Nilotinib

Umxholo

• Ngaphambi kokuba uthathe i-nilotinib,
• I-Nilotinib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko:

I-Nilotinib inokubangela ukwandiswa kwe-QT (isigqi senhliziyo esingaqhelekanga esingakhokelela ekuphelelweni amandla, ukulahleka kwengqondo, ukuxhamla, okanye ukufa ngokukhawuleza). Tshela ugqirha wakho ukuba wena okanye nabani na kusapho lwakho une-QT syndrome ende (imeko ezuzwe njengelifa apho umntu kunokwenzeka ukuba abe nokwandiswa kwe-QT) okanye unawo amanqanaba asezantsi e-potassium okanye wemagniziyam egazini lakho. , ukubetha kwentliziyo okungaqhelekanga, okanye isifo sesibindi. Tshela ugqirha wakho kunye nosokhemesti ukuba uthatha i-amiodarone (Nexterone, Pacerone); izinto zokubulala ezinje nge ketoconazole, itraconazole (Onmel, Sporanox), okanye voriconazole (Vfend); chloroquine (iPlaquenil); i-clarithromycin (i-Biaxin, kwi-Prevpac); iDisopyramide (iNorpace); i-erythromycin (i-EES, i-Eryc, i-PCE); amayeza athile kwintsholongwane kaGawulayo (i-HIV) okanye i-immunodeficiency syndrome (i-AIDS) efana ne-atazanavir (Reyataz), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, e Kaletra), kunye ne-saquinavir (i-Invirase) haloperidol (iHaldol); imethadone (iDolophine, iMethadose); moxifloxacin (Avelox); nefazodone; ipimozide (Orap); ukuvelisa; quinidine (kwiNuedexta); sotalol (Betapace, Betapace AF, abanye); telithromycin (Ketek); kunye ne-thioridazine. Ukuba ufumana naziphi na ezi mpawu zilandelayo, yeka ukuthatha i-nilotinib kwaye ubize ugqirha ngokukhawuleza: ukukhawuleza, ukubetha, okanye ukubetha kwentliziyo okungaqhelekanga; isiqaqa; ukulahleka kwengqondo; okanye ukuxhuzula.

Musa ukutya nakuphi na ukutya ubuncinci iiyure ezi-2 ngaphambi kokuba uthathe i-nilotinib kunye neyure e-1 emva kokuthatha eli yeza.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile, ezinje ngovavanyo lwegazi kunye nee-electrocardiograms (EKGs, iimvavanyo ezirekhoda umsebenzi wombane wentliziyo) ngaphambi kwaye ngexesha lonyango lwakho ukuze uqiniseke ukuba kukhuselekile ukuba ungathatha i-nilotinib.

Ugqirha wakho okanye usokhemesti uya kukunika uxwebhu lolwazi lwesigulana lomenzi (Isikhokelo seyeza) xa uqala unyango nge-nilotinib kwaye ngalo lonke ixesha ugcwalisa amayeza akho. Funda ulwazi ngononophelo kwaye ubuze ugqirha okanye usokhemesti ukuba unayo nayiphi na imibuzo. Ungandwendwela noLawulo lwezoKutya noLawulo lweziyobisi (FDA) iwebhusayithi (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) okanye iwebhusayithi yomenzi ukufumana isiKhokelo seMithi.

Thetha nogqirha wakho malunga neengozi zokuthatha i-nilotinib.

I-Nilotinib isetyenziselwa ukunyanga iintlobo ezithile ze-myeloid leukemia engapheliyo (i-CML; uhlobo lomhlaza weeseli ezimhlophe zegazi) abasandula ukufumanisa ukuba banayo le meko kubantu abadala nakubantwana abaneminyaka eli-1 ubudala nangaphezulu. Isetyenziselwa ukunyanga iintlobo ezithile ze-CML isifo sayo esinganyangekiyo ngempumelelo nge-imatinib (Gleevec) okanye abantu abadala abangakwaziyo ukuthatha imatinib. I-Nilotinib ikwasetyenziselwa ukunyanga iintlobo ezithile ze-CML kubantwana abaneminyaka eyi-1 ubudala okanye nangaphezulu abanesifo esinganyangekiyo ngempumelelo ngezinye iindlela zonyango ze-tyrosine kinase inhibitor. UNilotinib ukwiklasi yamayeza abizwa ngokuba yi-kinase inhibitors. Isebenza ngokuthintela isenzo seprotein engaqhelekanga ebonisa iiseli zomhlaza ukuba zande. Oku kunceda ukumisa okanye ukucothisa ukusasazeka kweeseli zomhlaza.

UNilotinib uza njengepilisi yokuthatha ngomlomo. Ihlala ithathwa ngaphandle kokutya kabini ngemini. I-Nilotinib kufuneka ithathwe ngaphandle kwesisu, ubuncinci iiyure ezi-2 ngaphambi okanye iyure e-1 emva kokutya nakuphi na ukutya. Thatha i-nilotinib malunga namaxesha afanayo yonke imihla. Zama ukubeka umthamo wakho malunga neeyure ezili-12 ngaphandle. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-nilotinib ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Gwinya zonke njengezingxobo ngeglasi yamanzi; ungahluleli, ungahlaleli, okanye uzityumze. Ukuba awukwazi ukuginya yonke njengezingxobo, xuba imixholo yecapsule kwitispuni enye yeapile. Ginya umxube kwangoko (kwisithuba semizuzu eli-15.) Musa ukuwugcina lo mxube ukuze uwusebenzise kwixesha elizayo.

Ugqirha wakho anganciphisa i-nilotinib dose okanye ayeke unyango lwakho kuxhomekeke ekusebenzeni kakuhle kweyeza kwaye ukuba unemiphumo emibi. Qhubeka uthathe i-nilotinib nokuba uziva uphilile. Ungayeki ukuthatha i-nilotinib ngaphandle kokuthetha nogqirha wakho.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-nilotinib,

• xelela ugqirha wakho kunye nosokhemisti ukuba ngaba uxabisa i-nilotinib, nawaphi na amanye amayeza, okanye naziphi na izithako kwiifomsile ze-nilotinib. Buza usokhemesti wakho okanye ujonge isiKhokelo seyeza ukuze ufumane uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo nolungabhaliswanga, iivithamini, kunye nezongezelelo zesondlo ozithathayo okanye oceba ukuzithatha. Qiniseka ngokukhankanya amayeza adweliswe kwicandelo LESILUMKISO ESIBALULEKILEYO kunye nokunye oku kulandelayo: ii-angiotensin-receptor blockers ezinje nge-irbesartan (Avapro, eAvalide) kunye ne-losartan (Cozaar, e-Hyzaar); ii-anticoagulants (’’ izinciphisi zegazi ’’) ezifana ne-warfarin (Coumadin, Jantoven); aripiprazole (Yenza); ii-benzodiazepines ezithile ezifana ne-alprazolam (Xanax), diazepam (Valium), midazolam, kunye ne-triazolam (Halcion); buspirone (Buspar); iibhlokhi ezithile ze-calcium blocker ezinje nge-amlodipine (Norvasc), diltiazem (Cardizem, Cartia, Tiazac, others), felodipine, nicardipine (Cardene), nifedipine (Adalat, Procardia), nisoldipine (Sular), kunye verapamil (Calan, Verelan, abanye) ; amayeza athile athoba i-cholesterol (ii-statins) kubandakanya i-atorvastatin (Lipitor), i-fluvastatin (i-Lescol XL), i-lovastatin (i-Altoprev), kunye ne-simvastatin (iZocor); I-chlorpheniramine (Chlor-Trimeton, okunye ukukhohlela kunye nemveliso ebandayo); dexamethasone; dihydroergotamine (DHE 45, Migranal); ergotamine (kwiCafergot, e-Ergomar); fentanyl (Actiq, Duragesic, Subsys); i-flecainide (iTambocor); amayeza athile okudakumba afana ne-amitriptyline, desipramine (Norpramin); duloxetine (ICymbalta); imipramine (Tofranil); paroxetine (Brisdelle, Paxil, Pexeva); kunye ne-venlafaxine (i-Effexor); amayeza athile omlomo weswekile afana ne-glipizide (Glucotrol) kunye ne-tolbutamide; amayeza athile acinezela amajoni omzimba njenge-cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), kunye ne-tacrolimus (Prograf); amayeza athile okubanjwa njenge-carbamazepine (i-Equetro, iTegretol, iTeril), i-phenobarbital, kunye ne-phenytoin (iDilantin, Phenytek); imeyilethi; iziyobisi ezithile ezichasayo (ii-NSAID) ezinjenge-celecoxib (Celebrex), diclofenac (Voltaren), ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn), kunye ne-piroxicam (Feldene); I-ondansetron (iZofran); ipropafenone (Rythmol); iiproton-pump inhibitors ezinje nge-esomeprazole (Nexium), lansoprazole (Prevacid), omeprazole (Prilosec), pantoprazole (Protonix), kunye ne-rabeprazole (AcipHex); ikwinine (Qualaquin); irifabutin (Mycobutin); irifampin (Rifadin); irifapentine (Priftin); irisperidone (iRisperdal); sildenafil (Viagra, Revatio); tamoxifen; testosterone (Androderm, Androgel, Striant, abanye); ixesha; Ubungakanani; tramadol (Ultram, kwi-Ultracet); ithenda kunye no-vincristine. Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga. Uninzi lwamanye amayeza anokusebenzisana ne-nilotinib, ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
• ukuba uthatha ii-antacids ezine-magnesium, i-aluminium (Maalox, Mylanta, Tums, others), okanye i-simethicone, thatha i-antacid 2 kwiiyure ngaphambi okanye ubuncinci kwiiyure ezimbini emva kokuba uthathe i-nilotinib.
• ukuba uthatha amayeza okugaya isisu, ukutsha, okanye izilonda ezinje nge-cimetidine (Tagamet), i-famotidine (i-Pepcid, kwi-Duexis), i-nizatidine (i-Axid), okanye i-ranitidine (i-Zantac), yithathe ubuncinci iiyure ezili-10 ngaphambi okanye ubuncinci iiyure emva kokuba uthathe i-nilotinib.
• xelela ugqirha wakho ukuba zeziphi iimveliso zemithi ozithathayo, ngakumbi iSt John's wort.
• xelela ugqirha wakho ukuba unestroke okanye uqhaqho ukuze ususe sonke isisu (isisu sisonke). Kwakhona xelela ugqirha wakho ukuba ukhe wehla okanye wehla ukuhamba kwegazi emilenzeni, naziphi na iingxaki zentliziyo, iingxaki zokopha, ukudumba kwenkunkuma (ukudumba kwepancreas, idlala elingasemva kwento evelisa izinto ukunceda ukwetyisa), okanye nayiphi na imeko yenza kube nzima kuwe ukwetyisa i-lactose (ubisi iswekile) okanye ezinye iiswekile.
• xelela ugqirha wakho ukuba ukhulelwe okanye ucwangcise ukukhulelwa. Akufanele ukhulelwe ngelixa uthatha i-nilotinib. Kuya kufuneka usebenzise ulawulo lokuzalwa olusebenzayo ukuthintela ukukhulelwa ngexesha lonyango lwakho nge-nilotinib kunye neentsuku ezili-14 emva kwedosi yakho yokugqibela. Thetha nogqirha wakho ngeendlela zolawulo lokuzalwa onokuzisebenzisa ngexesha lonyango lwakho. Ukuba ukhulelwe ngelixa uthatha i-nilotinib, biza ugqirha wakho ngokukhawuleza. I-Nilotinib inokwenzakalisa umntwana ongekazalwa.
• xelela ugqirha wakho ukuba uncelisa. Akufanelanga ukuncancisa ngelixa uthatha i-nilotinib kunye neentsuku ezili-14 emva kwedosi yakho yokugqibela.
• ukuba wenza utyando, kubandakanya utyando lwamazinyo, xelela ugqirha okanye ugqirha wamazinyo ukuba uthatha i-nilotinib.

Sukutya igrapefruit, usele ijusi yeziqhamo, okanye uthathe nasiphi na isongezo esine-grapefruit xa ukhupha la mayeza.

Tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yesiqhelo yokulinganisa Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

I-Nilotinib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• irhashalala
• ukurhawuzelela
• isicaphucaphu
• ukugabha
• urhudo
• ukuqhina
• isilungulela
• irhasi
• Ukuphelelwa ngumdla wokutya
• intloko ebuhlungu
• isiyezi
• ukudinwa
• ubunzima bokulala okanye ukulala
• ukubila ebusuku
• izihlunu zemithambo
• umqolo, ithambo, ilungu, ilungu lomzimba, okanye iintlungu zemisipha
• ukulahleka kweenwele
• isikhumba esomileyo okanye esibomvu
• ukuba ndindisholo, ukutshisa, okanye ukubetha ezandleni okanye ezinyaweni

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko:

• ukopha okungaqhelekanga okanye ukugruzuka
• igazi kumchamo
• enegazi okanye emnyama, ilindle
• intloko ngesiquphe, ukudideka, okanye utshintsho kumbono
• ukudinwa okungaqhelekanga okanye ubuthathaka
• Intlungu yesifuba okanye ukungonwabi
• iingxaki zokuhamba okanye ukuthetha
• ukuba ndindisholo
• utshintsho kumbala wolusu lomlenze
• iintlungu okanye imvakalelo ebandayo emilenzeni
• isisu esibuhlungu isicaphucaphu nokugabha
• umkhuhlane, ingqele, umqala obuhlungu, ukukhohlela okungapheliyo kunye nokudibana, okanye ezinye iimpawu zosulelo
• ulusu oluthuthu
• ukuqhawukelwa ngumphefumlo
• ukutyeba kwakho
• ukudumba kwezandla, amaqatha, iinyawo, okanye ubuso
• iintlungu okanye ukungaphatheki kakuhle kwindawo ephezulu yesisu
• ubumthubi besikhumba namehlo
• umchamo omnyama
• ukuchama amaxesha ngamaxesha kunesiqhelo

I-Nilotinib inokubangela ukuba abantwana bakhule kancinci. Ugqirha womntwana wakho uya kujonga ukukhula komntwana wakho ngononophelo ngelixa umntwana wakho ethatha i-nilotinib. Thetha nogqirha womntwana wakho malunga neengozi zokunika umntwana wakho eli yeza.

I-Nilotinib inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Iimpawu zokudlula ngaphezulu zinokubandakanya:

• umkhuhlane, umqala obuhlungu, ingqele, okanye ezinye iimpawu zosulelo
• ukugabha
• ukozela

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Tasigna^®