycobutin); irifapentine (Priftin); irisperidone (iRisperdal); isalmeterol (iSerevent, eAdvair); tadalafil (Adcirca); thioridazine; ticagrelor (Brilinta); i-tramadol (iConzip); i-triamcinolone (i-Nasacort); kunye ne-zolpidem (Ambien, Edluar, Intermezzo). Amanye amayeza amaninzi anokusebenzisana ne-darunavir, ke qiniseka ukuxelela ugqirha wakho malunga nawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu. Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga.
• ukuba uthatha i-didanosine (Videx), yithathe iyure enye ngaphambi okanye iiyure ezi-2 emva kokuba uthathe idarunavir.
• xelela ugqirha wakho ukuba ukhe unesifo seswekile okanye uneswekile ephezulu yegazi; hemophilia (ukuphazamiseka kwegazi apho igazi lingagqumi ngokufanelekileyo); ihepatitis (ukudumba kwesibindi okubangelwa yintsholongwane), i-cirrhosis (isifo esibangela ukonakala kwinyama yesibindi), okanye nasiphi na isifo sesibindi; okanye usulelo olungapheliyo okanye oluza luye lufane necytomegalovirus (CMV; usulelo lwentsholongwane olunokubangela iimpawu kwizigulana ezinamajoni omzimba abuthathaka), isifo se-mycobacterium avium tata (MAC; intsholongwane yebhaktiriya enokubangela iimpawu ezinzulu abantu abane-AIDS), inyumoniya, okanye isifo sephepha (i-TB; uhlobo losulelo lwemiphunga).
• xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye uncancisa. Ukuba ukhulelwe ngelixa uthatha i-darunavir, biza ugqirha wakho. Musa ukuncancisa xa wosulelwe yi-HIV okanye uthatha i-darunavir.
• Kuya kufuneka uyazi ukuba i-darunavir inokunciphisa ukusebenza kweendlela zokucwangcisa zehomoni (iipilisi zolawulo lokuzalwa, iipatches, iiringi, inaliti, okanye ukufakelwa). Thetha nogqirha wakho malunga nolawulo lokuzalwa olungelulo ihomoni olunjengendlela yokuthintela (isixhobo esivimba isidoda ukuba singene esibelekweni esifana nekhondom okanye uvalo) ukuthintela ukukhulelwa ngelixa uthatha eli yeza. Buza ugqirha wakho ukuba akuncede ukhethe indlela yolawulo lokuzalwa eya kukusebenzela.
• Kuya kufuneka uyazi ukuba amanqatha omzimba wakho anganyuka okanye ahambele kwiindawo ezahlukeneyo zomzimba wakho ezinje ngamabele akho, umqolo ongasentla, intamo, isifuba, kunye nendawo yesisu. Ukuphulukana namafutha emilenzeni, ezingalweni nasebusweni nako kunokwenzeka.
• Kuya kufuneka uyazi ukuba unokufumana i-hyperglycemia (inyuka kwiswekile esegazini lakho) ngelixa uthatha eli yeza, nokuba awukabinaso isifo seswekile. Tshela ugqirha wakho kwangoko ukuba unayo nayiphi na impawu zilandelayo ngelixa uthatha i-darunavir: ukunxanwa okugqithisileyo, ukuchama rhoqo, indlala enkulu, umbono ophuthileyo, okanye ubuthathaka. Kubaluleke kakhulu ukubiza ugqirha wakho nje ukuba ube nazo naziphi na ezi mpawu, kuba iswekile ephezulu yegazi enganyangekiyo inokubangela imeko embi ebizwa ngokuba yi ketoacidosis. I-Ketoacidosis inokuba sengozini yobomi ukuba ayinyangwa kwangoko. Iimpawu zeketoacidosis zibandakanya: umlomo owomileyo, isicaphucaphu kunye nokugabha, ukuphefumla kancinci, umphefumlo onuka iziqhamo, kunye nokwehla kwengqondo.
• Kuya kufuneka uyazi ukuba ngelixa uthatha amayeza ukunyanga usulelo lwe-HIV, amajoni akho omzimba angomelela kwaye aqale ukulwa nezinye izifo ezazisele zisemzimbeni wakho. Oku kunokubangela ukuba ube neempawu zolu sulelo. Ukuba uneempawu ezintsha okanye eziya zisanda nangaliphi na ixesha kunyango lwakho nge-darunavir, qiniseka ukuxelela ugqirha wakho.

Thetha nogqirha wakho malunga nokutya igrapefruit kunye nokusela ijusi yegrapefruit ngelixa uthatha eli yeza.

Ukuba uthatha i-darunavir kanye ngemini kwaye uphoswa idosi ngeeyure ezingaphantsi kwe-12, thatha idosi ephosiweyo ngokukhawuleza nje ukuba uyikhumbule kwaye emva koko uthathe idosi elandelayo ngexesha elimiselweyo. Nangona kunjalo, ukuba uphosa idosi ngaphezulu kweeyure ezili-12, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yethamo eqhelekileyo. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

Ukuba uthatha i-darunavir kabini ngemini kwaye uphosa idosi engaphantsi kweeyure ezingama-6, thatha idosi ephosiweyo ngokukhawuleza nje ukuba uyikhumbule kwaye emva koko uthathe idosi elandelayo ngexesha elimiselweyo. Nangona kunjalo, ukuba uphosa idosi ngaphezulu kweeyure ezingama-6, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yesiqhelo yedosi. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

IDarunavir inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• intloko ebuhlungu
• urhudo
• ukugabha
• isisu esibuhlungu
• ukuqhina

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu, yeka ukuthatha i-darunavir kwaye ubize ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:

• irhashalala
• Ukuxobuka okanye ukudumba kolusu
• izilonda zomlomo
• bomvu, ukudumba, ukurhawuzelela, okanye amehlo aneenyembezi
• izihlunu okanye amalungu ngokudibeneyo
• ifiva
• ukudumba, ukuthamba, ubomvu, okanye ezinye iimpawu zosulelo
• isicaphucaphu
• ukudinwa kakhulu
• Ukuphelelwa ngumdla wokutya
• iintlungu kwinxalenye ephezulu yesisu
• mthubi ulusu okanye amehlo
• ilindle elimdaka okanye elimnyama

IDarunavir inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya ku-odola uvavanyo oluthile ukuze aqiniseke ukuba kukhuselekile ukuba uthathe i-darunavir kwaye ujonge impendulo yomzimba wakho kwi-darunavir.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Prezista^®
• Prezcobix^® (Equlathe iDarunavir, Cobicistat)

• TMC-114