Axitinib

Umxholo

• Ngaphambi kokuthatha i-axitinib,
• I-Axitinib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana enye yezi mpawu, biza ugqirha ngokukhawuleza okanye ufumane uncedo lonyango olungxamisekileyo:
• Iimpawu libanda kungaquka oku kulandelayo:

I-Axitinib isetyenziswa yodwa ukunyanga i-renal cell carcinoma (RCC, uhlobo lomhlaza oluqala kwiiseli zezintso) kubantu abangakhange banyangwe ngempumelelo ngamanye amayeza. I-Axitinib isetyenziswa ngokudibanisa ne-avelumab (Bavencio) okanye i-pembrolizumab (Keytruda) ukunyanga i-renal cell carcinoma. I-Axitinib ikudidi lwamayeza abizwa ngokuba yi-kinase inhibitors. Isebenza ngokuthintela isenzo seprotein engaqhelekanga ebonisa iiseli zomhlaza ukuba zande. Oku kunceda ukucothisa okanye ukunqanda ukusasazeka kweeseli zomhlaza.

I-Axitinib iza njengecwecwe lokuthatha ngomlomo. Ihlala ithathwa kunye okanye ngaphandle kokutya amaxesha amabini ngemini. Thatha i-axitinib malunga namaxesha afanayo yonke imihla, malunga neeyure ezili-12 ukwahlukana. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-axitinib ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ginya iipilisi ngokupheleleyo ngeglasi yamanzi; ungahluleli, ungahlaleli, okanye uzityumze.

Ukuba uhlanza emva kokuthatha i-axitinib, ungathathi elinye idosi. Qhubeka neshedyuli yakho yesiqhelo.

Ugqirha wakho unokukuqala ngedosi esezantsi ye-axitinib kwaye ngokuthe ngcembe wandise idosi yakho, hayi ngaphezulu kwesinye kwiiveki ezi-2. Oku kuxhomekeke ekubeni lisebenza kanjani na iyeza kunye naziphi na iziphumo ebezingalindelekanga onokuzifumana. Thetha nogqirha wakho malunga nendlela oziva ngayo ngexesha lonyango lwakho. Qhubeka uthathe i-axitinib nokuba uziva uphilile. Sukuyeka ukuthatha i-axitinib ungakhange uthethe nogqirha wakho.

Buza usokhemesti okanye ugqirha wakho ngekopi yolwazi lomenzi wesigulana.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuthatha i-axitinib,

• xelela ugqirha wakho kunye nosokhemisti ukuba ngaba uxabisa i-axitinib, nawaphi na amanye amayeza, okanye naziphi na izithako kwiipilisi ze-axitinib. Buza usokhemesti wakho uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo nolungabhaliswanga, iivithamini, kunye nezongezelelo zesondlo ozithathayo okanye oceba ukuzithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: bosentan (Tracleer); carbamazepine (Carbatrol, Epitol, Tegretol); i-clarithromycin (i-Biaxin, kwi-Prevpac); itraconazole (Sporanox); ketoconazole (Nizoral); amayeza okunyanga i-HIV / AID kubandakanya i-atazanavir (Reyataz), i-efavirenz (Sustiva, e-Atripla), etravirine (Intelence), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir), kunye ne-saquinavir (Invirase); imodafinil (Provigil); nafcillin; nefazodone; phenobarbital; phenytoin (iDilantin, iPhenytek); irifabutin (Mycobutin); irifampin (Rifamate, Rifater); irifapentine (Priftin); amayeza e-steroid afana ne-dexamethasone (i-Decadron); telithromycin (Ketek); kunye ne-voriconazole (Vfend). Amanye amayeza amaninzi anokusebenzisana ne-axitinib, ke qiniseka ukuxelela ugqirha wakho malunga nawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
• xelela ugqirha wakho ukuba zeziphi iimveliso zamayeza ozithathayo, ngakumbi iSt John's wort.
• xelela ugqirha wakho ukuba unenxeba elingapholiyo, okanye ukuba ukhe wanengxaki yokopha; amahlwili egazi; igazi elonyukayo; isifo sentliziyo; isifo seswekile; amanqanaba aphezulu e-cholesterol; ukopha esiswini okanye emathunjini; umhlaza wobuchopho; i-pulmonary embolism (yegazi emiphungeni yakho); ukubetha okanye i-ministroke (TIA); okanye intliziyo; isibindi; okanye isifo se-thyroid.
• xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye ukuba ucwangcisa ukuba notata umntwana. Ukuba ungumfazi, kuya kufuneka uthathe uvavanyo lokukhulelwa ngaphambi kokuqala unyango kwaye usebenzise ulawulo lokuzalwa ukuthintela ukukhulelwa ngexesha lonyango lwakho kunye neveki e-1 emva kwedosi yakho yokugqibela. Ukuba uyindoda, wena kunye neqabane lakho labasetyhini kufuneka nisebenzise ulawulo lokuzalwa ngexesha lonyango kunye nakwiveki e-1 emva kwethamo lakho lokugqibela. Thetha nogqirha wakho malunga neendlela zokulawula ukuzalwa eziza kukusebenzela. Ukuba wena okanye iqabane lakho ukhulelwe ngelixa uthatha i-axitinib, biza ugqirha wakho. I-Axitinib inokwenzakalisa umntwana ongekazalwa.
• xelela ugqirha wakho ukuba uncelisa. Akufanele uncelise ngexesha lonyango lwakho kunye ne-axitinib kunye neeveki ezi-2 emva kwedosi yakho yokugqibela.
• Kuya kufuneka uyazi ukuba eli yeza linciphisa ukuchuma emadodeni nakwabasetyhini. Thetha nogqirha wakho malunga nemingcipheko yokuthatha i-axitinib.
• ukuba wenza utyando, kubandakanya utyando lwamazinyo, xelela ugqirha okanye ugqirha wamazinyo ukuba uthatha i-axitinib. Ugqirha wakho uya kukuxelela ukuba uyeke ukuthatha i-axitinib ubuncinci iintsuku ezi-2 ngaphambi kotyando lwakho kwaye xa kuya kukhuseleka ukuba uqale ukuthatha i-axitinib kwakhona emva kotyando lwakho.

Musa ukuyitya i-grapefruit okanye usele ijusi yeziqhamo ngelixa uthatha eli yeza.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Ukuba uphosa idosi ye-axitinib, tsiba idosi kwaye uthathe idosi yakho elandelayo ngexesha eliqhelekileyo. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

I-Axitinib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• urhudo
• ukunciphisa ukutya okanye ukukwazi ukungcamla izinto
• ukuhla ukusinda
• isicaphucaphu
• ukugabha
• ukuqhina
• ukudinwa
• ubuthathaka
• utshintsho kwisandi selizwi lakho
• ububomvu, iintlungu, ukuba ndindisholo, ukurhawuzelela, okanye ukurhawuzelela okanye ukuxobuka kolusu ezandleni nasezinyaweni
• ukukhohlela
• intlungu edibeneyo okanye yemisipha
• izilonda zomlomo
• isisu esibuhlungu
• intliziyo iyatshisa
• intloko ebuhlungu
• isiyezi
• irhashalala
• ukurhawuzelela
• isikhumba esomileyo
• uziva ushushu okanye uyabanda
• ulusu oluthuthu
• ukubetha kwentliziyo okukhawulezayo
• ukulahleka kweenwele
• kukhala ezindlebeni
• unxano
• Iimpawu
• inxeba okanye ukusika okungazukuphola

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana enye yezi mpawu, biza ugqirha ngokukhawuleza okanye ufumane uncedo lonyango olungxamisekileyo:

• iintlungu ezinzima zesisu
• ukuqhawukelwa ngumphefumlo
• ukudumba ezandleni okanye iinyawo
• ukopha okungaqhelekanga okanye ukugruzuka
• izitulo ezimnyama kunye nokulinda
• Igazi elibomvu ilindle
• ukugabha okunegazi
• ukugabha okubonakala ngathi yindawo yekofu
• iintlungu esifubeni okanye uxinzelelo
• iintlungu ezingalweni, emqolo, entanyeni, okanye emhlathini
• ukudumba, ukuthamba, ukufudumala, okanye ubomvu bomlenze
• ukuphazamiseka ngesiquphe okanye ubuthathaka bobuso, ingalo, okanye umlenze (ngakumbi kwelinye icala lomzimba)
• ukudideka ngesiquphe, ingxaki yokuthetha okanye ukuqonda
• inkathazo yequbuliso ukubona kwiliso elinye okanye omabini
• ukuhamba ngesiquphe ingxaki, isiyezi, ukuphulukana nokulingana okanye ukulungelelanisa
• intloko ebukhali ngesiquphe kungekho sizathu saziwayo
• ukuxhuzula
• ukulahleka kombono

I-Axitinib inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Iimpawu libanda kungaquka oku kulandelayo:

• isiyezi
• ukuxhuzula
• ukhohlela igazi

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile zebhu ukujonga impendulo yomzimba wakho kwi-axitinib. Ugqirha wakho uya kujonga uxinzelelo lwegazi rhoqo ngexesha lonyango lwakho nge-axitinib.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Inlyta^®