Crizotinib

Umxholo

• Ngaphambi kokuba uthathe i-crizotinib,
• ICrizotinib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu, biza ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:

I-Crizotinib isetyenziselwa ukunyanga iintlobo ezithile zomhlaza wesifo semiphunga esincinci (i-NSCLC) ethe yasasazeka kwizicwili ezikufutshane okanye kwamanye amalungu omzimba. Isetyenziselwa ukunyanga uhlobo oluthile lwe-anaplastic large cell lymphoma (ALCL) ebuyileyo okanye engaphenduliyo kolunye unyango kubantu abadala nakubantwana abaneminyaka eli-1 nangaphezulu. I-Crizotinib ikwiklasi yamayeza abizwa ngokuba yi-kinase inhibitors. Isebenza ngokuthintela isenzo sento ethile yendalo enokubakho enokufuneka ukunceda iiseli zomhlaza zande.

ICrizotinib iza njengephilisi emayithathwe ngomlomo. Ihlala ithathwa kunye okanye ngaphandle kokutya kabini ngemini. Thatha i-crizotinib ngeenxa zonke ngamaxesha afanayo yonke imihla. Landela umkhombandlela kwileyibhile yakho yonyango ngononophelo kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-crizotinib ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ginya zonke iifomsile; ungahluleli, ungahlaleli, okanye uzityumze. Musa ukuchukumisa iicapsule ezaphukileyo okanye ezaphukileyo.

Ugqirha wakho unokumisa okwethutyana okanye ngokusisigxina unyango lwakho, unciphise idosi, okanye akuxelele uthathe amayeza akho rhoqo xa uneziphumo ebezingalindelekanga ze-crizotinib. Xelela ugqirha wakho indlela oziva ngayo ngexesha lonyango lwakho.

Qhubeka uthathe i-crizotinib nokuba uziva uphilile. Ungayeki ukuthatha i-crizotinib ngaphandle kokuthetha nogqirha wakho.

Buza usokhemesti okanye ugqirha wakho ngekopi yolwazi lomenzi wesigulana.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-crizotinib,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabisa i-crizotinib, nawaphi na amanye amayeza, okanye naziphi na izithako kwiifomsisi ze-crizotinib Buza usokhemesti wakho okanye ujonge ulwazi lomenzi wesigulana uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba yeyiphi na amayeza kagqirha kunye nalawo angabhalwanga, iivithamini, kunye nezongezelelo zesondlo ozithathayo okanye oceba ukuzithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: amiodarone (Cordarone, Pacerone); ii-antibiotics ezithile ezifana ne-clarithromycin (Biaxin); amayeza athile okubola anje nge-itraconaozole (Sporanox), ketoconazole (Nizoral), kunye ne-voriconazole (Vfend); amayeza athile oxinzelelo lwegazi; chloroquine (Aralen); chlorpromazine (Thorazine); ikitalopram (uCelexa); icyclosporine (Gengraf, Neoral, Sandimmune); idigoxin (Lanoxin); dihydroergotamine (DHE 45, Migranal); iDisopyramide (iNorpace); dofetilide (iTikosyn); idroperol (Inapsine); ergotamine (Ergomar, eCafergot, eMigergot); i-erythromycin (i-EES, i-Erythrocin); fentanyl (Abstral, Actiq, Fentora, Lazanda, Onsolis); i-flecainide (iTambocor); amayeza athile kwintsholongwane kaGawulayo (i-HIV) efana ne-atazanavir (Reyataz), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, e-Kaletra), kunye ne-saquinavir (i-Invirase); amayeza athile okubanjwa afana ne-carbamazepine (Carbatrol, Equetro, Tegretol), phenobarbital, kunye ne phenytoin (Dilantin); mesoridazine (Serentil); imethadone (iDolophine); moxifloxacin (Avelox); nefazodone; ipentamidine (NebuPent, Pentam); ipimozide (Orap); ipropainamide (Pronestyl); quinidine (kwiNuedexta); rifabutin (Mycobutin), rifampin (Rimactane, Rifadin, eRifater); i-sirolimus (iRapamune); isotalol (iBetapace); itacrolimus (Prograf); telithromycin (Ketek); thioridazine (Mellaril); kunye ne-vandetanib (Caprelsa). Uninzi lwamanye amayeza anokusebenzisana ne-crizotinib, ke qiniseka ukuba uxelele ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu. Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga.
• xelela ugqirha wakho ukuba zeziphi iimveliso zemithi ozithathayo, ngakumbi iSt John's wort.
• xelela ugqirha wakho ukuba unaso okanye wakha waba ne-QT syndrome (ingxaki enqabileyo yentliziyo enokubangela ukubetha kwentliziyo ngokungaqhelekanga, ukuphelelwa ngamandla, okanye ukufa ngesiquphe), ukubetha kwentliziyo kancinci, ukusilela kwentliziyo, iingxaki zombono, iingxaki zemiphunga ngaphandle komhlaza wemiphunga okanye isifo sezintso.
• xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye uncancisa. Uya kufuneka ube novavanyo lokukhulelwa ngaphambi kokuba uqale unyango nge-crizotinib. Ukuba ungowasetyhini, kuya kufuneka usebenzise ulawulo lokuzalwa ngexesha lonyango lwakho kunye neentsuku ezingama-45 emva kwedosi yakho yokugqibela. Ukuba uyindoda, wena neqabane lakho labasetyhini nifanele nisebenzise ulawulo lokuzalwa ngexesha lonyango kunye nakwiintsuku ezingama-90 emva kwedosi yenu yokugqibela. Thetha nogqirha wakho malunga nendlela yolawulo lokuzalwa omele uyisebenzise. Ukuba ukhulelwa ngelixa uthatha i-crizotinib, biza ugqirha wakho ngokukhawuleza. ICrizotinib inokwenzakalisa umntwana ongekazalwa.
• xelela ugqirha wakho ukuba uncelisa. Musa ukuncancisa ngexesha lonyango lwakho kunye neentsuku ezingama-45 emva kwedosi yakho yokugqibela.
• Kuya kufuneka uyazi ukuba eli yeza linciphisa ukuchuma emadodeni nakwabasetyhini. Thetha nogqirha wakho malunga neengozi zokuthatha i-crizotinib.
• ukuba utyando, kubandakanya utyando lwamazinyo, xelela ugqirha okanye ugqirha wamazinyo ukuba uthatha i-crizotinib.
• Kuya kufuneka uyazi ukuba i-crizotinib inokubangela iingxaki kumbono, isiyezi kunye nokudinwa okugqithisileyo. Musa ukuqhuba imoto okanye usebenzise oomatshini de ube uyazi indlela elikuchaphazela ngayo eli yeza.

Musa ukuyitya i-grapefruit okanye usele ijusi yeziqhamo ngelixa uthatha eli yeza.

Thatha idosi ephosiweyo ngokukhawuleza nje ukuba uyikhumbule. Nangona kunjalo, ukuba kungaphantsi kweeyure ezingama-6 ngaphambi kokuba ucwangciselwe ukuthatha idosi yakho elandelayo, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yesiqhelo. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

ICrizotinib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• urhudo
• ukuqhina
• isisu esibuhlungu
• izilonda emlonyeni
• utshintsho kwisakhono sokungcamla ukutya
• isilungulela
• intloko ebuhlungu
• ukuba ndindisholo, ukutshisa, okanye ukubetha ezandleni okanye ezinyaweni
• ubunzima bokulala okanye ukulala

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu, biza ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:

• ukuqhawukelwa ngumphefumlo
• ukukhohlela
• ifiva
• ukudumba kweengalo, izandla, iinyawo, amaqatha okanye imilenze esezantsi
• iintlungu zesifuba
• ukubetha kwentliziyo kancinci
• irhashalala
• ubuthathaka
• ukudinwa kakhulu
• iintlungu kwindawo ephezulu yesisu
• isicaphucaphu
• ukugabha
• kunzima ukugwinya
• mthubi ulusu okanye amehlo
• umchamo omnyama
• ukurhawuzelela
• ifiva
• ukopha okungaqhelekanga okanye ukugruzuka
• umbono ophindwe kabini okanye ongacacanga
• utshintsho kumbono
• uvakalelo ekukhanyeni
• Ukubona ukukhanya ngokukhawuleza
• ukubona ii-float ezintsha okanye ezandisiweyo (amabala kumbono wakho)

ICrizotinib inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya ku-odola uvavanyo lwelebhu ngaphambi kokuba uqale unyango lwakho ukuze ubone ukuba umhlaza wakho unganyangwa nge-crizotinib kwaye uya kuyala novavanyo oluthile lwelebhu ngexesha lonyango lwakho ukujonga impendulo yomzimba wakho kwi-crizotinib. Ugqirha wakho uya kujonga ukubetha kwentliziyo yakho kunye noxinzelelo lwegazi rhoqo ngexesha lonyango lwakho.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Xalkori^®