I-Telaprevir

Umxholo

• Ngaphambi kokuba uthathe i-telaprevir,
• I-Telaprevir inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye nayiphi na kwezi zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:
• Iimpawu libanda kungaquka oku kulandelayo:

UTelaprevir akasafumaneki e-United States emva ko-Oktobha 16, 2014. Ukuba ngoku uthatha i-telaprevir, kuya kufuneka ubize ugqirha wakho ukuba axoxe ngokutshintshela kolunye unyango.

I-Telaprevir inokubangela ulusu okanye ulusu olusongela ubomi. Biza ugqirha wakho ngoko nangoko okanye ufune unyango olungxamisekileyo ukuba unazo naziphi na kwezi mpawu zilandelayo: irhashalala, iblister, okanye izilonda kulusu; ukurhawuzelela; ifiva; ukudumba kobuso; izilonda emlonyeni; okanye abomvu, adumbile, arhawuzele, okanye amehlo aneenyembezi. Ugqirha wakho angakuxelela ukuba uyeke ukuthatha i-telaprevir (kwaye mhlawumbi namanye amayeza) ukuba unolusu olutshintshayo; sukuyeka ukuthatha amayeza akho ngaphandle kokuba ugqirha ukuxelele ukuba wenze njalo. Ukuba ugqirha ukuxelela ukuba uyeke ukuthatha i-telaprevir ngenxa yotshintsho lolusu, akufuneki uphinde uyithathe.

I-Telaprevir isetyenziswa kunye namanye amayeza amabini (i-ribavirin [i-Copegus, i-Rebetol] kunye ne-peginterferon alfa [Pegasys]) ukunyanga i-hepatitis C engapheliyo (usulelo lwentsholongwane oluqhubekayo olonakalisa isibindi) kubantu abangekanyangwa le meko okanye imeko ayinakuphathwa ngempumelelo nge-ribavirin kunye ne-peginterferon alfa yodwa. UTelaprevir ukwiklasi yamayeza abizwa ngokuba zii-protease inhibitors. Isebenza ngokunciphisa inani le-virus ye-hepatitis C (HCV) emzimbeni. I-Telaprevir ayinako ukuthintela ukusasazeka kwe-hepatitis C kwabanye abantu.

I-Telaprevir iza njengecwecwe lokuthatha ngomlomo. Ihlala ithathwa amaxesha amabini ngosuku (zonke iiyure ezili-10 ukuya kwezili-14). Kufuneka utye isidlo okanye into yokutya equlathe malunga neegram ezingama-20 zamafutha kwisithuba semizuzu engama-30 phambi kokuba uthathe i-telaprevir. Imizekelo yokutya (iinguqulelo eziqhelekileyo, hayi ii-fat-fat or nonfat products) ezinokuthathwa nge-telaprevir zibandakanya: i-bagel eneshizi yekrimu, i-1/2 yekomityi yamantongomane, iipuni ezi-3 zebhotolo yamandongomane, 1 ikomityi ye-ayisi khilimu, ii-ounces ezi-2 zaseMelika okanye i-cheddar ushizi, ii-ounces ii-chips, okanye i-1/2 yekomityi yokuxuba. Buza ugqirha wakho ngeminye imizekelo yokutya okuqulethe iigram ezingama-20 zamafutha onokuwatya xa uthatha i-telaprevir. Musa ukuthatha i-telaprevir ngaphandle kokutya. Thatha i-telaprevir ngamaxesha afanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-telaprevir ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ginya iipilisi ngokupheleleyo; sukubahlulahlula, ubatyumze, okanye ubahlafune. Ukuba awukwazi ukuginya iipilisi zizonke, xelela ugqirha wakho.

Qhubeka nokuthatha i-telaprevir nokuba uziva uphilile. I-Telaprevir kufuneka ithathwe ngokudibanisa ne-peginterferon alfa kunye ne-ribavirin, ihlala iiveki ezili-12. I-Peginterferon alfa kunye ne-ribavirin zihlala ziqhubeka emva kokuba unyango lwe-telaprevir lugqityiwe. Ungayeki ukuthatha i-telaprevir, i-peginterferon alfa, okanye i-ribavirin, ngaphandle kokuba uxelelwe ngugqirha ukuba wenze njalo.

Ugqirha wakho okanye usokhemesti uya kukunika uxwebhu lolwazi lwesigulana lomenzi (Isikhokelo seyeza) xa uqala unyango nge-telaprevir kwaye ngalo lonke ixesha ugcwalisa amayeza akho. Funda ulwazi ngononophelo kwaye ubuze ugqirha okanye usokhemesti ukuba unayo nayiphi na imibuzo. Ungandwendwela noLawulo lwezoKutya noLawulo lweziyobisi (FDA) iwebhusayithi (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) okanye iwebhusayithi yomenzi ukufumana isiKhokelo seMithi.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-telaprevir,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabisa i-telaprevir, i-ribavirin (i-Copegus, i-Rebetol), i-peginterferon alfa (i-Pegasys), nawaphi na amanye amayeza, okanye ezinye izithako ezikwiipilisi ze-telaprevir. Buza usokhemesti wakho okanye ujonge isiKhokelo seyeza ukuze ufumane uluhlu lwezithako.
• xelela ugqirha wakho ukuba uthatha nawaphi na amayeza alandelayo okanye iimveliso zamayeza: alfuzosin (Uroxatral); icarbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Teril); i-cisapride (Propulsid) (engasekhoyo e-United States); amayeza e-ergot anje nge-dihydroergotamine (i-DHE 45, iMigranal), i-ergotamine (i-Ergomar, eCafergot, eMigergot), i-ergonovine, kunye ne-methylergonovine (Methergine); i-lovastatin (Altoprev, Mevacor, kwiGqwetha); i-midazolam ethathwe ngomlomo; phenobarbital, phenytoin (Dilantin, Phenytek); ipimozide (Orap); irifampin (Rifadin, Rimactane, eRifamate, eRifater); sildenafil (kuphela uphawu lweRevatio olusetyenziselwa isifo semiphunga); isimvastatin (iZocor, eSimcor, eVytorin); I-wort yaseSt. i-triazolam (iHalcion); kunye ne-tadalafil (kuphela i-Adcirca brand esetyenziselwa isifo semiphunga). Ugqirha wakho uya kukuxelela ukuba ungathathi i-telaprevir ukuba uthatha elinye okanye ngaphezulu kula mayeza.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo nolungabhaliswanga, iivithamini, kunye nezongezelelo zesondlo ozithathayo okanye oceba ukuzithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: alprazolam (Niravam, Xanax); ii-anticoagulants (’izinciphisi zegazi’) ezifana ne-warfarin (Coumadin, Jantoven); amayeza okubola afana ne-itraconazole (Onmel, Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), okanye voriconazole (Vfend); i-bosentan (iTracleer); budesonide (Pulmicort, Rhinocort, kwiSymbicort); iicalcium block blockers ezinje ngeamlodipine (Norvasc, eAmturnide, eTekamlo), diltiazem (Cardizem, Cartia XT, Dilacor, Diltzac, Dilt-CD, Tiazac, Taztia XT, abanye), felodipine (Plendil), nicardipine (Cardene), nifedipine (Afeditab CR, Adalat, Procardia), nisoldipine (Sular), kunye neverapamil (Calan, Covera, Verelan, eTarka); amayeza athile athoba i-cholesterol anje nge-atorvastatin (Lipitor, eCaduet, eLiptruzet), fluvastatin (Lescol), pitavastatin (Livalo), pravastatin (Pravachol), kunye ne rosuvastatin (Crestor); i-clarithromycin (i-Biaxin, kwi-Prevpac); colchicine (Colcrys, kwi-Col-probenecid); idigoxin (Lanoxin); efavirenz (Sustiva, eAtripla); erythromycin (EES, E-Mycin, abanye); I-escitalopram (iLexapro); fentanyl (Abstral, Actiq, Duragesic, Fentora, Lazanda, Subsys); i-fluticasone (eAdvair, Flonase, Flovent); Unyango lwehomoni (HRT); ii-immunosuppressants ezinje ngecyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), okanye tacrolimus (Prograf); amayeza e-erectile dysfunction (ED) njenge-sildenafil (Viagra), tadalafil (Cialis), okanye vardenafil (Levitra, Staxyn); amayeza okubetha kwentliziyo ngokungaqhelekanga njenge-amiodarone (Cordarone, Pacerone), flecainide, lidocaine (Lidoderm, Lidopen, Xylocaine), propafenone (Rhythmol), okanye i-quinidine; imethadone (iDolophine, iMethadose); Inaliti ye-midazolam; izinto zokucwangcisa ngomlomo (’iipilisi zoqingqo-nzala); i-steroids yomlomo efana ne-dexamethasone, i-methylprednisolone (iDepo-Medrol, iMedrol, iSolu-Medrol), kunye ne-prednisone (iRayos); repaglinide (Prandin, kwi Prandimet); irifabutin (Mycobutin); i-ritonavir (i-Norvir, e-Kaletra) isetyenziswa ngokudibeneyo nezinye i-HIV protease inhibitors ezinje nge atazanavir (Reyataz), darunavir (Prezista), fosamprenavir (Lexiva), kunye ne lopinavir (e Kaletra); isalmeterol (iSerevent, eAdvair); telithromycin (Ketek); i-tenofovir (iViread, eAtripla, eStrild, eTruvada); Itrazodone (Oleptro); kunye ne-zolpidem (Ambien, Edluar, Intermezzo, Zolpmist). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga. Amanye amayeza amaninzi anokusebenzisana ne-telaprevir, ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
• xelela ugqirha wakho ukuba ubufakelwe ilungu elithile. Xelela ugqirha wakho ukuba unayo okanye wakhe wanayo i-anemia (ayonelanga iiseli ezibomvu zegazi egazini ukuhambisa ioksijini kuwo wonke umzimba), igawuthi (ukuhlaselwa kwentlungu edibeneyo ebangelwa ngamanqanaba aphezulu e-uric acid egazini), intsholongwane kaGawulayo (i-HIV), iingxaki kumasosha akho omzimba, i-hepatitis B (HBV) okanye isifo sesibindi ngaphandle kwe-hepatitis C ..
• ukuba wenza utyando, kubandakanya utyando lwamazinyo, xelela ugqirha wakho okanye ugqirha wamazinyo ukuba uthatha i-telaprevir.
• xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye unokukhulelwa. Ukuba uyindoda, xelela ugqirha wakho ukuba iqabane lakho likhulelwe, liceba ukukhulelwa, okanye kunokwenzeka ukuba ukhulelwe. I-Telaprevir kufuneka ithathwe nge-ribavirin, enokwenzakalisa umntwana ongekazalwa. Kuya kufuneka usebenzise iindlela ezimbini zolawulo lokuzalwa ukukhusela ukukhulelwa kuwe okanye kwiqabane lakho ngexesha lonyango kunye nala mayeza kunye neenyanga ezi-6 emva konyango lwakho. Thetha nogqirha wakho malunga neendlela onokuzisebenzisa; izinto zokucwangcisa zehomoni (iipilisi zolawulo lokuzalwa, iziqwengana, izinto zokufakelwa, imisesane, okanye inaliti) ayinakusebenza kakuhle kubafazi abathatha la mayeza ukuya kuthi ga kwiiveki ezi-2 emva konyango. Wena okanye iqabane lakho kufuneka nivavanyelwe ukukhulelwa inyanga nenyanga ngexesha lonyango kunye neenyanga ezi-6 emva konyango. Ukuba wena okanye iqabane lakho ukhulelwe ngelixa uthatha la mayeza, biza ugqirha ngokukhawuleza.
• xelela ugqirha wakho ukuba uncelisa.

Lumka ngakumbi ukuba usele ulwelo ngokwaneleyo ngexesha lonyango lwakho neli yeza.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Ukuba ukhumbula idosi ephosiweyo kwisithuba seeyure ezingama-6 zexesha owawucwangciselwe ukulithatha, thatha idosi ephosiweyo ngesinekhi okanye isidlo (esiqulathe malunga neegram ezingama-20 zamafutha) ngoko nangoko. Nangona kunjalo, ukuba ngaphezulu kweeyure ezingama-6 okoko uthathe idosi, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yesiqhelo yedosi. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

I-Telaprevir inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• isicaphucaphu
• ukugabha
• urhudo
• utshintsho kwisakhono sokungcamla
• ukurhawuzelela
• Iimpawu
• ukungakhululeki, ukutshisa, okanye ukurhawuzelela ujikeleze umva

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye nayiphi na kwezi zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:

• ulusu oluthuthu
• isiyezi
• ukuqhawukelwa ngumphefumlo
• ukudinwa
• ubuthathaka
• ukwanda kokoma
• umchamo omnyama ngombala
• umlomo owomileyo
• Ukuncipha kokuchama rhoqo okanye isixa
• Unobunzima bokutya okanye ugabha kakhulu okanye urhudo.

I-Telaprevir inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Iimpawu libanda kungaquka oku kulandelayo:

• isicaphucaphu
• urhudo
• ukugabha
• intloko ebuhlungu
• Ukuphelelwa ngumdla wokutya
• utshintsho kwincasa

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile zelebhu ukujonga impendulo yomzimba wakho kwi-telaprevir.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Incivek^®