Inaliti yeCertololizumab

Umxholo

• Inaliti ye-Certolizumab isetyenziselwa ukunciphisa iimpawu zokuphazamiseka komzimba (iimeko apho amajoni omzimba ahlasela amalungu asempilweni kwaye abangela iintlungu, ukudumba kunye nomonakalo) kubandakanya oku kulandelayo:
• Ngaphambi kokusebenzisa inaliti ye-certolizumab,
• Inaliti ye-Certolizumab inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko okanye ufumane uncedo lonyango olungxamisekileyo:

Inaliti ye-Certolizumab inganciphisa amandla akho okulwa usulelo kwaye inyuse umngcipheko wokuba ufumane usulelo olunobungozi okanye olusongela ubomi kubandakanya isifo somngundo, ibhaktiriya kunye nentsholongwane enokuthi isasazeke emzimbeni. Ezi zifo zingafuna ukunyangwa esibhedlele kwaye zingabangela ukufa. Tshela ugqirha wakho ukuba uhlala ufumana naluphi na uhlobo losulelo okanye ukuba unayo okanye ucinga ukuba unalo naluphi na uhlobo losulelo ngoku. Oku kubandakanya usulelo oluncinci (njengokusikwa okuvulekileyo okanye izilonda), usulelo olufikayo (olufana nezilonda ezibandayo), kunye nosulelo olungapheliyo olungapheliyo. Xelela ugqirha wakho ukuba ukhe unesifo seswekile, i-hepatitis B (usulelo lwentsholongwane oluchaphazela isibindi), intsholongwane kaGawulayo, okanye nayiphi na imeko echaphazela amajoni akho omzimba, kwaye ukuba uhlala okanye ukhe waphila indawo ezinje ngeentlambo zomlambo iOhio neMississippi apho isifo somngundo siqheleke kakhulu. Buza ugqirha wakho ukuba awazi ukuba ngaba ezi zifo zixhaphakile kwindawo yakho. Tshela ugqirha wakho ukuba uthatha amayeza acothisa umsebenzi wamajoni omzimba afana ne-abatacept (Orencia), adalimumab (Humira), anakinra (Kineret), etanercept (Enbrel), golimumab (Simponi), infliximab (Remicade), methotrexate ( Otrexup, Rasuvo, Trexall), natalizumab (Tysabri), rituximab (Rituxan), steroids kubandakanya dexamethasone, methylprednisolone (Medrol), prednisolone (Prelone), kunye prednisone (Rayos), kunye tocilizumab (Actemra).

Ugqirha wakho uya kukubeka esweni ngeempawu zosulelo ngexesha nasemva konyango lwakho. Ukuba unayo nayiphi na le miqondiso ilandelayo ngaphambi kokuba uqale unyango lwakho okanye ukuba unazo naziphi na kwezi mpawu zilandelayo ngexesha okanye emva nje konyango lwakho, tsalela umnxeba ugqirha ngoko nangoko: umqala obuhlungu; ukukhohlela; ukukhohlela umchamo wegazi; ifiva; isisu esibuhlungu; urhudo; iimpawu ezifana nomkhuhlane; ukusika okanye izilonda; ukuhla ukusinda; ubuthathaka; ukubila; ubunzima bokuphefumla; ukuchama nzima, rhoqo, okanye okubuhlungu; okanye ezinye iimpawu zosulelo.

Usenokuba wosulelwe sisifo sephepha (i-TB; usulelo olubi lwemiphunga) okanye i-hepatitis B (intsholongwane echaphazela isibindi) kodwa ungenazo naziphi na iimpawu zesi sifo. Kule meko, ukusebenzisa inaliti ye-certolizumab kunokwenza usulelo lwakho lube lubi kakhulu kwaye kubangele ukuba ube neempawu. Ugqirha wakho uza kwenza uvavanyo lolusu ukuze abone ukuba unesifo se-TB esingasebenziyo kwaye angayalela ukuba kwenziwe uvavanyo lwegazi ukuze abone ukuba unesifo se-hepatitis B esingasebenziyo. Ukuba kunyanzelekile, ugqirha wakho uya kukunika amayeza ukunyanga olu suleleko ngaphambi kokuba uqale ukusebenzisa i-certolizumab. Xelela ugqirha wakho ukuba ukhe wakha okanye wakha wanayo na i-TB, ukuba ngaba wakhe wahlala okanye watyelela ilizwe apho ixhaphake kakhulu i-TB, okanye ukuba wakhe wakunye nomntu one-TB. Ukuba unazo naziphi na kwezi mpawu zilandelayo ze-TB, okanye ukuba uvela kwezi mpawu ngexesha lonyango lwakho, tsalela umnxeba kwangoko: ukukhohlela, ukwehla kobunzima, ukulahleka kwethoni yezihlunu, okanye umkhuhlane. Biza ugqirha wakho ngokukhawuleza ukuba unayo nayiphi na le mpawu yesifo sokudumba kwesibindi kohlobo B okanye ukuba ukhula kwezi mpawu ngexesha okanye emva konyango lwakho: ukudinwa kakhulu, ukuba tyheli kolusu okanye amehlo, ukungabi namdla, isicaphucaphu okanye ukugabha, iintlungu zemisipha, umchamo omnyama, intshukumo yombala wodongwe, umkhuhlane, ukugodola, iintlungu zesisu, okanye irhashalala.

Abanye abantwana kunye nolutsha abafumene amayeza afanayo ngenaliti ye-certolizumab bakhulisa umhlaza onobungozi okanye osongela ubomi kubandakanya i-lymphoma (umhlaza oqala kwiiseli ezilwa nosulelo). Abantwana kunye nolutsha akufuneki bafumane inaliti ye-certolizumab, kodwa kwezinye iimeko, ugqirha unokuthatha isigqibo sokuba inaliti ye-certolizumab lelona nyango lilungileyo lokunyanga imeko yomntwana. Ukuba inaliti ye-certolizumab imiselwe umntwana wakho, kuya kufuneka uthethe nogqirha womntwana wakho malunga neengozi kunye nezibonelelo zokusebenzisa eli yeza. Ukuba umntwana wakho uvela kwezi mpawu ngexesha lonyango, biza ugqirha ngokukhawuleza: ukuncipha kobunzima obungachazwanga; amadlala adumbayo entanyeni, phantsi kwempuphu, okanye kumphimbo; okanye ukugruzuka okulula okanye ukopha.

Ugqirha wakho okanye usokhemesti uya kukunika uxwebhu lolwazi lwesigulana lomenzi (Isikhokelo seyeza) xa uqala unyango ngenaliti ye-certolizumab kwaye ngalo lonke ixesha ugcwalisa amayeza akho. Funda ulwazi ngononophelo kwaye ubuze ugqirha okanye usokhemesti ukuba unayo nayiphi na imibuzo. Ungandwendwela noLawulo lwezoKutya noLawulo lweziyobisi (FDA) iwebhusayithi (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) okanye iwebhusayithi yomenzi ukufumana isiKhokelo seMithi.

Thetha nogqirha wakho malunga nomngcipheko wokusebenzisa inaliti ye-certolizumab.

Inaliti ye-Certolizumab isetyenziselwa ukunciphisa iimpawu zokuphazamiseka komzimba (iimeko apho amajoni omzimba ahlasela amalungu asempilweni kwaye abangela iintlungu, ukudumba kunye nomonakalo) kubandakanya oku kulandelayo:

• Isifo sikaCrohn (imeko apho umzimba uhlasela ulwelwesi lwendlela yokugaya, ebangela iintlungu, urhudo, ukwehla kobunzima, kunye nomkhuhlane) ongakhange uphuculwe xa unyangwa ngamanye amayeza,
• isifo samathambo (imeko apho umzimba uhlasela amalungu ayo, ubangela iintlungu, ukudumba, kunye nokuphulukana nomsebenzi),
• i-psoriatic arthritis (imeko ebangela iintlungu ngokudibeneyo kunye nokudumba kunye nezikali kulusu),
• i-ankylosing spondylitis esebenzayo (imeko apho umzimba uhlasela amalungu omqolo kunye nezinye iindawo ezibangela iintlungu, ukudumba, kunye nomonakalo odibeneyo) notshintsho olubonwe kwi-X-ray,
• i-axial spondyloarthritis engasebenziyo (imeko apho umzimba uhlasela amalungu omqolo kunye nezinye iindawo ezibangela iintlungu kunye neempawu zokudumba), kodwa ngaphandle kotshintsho olubonwe kwi-X-ray,
• I-plaque psoriasis (isifo solusu apho umbala obomvu, onamaxolo wenza iindawo ezithile zomzimba) kubantu abanokuxhamla kumayeza okanye kwi-phototherapy (unyango olubandakanya ukuveza ulusu kukukhanya kwe-ultraviolet).

Inaliti ye-Certolizumab ikudidi lwamayeza abizwa ngokuba yi-tumor necrosis factor (TNF) inhibitors. Isebenza ngokuthintela umsebenzi we-TNF, into esemzimbeni ebangela ukudumba.

Inaliti ye-Certolizumab iza njengomgubo wokuxutywa namanzi angenazintsholongwane kunye nokujova (ngaphantsi nje kwesikhumba) ngugqirha okanye umongikazi kwiofisi yezonyango nanjengesirinji esigcwaliswe kwangaphambili onokuthi uzitofe sona ngokwakho ekhaya. Xa isitofu se-certolizumab sisetyenziselwa ukunyanga isifo sikaCrohn, sihlala sinikwa rhoqo emva kweeveki ezimbini kwiidosi zokuqala ezintathu kwaye emva kweeveki ezine ixesha elide unyango lusaqhubeka. Xa isitofu se-certolizumab sisetyenziselwa ukunyanga i-rheumatoid arthritis, i-psoriatic arthritis, i-ankylosing spondylitis, okanye i-axial spondyloarthritis, ihlala inikwa iiveki ezimbini kwiidosi zokuqala ezintathu kwaye emva kweeveki ezi-2 okanye ezi-4 ukuba unyango luyaqhubeka. Xa isitofu se-certolizumab sisetyenziselwa ukunyanga i-plaque psoriasis, ihlala inikwa rhoqo kwiiveki ezi-2. Ukuba utofa inaliti ye-certolizumab ngokwakho, landela umkhombandlela kwileyibhile yakho kagqirha. Musa ukujova ngaphezulu okanye ngaphantsi kwe-certolizumab kunokuba umiselwe ngugqirha wakho.

Ukuba uyakujova isitofu se-certolizumab wedwa ekhaya okanye umhlobo okanye isalamane sikutofele iyeza, buza ugqirha wakho akubonise okanye umntu oza kutofa iyeza ukuba ungalitofa njani. Wena kunye nomntu oza kutofa iyeza kufuneka ufunde imiyalelo ebhaliweyo yokusetyenziswa okuza nonyango.

Phambi kokuba uvule iphakheji enamayeza akho, jonga ukuba uqiniseke ukuba iphakheji ayikrazulwanga, kwaye uphawu oluphazamisayo oluphezulu nolusezantsi kwephakheji alulahlekanga okanye lwaphukile kwaye umhla wokuphelelwa uprintwe kwiphakheji awuka udlulile. Emva kokuba uvule iphakheji, jonga kufutshane kulwelo olukusirinji. Umbane kufuneka ucace okanye ubutyheli obumbala kwaye akufuneki ubenamasuntswana amakhulu anemibala. Fowunela usokhemesti wakho, ukuba kukho naziphi na iingxaki kwiphakheji okanye kwisirinji. Musa ukutofa amayeza.

Unokufaka inaliti ye-certolizumab naphina esiswini okanye emathangeni ngaphandle kwenkaba yakho (iqhosha lesisu) kunye nendawo eyi-intshi ezi-2 ngeenxa zonke kuyo. Musa ukulifaka iyeza eluswini elithambileyo, elityumkileyo, elibomvu, okanye elilukhuni, okanye elinamanxeba okanye amanqaku olulekileyo. Musa ukujoba iyeza kwindawo enye ngaphezu kwesinye. Khetha indawo entsha ubuncinci i-intshi enye kude nendawo oyisebenzisileyo ngaphambi kokufaka iyeza. Ukuba ugqirha ukuxelele ukuba utofe iisirinji ezimbini ze-certolizumab yedosi nganye, khetha indawo eyahlukileyo yenaliti nganye.

Sukuphinda usebenzise iisirinji ezigcwaliswe ngaphambili kwaye ungaphindi iisirinji emva kokusetyenziswa. Lahla iisirinji ezisetyenzisiweyo kwisikhongozeli esinganyangekiyo. Buza usokhemesti wakho indlela yokulahla isikhongozeli.

Inaliti ye-Certolizumab inokunceda ukulawula iimpawu zakho, kodwa ayizukuyinyanga imeko yakho. Sukuyeka ukusebenzisa inaliti ye-certolizumab ngaphandle kokuthetha nogqirha wakho.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokusebenzisa inaliti ye-certolizumab,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabisa isitofu se-certolizumab; naliphi na elinye iyeza, i-latex okanye irabha, okanye nasiphi na isithako esiku-injection ye-certolizumab. Buza usokhemesti wakho okanye ujonge isikhokelo sonyango kuluhlu lwezithako. Ukuba uza kusebenzisa isirinji ekhethiweyo, xelela ugqirha wakho ukuba wena okanye umntu oza kufaka inaliti iyeza alikho kwi-latex.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ngokukhankanya amayeza adweliswe kwicandelo LESILUMKISO ESIBALULEKILEYO. Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga.
• xelela ugqirha wakho ukuba ukhe unesifo esichaphazela inkqubo yakho yeemvakalelo, njenge-multiple sclerosis (MS; isifo apho imithambo-luvo ingasebenzi kakuhle ibangela ubuthathaka, ukuba ndindisholo, ukuphulukana nokulungelelaniswa kwemisipha kunye neengxaki ngombono, intetho , kunye nolawulo lwesinyi) i-Guillain-Barré syndrome (ubuthathaka, ukurhawuzelela, kunye nokukhubazeka okunokwenzeka ngenxa yomonakalo we-nerve ngequbuliso) okanye i-optic neuritis (ukudumba kwemithambo-luvo othumela imiyalezo ukusuka esweni iye kwingqondo); Ukuba ndindisholo, ukutshisa, okanye ukubetha kulo naliphi na ilungu lomzimba wakho; ukuxhuzula; ukumelwa yintliziyo; naluphi na uhlobo lomhlaza; okanye iingxaki zokopha okanye izifo ezichaphazela igazi lakho.
• xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye uncancisa. Ukuba ukhulelwe ngelixa usebenzisa inaliti ye-certolizumab, tsalela ugqirha wakho.
• ukuba wenza utyando, kubandakanya utyando lwamazinyo, xelela ugqirha okanye ugqirha wamazinyo ukuba usebenzisa inaliti ye-certolizumab.
• awunalo ugonyo ngaphandle kokuthetha nogqirha wakho.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Faka isitofu esilahlekileyo ngokukhawuleza nje emva kokuba usikhumbule. Ukuba phantse lixesha ledosi yakho elandelayo, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yesiqhelo yedosi. Sukujoba idosi ephindwe kabini ukulungiselela eyilahlekileyo.

Inaliti ye-Certolizumab inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• ubomvu, ukurhawuzelela, iintlungu, okanye ukudumba kwindawo yenaliti
• intloko ebuhlungu
• umqolo obuhlungu

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko okanye ufumane uncedo lonyango olungxamisekileyo:

• ukudumba kobuso, umqala, ulwimi, imilebe, amehlo, izandla, iinyawo, amaqatha okanye imilenze esezantsi
• ukudinwa
• ukuqhawukelwa ngumphefumlo
• ubunzima bokuginya okanye ukuphefumla
• iintlungu zesifuba
• ukukhawuleza ukutyeba
• urhwebo
• kushushu
• isiyezi okanye isiqaqa
• irhashalala, ngakumbi ezidleleni okanye kwiingalo eziba mandundu elangeni
• ukugruzuka okanye ukopha okungaqhelekanga
• ulusu oluthuthu
• isikhumba esidumbileyo
• ukudinwa kakhulu
• ukuba ndindisholo okanye ukurhawuzelela
• iingxaki ngombono
• ubuthathaka kwiingalo okanye emilenzeni
• intlungu edibeneyo
• Ukuphelelwa ngumdla wokutya
• amabala abomvu anamaxolo kunye / okanye amaqhuma agcwalise ulusu kulusu

Abantu abadala abafumana inaliti ye-certolizumab banokubanakho ukukhula komhlaza wolusu, i-lymphoma, kunye nezinye iintlobo zomhlaza kunabantu abangayifumaniyo inaliti ye-certolizumab. Thetha nogqirha wakho malunga neengozi zokufumana eli yeza.

Inaliti ye-Certolizumab inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unayo nayiphi na ingxaki engaqhelekanga ngelixa usebenzisa eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina iibhotile kunye neesirinji ezifakiweyo kwibhokisi yokuqala engenayo ukuyikhusela ekukhanyeni nasekufikelelekeni kwabantwana. Gcina isitofu se-certolizumab kwifriji kwaye musa ukubanda.

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile zebhu ukujonga impendulo yomzimba wakho kwisitofu se-certolizumab.

Ngaphambi kokuba uvavanywe elebhu, xelela ugqirha wakho kunye nabasebenzi baselebhu ukuba usebenzisa inaliti ye-certolizumab.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

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