Inaliti yeRomidepsin

Umxholo

• Ngaphambi kokufumana inaliti ye-romidepsin,
• Inaliti yeRomidepsin inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana nayiphi na le mpawu, biza ugqirha wakho ngokukhawuleza:

Inaliti yeRomidepsin isetyenziselwa ukunyanga i-T-cell lymphoma (CTCL; iqela lomhlaza wamajoni omzimba aqala ukubonakala njengamaqhakuva esikhumba) kubantu abasele bephethwe ngamanye amayeza. Inaliti yeRomidepsin ikwasetyenziselwa ukunyanga i-peripheral T-cell lymphoma (PTCL; uhlobo lwe-non-Hodgkin's lymphoma) kubantu esele baphathwa ngamanye amayeza. Inaliti yeRomidepsin ikudidi lwamayeza abizwa ngokuba yi-histone deacetylase (HDAC) inhibitors. Isebenza ngokunciphisa ukukhula kweeseli zomhlaza.

Inaliti yeRomidepsin iza njengomgubo oxutywe nolwelo ukuze ifakwe ngaphakathi ngaphakathi (emthanjeni) ngaphezulu kweeyure ezi-4 ngugqirha okanye ngumongikazi. Ihlala inikwa ngeentsuku zoku-1, 8, kunye ne-15 zomjikelo weentsuku ezingama-28. Lo mjikelo unokuphindwaphindwa lo gama iyeza liqhubeka nokusebenza kwaye alibangeli ziphumo zibi.

Thetha nogqirha wakho malunga nayiphi na imiphumela emibi oyifumanayo ngexesha lonyango lwakho ngenaliti ye-romidepsin. Ukuba uneziphumo ebezingalindelekanga ezithile, ugqirha wakho angayeka unyango lwakho ngokusisigxina okanye okwexeshana kunye / okanye anciphise idosi yakho.

Buza usokhemesti okanye ugqirha wakho ngekopi yolwazi lomenzi wesigulana.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokufumana inaliti ye-romidepsin,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabana nenaliti ye-romidepsin, nawaphi na amanye amayeza, okanye naziphi na izithako kwi-injection ye-romidepsin. Buza usokhemesti wakho okanye ujonge ulwazi lwesigulana uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba yeyiphi na amayeza kagqirha kunye nalawo angabhaliswanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: ii-antibiotics ezithile ezifana ne-clarithromycin (Biaxin), erythromycin (EES, E-Mycin, Erythrocin), moxifloxacin (Avelox), kunye ne-telithromycin (Ketek); ii-anticoagulants (igazi elincinci) njenge-warfarin (Coumadin, Jantoven); ii-antifungals ezifana ne-itraconazole (Sporanox), ketoconazole (Nizoral), kunye ne-voriconazole (Vfend); i-cisapride (Propulsid) (ayifumaneki e-U.S.); dexamethasone; amayeza e-HIV (njenge-atazanavir (Reyataz), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (eKaletra, eNorvir), kunye ne-saquinavir (i-Invirase); amayeza okubetha kwentliziyo ngokungaqhelekanga njenge-amiodarone (Cordarone), i-disopyramide (i-Norpace), i-dofetilide (iTikosyn), i-procainamide (i-Procanbid, i-Pronestyl), i-quinidine (i-Quinidex), ne-sotalol (i-Betapace, i-Betapace AF); amayeza athile okubanjwa afana ne-carbamazepine (Epitol, Equetro, Tegretol), phenobarbital, kunye ne phenytoin (Dilantin); nefazodone; ipimozide (Orap); irifabutin (Mycobutin); irifampin (Rifadin, eRifamate, eRifater, eRimactane); irifapentine (Priftin); sparfloxacin (iZagam); okanye thioridazine (Mellaril). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga. Uninzi lwamanye amayeza anokuphinda asebenzisane nenaliti ye-romidepsin, ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
• xelela ugqirha wakho ukuba zeziphi iimveliso zemithi ozithathayo, ngakumbi iSt John's wort.
• xelela ugqirha wakho ukuba unesicaphucaphu, ukugabha, okanye urhudo ngaphambi kokuba uqale unyango lwakho ngenaliti ye-romidepsin. Xelela ugqirha wakho ukuba unayo okanye wakha wanethuba elide le-QT (ingxaki yentliziyo enqabileyo enokubangela ukubetha kwentliziyo ngokungaqhelekanga, ukubetha, okanye ukufa ngesiquphe), ukubetha kwentliziyo okungaqhelekanga okanye okukhawulezayo, kakhulu okanye potassium okanye imagnesium encinci egazini lakho. , i-hepatitis B (HBV; intsholongwane eyosulela isibindi kwaye inokubangela ukonakala kwesibindi okanye umhlaza wesibindi), Epstein Barr virus (EBV; intsholongwane ye-herpes ebangela isifo se-mononucleosis kwaye inxulunyaniswa nomhlaza othile), okanye isibindi, izintso, okanye isifo sentliziyo.
• xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye uncancisa. Ugqirha wakho unokujonga ukuba ukhulelwe ngaphambi kokuba uqale unyango lwakho. Kuya kufuneka usebenzise ulawulo lokuzalwa ukuthintela ukukhulelwa ngexesha lonyango lwakho ngenaliti ye-romidepsin kwaye ubuncinci kwinyanga enye emva kwethamo lakho lokugqibela. Nangona kunjalo, akufuneki usebenzise iihomoni (i-estrogen) zokucwangcisa (iipilisi zokulawula ukuzalwa, iipatches, iiringi, ukufakelwa, okanye inaliti) kuba inaliti ye-romidepsin inokumisa la mayeza ekusebenzeni njengoko kufanelekile. Ukuba uyindoda eneqabane lomfazi onokukhulelwa, qiniseka ukusebenzisa ulawulo lokuzalwa ngexesha lonyango lwakho ngenaliti ye-romidepsin kwaye ubuncinci kwinyanga enye emva kwethamo lakho lokugqibela. Thetha nogqirha wakho ngeendlela zolawulo lokuzalwa onokuzisebenzisa. Ukuba ukhulelwa ngelixa ufumana inaliti ye-romidepsin, tsalela ugqirha wakho. Inaliti yeRomidepsin inokwenzakalisa umntwana ongekazalwa. Akufanele uncancise ngexesha lonyango lwakho ngenaliti ye-romidepsin kwaye ubuncinci iveki enye emva kwedosi yakho yokugqibela.
• ukuba wenza utyando, kubandakanya utyando lwamazinyo, xelela ugqirha okanye ugqirha wamazinyo ukuba ufumana inaliti ye-romidepsin.

Qiniseka ukuba usele amanzi amaninzi ubuncinci iintsuku ezi-3 kulandela idosi nganye yenaliti ye-romidepsin.

Thetha nogqirha wakho malunga nokutya igrapefruit kunye nokusela ijusi yamagilebhisi ngelixa ufumana lamayeza.

Inaliti yeRomidepsin inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• isicaphucaphu
• ukugabha
• urhudo
• ukuqhina
• isisu esibuhlungu
• izilonda zomlomo
• intloko ebuhlungu
• Utshintsho lwengcamango
• Ukuphelelwa ngumdla wokutya
• ukurhawuzelela

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana nayiphi na le mpawu, biza ugqirha wakho ngokukhawuleza:

• ukudinwa okanye ubuthathaka
• ulusu oluthuthu
• ukuqhawukelwa ngumphefumlo
• iintlungu zesifuba
• ukubetha kwentliziyo ngokungaqhelekanga
• uziva unesiyezi okanye ufe isiqaqa
• ukugruzuka okulula okanye ukopha
• umkhuhlane, ukukhwehlela, iimpawu ezinjengomkhuhlane, iintlungu zemisipha, ukutshisa xa uchama, ukwanda kweengxaki zolusu, kunye neminye imiqondiso yosulelo (inokwenzeka ukuya kwiintsuku ezingama-30 emva konyango lwakho)
• irhashalala
• ukudumba okanye ukuxobuka kolusu
• ukudumba kwezandla, iinyawo, amaqatha okanye imilenze esezantsi

Inaliti yeRomidepsin inokubangela iingxaki zokuzala. Thetha nogqirha wakho malunga nemingcipheko yokufumana eli yeza ukuba ungathanda ukuba nabantwana.

Inaliti yeRomidepsin inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unayo nayiphi na ingxaki engaqhelekanga ngelixa ufumana eliyeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile zebhu ukujonga impendulo yomzimba wakho kwinaliti ye-romidepsin.

Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nenaliti ye-romidepsin.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

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